Abstract
Purpose: Psoriasis is inflammatory skin disease which has increased risk of cardiovascular disease. The etiology is unknown, yet. In cardiovascular disease, resistin which is secreted from adipose tissue, was found correlated with the levels of total cholesterol and LDL. In our study, we aimed to study the relation of serum resistin and lipid levels in patients with psoriasis and correlation of Psoriasis Area and Severity Index (PASI). Material and Methods: In Mustafa Kemal University, Faculty of Medicine, Department of Dermatology, thirty-seven healthy subjects (group I) and thirty-four patients with psoriasis (group II) were enrolled for two groups. The age, gender, blood pressure, body mass index (BMI) and PASI were determined. The level of resistin and lipid profile were studied in serum. Results: The level of resistin in patients with psoriasis (12,3±3,0 ng/ml) was found increased compared with healthy subjects (6,4±2,3 ng/ml) (p=0.001). The level of total cholesterol and LDL were increased in patients with psoriasis compared with healthy subjects, respectively (189±43 mg/dl;129±31 mg/dl) (p<0,05; p=0,01). The level of resistin was determined correlated positively with LDL (r=0,306). The level of resistin was found strong correlated positively with PASI (r=0,669). Conclusion: The high risk of cardiovascular disease in patients with psoriasis is known. In our study, the levels of resistin, total cholesterol, LDL which increase in cardiovascular disease, was found increased in patients with psoriasis and correlated with PASI. The level of resistin may be increased with increasing severity of the disease, so that it is thought to be significant determining like the lipid profile in patients with psoriasis.
References
- Pişkin G. Psoriyazisin patogenezi. Türkiye
- Klinikleri Dermatoloji Dergisi. [Pathogenesis of Psoriazis. Journal of Turkish Clinics Dermatology]. 2005;1:5-12.
- Neimann AL, Shin DB, Wang X et al: Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829-35.
- Balci D, Balci A, Karazincir S et al: Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis. J Eur Acad Dermatol Venereol. 2009;23:1-6.
- Schulz R, Rassaf T, Massion PB, Kelm M, Balligand JL. Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol Ther. 2005;108:225-56.
- Sahin M, Arslan Ç, Naziroglu M, Tunc E, Demirci M, Sutcu R et al. Asymmetric Dimethylarginine and Nitric Oxide Levels as Signs of Endothelial Dysfunction in Behcet’s Disease. Annals of Clinical & Laboratory Science. 2006;36:345-4.
- Bajaj DR, Mahesar SM, Devrajani BR, Iqbal MP. Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad. J Pak Med Assoc. 2009;59:512-5.
- Gisondi P, Ferrazzi A, Girolomoni G. Metabolic comorbidities and psoriasis. Acta Dermatovenerol Croat. 2010;18:297-304.
- Berger A. Resistin: a new hormone that links obesity with type 2 diabetes, BMJ 2001;322:193
- Steppan CM, Lazar MA. Resistin and obesity- associated insulin resistance. Trends in endocrinology & Metabolism. 2002;13:18-23.
- Steppan CM, Bailey ST, Bhat S Brown EJ, Banerjee RR, Wright CM et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12.
- Johnston A, Arnadottir S, Gudjonsson JE, Aphale A, Sigmarsdottir AA, Gunnarsson SI et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br J Dermatol. 2008;159:342-50.
- Kawashima K, Torii K, Furuhashi T, Saito C, Nishio E, Nishida E et al. Phototherapy reduces serum resistin levels in psoriasis patients. Photodermatol Photoimmunol Photomed. 2011;27:152-5.
- Johnston A, Arnadottir S, Gudjonsson JE, Aphale A, Sigmarsdottir AA, Gunnarsson SI et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br J Dermatol. 2008;159:342-50.
- Arican O, Aral M, Sasmaz S, Ciragil P. Serum levels of TNF-alpha, IFNgamma, IL-6, IL-8, IL- 12, IL-17 and IL-18 in ptients with active psoriasis and correlation with disease severity. Mediators In flamm 2005;2005:273-79.
- Gerdes S, Rostami-Yazdi M, Mrowietz U. Adipokines and psoriasis. Exp Dermatol. 2011;20:81-7.
- Gisondi P, Lora V, Bonauguri C, Russo A, Lippi G, Girolomoni G. Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. Br J Dermatol. 2013;168:749- 55.
- Ozdemir M, Yüksel M, Gökbel H, Okudan N, Mevlitoğlu I. Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin. J Dermatol. 2012;39:443-8.
- Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005;111:932-9.
- Takahashi H, Tsuji H, Honma M, Ishida- Yamamoto A, Iizuka H. Increased plasma resistin and decreased omentin levels in Japanese patients with psoriasis. Arch Dermatol Res. 2013;305:113-6.
- Johnston A, Arnadottir S, Gudjonsson JE, et al: Obesity in psoriasis: leptin and resistin as mediators of cutaneus inflammation. Br J Dermatol. 2008;159:342-50.
- Piskin S, Gurkok F, Ekuklu G, Senol M. Serum lipid levels in psoriasis. Yonsei Med J. 2003;44:24-6.
