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Secondary and Iatrogenic Effects of Prolotherapy

Year 2023, Volume: 4 Issue: 4, 34 - 44, 15.12.2023
https://doi.org/10.53445/batd.1287712

Abstract

Prolotherapy is a regenerative treatment application that aims to initiate the local inflammatory healing process by injecting biological substances. Some side effects observed due to the application of prolotherapy, which has recently found widespread use for the treatment of many diseases, are found in the literature. In this review, considerations, side effects and contraindications related to prolotherapy application are presented by considering literature search. Pubmed and Cochrane databases were scanned using the words "prolotherapy, side effects, adverse, contraindication " and articles published between 1960 and 2023 were examined. In general, prolotherapy is similar to other injection methods in terms of side effect profile and contraindications, however, it is predicted that the experience of the person performing the application and the use of a guiding imaging method in the application will help to reduce these side effects.

References

  • Alderman, D. (2007). Prolotherapy for low back pain. Practical Pain Management, 7(4), 58-63.
  • Arias-Vázquez, P. I., Tovilla-Zárate, C. A., Castillo-Avila, R. G., Legorreta-Ramírez, B. G., López-Narváez, M. L., Arcila-Novelo, R., & González-Castro, T. B. (2022). Hypertonic Dextrose Prolotherapy, an Alternative to Intra-Articular Injections With Hyaluronic Acid in the Treatment of Knee Osteoarthritis: Systematic Review and Meta-analysis. Am J Phys Med Rehabil, 101(9), 816-825. doi: 10.1097/phm.0000000000001918
  • Bertrand, H., Reeves, K. D., Bennett, C. J., Bicknell, S., & Cheng, A. L. (2016). Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Arch Phys Med Rehabil, 97(1), 17-25. doi: 10.1016/j.apmr.2015.08.412
  • Catapano, M., Zhang, K., Mittal, N., Sangha, H., Onishi, K., & de Sa, D. (2020). Effectiveness of Dextrose Prolotherapy for Rotator Cuff Tendinopathy: A Systematic Review. Pm r, 12(3), 288-300. doi: 10.1002/pmrj.12268
  • Çakmak, S. (2017). Kas-iskelet sistemi hastalıklarında proloterapi. Totbid Dergisi, 16, 282-286.
  • Dagenais, S., Caro, J., & Haldeman, S. (2008). A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J, 8(1), 8-20. doi: 10.1016/j.spinee.2007.10.005
  • Dagenais, S., Ogunseitan, O., Haldeman, S., Wooley, J. R., Zaldivar, F., & Kim, R. C. (2006). Acute toxicity pilot evaluation of proliferol in rats and swine. Int J Toxicol, 25(3), 171-181. doi: 10.1080/10915810600683218
  • Dagenais, S., Yelland, M. J., Del Mar, C., & Schoene, M. L. (2007). Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev, 2007(2), Cd004059. doi: 10.1002/14651858.CD004059.pub3
  • Eroğlu, A., Aylin, S., & Durmuş, B. (2016). Platelet-rich plasma vs prolotherapy in the management of knee osteoarthritis: randomized placebo-controlled trial. Spor Hekimliği Dergisi, 51(2), 034-043.
  • Farpour, H. R., & Fereydooni, F. (2017). Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial. Electron Physician, 9(11), 5663-5669. doi: 10.19082/5663
  • Geukens, J., Rabe, E., & Bieber, T. (1999). Embolia cutis medicamentosa of the foot after sclerotherapy. Eur J Dermatol, 9(2), 132-133.
  • Hakala, R. V. (2005). Prolotherapy (proliferation therapy) in the treatment of TMD. CRANIO®, 23(4), 283-288.
  • Hakala, R. V., & Ledermann, K. M. (2010). The use of prolotherapy for temporomandibular joint dysfunction. J Prolotherapy, 2(3), 439-446.
  • Hauser, R. A., & Sprague, I. S. (2014). Outcomes of prolotherapy in chondromalacia patella patients: improvements in pain level and function. Clin Med Insights Arthritis Musculoskelet Disord, 7, 13-20. doi: 10.4137/cmamd.s13098
  • Hosseini, B., Taheri, M., Pourroustaei Ardekani, R., Moradi, S., & Kazempour Mofrad, M. (2019). Periarticular hypertonic dextrose vs intraarticular hyaluronic acid injections: a comparison of two minimally invasive techniques in the treatment of symptomatic knee osteoarthritis. Open Access Rheumatology: Research and Reviews, 269-274.
  • Humphries, D. (2013). Embolia cutis medicamentosa after polidocanol injection of neovessels in Achilles tendinosis. Gd Rounds, 13, 12-16.
  • Hung, C. Y., Hsiao, M. Y., Chang, K. V., Han, D. S., & Wang, T. G. (2016). Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis. J Pain Res, 9, 847-857. doi: 10.2147/jpr.s118669
  • Jensen, K. T., Rabago, D. P., Best, T. M., Patterson, J. J., & Vanderby, R., Jr. (2008). Early inflammatory response of knee ligaments to prolotherapy in a rat model. J Orthop Res, 26(6), 816-823. doi: 10.1002/jor.20600
