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Impact of sexual and neurogenic lower urinary tract dysfunction on multiple sclerosis patients' quality of life and health perceptions

Year 2023, Volume: 48 Issue: 2, 448 - 456, 02.07.2023
https://doi.org/10.17826/cumj.1239533

Abstract

Purpose: To investigate the impact of neurogenic lower urinary tract dysfunction (NLUTD) and sexual dysfunction (SD) on multiple sclerosis (MS) patients' quality of life and health perceptions and evaluate the possible relationship with disease parameters.
Materials and Methods: A total of 192 patients with MS were included in the study. Along with the King's Health (KHQ) and COOP/WONCA questionnaires, Arizona Sexual Experience Scale (ASEX), Beck Depression Scale (BDI), Monitoring My Multiple Sclerosis Scale (MMMS) were used to evaluate the patients’ quality of life and self-perception of health.
Results: The median age of the patients was 39.5 years (18–66 years). In contrast, SD was present in 34.4%, 51.6% of the patients presented with NLUTD. Patients with NLUTD had significant differences in terms of age, education level, duration of disease, EDSS, BDI, ASEX, and MMMS scores. The majority of the study group had minor disability (82.8% had an EDSS score less than 3). Patients with SD showed higher disability, depression, and disrupted self-perception of their health status. In addition, quality of life measures correlated with the presence of NLUTD, SD and depression along with higher disability and altered self perception of their health status.
Conclusion: NLUTD and SD significantly effect quality of life and well being. Increasing awareness about the impact of NLUTD and SD symptoms in patients with MS will provide a comprehensive approach in clinical practice.

