Case Report
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Gastrik Skuamöz Hücreli Karsinom: Olgu Sunumu

Year 2019, Volume: 21 Issue: 3, 268 - 270, 30.12.2019
https://doi.org/10.18678/dtfd.656125

Abstract

Gastrik skuamöz hücreli karsinom nadir görülür ve çoğunlukla yaşlı bireyleri etkiler. Yetmiş sekiz yaşında kadın hasta bulantı, kusma, kilo kaybı ve epigastrik ağrı şikayeti ile başvurmuştur. Endoskopik incelemede posterior bölgede büyük kurvaturdan antrum'a kadar ülsero vejetatif bir kitle saptanmıştır. Özofagogastrik bileşke ve kardiya ayrıca normal olarak izlenmiştir. Hastaya tanı amaçlı endoskopik biyopsi yapılmıştır. Histopatolojik olarak, tümörün desmoplastik bir stromada infiltre yuvalar oluşturan atipik skuamöz hücrelerden meydana geldiği görülmüştür. İmmünohistokimyasal olarak neoplastik hücrelerde p40 ve p63 ile pozitiflik saptanmış olup CEA ile immünekspresyon izlenmemiştir. Başka bir organ kaynaklı buraya metastazı düşündürecek radyolojik bulgu da saptanmamıştır. Burada bir gastrik skuamöz hücreli karsinom vakası sunulmuş olup klinik ve morfolojik özellikleri literatür eşliğinde tartışılmıştır.

References

  • Fukuyama M, Rugge M, Washington MK. Tumor of the stomach. In: Carnerio F, Chan JKC, Cheung NYA et al., editors. Digestive system tumours, WHO classification of tumours., 5th ed. Lyon: IARC press; 2019. P.59-97.
  • Guzman Rojas P, Parikh J, Vishnubhotla P, Oharriz JJ. Primary gastric squamous cell carcinoma. Cureus. 2018;10(3):e2389.
  • Gülçiçek OB, Solmaz A, Özdoğan K, Erçetin C, Yavuz E, Yiğitbaş H, et al. Primary squamous cell carcinoma of the stomach. Ulus Cerrahi Derg. 2015;32(3):221-3.
  • Chen Y, Zhu H, Xu F, Cao Y, Gu X, Wan Y, et al. Clinicopathological characteristics, treatment, and prognosis of 21 patients with primary gastric squamous cell carcinoma. Gastroenterol Res Pract. 2016;2016:3062547.
  • Parks RE. Squamous neoplasms of the stomach. Am J Roentgenol Radium Ther Nucl Med. 1967;101(2):447-9.
  • Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14(2):101-12.
  • Zhou K, Faraz A, Magotra M, Tahir M. Exophytic primary gastric squamous cell carcinoma and H. pylori gastritis. BMJ Case Rep. 2019;12(7):e230310.
  • Yildirim Y, Akcali Z, Bilezikci B, Ozyilkan O. Primary squamous cell carcinoma of the stomach: a case report. Tumori. 2005;91(5):440-2.
  • Dursun M, Yaldiz M, Işikdoğan A, Yilmaz G, Canoruç F, Ormeci N, et al. Primary squamous cell carcinoma of the stomach: a case report and review of the literature. Eur J Gastroenterol Hepatol. 2003;15(3):329-30.
  • Akce M, Jiang R, Alese OB, Shaib WL, Wu C, Behera M, et al. Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis. J Gastrointest Oncol. 2019;10(1):85-94.
  • Vailas MG, Syllaios A, Hasemaki N, Sotiropoulou M, Mpaili E, Sarlanis H, et al. A type of neoplasia deadlier than gastric adenocarcinoma? Report of a case of primary gastric squamous cell carcinoma. World J Surg Oncol. 2019;17(1):113.

Gastric Squamous Cell Carcinoma: A Case Report

Year 2019, Volume: 21 Issue: 3, 268 - 270, 30.12.2019
https://doi.org/10.18678/dtfd.656125

Abstract

Gastric squamous cell carcinoma is rarely seen and affects mostly elder patients. A 78-year-old woman presented with nausea, vomiting, weight loss, and epigastric pain. There was an ulcero-vegetative mass in the posterior area from the large curvature to the antrum in the endoscopic examination. The gastroesophageal junction and cardia were also normal. We performed a diagnostic endoscopic biopsy. Histopathologically, it was composed of atypical squamous cells displaying infiltrating solid nests in a desmoplastic stroma. Immunohistochemically, the neoplastic cells also showed positivity for p40 and p63 and negativity for CEA. Besides, there was no radiological evidence of metastasis from other organs. We herein presented a case of gastric squamous cell carcinoma and discussed its clinical and morphological features with the literature.

