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The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm

Year 2023, Volume: 5 Issue: 2, 56 - 62, 06.09.2023

Mustafa Enes Demirel Ufuk Turan Kürşat Kormaz Ömer Çetin Hatice Güldal Mustafa Boğan

https://doi.org/10.55994/ejcc.1323023

Abstract

Objective: In this study, we aimed to investigate the relationship between preoperative inflammatory markers, length of hospital stay, and mortality in patients with abdominal aortic aneurysm (AAA) who underwent surgical repair.
Methods: A total of 83 patients diagnosed with AAA were included in the study. A complete blood count (CBC) was performed on the first visit (pre-op 0-1 hour) in all patients. Non-ruptured cases (AAA) and ruptured cases (AAA-R) were compared.
Results: 14.5% (n=12) of the patients died. Higher White blood cells and neutrophils were obtained in patients who died than in surviving patients (respectively, p=0.0002, p=0.001). Higher WBC and NALP in AAA-R patients were determined.
Conclusion: WBC and Neu's values were higher in AAA patients who died post-operatively and who were detected rupture pre-operatively but PLT and HB values were similar. Normal or near-normal HB and PLT values that will be seen in the first examination of AAA cases in the emergency department may mislead clinicians or cause them to display a more optimistic attitude.

Keywords

Abdominal aortic aneurysm Mortality White blood cell Neutrophil

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Thanks

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References

  • Michel JB, Martin-Ventura JL, Egido J, et al. Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans. Cardiovasc Res. 2011;90(1):18-27.
  • Kessler V, Klopf J, Eilenberg W, Neumayer C, Brostjan C. AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis. Biomedicines. 2022;10(1):94.
  • Wei L, Bu X, Wang X, Liu J, Ma A, Wang T. Global Burden of Aortic Aneurysm and Attributable Risk Factors from 1990 to 2017. Glob Heart. 2021;16(1):35.
  • Svensjö S, Björck M, Gürtelschmid M, Djavani Gidlund K, Hellberg A, Wanhainen A. Low prevalence of abdominal aortic aneurysm among 65-year-old Swedish men indicates a change in the epidemiology of the disease. Circulation. 2011;124(10):1118-1123.
  • Macaluso CR, McNamara RM. Evaluation and management of acute abdominal pain in the emergency department. Int J Gen Med. 2012;5:789-797.
  • Chaikof EL, Dalman RL, Eskandari MK, et al. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018;67(1):2-77.e2
  • Parkinson F, Ferguson S, Lewis P, Williams IM, Twine CP; South East Wales Vascular Network. Rupture rates of untreated large abdominal aortic aneurysms in patients unfit for elective repair. J Vasc Surg. 2015;61(6):1606-1612.
  • Patel SR, Ormesher DC, Smith SR, et al. A risk-adjusted and anatomically stratified cohort comparison study of open surgery, endovascular techniques and medical management for juxtarenal aortic aneurysms-the UK COMPlex AneurySm Study (UK-COMPASS): a study protocol. BMJ Open. 2021;11(11):e054493
  • Dahl M, Frost L, Søgaard R, Klausen IC, Lorentzen V, Lindholt J. A population-based screening study for cardiovascular diseases and diabetes in Danish postmenopausal women: acceptability and prevalence. BMC Cardiovasc Disord. 2018;18(1):20. Davis FM, Rateri DL, Daugherty A. Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies. Heart. 2014;100(19):1498-1505.
