Abstract
Castleman hastalığı, lenfoproliferatif hastalıkların heterojen bir grubu olup tek bir hastalık olarak düşünülmemelidir. Bu hastalık çeşitli klinik şekillerde ortaya çıkmaktadır. Üç histolojik çesidi olan hastalığın etyopatogenezinde IL-6, HİV ve HHV- 8 yer almaktadır. Bu hastalığı anlamada önemli yollar kat etmiş ve tedavi tecrübelerimiz rituximab, tokilizumab ve siltuximab gibi ilaçlarla artmış olsa da, halen etyolojisi, prognozu ve tedavisi hakkında cevapsız sorular bulunmaktadır. Aşağıdaki olgumuzda, meduller tiroid kanser tanısı ile takipte olan hasta boyunda kitle nedeni ile tarafımıza başvurmuş, boyun diseksiyonu sonrası patoloji sonucu castleman hastalığı olarak rapor edilmiştir.
Keywords
References
- Castleman B, Iversonl L, Menendez VP, et al. Localized Mediastinal Lymph Node Hyperplasia Resembling Thymoma. Cancer 1956; 9: 822-30.
- Gaba AR, Stein RS, Sweet DL, et al. Multicentric Giant Lymph Node Hyperplasia. Am J ClinPathol 1978; 69: 86-90.
- D.D. Weisenburger, B.N. Nathwani, C.D. Winberg, H. Rappaport. Multicentric Angiofollicular Lymph Node Hyperplasia: A Clinic Pathologic Study Of 16 Cases. Hum Pathol 1985; 16: 162–72
- A.C. Chan, K.W. Chan, J.K. Chan, W.Y. Au, W.K. Ho, W.M. Ng. Development of Follicular Dendritic Cell Sarcoma In Hyaline-Vascular Castleman Disease Of The Nasopharynx: Tracing Its Evolution By Sequential Biopsies. Histopathology 2001; 38: 510–8
- A. Gonzalez Garcia, M.A. Moreno Cobo, J.L. Patier de la Pena. Current Diagnosis And Treatment Of Castleman Disease. Rev Clin Esp 2016; 216: 146-56.
- Keller A. R., Hochholzer L., Castleman B. Hyaline Vascular and Plasma Cell Types Of Giant Lymph Node Hyperplasia Of The Mediastinum And Other Locations. Cancer 1972; 29: 670–83.
- Temirbekov D., Yazici Z. M., Ergelen R., Turgut H., Kayhan F. T. Castelman Disease Of The Parotid Gland: An Unusual Entity. Otolaryngologia Pol 2014; 68: 208–11.
- G. M. Chronowski, C. S. Ha, R. B. Wilder, F. Cabanillas, J. Manning, and J. D. Cox. Treatment Of Unicentric And Multicentric Castleman Disease And the Role Of Radiotherapy. Cancer 2001; 92: 670-76.
- B. Reece, R Ord, and J. Papadimitriou. Rare Presentation of Unicentric Castleman Disease In The Parotid Gland. Journal of Oral And Maxillofacial Surgery 2012; 70: 2114-7
- A. Dispenzieri: Castleman Disease, In: A. Dispenzieri, Stephen M. Ansell (Eds): Rare Hematological Malignancies. 2008:293–330
- A. Kumar, K. Aggarwal, H. Agrawal, S. Sharma, P.K Garg. Unicentric Castleman Disease: An Unusual Cause of An Isolated Neck Mass. Malays J Med Sci 2016; 23: 86–9.
Abstract
Castleman disease is a heterogeneous group of non clonal lymphoproliferative disorders, so it should not be considered as a single disease. This disease has a wide spectrum of clinical expressions. Three histological types have been reported. IL-6, HIV and HHV-8 are involved in the etiopathogenesis of Castleman disease. Despite recent significant advances in our understanding of this disease and the increasing therapeutic experience with rituximab, tocilizumab and siltuximab, there are still difficult questions concerning its etiology, prognosis and optimal treatment. In this paper, follow up patient with medullary thyroid cancer was admitted because of mass in the neck and neck dissection was performed, pathology result was reported as Castleman disease.
Keywords
References
- Castleman B, Iversonl L, Menendez VP, et al. Localized Mediastinal Lymph Node Hyperplasia Resembling Thymoma. Cancer 1956; 9: 822-30.
- Gaba AR, Stein RS, Sweet DL, et al. Multicentric Giant Lymph Node Hyperplasia. Am J ClinPathol 1978; 69: 86-90.
- D.D. Weisenburger, B.N. Nathwani, C.D. Winberg, H. Rappaport. Multicentric Angiofollicular Lymph Node Hyperplasia: A Clinic Pathologic Study Of 16 Cases. Hum Pathol 1985; 16: 162–72
- A.C. Chan, K.W. Chan, J.K. Chan, W.Y. Au, W.K. Ho, W.M. Ng. Development of Follicular Dendritic Cell Sarcoma In Hyaline-Vascular Castleman Disease Of The Nasopharynx: Tracing Its Evolution By Sequential Biopsies. Histopathology 2001; 38: 510–8
- A. Gonzalez Garcia, M.A. Moreno Cobo, J.L. Patier de la Pena. Current Diagnosis And Treatment Of Castleman Disease. Rev Clin Esp 2016; 216: 146-56.
- Keller A. R., Hochholzer L., Castleman B. Hyaline Vascular and Plasma Cell Types Of Giant Lymph Node Hyperplasia Of The Mediastinum And Other Locations. Cancer 1972; 29: 670–83.
- Temirbekov D., Yazici Z. M., Ergelen R., Turgut H., Kayhan F. T. Castelman Disease Of The Parotid Gland: An Unusual Entity. Otolaryngologia Pol 2014; 68: 208–11.
- G. M. Chronowski, C. S. Ha, R. B. Wilder, F. Cabanillas, J. Manning, and J. D. Cox. Treatment Of Unicentric And Multicentric Castleman Disease And the Role Of Radiotherapy. Cancer 2001; 92: 670-76.
- B. Reece, R Ord, and J. Papadimitriou. Rare Presentation of Unicentric Castleman Disease In The Parotid Gland. Journal of Oral And Maxillofacial Surgery 2012; 70: 2114-7
- A. Dispenzieri: Castleman Disease, In: A. Dispenzieri, Stephen M. Ansell (Eds): Rare Hematological Malignancies. 2008:293–330
- A. Kumar, K. Aggarwal, H. Agrawal, S. Sharma, P.K Garg. Unicentric Castleman Disease: An Unusual Cause of An Isolated Neck Mass. Malays J Med Sci 2016; 23: 86–9.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Case Report |
| Authors | |
| Publication Date | August 31, 2020 |
| Submission Date | October 22, 201 |
| Published in Issue | Year 2020 Volume: 9 Issue: 2 |