References

  • Fukuyama M, Rugge M, Washington MK. Tumor of the stomach. In: Carnerio F, Chan JKC, Cheung NYA et al., editors. Digestive system tumours, WHO classification of tumours., 5th ed. Lyon: IARC press; 2019. P.59-97.
  • Guzman Rojas P, Parikh J, Vishnubhotla P, Oharriz JJ. Primary gastric squamous cell carcinoma. Cureus. 2018;10(3):e2389.
  • Gülçiçek OB, Solmaz A, Özdoğan K, Erçetin C, Yavuz E, Yiğitbaş H, et al. Primary squamous cell carcinoma of the stomach. Ulus Cerrahi Derg. 2015;32(3):221-3.
  • Chen Y, Zhu H, Xu F, Cao Y, Gu X, Wan Y, et al. Clinicopathological characteristics, treatment, and prognosis of 21 patients with primary gastric squamous cell carcinoma. Gastroenterol Res Pract. 2016;2016:3062547.
  • Parks RE. Squamous neoplasms of the stomach. Am J Roentgenol Radium Ther Nucl Med. 1967;101(2):447-9.
  • Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14(2):101-12.
  • Zhou K, Faraz A, Magotra M, Tahir M. Exophytic primary gastric squamous cell carcinoma and H. pylori gastritis. BMJ Case Rep. 2019;12(7):e230310.
  • Yildirim Y, Akcali Z, Bilezikci B, Ozyilkan O. Primary squamous cell carcinoma of the stomach: a case report. Tumori. 2005;91(5):440-2.
  • Dursun M, Yaldiz M, Işikdoğan A, Yilmaz G, Canoruç F, Ormeci N, et al. Primary squamous cell carcinoma of the stomach: a case report and review of the literature. Eur J Gastroenterol Hepatol. 2003;15(3):329-30.
  • Akce M, Jiang R, Alese OB, Shaib WL, Wu C, Behera M, et al. Gastric squamous cell carcinoma and gastric adenosquamous carcinoma, clinical features and outcomes of rare clinical entities: a National Cancer Database (NCDB) analysis. J Gastrointest Oncol. 2019;10(1):85-94.
  • Vailas MG, Syllaios A, Hasemaki N, Sotiropoulou M, Mpaili E, Sarlanis H, et al. A type of neoplasia deadlier than gastric adenocarcinoma? Report of a case of primary gastric squamous cell carcinoma. World J Surg Oncol. 2019;17(1):113.
There are 11 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Mehmet Gamsızkan 0000-0001-9942-4898

Serkan Torun 0000-0003-3101-4934

Sami Doğan 0000-0003-2798-4049

Publication Date December 30, 2019
Submission Date December 6, 2019
Published in Issue Year 2019 Volume: 21 Issue: 3

Cite

APA Gamsızkan, M., Torun, S., & Doğan, S. (2019). Gastric Squamous Cell Carcinoma: A Case Report. Duzce Medical Journal, 21(3), 268-270. https://doi.org/10.18678/dtfd.656125
AMA Gamsızkan M, Torun S, Doğan S. Gastric Squamous Cell Carcinoma: A Case Report. Duzce Med J. December 2019;21(3):268-270. doi:10.18678/dtfd.656125
Chicago Gamsızkan, Mehmet, Serkan Torun, and Sami Doğan. “Gastric Squamous Cell Carcinoma: A Case Report”. Duzce Medical Journal 21, no. 3 (December 2019): 268-70. https://doi.org/10.18678/dtfd.656125.
EndNote Gamsızkan M, Torun S, Doğan S (December 1, 2019) Gastric Squamous Cell Carcinoma: A Case Report. Duzce Medical Journal 21 3 268–270.
IEEE M. Gamsızkan, S. Torun, and S. Doğan, “Gastric Squamous Cell Carcinoma: A Case Report”, Duzce Med J, vol. 21, no. 3, pp. 268–270, 2019, doi: 10.18678/dtfd.656125.
ISNAD Gamsızkan, Mehmet et al. “Gastric Squamous Cell Carcinoma: A Case Report”. Duzce Medical Journal 21/3 (December 2019), 268-270. https://doi.org/10.18678/dtfd.656125.
JAMA Gamsızkan M, Torun S, Doğan S. Gastric Squamous Cell Carcinoma: A Case Report. Duzce Med J. 2019;21:268–270.
MLA Gamsızkan, Mehmet et al. “Gastric Squamous Cell Carcinoma: A Case Report”. Duzce Medical Journal, vol. 21, no. 3, 2019, pp. 268-70, doi:10.18678/dtfd.656125.
Vancouver Gamsızkan M, Torun S, Doğan S. Gastric Squamous Cell Carcinoma: A Case Report. Duzce Med J. 2019;21(3):268-70.