Case Report
Year 2019,
Volume: 3 Issue: 1, 49 - 53, 30.04.2019
Abstract
Viral pneumonias are
important causes of mortality and morbidity in children under two years of age.
Human metapneumovirus
has been isolated from the airways in recent years and causes different
clinical pictures ranging from mild upper respiratory tract infection to
bronchiolitis and pneumonia. Pneumonia and
pneumothorax was detected in a 13-month-old male
patient who was admitted to the pediatric intensive care unit due to
respiratory distress and oxygen demand. Thorax tube was inserted in the
right lung. Human metapneumovirus detected in nasopharynx swab PCR and IVIG
treatment was performed due to severe clinical picture. Especially in pediatric
infants with viral pneumonia, hMPV should be considered as a causative agent
and should be predicted that the disease may be seen with a more severe
clinical picture.
References
- 1. Boivin G, De Serres G, CôtéS, Gilca R, Abed Y, Rochette L, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 2003; 9: 634.
- 2. Akçalı S, Yılmaz N, Güler Ö, Şanildağ T, Anıl M. Alt solunum yolu enfeksiyonu olan çocuklarda solunum yolu viral etkenlerinin sıklığı / Frequency of respiratory viruses in children with lower respiratory tract infection. Türk Ped Arş 2013; 215-220.
- 3. Van den Hoogen BG, de Jong JC, Groen J. A newly discovered human pneumovirüs isolated from young children with respiratory tract disease. Nat Med 2001; 7: 719-724.
- 4. Agapov E, Sumino KC, Gaudreault-Keener M, Storch GA, Holtzman MJ. Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness. J Infect Dis 2006; 193: 396-403.
- 5. Peiris JS, Tang WH, Chan KH, Khong PL, Guan Y, Lau YL, et al. Children with respiratory disease associated with metapneuömovirus in Hong Kong. Emerg İnfect dis 2003; 9: 628-633.
- 6. Parlakay AÖ, Kara A. Yeni solunum virüsleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2010; 53: 59-65.
- 7. Schuster JE, Williams JV. Human Metapneumovirus. Microbiol Spectr 2014; 2. doi: 10.1128/microbiolspec.AID-0020-2014.
- 8. Schuster Jennifer E, Williams John V, Human Metapneumovirus. Pediatr Rev 2013; 34: 558–565.
- 9. Barr R, McGalliard R, Drysdale SB. Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006-2014. JClin Virol 2019 Mar; 112: 15-19.
- 10. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM. et al. Human metapneumovirus and lower respiratory tract disease in otherwise healty infants and children. N Engl J Med 2004; 350: 443-50.
- 11. Taniguchi A, Kawada JI, Go K, Fujishiro N, Hosokawa Y, Maki Y, et al. Comparison of clinical characteristics of human metapneumovirus and. respiratory syncytial virus infection in hospitalized young children. Jpn J Infect Dis 2019; 28. doi: 10.7883/yoken.JJID.2018.480.
- 12. Xepapadaki P, Psarras S, Bossios A, Tsolia M, Gourgiotis D, Liapi-Adamidou G. Human Metapneumovirus as a causative agent of acute bronchiolitis in infants. J Clin Virol 2004; 30: 267.
- 13. Edwards KM, Zhu Y, Griffin MR, Weinberg GA, Hall CB, Szilagyi PG, et al. New Vaccine Surveillance Network. Burden of human metapneumovirus infection in young children. N Engl J Med 2013 Feb 14; 368: 633-643.
- 14. Hilmes MA, Daniel Dunnavant F, Singh SP, Ellis WD, Payne DC, Zhu Y,et al. Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol 2017; 47: 1745-1750.
- 15. Claire M. Midgley, Jill K. Baber, Holly M. Biggs, Twila Singh, Michelle Feist, Tracy K. Miller, et al. Notes from the Field: Severe Human Metapneumovirus Infections - North Dakota, 2016. Weekly / May 12, 2017 / 66; 486-488.
- 16. Kumar P, Srivastava M. Prophylactic and therapeutic approaches for human metapneumovirus. Virusdisease 2018 Dec; 29: 434-444.
- 17. Dokos C, Masjosthusmann K, Rellensma nn G, Werner C, Schuler-Luttmann S, Muller KM, et al. Fatal human metapneumovirus infection following allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 2013; 15: 97-101.
- 18. Park S, Baek S, Lee S, Choi S, Kim YS, Woo JH, et al. Efficacy of oral ribavirin in hematologic disease patients with paramyxovirus infection: analytic strategy using propensity scores. Antimicrob Agents Chemother 2013; 57: 983-989.
- 19. Shachor-Meyouhas Y, Kassis I, Ben-Barak A. Treatment with oral ribavirin and IVIG of severe human metapneumovirus pneumonia (HMPV) in immune compromised child. Pediatr Blood Cancer 2011; 57: 350-351.
- 20. Bonney D, Razali H, Turner A, Will A. Successful treatment of human metapneumovirus pneumonia using combination therapy with intravenous ribavirin and immune globulin. Br J Haematol 2009; 145: 665-678.