  • Keplinger, J. E., & Bucy, P. C. (1960). Paraplegia from treatment with sclerosing agents. Report of a case. Jama, 173, 1333-1335. doi: 10.1001/jama.1960.03020300045014
  • Kim, W. M., Lee, H. G., Jeong, C. W., Kim, C. M., & Yoon, M. H. (2010). A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain. J Altern Complement Med, 16(12), 1285-1290. doi: 10.1089/acm.2010.0031
  • Maxwell, N. J., Ryan, M. B., Taunton, J. E., Gillies, J. H., & Wong, A. D. (2007). Sonographically guided intratendinous injection of hyperosmolar dextrose to treat chronic tendinosis of the Achilles tendon: a pilot study. AJR Am J Roentgenol, 189(4), W215-220. doi: 10.2214/ajr.06.1158
  • Mustafa, R., Güngörmüs, M., & Mollaoglu, N. (2018). Evaluation of the efficacy of different concentrations of dextrose prolotherapy in temporomandibular joint hypermobility treatment. Journal of Craniofacial Surgery, 29(5), e461-e465.
  • Ohberg, L., & Alfredson, H. (2002). Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med, 36(3), 173-175; discussion 176-177. doi: 10.1136/bjsm.36.3.173
  • Ongley, M., Dorman, T., Klein, R., Eek, B., & Hubert, L. (1987). A new approach to the treatment of chronic low back pain. The Lancet, 330(8551), 143-146.
  • Örsçelik, A., & Solmaz, İ. (2023). Popüler Bir Tamamlayici Tip Tedavisi: Proloterapİ. SDÜ Tıp Fakültesi Dergisi, 30(1), 135-142.
  • Özcan, E., & Sert, A. T. (2016). Kas iskelet ağrısı tedavisinde proloterapinin kanıta dayalı kullanımı. Turkish Journal of Physical Medicine & Rehabilitation/Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 62(2).
  • Pishgahi, A., Abolhasan, R., Shakouri, S. K., Soltani-Zangbar, M. S., Dareshiri, S., Ranjbar Kiyakalayeh, S., . . . Yousefi, M. (2020). Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial. Iran J Allergy Asthma Immunol, 19(3), 243-252. doi: 10.18502/ijaai.v19i3.3452
  • Rabago, D., Mundt, M., Zgierska, A., & Grettie, J. (2015). Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes. Complementary therapies in medicine, 23(3), 388-395.
  • Rabago, D., & Nourani, B. (2017). Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review. Curr Rheumatol Rep, 19(6), 34. doi: 10.1007/s11926-017-0659-3
  • Rabago, D., Patterson, J. J., Mundt, M., Kijowski, R., Grettie, J., Segal, N. A., & Zgierska, A. (2013). Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. The Annals of Family Medicine, 11(3), 229-237.
  • Rabago, D., Slattengren, A., & Zgierska, A. (2010). Prolotherapy in primary care practice. Prim Care, 37(1), 65-80. doi: 10.1016/j.pop.2009.09.013
  • Rahimzadeh, P., Imani, F., Faiz, S. H. R., Entezary, S. R., Nasiri, A. A., & Ziaeefard, M. (2014). Investigation the efficacy of intra-articular prolotherapy with erythropoietin and dextrose and intra-articular pulsed radiofrequency on pain level reduction and range of motion improvement in primary osteoarthritis of knee. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19(8), 696.
  • Reeves, K. D., & Hassanein, K. (2000). Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med, 6(2), 68-74, 77-80.
  • Scarpone, M., Rabago, D. P., Zgierska, A., Arbogast, G., & Snell, E. (2008). The efficacy of prolotherapy for lateral epicondylosis: a pilot study. Clin J Sport Med, 18(3), 248-254. doi: 10.1097/JSM.0b013e318170fc87
  • Schneider, R. C., Williams, J. J., & Liss, L. (1959). Fatality after injection of sclerosing agent to precipitate fibro-osseous proliferation. J Am Med Assoc, 170(15), 1768-1772. doi: 10.1001/jama.1959.03010150012003
  • Solmaz, İ., Akpancar, S., Örsçelik, A., Yener-Karasimav, Ö., & Gül, D. (2019). Dextrose injections for failed back surgery syndrome: a consecutive case series. Eur Spine J, 28(7), 1610-1617. doi: 10.1007/s00586-019-06011-3
  • Vijayendranath Nayak, S., Gunasheela, S., Karthik, M., & Hegde, A. (2020). Healing by Inflammation-Prolotherapy. Case Rep Dent Sci, 1(1), 9-14.
  • Waldman, S. D. (2011). Pain management E-book: Elsevier Health Sciences.
  • Waluyo, Y., Artika, S. R., Insani Nanda, W., Gunawan, A., & Zainal, A. T. F. (2023). Efficacy of Prolotherapy for Osteoarthritis: A Systematic Review. J Rehabil Med, 55, jrm00372. doi: 10.2340/jrm.v55.2572
  • Yelland, M. J., Glasziou, P. P., Bogduk, N., Schluter, P. J., & McKernon, M. (2004). Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized trial. Spine (Phila Pa 1976), 29(1), 9-16; discussion 16. doi: 10.1097/01.brs.0000105529.07222.5b
  • Zhu, M., Rabago, D., Chung, V. C., Reeves, K. D., Wong, S. Y., & Sit, R. W. (2022). Effects of Hypertonic Dextrose Injection (Prolotherapy) in Lateral Elbow Tendinosis: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil, 103(11), 2209-2218. doi: 10.1016/j.apmr.2022.01.166