Abstract
Amaç: Psöriasis, artmış kardiyovasküler hastalık (KVH) riski bulunan inflamatuar deri hastalığıdır. Henüz etyolojisi tam olarak belirlenememiştir. KVH’da yağ dokusundan salgılanan resistinin serum total kolesterol, LDL, trigliserid seviyeleriyle pozitif korelasyon gösterdiği belirtilmiştir. Bizim çalışmamızda da amacımız serum resistin seviyeleriyle lipid profilinin psoriasis hastalarında ilişkisini ve Psöriazis alan şiddet endeksi (PAŞİ) ile korelasyonunu araştırmaktır. Materyal ve Metod: Mustafa Kemal Üniversitesi Tıp Fakültesi Dermatoloji polikliniğine başvuran sağlıklı kişilerden kontrol grubu; grup I (n=34) ve psoriasis tanısı konulan hastalardan hasta grubu; grup II (n=37) olmak üzere iki grup oluşturuldu. Yaş, cinsiyet, tansiyon, BMI değerleri ve PAŞİ skorlaması tespit edildi. Gruplardan toplanan serum örneklerinde resistin seviyesi, lipid profiline bakıldı. Araştırma Makalesi / Research Article 282 Yılmaz ve ark.. Cukurova Medical Journal Bulgular: Psoriasis hastalarını kontrol grubuyla kıyaslandığında serum resistin seviyeleri (grup I: 6,4±2,3 ng/ml; grup II: 12,3±3,0 ng/ml), total kolesterol (grup I: 167±31 mg/dl; grup II: 189±43 mg/dl), LDL seviyeleri (grup I: 90±21 mg/dl; grup II: 129±31 mg/dl) anlamlı olarak hastalarda yüksek tespit edildi (sırasıyla p=0.001; p<0,05; p=0,01). Serum resistin seviyesiyle LDL kolesterolün pozitif korelasyon gösterdiği saptandı (r=0,306). PAŞİ skorlamasının serum resistin seviyeleriyle güçlü pozitif korelasyon gösterdiği tespit edildi (r=0,669). Sonuç: Psoriasis hastalığında artan kardiyovasküler hastalık riskin olduğu bilinmektedir. Bizim çalışmamızda da kardiyovasküler hastalıkta arttığı tespit edilmiş resistin ve total kolesterol ve LDL seviyelerinin psoriasis hastalarında arttığı ve hastalığın şiddetini gösteren PAŞİ skorlamasıyla korele olduğu bulunmuştur. Hastalığın şiddetinin artmasıyla yükselmiş olabileceğini tesp
References
- Pişkin G. Psoriyazisin patogenezi. Türkiye
- Klinikleri Dermatoloji Dergisi. [Pathogenesis of Psoriazis. Journal of Turkish Clinics Dermatology]. 2005;1:5-12.
- Neimann AL, Shin DB, Wang X et al: Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829-35.
- Balci D, Balci A, Karazincir S et al: Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis. J Eur Acad Dermatol Venereol. 2009;23:1-6.
- Schulz R, Rassaf T, Massion PB, Kelm M, Balligand JL. Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol Ther. 2005;108:225-56.
- Sahin M, Arslan Ç, Naziroglu M, Tunc E, Demirci M, Sutcu R et al. Asymmetric Dimethylarginine and Nitric Oxide Levels as Signs of Endothelial Dysfunction in Behcet’s Disease. Annals of Clinical & Laboratory Science. 2006;36:345-4.
- Bajaj DR, Mahesar SM, Devrajani BR, Iqbal MP. Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad. J Pak Med Assoc. 2009;59:512-5.
- Gisondi P, Ferrazzi A, Girolomoni G. Metabolic comorbidities and psoriasis. Acta Dermatovenerol Croat. 2010;18:297-304.
- Berger A. Resistin: a new hormone that links obesity with type 2 diabetes, BMJ 2001;322:193
- Steppan CM, Lazar MA. Resistin and obesity- associated insulin resistance. Trends in endocrinology & Metabolism. 2002;13:18-23.
- Steppan CM, Bailey ST, Bhat S Brown EJ, Banerjee RR, Wright CM et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12.
- Johnston A, Arnadottir S, Gudjonsson JE, Aphale A, Sigmarsdottir AA, Gunnarsson SI et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br J Dermatol. 2008;159:342-50.
- Kawashima K, Torii K, Furuhashi T, Saito C, Nishio E, Nishida E et al. Phototherapy reduces serum resistin levels in psoriasis patients. Photodermatol Photoimmunol Photomed. 2011;27:152-5.
- Johnston A, Arnadottir S, Gudjonsson JE, Aphale A, Sigmarsdottir AA, Gunnarsson SI et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br J Dermatol. 2008;159:342-50.
- Arican O, Aral M, Sasmaz S, Ciragil P. Serum levels of TNF-alpha, IFNgamma, IL-6, IL-8, IL- 12, IL-17 and IL-18 in ptients with active psoriasis and correlation with disease severity. Mediators In flamm 2005;2005:273-79.
- Gerdes S, Rostami-Yazdi M, Mrowietz U. Adipokines and psoriasis. Exp Dermatol. 2011;20:81-7.
- Gisondi P, Lora V, Bonauguri C, Russo A, Lippi G, Girolomoni G. Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. Br J Dermatol. 2013;168:749- 55.
- Ozdemir M, Yüksel M, Gökbel H, Okudan N, Mevlitoğlu I. Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin. J Dermatol. 2012;39:443-8.
- Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005;111:932-9.
- Takahashi H, Tsuji H, Honma M, Ishida- Yamamoto A, Iizuka H. Increased plasma resistin and decreased omentin levels in Japanese patients with psoriasis. Arch Dermatol Res. 2013;305:113-6.
- Johnston A, Arnadottir S, Gudjonsson JE, et al: Obesity in psoriasis: leptin and resistin as mediators of cutaneus inflammation. Br J Dermatol. 2008;159:342-50.
- Piskin S, Gurkok F, Ekuklu G, Senol M. Serum lipid levels in psoriasis. Yonsei Med J. 2003;44:24-6.
Details
| Primary Language | English |
|---|---|
| Journal Section | Research |
| Authors | |
| Publication Date | September 28, 2015 |
| Published in Issue | Year 2015 Volume: 40 Issue: 2 |
