Research Article
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Year 2021, Volume: 15 Issue: 3, 207 - 215, 31.12.2021

Abstract

References

  • Shakiba A. The role of the cerebellum in neurobiology of psychiatric disorders. Neurol Clin 2014;32:1105–15.
  • Standring S. Gray’s anatomy: the anatomical basis of clinical practice. 41th ed. London: Churchill Livingstone Elsevier; 2016. p. 331–50.
  • Baumann O, Mattingley JB. Functional topography of primary emotion processing in the human cerebellum. Neuroimage 2012;61: 805–11.
  • Kansal K, Yang Z, Fishman AM, Sair HI, Ying SH, Jedynak BM, Prince JL, Onyike CU. Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration. Brain 2017;140: 707–20.
  • Stoodley CJ, Schmahmann JD. Functional topography of the human cerebellum. Handb Clin Neurol 2018;154:59–70.
  • Depping MS, Wolf ND, Vasic N, Sambataro F, Hirjak D, Thomann PA, Wolf RC. Abnormal cerebellar volume in acute and remitted major depression. Prog Neuropsychopharmacol Biol Psychiatry 2016;71:97–102.
  • Schmahmann JD. The cerebellum and cognition. Neurosci Lett 2019;688:62–75.
  • American Psychiatric Association. Diagnostic and Statistical manual of mental disorders. 4th ed. Washington DC: American Psychiatric Press;2000. p. 429–85.
  • Lai CH. Gray matter volume in major depressive disorder: a meta-analysis of voxel-based morphometry studies. Psychiatry Res 2013; 211:37–46.
  • Peng W, Chen Z, Yin L, Jia Z, Gong Q. Essential brain structural alterations in major depressive disorder: a voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord 2016;15: 114–23.
  • Escalona PR, Early B, McDonald WM, Doraiswamy PM, Shah SA, Husain MM, Boyko OB, Figiel GS, Ellinwood EH, Nemeroff CB, Krishnan KRR. Reduction of cerebellar volume in major depression: a controlled MRI study. Depression 1993;1:156–8.
  • Depping MS, Nolte HM, Hirjak D, Palm E, Hofer S, Stieltjes B, Maier-Hein K, Sambataro F, Wolf RC, Thomann PA. Cerebellar volume change in response to electroconvulsive therapy in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2017;73:31–5.
  • Bogoian HR, King TZ, Turner JA, Semmel ES, Dotson VM. Linking depressive symptom dimensions to cerebellar subregion volumes in later life. Transl Psychiatry 2020;10:201.
  • Manjón JV, Coupé P. VolBrain: an online MRI brain volumetry system. Front Neuroinform 2016;10:1–14.
  • Romero JE, Coupé P, Giraud R, Ta VT, Fonov V, Park MTM, Mallar Chakravarty M, Voineskos AN, Manjón JV. CERES: a new cerebellum lobule segmentation method. Neuroimage 2017;147: 916–24.
  • Yılmaz S, Tokpinar A, Acer N, Degirmencioglu L, Ates S, Bastepe Gray S. Evaluation of cerebellar volume in adult Turkish male individuals: comparison of three methods in magnetic resonance imaging. Erciyes Medical Journal 2020;42:405–11.
  • Butcher JN, Taylor J, Cynthia Fekken G. Objective personality assessment with adults. Comprehensive Clinical Psychology 1998;4: 418.
  • Merino-Munoz P, Perez-Contreras J, Aedo-Munoz E. The percentage change and differences in sport: a practical easy tool to calculate. Sport Performance & Science Reports 2020;118:446–50.
  • Baldaçara L, Borgio JGF, Moraes, dos Santos Moraes WA, Lacerda ALT, Montaño MBMM, Jackowski AP. Cerebellar volume in patients with dementia. Braz J Psychiatry 2011;33: 122–9.
  • Laidi C, d’Albis MA, Wessa M, Linke J, Phillips ML, Delavest M, Bellivier F, Versace A, Almeida J, Sarrazin S, Poupon C, Le Dual K, Daban C, Hamdani N, Leboyer M, Houenou J. Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features. Acta Psychiatr Scand 2015;131:223–33.
  • Sahin C, Avnioglu S, Ozen O, Candan B. Analysis of cerebellum with magnetic resonance 3D T1 sequence in individuals with chronic subjective tinnitus. Acta Neurol Belg 2020;121:1641–7.
  • Özen Ö, Aslan F. Morphometric evaluation of cerebellar structures in late monocular blindness. Int Ophthalmol 2021;41:769–76
  • Czéh B, Michaelis T, Watanabe T, Frahm J, De Biurrun G, van Kampen M, Bartolomucci A, Fuchs E. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 2001;98:12796–801.
  • Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression. Nat Med 2001;7:541–7.
  • Diamond A. Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex. Child Dev 2000;71:44–56.
  • Schmahmann JD, Weilburg JB, Sherman JC. The neuropsychiatry of the cerebellum – insights from the clinic. Cerebellum 2007;6:254– 67.
  • Escalona PR, McDonald WM, Doraiswamy PM, Boyko OB, Husain MM, Figiel GS, Laskowitz D, Ellinwood Jr DE, Krishnan KR. In vivo stereological assessment of human cerebellar volume: effects of gender and age. AJNR Am J Neuroradiol 1991;12:927–9.
  • Filipek PA, Richelme C, Kennedy DN, Caviness Jr VS. The young adult human brain: an MRI-based morphometric analysis. Cereb Cortex 1994;4:344–60.
  • Rhyu IJ, Cho TH, Lee NJ, Uhm CS, Kim H, Suh YS. Magnetic resonance image-based cerebellar volumetry in healthy Korean adults. Neurosci Lett 1999;270:149–52.
  • Raz N, Gunning-Dixon F, Head D, Williamson A, Acker JD. Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adults. AJNR Am J Neuroradiol 2001;22: 1161–7.
  • Kim NY, Lee SC, Shin JC, Park JE, Kim YW. Voxel-based lesion symptom mapping analysis of depressive mood in patients with isolated cerebellar stroke: a pilot study. Neuroimage Clin 2017;13:39– 45.

Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method

Year 2021, Volume: 15 Issue: 3, 207 - 215, 31.12.2021

Abstract

Objectives: Besides the well-known sensorimotor control function, the cerebellum is also associated with cognitive functions and mood via the cerebral-cerebellar circuit. This study aimed to investigate possible cerebellar morphometric changes in untreated patients with depression.
Methods: Brain magnetic resonance (MR) images of 40 adults (age: 18–50 years), including 20 untreated depression patients and 20 healthy controls were analysed prospectively. Intracranial cavity and total cerebellar volumes were measured by using VolBrain. The cerebellum segmentation was performed with CERES to obtain the total gray matter volumes and cortical thickness of the lobules.
Results: Total cerebellar volume was 141.27±13.12 cm3 in the depressed group and 142.63±8.01 cm3 in the control group (p>0.05). The difference between males and females in the depressed group was not statistically significant (p>0.05). Total cerebellar volume was approximately 11% of total intracranial volume in both groups. The cortical thickness of lobule V (right-total), lobule VIIIB (right), and lobule IX (right) was smaller in the depressed group, independent of sex (p<0.05). Lobule V, VIIIB and IX volume was smaller and Crus-I cortical thickness was increased in depressed females (p<0.05).
Conclusion: The cerebellar volume and cortical thickness of cerebellar lobules in patients with depression show significant differences compared to healthy subjects.