Proloterapinin Sekonder ve İyatrojenik Etkileri

Year 2023, Volume: 4 Issue: 4, 34 - 44, 15.12.2023
https://doi.org/10.53445/batd.1287712

Abstract

Proloterapi, biyolojik maddelerin enjekte edilerek lokal inflamatuar iyileşme sürecini başlatmayı hedefleyen rejeneratif bir tedavi uygulamasıdır. Son zamanlarda birçok hastalığın tedavisine yönelik yaygın kullanım alanı bulan proloterapi uygulamasına bağlı gözlemlenen bazı yan etkiler literatürde sunulmuştur. Bu derlememizde proloterapi uygulaması ile ilişkili uygulamada dikkat edilmesi gereken hususlar, yan etkiler ve kontrendikasyon durumları genel olarak incelenmiştir. Genel olarak proloterapi, yan etki profili ve kontrendikasyonlar açısından diğer enjeksiyon yöntemleri ile benzerlik göstermekte, ancak, uygulamayı yapan kişinin tecrübesi ve uygulamada rehber bir görüntüleme yöntemi kullanılmasının yan etkilerin azalmasına yardımcı olacağı öngörülmektedir

References

  • Alderman, D. (2007). Prolotherapy for low back pain. Practical Pain Management, 7(4), 58-63.
  • Arias-Vázquez, P. I., Tovilla-Zárate, C. A., Castillo-Avila, R. G., Legorreta-Ramírez, B. G., López-Narváez, M. L., Arcila-Novelo, R., & González-Castro, T. B. (2022). Hypertonic Dextrose Prolotherapy, an Alternative to Intra-Articular Injections With Hyaluronic Acid in the Treatment of Knee Osteoarthritis: Systematic Review and Meta-analysis. Am J Phys Med Rehabil, 101(9), 816-825. doi: 10.1097/phm.0000000000001918
  • Bertrand, H., Reeves, K. D., Bennett, C. J., Bicknell, S., & Cheng, A. L. (2016). Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Arch Phys Med Rehabil, 97(1), 17-25. doi: 10.1016/j.apmr.2015.08.412
  • Catapano, M., Zhang, K., Mittal, N., Sangha, H., Onishi, K., & de Sa, D. (2020). Effectiveness of Dextrose Prolotherapy for Rotator Cuff Tendinopathy: A Systematic Review. Pm r, 12(3), 288-300. doi: 10.1002/pmrj.12268
  • Çakmak, S. (2017). Kas-iskelet sistemi hastalıklarında proloterapi. Totbid Dergisi, 16, 282-286.
  • Dagenais, S., Caro, J., & Haldeman, S. (2008). A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J, 8(1), 8-20. doi: 10.1016/j.spinee.2007.10.005
  • Dagenais, S., Ogunseitan, O., Haldeman, S., Wooley, J. R., Zaldivar, F., & Kim, R. C. (2006). Acute toxicity pilot evaluation of proliferol in rats and swine. Int J Toxicol, 25(3), 171-181. doi: 10.1080/10915810600683218
  • Dagenais, S., Yelland, M. J., Del Mar, C., & Schoene, M. L. (2007). Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev, 2007(2), Cd004059. doi: 10.1002/14651858.CD004059.pub3
  • Eroğlu, A., Aylin, S., & Durmuş, B. (2016). Platelet-rich plasma vs prolotherapy in the management of knee osteoarthritis: randomized placebo-controlled trial. Spor Hekimliği Dergisi, 51(2), 034-043.
  • Farpour, H. R., & Fereydooni, F. (2017). Comparative effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis: A randomized clinical trial. Electron Physician, 9(11), 5663-5669. doi: 10.19082/5663
  • Geukens, J., Rabe, E., & Bieber, T. (1999). Embolia cutis medicamentosa of the foot after sclerotherapy. Eur J Dermatol, 9(2), 132-133.
  • Hakala, R. V. (2005). Prolotherapy (proliferation therapy) in the treatment of TMD. CRANIO®, 23(4), 283-288.
