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Fibrinojen/Albümin Oranının COVID-19 Hastalarının Prognozundaki Değeri

Year 2022, Volume: 24 Issue: 2, 176 - 181, 30.08.2022
https://doi.org/10.18678/dtfd.1108086

Abstract

Amaç: Fibrinojen ve albümin inflamasyonda rol oynayabilen proteinlerdendir. Bu çalışmada, koronavirüs hastalığı 2019 (coronavirus disease 2019, COVID-19) hastalarında fibrinojen, albümin ve fibrinojen/albümin oranı (FAR) düzeylerinin hastalık şiddeti ve prognoz belirteçleri olarak rolünün araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Çalışmada Mart ve Mayıs 2020 tarihleri arasında COVID-19 tanısı ile Sakarya Eğitim ve Araştırma Hastanesi Nöroloji Kliniği’ne yatırılan 19 ve 84 yaş arasındaki 71 hasta geriye dönük olarak analiz edildi. Hastaların fibrinojen, albümin, FAR, D-dimer, trombosit ve C-reaktif protein (CRP) düzeyleri, hastanede kalış süresinin uzunluğu, hayatta kalma ve COVID-19 klinik şiddetine göre karşılaştırıldı.
Bulgular: Hastaların 28’i (%39,4) erkek ve 43’ü (%60,6) kadın olup yaş ortalaması 55,7±20,7 yıl idi. COVID-19 klinik şiddetine göre ayrılmış olan gruplar arasında yaş, fibrinojen, albümin, FAR, D-dimer ve CRP değerleri açısından anlamlı bir farklılık vardı (tüm p değerleri <0,001). Ayrıca, hastanede daha uzun süre yatan hastalarda fibrinojen, FAR, D-dimer ve CRP değerleri anlamlı olarak daha yüksek bulunurken, bu hastalarda albümin düzeyleri daha düşüktü (tüm p değerleri <0,001). Hayatta kalamayan hastalarda yaşayan hastalara göre FAR değerleri daha yüksek ve albümin değerleri daha düşüktü (sırasıyla, p=0.025 ve p<0.001).
Sonuç: FAR seviyeleri, COVID-19 hastalarında ölüm riskini tahmin etmede faydalı olabilir. Ayrıca hastalığın şiddeti ve hastanede kalış süresi arttıkça daha yüksek seviyelere sahip olduğu için prognozu belirlemede de yardımcı ve faydalı olabilir.

References

  • Küçükceran K, Ayranci MK, Girişgin AS, Koçak S. Predictive value of D-dimer/albumin ratio and fibrinogen/albumin ratio for in-hospital mortality in patients with COVID-19. Int J Clin Pract. 2021;75(7):e14263.
  • Karabela ŞN, Kart Yaşar K. Laboratory tests in the diagnosis of COVID-19. Duzce Med J. 2020;22(S1):5-9.
  • Wool GD, Miller JL. The impact of COVID-19 disease on platelets and coagulation. Pathobiology. 2021;88(1):15-27.
  • Gerotziafas GT, Catalano M, Colgan MP, Pecsvarady Z, Wautrecht JC, Fazeli B, et al. Guidance for the management of patients with vascular disease or cardiovascular risk factors and COVID-19: position paper from VAS-European Independent Foundation in Angiology/Vascular Medicine. Thromb Haemost. 2020;120(12):1597-628.
  • Zakai NA, McClure LA, Judd SE, Kissela B, Howard G, Safford M, et al. D-dimer and the risk of stroke and coronary heart disease. The reasons for geographic and racial differences in stroke (REgARDS) study. Thromb Haemost. 2017;117(3):618-24.
  • Kotan D, Taydaş O, Ateş ÖF, Öztürk MH. Investigating the frequency of stroke in SARS-CoV-2 cases in Sakarya City, Turkey. Duzce Med J. 2020;22(S1):51-5.
  • Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low albumin levels are associated with mortality risk in hospitalized patients. Am J Med. 2017;130(12):1465.e11-9.
  • Karahan O, Yavuz C, Kankilic N, Demirtas S, Tezcan O, Caliskan A, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagul Fibrinolysis. 2016;27(6):684-90.
  • Xin H, Jiang F, Xue A, Liang J, Zhang J, Yang F, et all. Risk factors associated with occurrence of COVID-19 among household persons exposed to patients with confirmed COVID-19 in Qingdao Municipal, China. Transbound Emerg Dis. 2021;68(2):782-8.
  • Rostami M, Mansouritorghabeh H. D-dimer level in COVID-19 infection: a systematic review. Expert Rev Hematol. 2020;13(11):1265-75.
  • Creel-Bulos C, Liu M, Auld SC, Gaddh M, Kempton CL, Sharifpour M, et al. Trends and diagnostic value of D-dimer levels in patients hospitalized with coronavirus disease 2019. Medicine (Baltimore). 2020;99(46):e23186.
  • He X, Yao F, Chen J, Wang Y, Fang X, Lin X, et al. The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients. Sci Rep. 2021;11(1):1830.
  • Huang W, Li C, Wang Z, Wang H, Zhou N, Jiang J, et al. Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases. Sci China Life Sci. 2020;63(11):1678-87.
  • Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-8.
  • Velavan TP, Meyer CG. Mild versus severe COVID-19: Laboratory markers. Int J Infect Dis. 2020;95:304-7.
  • Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, et al. Association between platelet parameters and mortality in coronavirus disease 2019: retrospective cohort study. Platelets. 2020;31(4):490-6.
  • Yang X, Yang Q, Wang Y, Wu Y, Xu J, Yu Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020;18(6):1469-72.
  • Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
  • Fan BE, Chong VCL, Chan SSW, Lim GH, Lim KGE, Tan GB, et al. Hematologic parameters in patients with COVID‐19 infection. Am J Hematol. 2020;95(6):E131-4.
  • Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic features, and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020;323(15):1488-94.
  • Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-43.
  • Mani Mishra P, Uversky VN, Nandi CK. Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2. Med Hypotheses. 2020;140:109790.
  • Chojkier M. Inhibition of albumin synthesis in chronic diseases: molecular mechanisms. J Clin Gastroenterol. 2005;39(4 Suppl 2):S143-6.
  • Koh YW, Lee HW. Prognostic impact of C-reactive protein/albumin ratio on the overall survival of patients with advanced nonsmall cell lung cancers receiving palliative chemotherapy. Medicine (Baltimore). 2017;96(19):e6848.
  • Tang N, Li DJ, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-7.
  • Liu F, Xu A, Zhang Y, Xuan W, Yan T, Pan K, et al. Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression. Int J Infect Dis. 2020;95:183-91.

