Research Article
Year 2023,
Volume: 3 Issue: 4, 123 - 131, 29.10.2023
Abstract
Introduction: Familial Mediterranean Fever (FMF) is a common autoinflammatory disease, especially in Mediterranean populations. FMF typically occurs with fever and serositis attacks and can negatively affect the individual's life. In our study, we aimed to investigate the effects of working conditions and the disease course on the work life of FMF patients.
Methods: The adult patients with pathogenic or likely pathogenic mutations in the MEFV gene who applied to our medical genetic outpatient clinic of the Faculty of Medicine, Çanakkale Onsekiz Mart University between 01.01.2010 and 01.08.2020 were included in our study. We created a questionnaire of 34 questions, which included sociodemographic data, information about the FMF course of the patients, and the effects of work conditions and FMF on the work life of these patients. The questionnaire link, created over Google Drive, was sent to the patient's current mobile phone numbers via text message, and the answers received until 31.12.2020 were evaluated.
Results: A total of 154 survey responses were obtained, and 113 were eligible for our study. Twenty-four of 104 (23.1%) participants who have worked in any job so far stated that they have changed or quit their jobs because of increased or worsening FMF attacks. Of 72 participants who have been working actively for the last year, 4 (5.6%) of them we are reported that they have a health problem in the workplace due to FMF disease. The statistically significant relationships were found between the FMF-induced changing or quitting job and the attack number in the last year regardless of attack severity, work-related adverse psychological effects, the mode of transportation to work, and the physical conditions in the working environment.
Conclusion: We suggest that the regulation of work environments, considering the factors that trigger attacks in FMF patients, will contribute to the increase in quality of life and work performance in these patients.
References
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- Dinc A. Non-periodic leg pain in patients with familial Mediterranean fever. Ann Rheum Dis. 2000;59(400).
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Year 2023,
Volume: 3 Issue: 4, 123 - 131, 29.10.2023
Abstract
References
- Alghamdi M. Familial Mediterranean fever, review of the literature. Clin Rheumatol. 2017;36(8):1707–13.
- Ben-Chetrit E, Touitou I. Familial Mediterranean fever in the world. Arthritis Care Res. 2009;61(10):1447–53.
- Shohat M. Familial Mediterranean Fever. 2000 Aug 8 [Updated 2016 Dec 15]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington S 1993-2021. A from: https://www. ncbi. nlm. nih. gov/books/NBK1227. No Title.
- Sönmez HE, Batu ED, Özen S. Familial mediterranean fever: Current perspectives. J Inflamm Res. 2016;9:13–20.
- Rowczenio DM, Iancu DS, Trojer H, Gilbertson JA, Gillmore JD, Wechalekar AD, et al. Autosomal dominant familial Mediterranean fever in Northern European Caucasians associated with deletion of p.M694 residue-A case series and genetic exploration. Rheumatol (United Kingdom). 2017;56(2):209–13.
- Stoffels M, Szperl A, Simon A, Netea MG, Plantinga TS, Van Deuren M, et al. MEFV mutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease. Ann Rheum Dis. 2014;73(2):455–61.
- Kishida D, Nakamura A, Yazaki M, Oka K, Tsuchiya-Suzuki A, Ichikawa T, et al. Triggering factors for febrile attacks in Japanese patients with familial Mediterranean fever. Clin Exp Rheumatol. 2020;38(5):76–9.
- Kaplanoğlu E. Mesleki Stresin Temel Nedenleri Ve Muhtemel Sonuçları: Manisa İlindeki SMMM’ler Üzerine Bir Araştırma. Muhasebe ve Finans Derg. 2014;(64):131–50.
- Yaşar Bilge NŞ, Sari İ, Solmaz D, Şenel S, Emmungil H, Kiliç L, et al. The distribution of MEFV mutations in Turkish FMF patienmulticenter study representing results of anatolia. Turkish J Med Sci. 2019;49(2):472–7.