  • Hakala, R. V., & Ledermann, K. M. (2010). The use of prolotherapy for temporomandibular joint dysfunction. J Prolotherapy, 2(3), 439-446.
  • Hauser, R. A., & Sprague, I. S. (2014). Outcomes of prolotherapy in chondromalacia patella patients: improvements in pain level and function. Clin Med Insights Arthritis Musculoskelet Disord, 7, 13-20. doi: 10.4137/cmamd.s13098
  • Hosseini, B., Taheri, M., Pourroustaei Ardekani, R., Moradi, S., & Kazempour Mofrad, M. (2019). Periarticular hypertonic dextrose vs intraarticular hyaluronic acid injections: a comparison of two minimally invasive techniques in the treatment of symptomatic knee osteoarthritis. Open Access Rheumatology: Research and Reviews, 269-274.
  • Humphries, D. (2013). Embolia cutis medicamentosa after polidocanol injection of neovessels in Achilles tendinosis. Gd Rounds, 13, 12-16.
  • Hung, C. Y., Hsiao, M. Y., Chang, K. V., Han, D. S., & Wang, T. G. (2016). Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis. J Pain Res, 9, 847-857. doi: 10.2147/jpr.s118669
  • Jensen, K. T., Rabago, D. P., Best, T. M., Patterson, J. J., & Vanderby, R., Jr. (2008). Early inflammatory response of knee ligaments to prolotherapy in a rat model. J Orthop Res, 26(6), 816-823. doi: 10.1002/jor.20600
  • Keplinger, J. E., & Bucy, P. C. (1960). Paraplegia from treatment with sclerosing agents. Report of a case. Jama, 173, 1333-1335. doi: 10.1001/jama.1960.03020300045014
  • Kim, W. M., Lee, H. G., Jeong, C. W., Kim, C. M., & Yoon, M. H. (2010). A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain. J Altern Complement Med, 16(12), 1285-1290. doi: 10.1089/acm.2010.0031
  • Maxwell, N. J., Ryan, M. B., Taunton, J. E., Gillies, J. H., & Wong, A. D. (2007). Sonographically guided intratendinous injection of hyperosmolar dextrose to treat chronic tendinosis of the Achilles tendon: a pilot study. AJR Am J Roentgenol, 189(4), W215-220. doi: 10.2214/ajr.06.1158
  • Mustafa, R., Güngörmüs, M., & Mollaoglu, N. (2018). Evaluation of the efficacy of different concentrations of dextrose prolotherapy in temporomandibular joint hypermobility treatment. Journal of Craniofacial Surgery, 29(5), e461-e465.
  • Ohberg, L., & Alfredson, H. (2002). Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med, 36(3), 173-175; discussion 176-177. doi: 10.1136/bjsm.36.3.173
  • Ongley, M., Dorman, T., Klein, R., Eek, B., & Hubert, L. (1987). A new approach to the treatment of chronic low back pain. The Lancet, 330(8551), 143-146.
  • Örsçelik, A., & Solmaz, İ. (2023). Popüler Bir Tamamlayici Tip Tedavisi: Proloterapİ. SDÜ Tıp Fakültesi Dergisi, 30(1), 135-142.
  • Özcan, E., & Sert, A. T. (2016). Kas iskelet ağrısı tedavisinde proloterapinin kanıta dayalı kullanımı. Turkish Journal of Physical Medicine & Rehabilitation/Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 62(2).
  • Pishgahi, A., Abolhasan, R., Shakouri, S. K., Soltani-Zangbar, M. S., Dareshiri, S., Ranjbar Kiyakalayeh, S., . . . Yousefi, M. (2020). Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial. Iran J Allergy Asthma Immunol, 19(3), 243-252. doi: 10.18502/ijaai.v19i3.3452
  • Rabago, D., Mundt, M., Zgierska, A., & Grettie, J. (2015). Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes. Complementary therapies in medicine, 23(3), 388-395.