  • Bhutta H, Agha R, Wong J, Tang TY, Wilson YG, Walsh SR. Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study. Vasc Endovascular Surg. 2011;45(3):227-231.
  • Siminiak T, Flores NA, Sheridan DJ. Neutrophil interactions with endothelium and platelets: possible role in the development of cardiovascular injury. Eur Heart J. 1995;16(2):160-170.
  • Haumer M, Amighi J, Exner M, et al. Association of neutrophils and future cardiovascular events in patients with peripheral artery disease. J Vasc Surg. 2005;41(4):610-617.
  • Ommen SR, Gibbons RJ, Hodge DO, Thomson SP. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol. 1997;79(6):812-814.
  • Zhang L, Wang Y. B lymphocytes in abdominal aortic aneurysms. Atherosclerosis. 2015;242(1):311-317.
  • Lv BJ, Li J, Cheng X. T lymphocytes and aortic aneurysms. Sci China Life Sci. 2014;57(8):795-801.
  • Ntalouka MP, Nana P, Kouvelos GN, et al. Association of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio with Adverse Events in Endovascular Repair for Abdominal Aortic Aneurysm. J Clin Med. 2021;10(5):1083
  • Yıldız S, Kazğan A, Tabara M, Atmaca M. The Relationship Between Impulsivity Level and Neutrophil / Lymphocyte Ratio, Platelet/ Lymphocyte Ratio and Mean Platelet Volume in Individuals Diagnosed with Gambling Disorder. Medical Records. 2021; 3(3): 177-183.
  • Balta S, Celik T, Mikhailidis DP, et al. The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio. Clin Appl Thromb Hemost. 2016;22(5):405-411.
  • Lareyre F, Carboni J, Chikande J, et al. Association of Platelet to Lymphocyte Ratio and Risk of 30-Day Postoperative Complications in Patients Undergoing Abdominal Aortic Surgical Repair. Vasc Endovascular Surg. 2019;53(1):5-11.
  • Kasius KM, Frijns CJ, Algra A, Rinkel GJ. Association of platelet and leukocyte counts with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. Cerebrovasc Dis. 2010;29(6):576-583.
  • Yun S, Yi HJ, Lee DH, Sung JH. Systemic Inflammation Response Index and Systemic Immune-inflammation Index for Predicting the Prognosis of Patients with Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(8):105861.
  • Ko DE, Yoon HJ, Nam SB, Song SW, Lee G, Ham SY. Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study. J Clin Med. 2021;10(22):5410.
  • Nejim B, Chau M, Ramirez Castello C, Aziz F, Flohr TR. Preoperative leukocytosis among female patients predicts poor postoperative outcomes following endovascular aneurysm repair for intact infrarenal abdominal aortic aneurysms. J Vasc Surg. 2021;74(6):1843-1852.e3.
  • Morotti A, Phuah CL, Anderson CD, et al. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016;47(6):1473-1478.
  • Chung J, Corriere MA, Veeraswamy RK, et al. Risk factors for late mortality after endovascular repair of the thoracic aorta. J Vasc Surg. 2010;52(3):549-555.
  • Tao C, Wang J, Hu X, Ma J, Li H, You C. Clinical Value of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2017;26(3):393-401.
  • Lareyre F, Raffort J, Le D, et al. High Neutrophil to Lymphocyte Ratio Is Associated With Symptomatic and Ruptured Thoracic Aortic Aneurysm. Angiology. 2018;69(8):686-691.
  • Çelik K, Demirel ME. Aort anevrizmaları. Yürümez Y.(Editor). Cardiovascular Emergencies. 1. Edition. Ankara: Türkiye Klinikleri; 2022. p.96-102.

Year 2023, Volume: 5 Issue: 2, 56 - 62, 06.09.2023

Mustafa Enes Demirel Ufuk Turan Kürşat Kormaz Ömer Çetin Hatice Güldal Mustafa Boğan