- Soriano A, Manna R. Familial Mediterranean fever: New phenotypes. Autoimmun Rev [Internet]. 2012;12(1):31–7. Available from: http://dx.doi.org/10.1016/j.autrev.2012.07.019
- INFEVERS:an online database for autoinflammatory mutations. [Internet]. Available from: https://infevers.umai-montpellier.fr/ Accessed ( 2021-03-23 )
- Cekin N, Akyurek ME, Pinarbasi E, Ozen F. MEFV mutations and their relation to major clinical symptoms of Familial Mediterranean Fever. Gene [Internet]. 2017;626:9–13. Available from: http://dx.doi.org/10.1016/j.gene.2017.05.013
- Marek-Yagel D, Berkun Y, Padeh S, Abu A, Reznik-Wolf H, Livneh A, et al. Clinical disease among patients heterozygous for familial Mediterranean fever. Arthritis Rheum. 2009;60(6):1862–6.
- Moradian MM, Sarkisian T, Ajrapetyan H, Avanesian N. Genotype-phenotype studies in a large cohort of Armenian patients with familial Mediterranean fever suggest clinical disease with heterozygous MEFV mutations. J Hum Genet [Internet]. 2010;55(6):389–93. Available from: http://dx.doi.org/10.1038/jhg.2010.52
- Ozen S, Demirkaya E, Erer B, Livneh A, Ben-Chetrit E, Giancane G, et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016;75(4):644–51.
- Yenokyan G, Armenian HK. Triggers for attacks in familial mediterranean fever: Application of the case-crossover design. Am J Epidemiol. 2012;175(10):1054–61.
- Karadag O, Tufan A, Yazisiz V, Ureten K, Yilmaz S, Cinar M, et al. The factors considered as trigger for the attacks in patients with familial Mediterranean fever. Rheumatol Int. 2013;33(4):893–7.
- Cebicci H, Aykac Cebicci M, Sahan M, Gurbuz S, Karaca B, Karakus A, et al. Triggers for attacks in familial Mediterranean fever: Are there any regional or ethnic differences? Acta Medica Mediterr. 2014;30(6):1349–53.
- Gidron Y, Berkovitch M, Press J. Psychosocial correlates of incidence of attacks in children with Familial Mediterranean Fever. J Behav Med. 2003;26(2):95–104.
- Deger SM, Ozturk MA, Demirag MD, Aslan S, Goker B, Haznedaroglu S, et al. Health-related quality of life and its associations with mood condition in familial Mediterranean fever patients. Rheumatol Int. 2011;31(5):623–8.
- Kucuksahin O, Omma A, Ozdemirel AE, Tecer D, Ulutas S, Maras Y, et al. Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity. Int J Rheum Dis. 2018;21(10):1849–56.
- Avagyan T, Amaryan G, Budumyan A, Hayrapetyan A TA. Influence of some environmental factors on manifestation of familial Mediterranean fever in children: clinical and genetic aspects. Caucaus J Heal Sci Public Heal. 2018;2(2).
- Alayli G, Durmus D, Ozkaya O, Sen HE, Nalcacioglu H, Bilgici A, et al. Functional capacity, strength, and quality of life in children and youth with familial Mediterranean fever. Pediatr Phys Ther. 2014;26(3):347–52.
- Dinc A. Non-periodic leg pain in patients with familial Mediterranean fever. Ann Rheum Dis. 2000;59(400).
- Babaoglu H, Varan O, Atas N, Satis H, Salman R, Ozturk MA, et al. Detection of Familial Mediterranean Fever attacks by using a connected activity tracker and assessment of impact of attacks to daily physical activities: a pilot study. Clin Rheumatol. 2019;38(7):1941–6.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | October 29, 2023 |
| Submission Date | October 3, 2023 |
| Published in Issue | Year 2023 Volume: 3 Issue: 4 |
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