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Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism

Year 2016, Volume: 6 Issue: 1, 44 - 47, 13.05.2016

Abstract

The effect of genes on individual athletic performance is accepted; however, the extent of their effects remains elusive. To date, many studies on different genomic regions that are considered to have an effect on human athletic performance and sportsmen in different types of sports, such as football, basketball, judo, and wrestling, have been conducted. However, the number of these studies with Turkish players as subjects is not adequate. This literature review aimed to collate the results of alpha- actinin- 3 (ACTN3) R577X polymorphisms of Turkish athletes after an extensive literature survey. After the survey, we could reach 518 players, including football, basketball, and wrestling players. Of these, 234 were RR (45%), 207 (40%) were RX, and the rest were XX. Power and sprinter R allele counts were 665 (64%), and the endurance allele count was 371 (36%). According to the obtained data, the number and percentage of RR+RX genotypes and R allele were higher than those of XX genotype and X allele. We consider that this first report will be an informative source of information for Turkish players in the terms of ACTN3 R577X polymorphism and Turkish sportsman and will be a valuable guide for new researches.

References

  • Ulucan K, Yalcin S, Akbas B, Konuk M. Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball play- ers. The Journal of Neurobehavioral Sciences 2014; 1: 37-40. [CrossRef]
  • Foley KS, Young PW. The non-muscle functions of actinins: an update. Biochem J 2014; 459:1-13. [CrossRef]
  • Otey CA, Carpen O. Alpha-actinin revisited: a fresh look at an old player. Cell Motil Cytoskeleton 2004; 58: 104-11. [CrossRef]
  • Murphy A, Young PW. The actinin family of actin cross-linking proteins – a genetic perspective. Cell & Bioscience 2015; 5: 49 [CrossRef]
  • Seto JT, Quinlan KGR, Lek M, Zheng XF, Garton F, MacArthur DG, et al. ACTN3 genotype influences muscle performance through the regula- tion of calcineurin signaling. J Clin Invest 2013; 123: 4255-63. [CrossRef]
  • MacArthur DG, North KN. ACTN3: A genetic influence on muscle function and athletic performance. Exerc Sport Sci Rev 2007; 35: 30-4. [CrossRef]
  • Lek M, Quinlan KG, North KN. The evolution of skeletal muscle perfor- mance: gene duplication and divergence of human sarcomeric alpha-ac- tinins. Bioessays 2010; 32: 17-25. [CrossRef]
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, et al. ACTN3 genotype, athletic status, and life course physical capability: me- ta-analysis of the published literature and findings from nine studies. Hum Mutat 2011; 32: 1008-18. [CrossRef]
  • Ma F, Yang Y, Li X, Hardy R, Cooper C, Deary IJ, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms: a sys- tematic review and meta-analysis. PLoS One 2013; 8: e54685.
  • Eynon N, Duarte JA, Oliveira J, Sagiv M, Yamin C, Meckel Y, et al. ACTN3 R577X polymorphism and Israeli top-level athletes. Int J Sports Med 2009; 30: 695-8. [CrossRef]
  • Niemi AK, Majamaa K. Mitochondrial DNA and ACTN3 genotypes in Finn- ish elite endurance and sprint athletes. Eur J Hum Genet 2005; 13: 965-9. [CrossRef]
  • Doring FE, Onur S, Geisen U, Boulay MR, Pérusse L, Rankinen T, et al. ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study. J Sports Sci 2010; 28: 1355-9. [CrossRef]
  • Ulucan K, Göle S. ACE I/D Polymorphism Determination in Turkish Elite Wind-surfers. Sport Science Review. 2014; 23(1-2): 79-84.
  • Wang G, Mikami E, Chiu LL, DE Perini A, Deason M, Fuku N, et al. Associ- ation analysis of ACE and ACTN3 in elite Caucasian and East Asian swim- mers. Med Sci Sports Exerc. 2013; 45: 892-900. [CrossRef]
  • Zilberman-Schapira G, Chen J, Gerstein M. On sports and genes. Recent Pat DNA Gene Seq 2012; 6: 180-8. [CrossRef]
  • Massidda M, Bachis V, Corrias L, Piras F, Scorcu M, Culigioni C, et al. ACTN3 R577X polymorphism is not associated with team sport athletic status in Italians. Sports Medicine 2015.
  • Ulucan K, Ciloglu F, Sesal C, Ergec D, Kırac D, Sahin İ,et al. ACTN3 Gene R577XPolymorphism inTurkish Sprint/Power Athletes. Medimedgen Ab- stract Book. 2009; pp.33.
  • Kasımay Ö, Sevinç D, İşeri Ö, Ulucan K, Ünal M, Güney Aİ. Skeletal muscle gene ACTN3 and physicalperformance: genotype- phenotype corela- tion. Journal of Sports Science and Medicine Suppl 2009; 11: 121.
  • Şanlısoy F, Altıntaş N, Büyükyazı G, Candan N. Ege bölgesi elit sporcu- larının ACTN3 R577X genotip dağılımının araştırılması. Cumhuriyet Med- ical Journal 2011; 33: 153-9.
  • Günel T, Gümüşoğlu E, Hosseini MK, Yilmaz YE, Dolekcap I, Aydinli K. Effect of angiotensin I-converting enzyme and α-actinin-3 gene poly- morphisms on sport performance. Molecular Medicine Reports 2014; 9: 1422-6. [CrossRef]
  • Ulucan K, Bayyurt GM, Konuk M,Güney AI. (2014). Effect of alpha-acti- nin-3 gene on trained and untrained Turkish middle-school children’s sprinting performance: a pilot study. Biological Rhythm Research 2014; 45: 509-14.
  • Yamak B, Yuce M, Bagci H, İmamoğlu O. (2015). Association between Sport Performance and Alpha-Actinin-3 Gene R577X Polymorphism. In- ternational Journal of Human Genetics 2015; 15: 13-9.
  • Ulucan K, Göle S, Altindas N, Güney AI. Preliminary findings of alpha-ac- tinin-3 gene distribution in Turkish elite windsurfers. Balkan journal of medical genetics 2013; 16: 69-72. [CrossRef]
  • Ulucan K, Sercan C, Biyikli T. Distribution of angiotensin-I converting enzyme insertion/ deletion and α-actinin- 3 codon 577 polymorphisms in Turkish male soccer players. Genetics and Epigenetics 2015; 7: 1-4. [CrossRef]
  • Egorova ES, Borisova AV, Mustafina LJ, Arkhipova AA, Gabbasov RT, Dru- zhevskaya AM, et al. The polygenic profile of Russian football players. Journal of Sports Sciences 2014; 32: 1286-93. [CrossRef]
  • Santiago C, Gonzalez-Freire M, Serratosa L, Morate FJ, Meyer T, Go- mez-Gallego F, et al. ACTN3 genotype in professional soccer players. British Journal of Sports Medicine 2008; 42: 71-3. [CrossRef]
  • Pimenta EM, Coelho DB, Cruz IR, Morandi RF, Veneroso CE, Azambuja- Pussi- eldi G, et al. The ACTN3 genotype in soccer players in response to acute eccentric training. Eur J Appl Physiol 2012; 112: 1495-503. [CrossRef]
  • Ulucan K, Çam N, Sercan C, Akbaş B, Uyumaz F, Yalçın S. Genç Basket- bolcularda Anjiotensin Dönüştürücü Enzim (ACE I/D) ve Alfa- Aktinin-3 (ACTN3 R577X) Gen Polimorfizimlerinin Belirlenmesi İçin Pilot Bir Çalış- ma. Hacettpe Spor Bilimleri Dergisi 2015; 26: 44-50.
  • Garatachea N, Verde Z, Santos-Lozano A, Yvert T, Rodriguez-Romo G, Sarasa FJ, et al. ACTN3 R577X polymorphism and explosive leg-muscle power in elite basketball players. Int J Sports Physiol Perform 2014; 9: 226-32. [CrossRef]
  • Sessa F, Chetta M, Petito A, Franzetti M, Bafunno V, Pisanelli D, et al. Gene Polymorphisms and Sport Attitude in Italian Athletes. Genetic Test Mol Biomarkers 2011; 15: 285-90. [CrossRef]
  • Ulucan K. Need For Sports Genetics. J Investig Genomics 2015; 2: 21. [CrossRef]

Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti

Year 2016, Volume: 6 Issue: 1, 44 - 47, 13.05.2016

Abstract

Genlerin atletik performans üzerine etkisi kabul edilmekle birlikte etkinin boyutları halen araştırma konusudur. Günümüze kadar atletik performansa etki ettiği düşünülen genetik gölgeler ve futbol, basketbol, judo, güreş gibi farklı spor branşlarına ait sporcular üzerinde birçok çalışma gerçekleştirilmiştir. Ancak Türk sporcular için bu çalışmalar literatür ile karşılaştırıldığında daha az sayıdadır. Bu derlemede günümüze kadar gerçekleştirilen Türk sporcuların alfa- aktinin-3 geni (ACTN3) R577X polimorfizm sonuçlarını, detaylı bir literatür taraması sonucunda bir araya getirmeyi amaçladık. İlgili literatür taramasının ardından aralarında futbol, basketbol, güreş gibi farklı spor dallarından toplam 518 sporcunun analiz sonuçlarına ulaştık. Bu sporcuların 234’ünün (%45) RR, 207’sinin (%40) RX ve 77’sinin (%15) XX genotipinde olduğu görülmektedir. Sporculardaki sprinter ve güç alleli olan R alleli 665 (%64), dayanıklılık alleli olan X alleli ise 371 (%36) olarak bulunmuştur. Elde ettiğimiz verilere göre RR + RX genotipleri ve R alleli, XX genotipi ve X alleline göre sayı ve yüzde bazında daha yüksektir. Gerçekleştirilen bu literatür taraması, Türk sporcularda ACTN3 R577X polimorfizmi dağılımları bakımından gerçekleştirilen ilk çalışma olup Türk sporcular için iyi bir veri olacağını, yapılacak sonraki çalışmalar için de iyi bir kaynak olacağını düşünmekteyiz.

