Research Article
BibTex RIS Cite

Kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor pozitifliği: gebelik öncesi danışmanlığın önemi

Year 2023, Volume: 48 Issue: 1, 278 - 282, 31.03.2023
https://doi.org/10.17826/cumj.1168878

Abstract

Amaç: BU çalışmanın amacı kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor (APCA) pozitifliğinin anlamını göstermektir.
Gereç ve Yöntem: Bu retrospektif kohort, deri hastalıkları ve kötü obstetrik geçmişi olan 63 kadından oluşuyordu. Hastalar kontrol (sadece deri hastalıkları olan kadınlar, n=50) ve çalışma grubu (deri hastalıkları ve APCA pozitifliği olan kadınlar, n=13) olarak gruplandırılmıştır. Çalışma ve kontrol grubu demografik bulgular, BOI ve plasentaya bağlı obstetrik komplikasyonlarla ilişkili risk faktörleri açısından karşılaştırıldı.
Bulgular: APCA (+) ve APCA (–) grupları; yaş, gravida, parite, BOI ve düşük sayısı gibi demografik bulgular açısından istatistiksel olarak anlamlı farklılık göstermedi. APCA (+) vakaların %69,2'sinin (9/13) iki veya daha fazla deri hastalığına sahip olduğunu, ancak bu oranın APCA (-) olanlarda %34 bulunduğunu gösterdik. APCA (+) ve APCA (–) grupları arasında tekli ve çoklu deri hastalığı varlığı açısından istatistiksel olarak anlamlı fark vardı. APCA (+) ve APCA (-) hastalar arasında obstetrik komplikasyonlarla ilişkili risk faktörlerinin (bağışıklık sistemi sorunları, MTHFR polimorfizmleri, kalıtsal trombofili ve diyabetes mellitus tip-2 gibi) varlığı açısından istatistiksel olarak anlamlı bir farklılık gösteremedik.
Sonuç: Obstetrik komplikasyonlar için risk faktörü olan APCA pozitifliğinin, gebelik öncesi danışma sırasında belirlenmesi, kötü obstetrik öykü ve dermatolojik sorunları olan hastalarda çoklu deri hastalıklarının önceden belirlenmesinde önemli rol oynayabilir.

References

  • Beksac B, Donmez HG, Cagan M, Unal C, Fadiloglu E, Beksac MS. Acrochordons and autoimmunity: Significance of preconceptional counseling. Hum Antibodies. 2020;28:335-9.
  • Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol. 2012;22:106-10.
  • Beksac B, Donmez HG. Association of bacterial vaginosis and skin disorders in patients with autoimmune antibody positivity. Gynecol Obstet Reprod Med. 2021;27:150-3.
  • Hu Y, Zhu Y, Lian N, Chen M, Bartke A, Yuan R. Metabolic syndrome and skin diseases. Front Endocrinol (Lausanne). 2019;10:788.
  • Rusak E, Chobot A, Krzywicka A, Wenzlau J. Anti-parietal cell antibodies- diagnostic significance. Adv Med Sci. 2016;61:175-9.
  • Fadiloglu E, Unal C, Beksac MS. Management and the pregnancy outcomes of patients positive for anti-parietal cell antibody. Hum Antibodies. 2019;27:111-6.
  • Ünal C, Fadiloglu E, Beksac MS. Pregnancy outcomes of the patients with anti-smooth muscle antibody positivity. Hum Antibodies. 2019;27:167-70.
  • Tanacan A, Beksac MS, Orgul G, Duru S, Sener B, Karaagaoglu E. Impact of extractable nuclear antigen, anti-double stranded DNA, antiphospholipid antibody, and anticardiolipin antibody positivity on obstetrical complications and pregnancy outcomes. Hum Antibodies. 2019;27:135-41.
  • Mumusoglu S, Beksac MS, Ekiz A, Ozdemir P, Hascelik G. Does the presence of autoantibodies without autoimmune diseases and hereditary thrombophilia have an effect on recurrent pregnancy loss? J Matern Fetal Neonatal Med. 2016;29:2352-7.
  • Cagan M, Okuducu U, Donmez HG, Beksac MS. Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and Methylenetetrahydrofolate reductase polymorphisms. Hum Antibodies. 2022;30:59-65.
  • Beksac MS, Tanacan A, Ozten G, Cakar AN. Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation. J Matern Fetal Neonatal Med. 2022;35:1546-53.
  • Beksac MS, Donmez HG. Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling. Hum Antibodies. 2021;29:249-54.
  • Beksac MS, Donmez HG. Impact of hydroxychloroquine on the gestational outcomes of pregnant women with immune system problems that necessitate the use of the drug. J Obstet Gynaecol Res. 2021;47:570-5.
  • Beksac B, Donmez HG, Beksac MS. Association of high levels of C-reactive protein with skin disorders in women having poor obstetric history. Obstet Ginecol (Bucur). 2021;69:58-61.
  • Lorini R, Orecchia G, Martinetti M, Dugoujon JM, Cuccia M. Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms. Autoimmunity. 1992;11:255-60.
  • Kumar B, Sharma VK, Sehgal S. Antismooth muscle and antiparietal cell antibodies in Indians with alopecia areata. Int J Dermatol. 1995;34:542-5.
  • Beksac B, Donmez HG, Beksac MS. Poor obstetric history, skin disorders and type-2 diabetes mellitus. Obstet Ginecol (Bucur). 2022;70:20-3

Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling

Year 2023, Volume: 48 Issue: 1, 278 - 282, 31.03.2023
https://doi.org/10.17826/cumj.1168878

Abstract

Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders.
Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history. Patients were grouped into the control (women with skin disorders only, n=50) and study groups (women with skin disorders and APCA positivity, n=13). The study groups were compared in terms of demographic findings, BOI, and risk factors for placenta-related obstetric complications.
Results: APCA (+) and APCA (–) groups showed no statistically significant difference in terms of demographic findings such as age, gravidity, parity, BOI, and the number of miscarriages.. We have demonstrated that 69.2% (9/13) of the APCA (+) cases have two or more skin diseases, while 34% of APCA (-) women have multiple skin diseases. There was a statistically significant difference between APCA (+) and APCA (–) groups in terms of the presence of single or multiple skin diseases (p=0.029). We could not demonstrate a statistically significant difference between APCA (+) and APCA (–) patients in terms of the presence of risk factors for obstetric complications such as immune system problems, MTHFR polymorphisms, hereditary thrombophilia, and diabetes mellitus type-2.
Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.

References

  • Beksac B, Donmez HG, Cagan M, Unal C, Fadiloglu E, Beksac MS. Acrochordons and autoimmunity: Significance of preconceptional counseling. Hum Antibodies. 2020;28:335-9.
  • Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol. 2012;22:106-10.
  • Beksac B, Donmez HG. Association of bacterial vaginosis and skin disorders in patients with autoimmune antibody positivity. Gynecol Obstet Reprod Med. 2021;27:150-3.
  • Hu Y, Zhu Y, Lian N, Chen M, Bartke A, Yuan R. Metabolic syndrome and skin diseases. Front Endocrinol (Lausanne). 2019;10:788.
  • Rusak E, Chobot A, Krzywicka A, Wenzlau J. Anti-parietal cell antibodies- diagnostic significance. Adv Med Sci. 2016;61:175-9.
  • Fadiloglu E, Unal C, Beksac MS. Management and the pregnancy outcomes of patients positive for anti-parietal cell antibody. Hum Antibodies. 2019;27:111-6.
  • Ünal C, Fadiloglu E, Beksac MS. Pregnancy outcomes of the patients with anti-smooth muscle antibody positivity. Hum Antibodies. 2019;27:167-70.
  • Tanacan A, Beksac MS, Orgul G, Duru S, Sener B, Karaagaoglu E. Impact of extractable nuclear antigen, anti-double stranded DNA, antiphospholipid antibody, and anticardiolipin antibody positivity on obstetrical complications and pregnancy outcomes. Hum Antibodies. 2019;27:135-41.
  • Mumusoglu S, Beksac MS, Ekiz A, Ozdemir P, Hascelik G. Does the presence of autoantibodies without autoimmune diseases and hereditary thrombophilia have an effect on recurrent pregnancy loss? J Matern Fetal Neonatal Med. 2016;29:2352-7.
  • Cagan M, Okuducu U, Donmez HG, Beksac MS. Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and Methylenetetrahydrofolate reductase polymorphisms. Hum Antibodies. 2022;30:59-65.
  • Beksac MS, Tanacan A, Ozten G, Cakar AN. Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation. J Matern Fetal Neonatal Med. 2022;35:1546-53.
  • Beksac MS, Donmez HG. Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling. Hum Antibodies. 2021;29:249-54.
  • Beksac MS, Donmez HG. Impact of hydroxychloroquine on the gestational outcomes of pregnant women with immune system problems that necessitate the use of the drug. J Obstet Gynaecol Res. 2021;47:570-5.
  • Beksac B, Donmez HG, Beksac MS. Association of high levels of C-reactive protein with skin disorders in women having poor obstetric history. Obstet Ginecol (Bucur). 2021;69:58-61.
  • Lorini R, Orecchia G, Martinetti M, Dugoujon JM, Cuccia M. Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms. Autoimmunity. 1992;11:255-60.
  • Kumar B, Sharma VK, Sehgal S. Antismooth muscle and antiparietal cell antibodies in Indians with alopecia areata. Int J Dermatol. 1995;34:542-5.
  • Beksac B, Donmez HG, Beksac MS. Poor obstetric history, skin disorders and type-2 diabetes mellitus. Obstet Ginecol (Bucur). 2022;70:20-3
There are 17 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Burcu Beksac 0000-0001-5726-0696

Hanife Guler Donmez 0000-0002-7413-4939

Murat Cagan 0000-0003-0629-4401

M.sinan Beksac 0000-0001-6362-787X

Publication Date March 31, 2023
Acceptance Date March 15, 2023
Published in Issue Year 2023 Volume: 48 Issue: 1

Cite

MLA Beksac, Burcu et al. “Anti-Parietal Cell Antibody Positivity in Women With Poor Obstetric History and Skin Disorders: Significance of Preconception Counseling”. Cukurova Medical Journal, vol. 48, no. 1, 2023, pp. 278-82, doi:10.17826/cumj.1168878.