  • Rabago, D., & Nourani, B. (2017). Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review. Curr Rheumatol Rep, 19(6), 34. doi: 10.1007/s11926-017-0659-3
  • Rabago, D., Patterson, J. J., Mundt, M., Kijowski, R., Grettie, J., Segal, N. A., & Zgierska, A. (2013). Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. The Annals of Family Medicine, 11(3), 229-237.
  • Rabago, D., Slattengren, A., & Zgierska, A. (2010). Prolotherapy in primary care practice. Prim Care, 37(1), 65-80. doi: 10.1016/j.pop.2009.09.013
  • Rahimzadeh, P., Imani, F., Faiz, S. H. R., Entezary, S. R., Nasiri, A. A., & Ziaeefard, M. (2014). Investigation the efficacy of intra-articular prolotherapy with erythropoietin and dextrose and intra-articular pulsed radiofrequency on pain level reduction and range of motion improvement in primary osteoarthritis of knee. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19(8), 696.
  • Reeves, K. D., & Hassanein, K. (2000). Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med, 6(2), 68-74, 77-80.
  • Scarpone, M., Rabago, D. P., Zgierska, A., Arbogast, G., & Snell, E. (2008). The efficacy of prolotherapy for lateral epicondylosis: a pilot study. Clin J Sport Med, 18(3), 248-254. doi: 10.1097/JSM.0b013e318170fc87
  • Schneider, R. C., Williams, J. J., & Liss, L. (1959). Fatality after injection of sclerosing agent to precipitate fibro-osseous proliferation. J Am Med Assoc, 170(15), 1768-1772. doi: 10.1001/jama.1959.03010150012003
  • Solmaz, İ., Akpancar, S., Örsçelik, A., Yener-Karasimav, Ö., & Gül, D. (2019). Dextrose injections for failed back surgery syndrome: a consecutive case series. Eur Spine J, 28(7), 1610-1617. doi: 10.1007/s00586-019-06011-3
  • Vijayendranath Nayak, S., Gunasheela, S., Karthik, M., & Hegde, A. (2020). Healing by Inflammation-Prolotherapy. Case Rep Dent Sci, 1(1), 9-14.
  • Waldman, S. D. (2011). Pain management E-book: Elsevier Health Sciences.
  • Waluyo, Y., Artika, S. R., Insani Nanda, W., Gunawan, A., & Zainal, A. T. F. (2023). Efficacy of Prolotherapy for Osteoarthritis: A Systematic Review. J Rehabil Med, 55, jrm00372. doi: 10.2340/jrm.v55.2572
  • Yelland, M. J., Glasziou, P. P., Bogduk, N., Schluter, P. J., & McKernon, M. (2004). Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized trial. Spine (Phila Pa 1976), 29(1), 9-16; discussion 16. doi: 10.1097/01.brs.0000105529.07222.5b
  • Zhu, M., Rabago, D., Chung, V. C., Reeves, K. D., Wong, S. Y., & Sit, R. W. (2022). Effects of Hypertonic Dextrose Injection (Prolotherapy) in Lateral Elbow Tendinosis: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil, 103(11), 2209-2218. doi: 10.1016/j.apmr.2022.01.166
There are 41 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Review Articles
Authors

Hacı Ahmet Aydemir 0000-0001-9656-5089

Publication Date December 15, 2023
Published in Issue Year 2023 Volume: 4 Issue: 4

Cite

APA Aydemir, H. A. (2023). Proloterapinin Sekonder ve İyatrojenik Etkileri. Bütünleyici Ve Anadolu Tıbbı Dergisi, 4(4), 34-44. https://doi.org/10.53445/batd.1287712

Bütünleyici ve Anadolu Tıbbı Dergisi

Journal of Integrative and Anatolian Medicine