References

  • Ulucan K, Yalcin S, Akbas B, Konuk M. Analysis of Solute Carrier Family 6 Member 4 Gene promoter polymorphism in young Turkish basketball play- ers. The Journal of Neurobehavioral Sciences 2014; 1: 37-40. [CrossRef]
  • Foley KS, Young PW. The non-muscle functions of actinins: an update. Biochem J 2014; 459:1-13. [CrossRef]
  • Otey CA, Carpen O. Alpha-actinin revisited: a fresh look at an old player. Cell Motil Cytoskeleton 2004; 58: 104-11. [CrossRef]
  • Murphy A, Young PW. The actinin family of actin cross-linking proteins – a genetic perspective. Cell & Bioscience 2015; 5: 49 [CrossRef]
  • Seto JT, Quinlan KGR, Lek M, Zheng XF, Garton F, MacArthur DG, et al. ACTN3 genotype influences muscle performance through the regula- tion of calcineurin signaling. J Clin Invest 2013; 123: 4255-63. [CrossRef]
  • MacArthur DG, North KN. ACTN3: A genetic influence on muscle function and athletic performance. Exerc Sport Sci Rev 2007; 35: 30-4. [CrossRef]
  • Lek M, Quinlan KG, North KN. The evolution of skeletal muscle perfor- mance: gene duplication and divergence of human sarcomeric alpha-ac- tinins. Bioessays 2010; 32: 17-25. [CrossRef]
  • Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, et al. ACTN3 genotype, athletic status, and life course physical capability: me- ta-analysis of the published literature and findings from nine studies. Hum Mutat 2011; 32: 1008-18. [CrossRef]
  • Ma F, Yang Y, Li X, Hardy R, Cooper C, Deary IJ, et al. The association of sport performance with ACE and ACTN3 genetic polymorphisms: a sys- tematic review and meta-analysis. PLoS One 2013; 8: e54685.
  • Eynon N, Duarte JA, Oliveira J, Sagiv M, Yamin C, Meckel Y, et al. ACTN3 R577X polymorphism and Israeli top-level athletes. Int J Sports Med 2009; 30: 695-8. [CrossRef]
  • Niemi AK, Majamaa K. Mitochondrial DNA and ACTN3 genotypes in Finn- ish elite endurance and sprint athletes. Eur J Hum Genet 2005; 13: 965-9. [CrossRef]
  • Doring FE, Onur S, Geisen U, Boulay MR, Pérusse L, Rankinen T, et al. ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study. J Sports Sci 2010; 28: 1355-9. [CrossRef]
  • Ulucan K, Göle S. ACE I/D Polymorphism Determination in Turkish Elite Wind-surfers. Sport Science Review. 2014; 23(1-2): 79-84.
  • Wang G, Mikami E, Chiu LL, DE Perini A, Deason M, Fuku N, et al. Associ- ation analysis of ACE and ACTN3 in elite Caucasian and East Asian swim- mers. Med Sci Sports Exerc. 2013; 45: 892-900. [CrossRef]
  • Zilberman-Schapira G, Chen J, Gerstein M. On sports and genes. Recent Pat DNA Gene Seq 2012; 6: 180-8. [CrossRef]
  • Massidda M, Bachis V, Corrias L, Piras F, Scorcu M, Culigioni C, et al. ACTN3 R577X polymorphism is not associated with team sport athletic status in Italians. Sports Medicine 2015.
  • Ulucan K, Ciloglu F, Sesal C, Ergec D, Kırac D, Sahin İ,et al. ACTN3 Gene R577XPolymorphism inTurkish Sprint/Power Athletes. Medimedgen Ab- stract Book. 2009; pp.33.
  • Kasımay Ö, Sevinç D, İşeri Ö, Ulucan K, Ünal M, Güney Aİ. Skeletal muscle gene ACTN3 and physicalperformance: genotype- phenotype corela- tion. Journal of Sports Science and Medicine Suppl 2009; 11: 121.
  • Şanlısoy F, Altıntaş N, Büyükyazı G, Candan N. Ege bölgesi elit sporcu- larının ACTN3 R577X genotip dağılımının araştırılması. Cumhuriyet Med- ical Journal 2011; 33: 153-9.
  • Günel T, Gümüşoğlu E, Hosseini MK, Yilmaz YE, Dolekcap I, Aydinli K. Effect of angiotensin I-converting enzyme and α-actinin-3 gene poly- morphisms on sport performance. Molecular Medicine Reports 2014; 9: 1422-6. [CrossRef]
  • Ulucan K, Bayyurt GM, Konuk M,Güney AI. (2014). Effect of alpha-acti- nin-3 gene on trained and untrained Turkish middle-school children’s sprinting performance: a pilot study. Biological Rhythm Research 2014; 45: 509-14.
  • Yamak B, Yuce M, Bagci H, İmamoğlu O. (2015). Association between Sport Performance and Alpha-Actinin-3 Gene R577X Polymorphism. In- ternational Journal of Human Genetics 2015; 15: 13-9.
  • Ulucan K, Göle S, Altindas N, Güney AI. Preliminary findings of alpha-ac- tinin-3 gene distribution in Turkish elite windsurfers. Balkan journal of medical genetics 2013; 16: 69-72. [CrossRef]
  • Ulucan K, Sercan C, Biyikli T. Distribution of angiotensin-I converting enzyme insertion/ deletion and α-actinin- 3 codon 577 polymorphisms in Turkish male soccer players. Genetics and Epigenetics 2015; 7: 1-4. [CrossRef]
  • Egorova ES, Borisova AV, Mustafina LJ, Arkhipova AA, Gabbasov RT, Dru- zhevskaya AM, et al. The polygenic profile of Russian football players. Journal of Sports Sciences 2014; 32: 1286-93. [CrossRef]
  • Santiago C, Gonzalez-Freire M, Serratosa L, Morate FJ, Meyer T, Go- mez-Gallego F, et al. ACTN3 genotype in professional soccer players. British Journal of Sports Medicine 2008; 42: 71-3. [CrossRef]
  • Pimenta EM, Coelho DB, Cruz IR, Morandi RF, Veneroso CE, Azambuja- Pussi- eldi G, et al. The ACTN3 genotype in soccer players in response to acute eccentric training. Eur J Appl Physiol 2012; 112: 1495-503. [CrossRef]
  • Ulucan K, Çam N, Sercan C, Akbaş B, Uyumaz F, Yalçın S. Genç Basket- bolcularda Anjiotensin Dönüştürücü Enzim (ACE I/D) ve Alfa- Aktinin-3 (ACTN3 R577X) Gen Polimorfizimlerinin Belirlenmesi İçin Pilot Bir Çalış- ma. Hacettpe Spor Bilimleri Dergisi 2015; 26: 44-50.
  • Garatachea N, Verde Z, Santos-Lozano A, Yvert T, Rodriguez-Romo G, Sarasa FJ, et al. ACTN3 R577X polymorphism and explosive leg-muscle power in elite basketball players. Int J Sports Physiol Perform 2014; 9: 226-32. [CrossRef]
  • Sessa F, Chetta M, Petito A, Franzetti M, Bafunno V, Pisanelli D, et al. Gene Polymorphisms and Sport Attitude in Italian Athletes. Genetic Test Mol Biomarkers 2011; 15: 285-90. [CrossRef]
  • Ulucan K. Need For Sports Genetics. J Investig Genomics 2015; 2: 21. [CrossRef]
There are 31 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Korkut Ulucan