The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients

Year 2022, Volume: 24 Issue: 2, 176 - 181, 30.08.2022
https://doi.org/10.18678/dtfd.1108086

Abstract

Aim: Fibrinogen and albumin are proteins that play a role in inflammation. In this study, it was aimed to investigate the role of fibrinogen, albumin, and fibrinogen/albumin ratio (FAR) levels as markers of disease severity and prognosis in coronavirus disease 2019 (COVID-19) patients.
Material and Methods: Seventy-one patients aged between 19 and 84 years diagnosed with COVID-19 who were hospitalized in Sakarya University Training and Research Hospital, Neurology Department between March and May 2020 were analyzed retrospectively. Fibrinogen, albumin, FAR, D-dimer, platelet, and C-reactive protein (CRP) levels of the patients were compared according to the length of hospitalization duration, survival, and clinical severity of COVID-19.
Results: Twenty-eight (%39.4) of the patients were male and 43 (%60.6) were female, and the mean age was 55.7±20.7 years. There was a significant difference between the groups of COVID-19 clinical severity in terms of age, fibrinogen, albumin, FAR, D-dimer, and CRP values (all p values were <0.001). Also, significantly higher fibrinogen, FAR, D-dimer, and CRP values were found in patients hospitalized longer, while the albumin level was lower in these patients (all p values were <0.001). FAR values were higher and albumin values were lower in non-surviving patients compared to surviving patients (p=0.025 and p<0.001, respectively).
Conclusion: FAR levels may be useful in predicting mortality risk in COVID-19 patients. In addition, it may be helpful and useful in determining the prognosis since it has higher levels as the severity of the disease and the length of hospital stay increase.