References

  • Shakiba A. The role of the cerebellum in neurobiology of psychiatric disorders. Neurol Clin 2014;32:1105–15.
  • Standring S. Gray’s anatomy: the anatomical basis of clinical practice. 41th ed. London: Churchill Livingstone Elsevier; 2016. p. 331–50.
  • Baumann O, Mattingley JB. Functional topography of primary emotion processing in the human cerebellum. Neuroimage 2012;61: 805–11.
  • Kansal K, Yang Z, Fishman AM, Sair HI, Ying SH, Jedynak BM, Prince JL, Onyike CU. Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration. Brain 2017;140: 707–20.
  • Stoodley CJ, Schmahmann JD. Functional topography of the human cerebellum. Handb Clin Neurol 2018;154:59–70.
  • Depping MS, Wolf ND, Vasic N, Sambataro F, Hirjak D, Thomann PA, Wolf RC. Abnormal cerebellar volume in acute and remitted major depression. Prog Neuropsychopharmacol Biol Psychiatry 2016;71:97–102.
  • Schmahmann JD. The cerebellum and cognition. Neurosci Lett 2019;688:62–75.
  • American Psychiatric Association. Diagnostic and Statistical manual of mental disorders. 4th ed. Washington DC: American Psychiatric Press;2000. p. 429–85.
  • Lai CH. Gray matter volume in major depressive disorder: a meta-analysis of voxel-based morphometry studies. Psychiatry Res 2013; 211:37–46.
  • Peng W, Chen Z, Yin L, Jia Z, Gong Q. Essential brain structural alterations in major depressive disorder: a voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord 2016;15: 114–23.
  • Escalona PR, Early B, McDonald WM, Doraiswamy PM, Shah SA, Husain MM, Boyko OB, Figiel GS, Ellinwood EH, Nemeroff CB, Krishnan KRR. Reduction of cerebellar volume in major depression: a controlled MRI study. Depression 1993;1:156–8.
  • Depping MS, Nolte HM, Hirjak D, Palm E, Hofer S, Stieltjes B, Maier-Hein K, Sambataro F, Wolf RC, Thomann PA. Cerebellar volume change in response to electroconvulsive therapy in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2017;73:31–5.
  • Bogoian HR, King TZ, Turner JA, Semmel ES, Dotson VM. Linking depressive symptom dimensions to cerebellar subregion volumes in later life. Transl Psychiatry 2020;10:201.
  • Manjón JV, Coupé P. VolBrain: an online MRI brain volumetry system. Front Neuroinform 2016;10:1–14.
  • Romero JE, Coupé P, Giraud R, Ta VT, Fonov V, Park MTM, Mallar Chakravarty M, Voineskos AN, Manjón JV. CERES: a new cerebellum lobule segmentation method. Neuroimage 2017;147: 916–24.
  • Yılmaz S, Tokpinar A, Acer N, Degirmencioglu L, Ates S, Bastepe Gray S. Evaluation of cerebellar volume in adult Turkish male individuals: comparison of three methods in magnetic resonance imaging. Erciyes Medical Journal 2020;42:405–11.
  • Butcher JN, Taylor J, Cynthia Fekken G. Objective personality assessment with adults. Comprehensive Clinical Psychology 1998;4: 418.
  • Merino-Munoz P, Perez-Contreras J, Aedo-Munoz E. The percentage change and differences in sport: a practical easy tool to calculate. Sport Performance & Science Reports 2020;118:446–50.
  • Baldaçara L, Borgio JGF, Moraes, dos Santos Moraes WA, Lacerda ALT, Montaño MBMM, Jackowski AP. Cerebellar volume in patients with dementia. Braz J Psychiatry 2011;33: 122–9.
  • Laidi C, d’Albis MA, Wessa M, Linke J, Phillips ML, Delavest M, Bellivier F, Versace A, Almeida J, Sarrazin S, Poupon C, Le Dual K, Daban C, Hamdani N, Leboyer M, Houenou J. Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features. Acta Psychiatr Scand 2015;131:223–33.
  • Sahin C, Avnioglu S, Ozen O, Candan B. Analysis of cerebellum with magnetic resonance 3D T1 sequence in individuals with chronic subjective tinnitus. Acta Neurol Belg 2020;121:1641–7.
  • Özen Ö, Aslan F. Morphometric evaluation of cerebellar structures in late monocular blindness. Int Ophthalmol 2021;41:769–76
  • Czéh B, Michaelis T, Watanabe T, Frahm J, De Biurrun G, van Kampen M, Bartolomucci A, Fuchs E. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 2001;98:12796–801.
  • Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression. Nat Med 2001;7:541–7.
  • Diamond A. Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex. Child Dev 2000;71:44–56.
  • Schmahmann JD, Weilburg JB, Sherman JC. The neuropsychiatry of the cerebellum – insights from the clinic. Cerebellum 2007;6:254– 67.
  • Escalona PR, McDonald WM, Doraiswamy PM, Boyko OB, Husain MM, Figiel GS, Laskowitz D, Ellinwood Jr DE, Krishnan KR. In vivo stereological assessment of human cerebellar volume: effects of gender and age. AJNR Am J Neuroradiol 1991;12:927–9.
  • Filipek PA, Richelme C, Kennedy DN, Caviness Jr VS. The young adult human brain: an MRI-based morphometric analysis. Cereb Cortex 1994;4:344–60.
  • Rhyu IJ, Cho TH, Lee NJ, Uhm CS, Kim H, Suh YS. Magnetic resonance image-based cerebellar volumetry in healthy Korean adults. Neurosci Lett 1999;270:149–52.
  • Raz N, Gunning-Dixon F, Head D, Williamson A, Acker JD. Age and sex differences in the cerebellum and the ventral pons: a prospective MR study of healthy adults. AJNR Am J Neuroradiol 2001;22: 1161–7.
  • Kim NY, Lee SC, Shin JC, Park JE, Kim YW. Voxel-based lesion symptom mapping analysis of depressive mood in patients with isolated cerebellar stroke: a pilot study. Neuroimage Clin 2017;13:39– 45.
There are 31 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Güzin Özmen