https://doi.org/10.55994/ejcc.1323023

Abstract

Project Number

-

References

  • Michel JB, Martin-Ventura JL, Egido J, et al. Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans. Cardiovasc Res. 2011;90(1):18-27.
  • Kessler V, Klopf J, Eilenberg W, Neumayer C, Brostjan C. AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis. Biomedicines. 2022;10(1):94.
  • Wei L, Bu X, Wang X, Liu J, Ma A, Wang T. Global Burden of Aortic Aneurysm and Attributable Risk Factors from 1990 to 2017. Glob Heart. 2021;16(1):35.
  • Svensjö S, Björck M, Gürtelschmid M, Djavani Gidlund K, Hellberg A, Wanhainen A. Low prevalence of abdominal aortic aneurysm among 65-year-old Swedish men indicates a change in the epidemiology of the disease. Circulation. 2011;124(10):1118-1123.
  • Macaluso CR, McNamara RM. Evaluation and management of acute abdominal pain in the emergency department. Int J Gen Med. 2012;5:789-797.
  • Chaikof EL, Dalman RL, Eskandari MK, et al. The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm. J Vasc Surg. 2018;67(1):2-77.e2
  • Parkinson F, Ferguson S, Lewis P, Williams IM, Twine CP; South East Wales Vascular Network. Rupture rates of untreated large abdominal aortic aneurysms in patients unfit for elective repair. J Vasc Surg. 2015;61(6):1606-1612.
  • Patel SR, Ormesher DC, Smith SR, et al. A risk-adjusted and anatomically stratified cohort comparison study of open surgery, endovascular techniques and medical management for juxtarenal aortic aneurysms-the UK COMPlex AneurySm Study (UK-COMPASS): a study protocol. BMJ Open. 2021;11(11):e054493
  • Dahl M, Frost L, Søgaard R, Klausen IC, Lorentzen V, Lindholt J. A population-based screening study for cardiovascular diseases and diabetes in Danish postmenopausal women: acceptability and prevalence. BMC Cardiovasc Disord. 2018;18(1):20. Davis FM, Rateri DL, Daugherty A. Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies. Heart. 2014;100(19):1498-1505.
  • Bhutta H, Agha R, Wong J, Tang TY, Wilson YG, Walsh SR. Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study. Vasc Endovascular Surg. 2011;45(3):227-231.
  • Siminiak T, Flores NA, Sheridan DJ. Neutrophil interactions with endothelium and platelets: possible role in the development of cardiovascular injury. Eur Heart J. 1995;16(2):160-170.
  • Haumer M, Amighi J, Exner M, et al. Association of neutrophils and future cardiovascular events in patients with peripheral artery disease. J Vasc Surg. 2005;41(4):610-617.
  • Ommen SR, Gibbons RJ, Hodge DO, Thomson SP. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol. 1997;79(6):812-814.
  • Zhang L, Wang Y. B lymphocytes in abdominal aortic aneurysms. Atherosclerosis. 2015;242(1):311-317.
  • Lv BJ, Li J, Cheng X. T lymphocytes and aortic aneurysms. Sci China Life Sci. 2014;57(8):795-801.
  • Ntalouka MP, Nana P, Kouvelos GN, et al. Association of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio with Adverse Events in Endovascular Repair for Abdominal Aortic Aneurysm. J Clin Med. 2021;10(5):1083
  • Yıldız S, Kazğan A, Tabara M, Atmaca M. The Relationship Between Impulsivity Level and Neutrophil / Lymphocyte Ratio, Platelet/ Lymphocyte Ratio and Mean Platelet Volume in Individuals Diagnosed with Gambling Disorder. Medical Records. 2021; 3(3): 177-183.
  • Balta S, Celik T, Mikhailidis DP, et al. The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio. Clin Appl Thromb Hemost. 2016;22(5):405-411.
  • Lareyre F, Carboni J, Chikande J, et al. Association of Platelet to Lymphocyte Ratio and Risk of 30-Day Postoperative Complications in Patients Undergoing Abdominal Aortic Surgical Repair. Vasc Endovascular Surg. 2019;53(1):5-11.
  • Kasius KM, Frijns CJ, Algra A, Rinkel GJ. Association of platelet and leukocyte counts with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. Cerebrovasc Dis. 2010;29(6):576-583.
  • Yun S, Yi HJ, Lee DH, Sung JH. Systemic Inflammation Response Index and Systemic Immune-inflammation Index for Predicting the Prognosis of Patients with Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(8):105861.
  • Ko DE, Yoon HJ, Nam SB, Song SW, Lee G, Ham SY. Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study. J Clin Med. 2021;10(22):5410.
  • Nejim B, Chau M, Ramirez Castello C, Aziz F, Flohr TR. Preoperative leukocytosis among female patients predicts poor postoperative outcomes following endovascular aneurysm repair for intact infrarenal abdominal aortic aneurysms. J Vasc Surg. 2021;74(6):1843-1852.e3.
  • Morotti A, Phuah CL, Anderson CD, et al. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016;47(6):1473-1478.
  • Chung J, Corriere MA, Veeraswamy RK, et al. Risk factors for late mortality after endovascular repair of the thoracic aorta. J Vasc Surg. 2010;52(3):549-555.
  • Tao C, Wang J, Hu X, Ma J, Li H, You C. Clinical Value of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio After Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2017;26(3):393-401.
  • Lareyre F, Raffort J, Le D, et al. High Neutrophil to Lymphocyte Ratio Is Associated With Symptomatic and Ruptured Thoracic Aortic Aneurysm. Angiology. 2018;69(8):686-691.
  • Çelik K, Demirel ME. Aort anevrizmaları. Yürümez Y.(Editor). Cardiovascular Emergencies. 1. Edition. Ankara: Türkiye Klinikleri; 2022. p.96-102.
There are 28 citations in total.