References

  • Brownlee WJ, Hardy TA, Fazekas F, Miiler DH. Diagnosis of multiple sclerosis: progress and challenges. Lancet. 2017;389:1336–46.
  • Lakin L, Davis BE, Binns CC, Currie KM, Rensel MR. Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms-a narrative eeview. Neurol Ther. 2021;10:75-98.
  • Rezapour A, AlmasianKia A, Goodarzi S, Hasoumi M, Nouraei Motlagh S, Vahedi S. The impact of disease characteristics on multiple sclerosis patients' quality of life. Epidemiol Health. 2017;39:e2017008.
  • Pappalardo A, Chisari CG, Montanari E, Pesci I, Borriello G, Pozzilli C et al. The clinical value of COOP/WONCA charts in assessment of HRQoL in a large cohort of relapsing-remitting multiple sclerosis patients: Results of a multicenter study. MultScler Relat Disord. 2017;17:154-71.
  • Bass AD, Van Wijmeersch B, Mayer L, Maurer M, Boster A, Mandel M et al. Effect of multiple sclerosis on daily activities, emotional well-being, and relationships: The global vs MS survey. Int J MS Care. 2020;22:158-64.
  • Vitkova M, Rosenberger J, Krokavcova M, Mäurer M, Boster A, Mandel M et al. Health-related quality of life in multiple sclerosis patients with bladder, bowel and sexual dysfunction. Disabil Rehabil. 2014;36:987–92.
  • Domingo S, Kinzy T, Thompson N, Gales S, Stone L, Sullivan A. Factors associated with sexual dysfunction in individuals with multiple sclerosis: Implications for assessment and treatment. Int J MS Care. 2018;20:191–7.
  • Altmann P, Leithner K, Leutmezer F, Gales S, Stone L, Sullivan A. Sexuality and ultiple sclerosis:patient and doctor perspectives. J Sex Med. 2021;18:743-9.
  • Çelik DB, Poyraz EÇ, Bingol A, Idiman E, Ozakbaş S, Kaya D. Sexual dysfunction ın multiple sclerosis: gender differences. J Neurol Sci. 2013;324:17-20.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33:1444–52.
  • Kelleher CJ, Cardozo LD, Salvatore S. A new questionnaire to assess the quality of life of urinary incontinent women. Br J Obstet Gynaecol. 1997;104:1374–9.
  • Akkoc Y, Karapolat H, Eyigor S, Yesil H, Yüceyar N. Quality of life in multiple sclerosis patients with urinary disorders: reliability and validity of the Turkish version of King's health questionnaire. Neurol Sci. 2011;32:417-42.
  • Soykan A. The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Impot Res. 2004;16:531-4.
  • Mc Gahuey CA, Gelenberg AJ, Francisco AL, Moreno FA, Delgado PL, McKnight KM et al. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther. 2000;26:25-40.
  • Minden SL, Feinstein A, Kalb RC, Miller D, Mohr DC, Patten SB et al. Evidence based guideline: assessment and management of psychiatric disorders in individuals with MS: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2014;82:174–81.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-71.
  • Hisli N. Beck Depresyon Envanterinin üniversite öğrencileri için geçerliği, güvenirliği. Psikoloji dergisi.1989;7:3-13.
  • Calıskan ARG, Uzuner A. Turkish validity study of COOP-WONCA functional status scales in a group of type 2 diabetes patients. Jour Turk Fam Phy. 2016;7:54-76.
  • Davidson M. Dartmouth COOP Charts. In Encyclopedia of quality of life and well-being research. (Ed Michalos AC): 1424-6. Dordrecht: Springer, Netherlands, 2016.
  • Taghipour M, Salavati M, Nabavi SM, Akhbari B, Takamjani IB, Negahban H et al. Translation, cross-cultural adaptation and validation of the Persian version of COOP/WONCA charts in Persian-speaking Iranians with multiple sclerosis. Disabil Rehabil. 2018;40:667-72.
  • Gulick EE, Namey M, Halper J. Monitoring my multiple sclerosis. Int J MS Care. 2011;13:137-45.
  • Polat C, Tülek Z, Kürtüncü M, eraksoy M. Validity and reliability of the Turkish version of the Monitoring My Multiple Sclerosis Scale. Noro Psikiyatr Ars. 2017;54:131-6.
  • Parker LS, Topcu G, De Boos D, das Nair R. The notion of "invisibility" in people's experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis. Disabil Rehabil. 2021;43:3276-90.
  • Di Filippo M, Proietti S, Gaetani L, Gubbiotti M, Di Gregorio M, Eusebi P et al. Lower urinary tract symptoms and urodynamic dysfunction in clinically isolated syndromes suggestive of multiple sclerosis. Eur J Neurol. 2014;21:648–53.
  • Aharony SM, Lam O, Corcos J. Treatment of lower urinary tract symptoms in multiple sclerosis patients: Review of the literature and current guidelines. Can Urol Assoc J. 2017;11:E110.
  • Koseoglu M, Gozubatik Celik RG, Tutuncu M, Bingol A, Deringol D, Ataklı D. Sexual dysfunction and associated risk factors in multiple sclerosis. J Surg Med 2020;4:779-83.
  • Kisic-Tepavcevic D, Pekmezovic T, Trajkovic G, Stojsavljevic N, Dujmovic I, Mesaros S et al. Sexual dysfunction in multiple sclerosis: a 6-year follow-up study. J Neurol Sci. 2015; 358:317–23.
  • Mohammad K, Rimaz SH, Dastoorpour M, Sadeghi M, Majdzadeh SR. Quality of life and related factors among multiple sclerosis patients. Sjsph. 2014;11:1–14.
  • Nazari F, Shaygannejad V, Mohammadi Sichani M, Mansourian M, Hajhashemi V. Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study. BMC Urol. 2020;20:62.
  • Reese PR, Pleil AM, Okano GJ, Kelleher CJ. Multinational study of reliability and validity of the King's health questionnaire in patients with overactive bladder. Qual Life Res. 2003;12:427-42.

Cinsel ve nörojenik alt üriner sistem disfonksiyonunun multipl skleroz hastalarının yaşam kalitesi ve sağlık algıları üzerindeki etkisi

Year 2023, Volume: 48 Issue: 2, 448 - 456, 02.07.2023
https://doi.org/10.17826/cumj.1239533