Year 2019,
Volume: 3 Issue: 1, 49 - 53, 30.04.2019
Abstract
Viral
pnömoniler iki yaş altı çocuklarda mortalite ve morbiditenin önemli
sebeplerindendir. İnsan metapnömovirüs son yıllarda solunum yollarından izole
edilmiş, hafif üst solunum yolu enfeksiyonundan bronşiolit ve pnömoniye kadar
varan farklı klinik tablolara yol açan bir virüsdür. Solunum sıkıntısı ve
oksijen ihtiyacı nedeniyle çocuk yoğun bakım ünitesine yatışı yapılan, pnömoni
ve pnömotoraks saptanan 13 aylık erkek hasta, sağ akciğere toraks tüpü takıldı.
Nazofarenks
sürüntüsü PCR incelemesinde insan metapnömovirüs saptanan hastaya ağır klinik
tablo nedeniyle IVIG tedavisi uygulandı. Özellikle viral pnömoni düşünülen süt
çocuklarında daha nadir görülen hMPV gibi virüslerde etken olarak düşünülmeli
ve hastalığın daha ağır klinik tablo ile seyredebileceği öngörülmelidir.
References
- 1. Boivin G, De Serres G, CôtéS, Gilca R, Abed Y, Rochette L, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 2003; 9: 634.
- 2. Akçalı S, Yılmaz N, Güler Ö, Şanildağ T, Anıl M. Alt solunum yolu enfeksiyonu olan çocuklarda solunum yolu viral etkenlerinin sıklığı / Frequency of respiratory viruses in children with lower respiratory tract infection. Türk Ped Arş 2013; 215-220.
- 3. Van den Hoogen BG, de Jong JC, Groen J. A newly discovered human pneumovirüs isolated from young children with respiratory tract disease. Nat Med 2001; 7: 719-724.
- 4. Agapov E, Sumino KC, Gaudreault-Keener M, Storch GA, Holtzman MJ. Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness. J Infect Dis 2006; 193: 396-403.
- 5. Peiris JS, Tang WH, Chan KH, Khong PL, Guan Y, Lau YL, et al. Children with respiratory disease associated with metapneuömovirus in Hong Kong. Emerg İnfect dis 2003; 9: 628-633.
- 6. Parlakay AÖ, Kara A. Yeni solunum virüsleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2010; 53: 59-65.
- 7. Schuster JE, Williams JV. Human Metapneumovirus. Microbiol Spectr 2014; 2. doi: 10.1128/microbiolspec.AID-0020-2014.
- 8. Schuster Jennifer E, Williams John V, Human Metapneumovirus. Pediatr Rev 2013; 34: 558–565.
- 9. Barr R, McGalliard R, Drysdale SB. Human metapneumovirus in paediatric intensive care unit (PICU) admissions in the United Kingdom (UK) 2006-2014. JClin Virol 2019 Mar; 112: 15-19.
- 10. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM. et al. Human metapneumovirus and lower respiratory tract disease in otherwise healty infants and children. N Engl J Med 2004; 350: 443-50.
- 11. Taniguchi A, Kawada JI, Go K, Fujishiro N, Hosokawa Y, Maki Y, et al. Comparison of clinical characteristics of human metapneumovirus and. respiratory syncytial virus infection in hospitalized young children. Jpn J Infect Dis 2019; 28. doi: 10.7883/yoken.JJID.2018.480.
- 12. Xepapadaki P, Psarras S, Bossios A, Tsolia M, Gourgiotis D, Liapi-Adamidou G. Human Metapneumovirus as a causative agent of acute bronchiolitis in infants. J Clin Virol 2004; 30: 267.
- 13. Edwards KM, Zhu Y, Griffin MR, Weinberg GA, Hall CB, Szilagyi PG, et al. New Vaccine Surveillance Network. Burden of human metapneumovirus infection in young children. N Engl J Med 2013 Feb 14; 368: 633-643.
- 14. Hilmes MA, Daniel Dunnavant F, Singh SP, Ellis WD, Payne DC, Zhu Y,et al. Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol 2017; 47: 1745-1750.
- 15. Claire M. Midgley, Jill K. Baber, Holly M. Biggs, Twila Singh, Michelle Feist, Tracy K. Miller, et al. Notes from the Field: Severe Human Metapneumovirus Infections - North Dakota, 2016. Weekly / May 12, 2017 / 66; 486-488.
- 16. Kumar P, Srivastava M. Prophylactic and therapeutic approaches for human metapneumovirus. Virusdisease 2018 Dec; 29: 434-444.
- 17. Dokos C, Masjosthusmann K, Rellensma nn G, Werner C, Schuler-Luttmann S, Muller KM, et al. Fatal human metapneumovirus infection following allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 2013; 15: 97-101.
- 18. Park S, Baek S, Lee S, Choi S, Kim YS, Woo JH, et al. Efficacy of oral ribavirin in hematologic disease patients with paramyxovirus infection: analytic strategy using propensity scores. Antimicrob Agents Chemother 2013; 57: 983-989.
- 19. Shachor-Meyouhas Y, Kassis I, Ben-Barak A. Treatment with oral ribavirin and IVIG of severe human metapneumovirus pneumonia (HMPV) in immune compromised child. Pediatr Blood Cancer 2011; 57: 350-351.
- 20. Bonney D, Razali H, Turner A, Will A. Successful treatment of human metapneumovirus pneumonia using combination therapy with intravenous ribavirin and immune globulin. Br J Haematol 2009; 145: 665-678.
There are 20 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Case Report |
| Authors | |
| Publication Date | April 30, 2019 |
| Acceptance Date | March 25, 2019 |
| Published in Issue | Year 2019 Volume: 3 Issue: 1 |
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