Duygu Akın Saygın This is me 0000-0003-4260-9263

İsmihan İlknur Uysal This is me 0000-0003-2939-9767

Seral Özşen This is me 0000-0001-5332-8665

Yahya Paksoy This is me 0000-0003-4505-2288

Özkan Güler This is me 0000-0002-7775-3962

Publication Date December 31, 2021
Published in Issue Year 2021 Volume: 15 Issue: 3

Cite

APA Özmen, G., Akın Saygın, D., Uysal, İ. İ., Özşen, S., et al. (2021). Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method. Anatomy, 15(3), 207-215.
AMA Özmen G, Akın Saygın D, Uysal İİ, Özşen S, Paksoy Y, Güler Ö. Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method. Anatomy. December 2021;15(3):207-215.
Chicago Özmen, Güzin, Duygu Akın Saygın, İsmihan İlknur Uysal, Seral Özşen, Yahya Paksoy, and Özkan Güler. “Quantitative Evaluation of the Cerebellum in Patients With Depression and Healthy Adults by VolBrain Method”. Anatomy 15, no. 3 (December 2021): 207-15.
EndNote Özmen G, Akın Saygın D, Uysal İİ, Özşen S, Paksoy Y, Güler Ö (December 1, 2021) Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method. Anatomy 15 3 207–215.
IEEE G. Özmen, D. Akın Saygın, İ. İ. Uysal, S. Özşen, Y. Paksoy, and Ö. Güler, “Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method”, Anatomy, vol. 15, no. 3, pp. 207–215, 2021.
ISNAD Özmen, Güzin et al. “Quantitative Evaluation of the Cerebellum in Patients With Depression and Healthy Adults by VolBrain Method”. Anatomy 15/3 (December 2021), 207-215.
JAMA Özmen G, Akın Saygın D, Uysal İİ, Özşen S, Paksoy Y, Güler Ö. Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method. Anatomy. 2021;15:207–215.
MLA Özmen, Güzin et al. “Quantitative Evaluation of the Cerebellum in Patients With Depression and Healthy Adults by VolBrain Method”. Anatomy, vol. 15, no. 3, 2021, pp. 207-15.
Vancouver Özmen G, Akın Saygın D, Uysal İİ, Özşen S, Paksoy Y, Güler Ö. Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method. Anatomy. 2021;15(3):207-15.

Anatomy is the official journal of Turkish Society of Anatomy and Clinical Anatomy (TSACA).