Abstract

Amaç: Nörojenik alt üriner sistem disfonksiyonu (NLUTD) ve cinsel disfonksiyonun (CD) multipl skleroz hastalarının yaşam kalitesi ve sağlık algıları üzerindeki etkisini araştırmak ve hastalık parametreleri ile olası ilişkisini değerlendirmek.
Gereç ve Yöntem: Çalışmaya toplam 192 MS hastası dahil edildi. Hastaların yaşam kalitelerini ve sağlık algılarını değerlendirmek için King’s Yaşam anketi (KHQ) ve COOP/WONCA anketleri yanı sıra Arizona cinsel deneyim ölçeği (ASEX), Beck depresyon ölçeği (BDÖ), Multipl skleroz izlem ölçeği (MMMS) kullanıldı.
Bulgular: Hastaların yaş ortancası 39,5 (18-66) idi. Hastaların % 34,4’ünde CD mevcutken, % 51,6’sında NLUTD mevcuttu. NLUTD olan hastaların yaş, eğitim düzeyi, hastalık süresi, EDSS, BDÖ, ASEX ve MMMS skorları açısından anlamlı fark vardı. Çalışma grubunun büyük çoğunluğunun hafif özürlüğü vardı (% 82,8’inin EDSS puanı üçten azdı). CD olan hastalarda daha fazla özürlülük, depresyon ve sağlık durumlarına ilişkin algılarında bozulma görüldü. Ek olarak, yaşam kalitesi ölçümleri, NLUTD, CD ve depresyon varlığıyle birlikte daha fazla özürlülük ve sağlık durumlarıyla ilişkili değişen algıları ile korele olarak bulundu.
Sonuç: NLUTD ve CD yaşam kalitesini ve iyilik halini önemli ölçüde etkiler. MS’li hastalarda NLUTD ve CD semptomlarının etkisi konusunda farkındalığın artması, klinik pratikte kapsamlı bir yaklaşım sağlayacaktır.