Publication Date May 13, 2016
Submission Date May 13, 2016
Published in Issue Year 2016 Volume: 6 Issue: 1

Cite

APA Ulucan, K. (2016). Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti. Clinical and Experimental Health Sciences, 6(1), 44-47.
AMA Ulucan K. Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti. Clinical and Experimental Health Sciences. May 2016;6(1):44-47.
Chicago Ulucan, Korkut. “Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti”. Clinical and Experimental Health Sciences 6, no. 1 (May 2016): 44-47.
EndNote Ulucan K (May 1, 2016) Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti. Clinical and Experimental Health Sciences 6 1 44–47.
IEEE K. Ulucan, “Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti”, Clinical and Experimental Health Sciences, vol. 6, no. 1, pp. 44–47, 2016.
ISNAD Ulucan, Korkut. “Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti”. Clinical and Experimental Health Sciences 6/1 (May 2016), 44-47.
JAMA Ulucan K. Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti. Clinical and Experimental Health Sciences. 2016;6:44–47.
MLA Ulucan, Korkut. “Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti”. Clinical and Experimental Health Sciences, vol. 6, no. 1, 2016, pp. 44-47.
Vancouver Ulucan K. Spor Genetiği Açısından Türk Sporcuların ACTN3 R577X Polimorfizm Literatür Özeti. Clinical and Experimental Health Sciences. 2016;6(1):44-7.

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