References

  • Küçükceran K, Ayranci MK, Girişgin AS, Koçak S. Predictive value of D-dimer/albumin ratio and fibrinogen/albumin ratio for in-hospital mortality in patients with COVID-19. Int J Clin Pract. 2021;75(7):e14263.
  • Karabela ŞN, Kart Yaşar K. Laboratory tests in the diagnosis of COVID-19. Duzce Med J. 2020;22(S1):5-9.
  • Wool GD, Miller JL. The impact of COVID-19 disease on platelets and coagulation. Pathobiology. 2021;88(1):15-27.
  • Gerotziafas GT, Catalano M, Colgan MP, Pecsvarady Z, Wautrecht JC, Fazeli B, et al. Guidance for the management of patients with vascular disease or cardiovascular risk factors and COVID-19: position paper from VAS-European Independent Foundation in Angiology/Vascular Medicine. Thromb Haemost. 2020;120(12):1597-628.
  • Zakai NA, McClure LA, Judd SE, Kissela B, Howard G, Safford M, et al. D-dimer and the risk of stroke and coronary heart disease. The reasons for geographic and racial differences in stroke (REgARDS) study. Thromb Haemost. 2017;117(3):618-24.
  • Kotan D, Taydaş O, Ateş ÖF, Öztürk MH. Investigating the frequency of stroke in SARS-CoV-2 cases in Sakarya City, Turkey. Duzce Med J. 2020;22(S1):51-5.
  • Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low albumin levels are associated with mortality risk in hospitalized patients. Am J Med. 2017;130(12):1465.e11-9.
  • Karahan O, Yavuz C, Kankilic N, Demirtas S, Tezcan O, Caliskan A, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagul Fibrinolysis. 2016;27(6):684-90.
  • Xin H, Jiang F, Xue A, Liang J, Zhang J, Yang F, et all. Risk factors associated with occurrence of COVID-19 among household persons exposed to patients with confirmed COVID-19 in Qingdao Municipal, China. Transbound Emerg Dis. 2021;68(2):782-8.
  • Rostami M, Mansouritorghabeh H. D-dimer level in COVID-19 infection: a systematic review. Expert Rev Hematol. 2020;13(11):1265-75.
  • Creel-Bulos C, Liu M, Auld SC, Gaddh M, Kempton CL, Sharifpour M, et al. Trends and diagnostic value of D-dimer levels in patients hospitalized with coronavirus disease 2019. Medicine (Baltimore). 2020;99(46):e23186.
  • He X, Yao F, Chen J, Wang Y, Fang X, Lin X, et al. The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients. Sci Rep. 2021;11(1):1830.
  • Huang W, Li C, Wang Z, Wang H, Zhou N, Jiang J, et al. Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases. Sci China Life Sci. 2020;63(11):1678-87.
  • Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-8.
  • Velavan TP, Meyer CG. Mild versus severe COVID-19: Laboratory markers. Int J Infect Dis. 2020;95:304-7.
  • Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, et al. Association between platelet parameters and mortality in coronavirus disease 2019: retrospective cohort study. Platelets. 2020;31(4):490-6.
  • Yang X, Yang Q, Wang Y, Wu Y, Xu J, Yu Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020;18(6):1469-72.
  • Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
  • Fan BE, Chong VCL, Chan SSW, Lim GH, Lim KGE, Tan GB, et al. Hematologic parameters in patients with COVID‐19 infection. Am J Hematol. 2020;95(6):E131-4.
  • Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic features, and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020;323(15):1488-94.
  • Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-43.
  • Mani Mishra P, Uversky VN, Nandi CK. Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2. Med Hypotheses. 2020;140:109790.
  • Chojkier M. Inhibition of albumin synthesis in chronic diseases: molecular mechanisms. J Clin Gastroenterol. 2005;39(4 Suppl 2):S143-6.
  • Koh YW, Lee HW. Prognostic impact of C-reactive protein/albumin ratio on the overall survival of patients with advanced nonsmall cell lung cancers receiving palliative chemotherapy. Medicine (Baltimore). 2017;96(19):e6848.
  • Tang N, Li DJ, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-7.
  • Liu F, Xu A, Zhang Y, Xuan W, Yan T, Pan K, et al. Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression. Int J Infect Dis. 2020;95:183-91.
There are 26 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Esen Çiçekli 0000-0003-2352-8150

Saadet Sayan 0000-0002-7628-560X

Elif Sarıca Darol 0000-0001-9355-5213

Dilcan Kotan 0000-0002-3101-4742

Publication Date August 30, 2022
Submission Date April 23, 2022
Published in Issue Year 2022 Volume: 24 Issue: 2

Cite

APA Çiçekli, E., Sayan, S., Sarıca Darol, E., Kotan, D. (2022). The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients. Duzce Medical Journal, 24(2), 176-181. https://doi.org/10.18678/dtfd.1108086
AMA Çiçekli E, Sayan S, Sarıca Darol E, Kotan D. The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients. Duzce Med J. August 2022;24(2):176-181. doi:10.18678/dtfd.1108086
Chicago Çiçekli, Esen, Saadet Sayan, Elif Sarıca Darol, and Dilcan Kotan. “The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients”. Duzce Medical Journal 24, no. 2 (August 2022): 176-81. https://doi.org/10.18678/dtfd.1108086.
EndNote Çiçekli E, Sayan S, Sarıca Darol E, Kotan D (August 1, 2022) The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients. Duzce Medical Journal 24 2 176–181.
IEEE E. Çiçekli, S. Sayan, E. Sarıca Darol, and D. Kotan, “The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients”, Duzce Med J, vol. 24, no. 2, pp. 176–181, 2022, doi: 10.18678/dtfd.1108086.
ISNAD Çiçekli, Esen et al. “The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients”. Duzce Medical Journal 24/2 (August 2022), 176-181. https://doi.org/10.18678/dtfd.1108086.
JAMA Çiçekli E, Sayan S, Sarıca Darol E, Kotan D. The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients. Duzce Med J. 2022;24:176–181.
MLA Çiçekli, Esen et al. “The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients”. Duzce Medical Journal, vol. 24, no. 2, 2022, pp. 176-81, doi:10.18678/dtfd.1108086.
Vancouver Çiçekli E, Sayan S, Sarıca Darol E, Kotan D. The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients. Duzce Med J. 2022;24(2):176-81.