References

  • Brownlee WJ, Hardy TA, Fazekas F, Miiler DH. Diagnosis of multiple sclerosis: progress and challenges. Lancet. 2017;389:1336–46.
  • Lakin L, Davis BE, Binns CC, Currie KM, Rensel MR. Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms-a narrative eeview. Neurol Ther. 2021;10:75-98.
  • Rezapour A, AlmasianKia A, Goodarzi S, Hasoumi M, Nouraei Motlagh S, Vahedi S. The impact of disease characteristics on multiple sclerosis patients' quality of life. Epidemiol Health. 2017;39:e2017008.
  • Pappalardo A, Chisari CG, Montanari E, Pesci I, Borriello G, Pozzilli C et al. The clinical value of COOP/WONCA charts in assessment of HRQoL in a large cohort of relapsing-remitting multiple sclerosis patients: Results of a multicenter study. MultScler Relat Disord. 2017;17:154-71.
  • Bass AD, Van Wijmeersch B, Mayer L, Maurer M, Boster A, Mandel M et al. Effect of multiple sclerosis on daily activities, emotional well-being, and relationships: The global vs MS survey. Int J MS Care. 2020;22:158-64.
  • Vitkova M, Rosenberger J, Krokavcova M, Mäurer M, Boster A, Mandel M et al. Health-related quality of life in multiple sclerosis patients with bladder, bowel and sexual dysfunction. Disabil Rehabil. 2014;36:987–92.
  • Domingo S, Kinzy T, Thompson N, Gales S, Stone L, Sullivan A. Factors associated with sexual dysfunction in individuals with multiple sclerosis: Implications for assessment and treatment. Int J MS Care. 2018;20:191–7.
  • Altmann P, Leithner K, Leutmezer F, Gales S, Stone L, Sullivan A. Sexuality and ultiple sclerosis:patient and doctor perspectives. J Sex Med. 2021;18:743-9.
  • Çelik DB, Poyraz EÇ, Bingol A, Idiman E, Ozakbaş S, Kaya D. Sexual dysfunction ın multiple sclerosis: gender differences. J Neurol Sci. 2013;324:17-20.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33:1444–52.
  • Kelleher CJ, Cardozo LD, Salvatore S. A new questionnaire to assess the quality of life of urinary incontinent women. Br J Obstet Gynaecol. 1997;104:1374–9.
  • Akkoc Y, Karapolat H, Eyigor S, Yesil H, Yüceyar N. Quality of life in multiple sclerosis patients with urinary disorders: reliability and validity of the Turkish version of King's health questionnaire. Neurol Sci. 2011;32:417-42.
  • Soykan A. The reliability and validity of Arizona sexual experiences scale in Turkish ESRD patients undergoing hemodialysis. Int J Impot Res. 2004;16:531-4.
  • Mc Gahuey CA, Gelenberg AJ, Francisco AL, Moreno FA, Delgado PL, McKnight KM et al. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther. 2000;26:25-40.
  • Minden SL, Feinstein A, Kalb RC, Miller D, Mohr DC, Patten SB et al. Evidence based guideline: assessment and management of psychiatric disorders in individuals with MS: report of the guideline development subcommittee of the American Academy of Neurology. Neurology. 2014;82:174–81.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-71.
  • Hisli N. Beck Depresyon Envanterinin üniversite öğrencileri için geçerliği, güvenirliği. Psikoloji dergisi.1989;7:3-13.
  • Calıskan ARG, Uzuner A. Turkish validity study of COOP-WONCA functional status scales in a group of type 2 diabetes patients. Jour Turk Fam Phy. 2016;7:54-76.
  • Davidson M. Dartmouth COOP Charts. In Encyclopedia of quality of life and well-being research. (Ed Michalos AC): 1424-6. Dordrecht: Springer, Netherlands, 2016.
  • Taghipour M, Salavati M, Nabavi SM, Akhbari B, Takamjani IB, Negahban H et al. Translation, cross-cultural adaptation and validation of the Persian version of COOP/WONCA charts in Persian-speaking Iranians with multiple sclerosis. Disabil Rehabil. 2018;40:667-72.
  • Gulick EE, Namey M, Halper J. Monitoring my multiple sclerosis. Int J MS Care. 2011;13:137-45.
  • Polat C, Tülek Z, Kürtüncü M, eraksoy M. Validity and reliability of the Turkish version of the Monitoring My Multiple Sclerosis Scale. Noro Psikiyatr Ars. 2017;54:131-6.
  • Parker LS, Topcu G, De Boos D, das Nair R. The notion of "invisibility" in people's experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis. Disabil Rehabil. 2021;43:3276-90.
  • Di Filippo M, Proietti S, Gaetani L, Gubbiotti M, Di Gregorio M, Eusebi P et al. Lower urinary tract symptoms and urodynamic dysfunction in clinically isolated syndromes suggestive of multiple sclerosis. Eur J Neurol. 2014;21:648–53.
  • Aharony SM, Lam O, Corcos J. Treatment of lower urinary tract symptoms in multiple sclerosis patients: Review of the literature and current guidelines. Can Urol Assoc J. 2017;11:E110.
  • Koseoglu M, Gozubatik Celik RG, Tutuncu M, Bingol A, Deringol D, Ataklı D. Sexual dysfunction and associated risk factors in multiple sclerosis. J Surg Med 2020;4:779-83.
  • Kisic-Tepavcevic D, Pekmezovic T, Trajkovic G, Stojsavljevic N, Dujmovic I, Mesaros S et al. Sexual dysfunction in multiple sclerosis: a 6-year follow-up study. J Neurol Sci. 2015; 358:317–23.
  • Mohammad K, Rimaz SH, Dastoorpour M, Sadeghi M, Majdzadeh SR. Quality of life and related factors among multiple sclerosis patients. Sjsph. 2014;11:1–14.
  • Nazari F, Shaygannejad V, Mohammadi Sichani M, Mansourian M, Hajhashemi V. Quality of life among patients with multiple sclerosis and voiding dysfunction: a cross-sectional study. BMC Urol. 2020;20:62.
  • Reese PR, Pleil AM, Okano GJ, Kelleher CJ. Multinational study of reliability and validity of the King's health questionnaire in patients with overactive bladder. Qual Life Res. 2003;12:427-42.
There are 30 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Neslihan Eşkut 0000-0003-1882-8992

Aslı Köşkderelioğlu 0000-0002-7828-6382

Early Pub Date July 10, 2023
Publication Date July 2, 2023
Acceptance Date May 27, 2023
Published in Issue Year 2023 Volume: 48 Issue: 2

Cite

MLA Eşkut, Neslihan and Aslı Köşkderelioğlu. “Impact of Sexual and Neurogenic Lower Urinary Tract Dysfunction on Multiple Sclerosis patients’ Quality of Life and Health Perceptions”. Cukurova Medical Journal, vol. 48, no. 2, 2023, pp. 448-56, doi:10.17826/cumj.1239533.