Details

Primary Language English
Subjects Emergency Medicine
Journal Section Original Articles
Authors

Mustafa Enes Demirel 0000-0001-5187-5737

Ufuk Turan Kürşat Kormaz 0000-0002-6107-2943

Ömer Çetin 0000-0003-3588-2077

Hatice Güldal 0000-0003-1973-5990

Mustafa Boğan 0000-0002-3238-1827

Project Number -
Early Pub Date September 6, 2023
Publication Date September 6, 2023
Submission Date July 5, 2023
Acceptance Date August 24, 2023
Published in Issue Year 2023 Volume: 5 Issue: 2

Cite

APA Demirel, M. E., Kormaz, U. T. K., Çetin, Ö., Güldal, H., et al. (2023). The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm. Eurasian Journal of Critical Care, 5(2), 56-62. https://doi.org/10.55994/ejcc.1323023
AMA Demirel ME, Kormaz UTK, Çetin Ö, Güldal H, Boğan M. The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm. Eurasian j Crit Care. September 2023;5(2):56-62. doi:10.55994/ejcc.1323023
Chicago Demirel, Mustafa Enes, Ufuk Turan Kürşat Kormaz, Ömer Çetin, Hatice Güldal, and Mustafa Boğan. “The Effect of White Blood Cell and Platelet Values on Mortality in Patients With Abdominal Aortic Aneurysm”. Eurasian Journal of Critical Care 5, no. 2 (September 2023): 56-62. https://doi.org/10.55994/ejcc.1323023.
EndNote Demirel ME, Kormaz UTK, Çetin Ö, Güldal H, Boğan M (September 1, 2023) The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm. Eurasian Journal of Critical Care 5 2 56–62.
IEEE M. E. Demirel, U. T. K. Kormaz, Ö. Çetin, H. Güldal, and M. Boğan, “The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm”, Eurasian j Crit Care, vol. 5, no. 2, pp. 56–62, 2023, doi: 10.55994/ejcc.1323023.
ISNAD Demirel, Mustafa Enes et al. “The Effect of White Blood Cell and Platelet Values on Mortality in Patients With Abdominal Aortic Aneurysm”. Eurasian Journal of Critical Care 5/2 (September 2023), 56-62. https://doi.org/10.55994/ejcc.1323023.
JAMA Demirel ME, Kormaz UTK, Çetin Ö, Güldal H, Boğan M. The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm. Eurasian j Crit Care. 2023;5:56–62.
MLA Demirel, Mustafa Enes et al. “The Effect of White Blood Cell and Platelet Values on Mortality in Patients With Abdominal Aortic Aneurysm”. Eurasian Journal of Critical Care, vol. 5, no. 2, 2023, pp. 56-62, doi:10.55994/ejcc.1323023.
Vancouver Demirel ME, Kormaz UTK, Çetin Ö, Güldal H, Boğan M. The effect of white blood cell and platelet values on mortality in patients with abdominal aortic aneurysm. Eurasian j Crit Care. 2023;5(2):56-62.
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