The Maternal, Cord Blood and Neonatal Serum Ischemia-Modified Albumin Levels in Different Modes of Delivery
Abstract
Background: Human serum albumin modifies in response to ischemic events and affinity of N-terminal decreases for metal especially for cobalt. This modification results in the formation of ischemia modified albumin (IMA). The IMA rises immediately after ischemic event and remains high for several hours after cessation of ischemia. The purpose of this study was to investigate the effects of mode of delivery on the IMA levels in mothers and their term infants, and to determine which mode causes much oxidative stress.
Study Design: The cases were grouped according to the mode of delivery: vaginal delivery group (VD, n=40) and cesarean group (C/S, n=40). The serum samples were collected from mothers before delivery (pre-delivery), from the cord blood (CB) and from the infants at the 24th hour after birth according to the following criteria: (1) singleton live birth, (2) gestational age between 37- 41 6/7 weeks, (3) birth weight of 2500 and 4000 g, and (4) Apgar scores ≥ 8 at 5 min. The IMA levels of both groups were compared.
Results: The pre-delivery serum IMA levels were similar between two groups. The cord blood IMA levels were significantly higher in C/S group than those with VD group (0.694±0.113 vs 0.642±0.084, p=0.021). The serum IMA levels were higher in infants born by C/S compared with those born by VD, but the result was not statistically significant.
Conclusion: Our results showed the IMA levels in infants and cord blood was influenced by the way of delivery and supported that oxidative stress is reduced in vaginally delivered infants.
References
- Hussain T, Murtaza G, Metwally E, et al. The Role of Oxidative Stress and Antioxidant Balance in Pregnancy. Mediators Inflamm 2021:27;2021: 9962860.
- Ozsurekci Y, Aykac K. Oxidative Stress Related Diseases in Newborns. Oxid Med Cell Longev 2016; 2016:2768365.
- Adekanle DA, Oparinde DP, Atiba AS, et al. Effect of different modes of delivery on cord blood oxidative stress markers. Int J Biomed Sci 2013; 9:249-254.
- Wilinska M, Borszewska-Kornacka MK, Niemiec T, Jakiel G. Oxidative stress and total antioxidant status in term newborns and their mothers. Ann Agric Environ Med 2015; 22:736-740.
- Nejad RK, Goodarzi MT, Shfiee G, Pezeshki N, Sohrabi M. Comparison of Oxidative Stress Markers and Serum Cortisol between Normal Labor and Selective Cesarean Section Born Neonates. J Clin Diagn Res 2016;10: BC01-03.
- Mutlu B, Aksoy N, Cakir H, Celİk H, Erel O. The effects of the mode of delivery on oxidative-antioxidative balance. J Matern Fetal Neonatal Med 2011; 24:1367-1370.
- Dominguez-Rodriguez A, Abreu-Gonzalez P. Current role of ischemia-modified albumin in routine clinical practice. Biomarkers 2010; 15:655-662.
- Sinha MK, Roy D, Gaze DC, Collinson PO, Kaski JC. Role of “Ischemia modified albumin”, a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes. Emerg Med J 2004; 21:29-34.
- Bilgi M, Keser A, Katlandur H et al. Evaluation of the Relationship Between Microalbuminuria and Urine Ischemia-Modified Albumin Levels in Patients with Diabetic Nephropathy. J Clin Lab Anal 2017;31: e22058.
- Kaefer M, Piva SJ, De Carvalho JA et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem 2010; 43:450-454.
- Talat MA, Saleh RM, Shehab MM, Khalifa NA, Sakr MMH, Elmesalamy WM. Evaluation of the role of ischemia modified albumin in neonatal hypoxic-ischemic encephalopathy. Clin Exp Pediatr 2020; 63: 329-334.
- Iacovidou N, Briana DD, Boutsikou M, et al. Cord blood ischemia-modified albumin levels in normal and intrauterine growth restricted pregnancies. Mediators Inflamm 2008:523081.
- Caglar GS, Tasci Y, Goktolga U, et al. Maternal and umbilical cord ischemia-modified albumin levels in nonreassuring fetal heart rate tracings regarding the mode of delivery. J Matern Fetal Neonatal Med 2013; 26:528-531.
- Özdemir ÖM, Özdemir E, Enli Y, Öztekin Ö, Ergin H. Ischemia-modified albumin in preterm infants born to mothers with pre-eclampsia. Pediatr Int 2018; 60:553-559.
- Oztekın O, Kalay S, Tayman C, Namuslu M, Celık HT. Levels of ischemia-modified albumin in transient tachypnea of the newborn. Am J Perinatol 2015; 30:193-198.
- Wang K, Tao G, Sun Z, Sylvester KG. Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis. Gastroenterol Res Pract 2019; 2019: 8413698.
- Erol S, Unal S, Demirel N, et al. Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. J Matern Fetal Neonatal Med 2018; 31:3133-3138.
- Kahveci H, Tayman C, Laloğlu F, et al. Relationship Between Hemodynamically Significant Ductus Arteriosus and Ischemia-Modified Albumin in Premature Infants. Indian J Clin Biochem 2016; 31:231-236.
- Ulubas Isik D, Akdaş Reis Y, Bas AY, et al. The effect of the modes of delivery on the maternal and neonatal dynamic thiol-disulfide homeostasis. J Matern Fetal Neonatal Med 2019; 32:3993-3997.
- Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med 2000; 19:311-315.
- Shevtsova A, Gordiienko I, Tkachenko V, Ushakova G. Ischemia-Modified Albumin: Origins and Clinical Implications. Dis Markers 2021; 2021: 9945424.
- van Rijn BB, Franx A, Sikkema JM, van Rijn HJ, Bruinse HW, Voorbij HA. Ischemia modified albumin in normal pregnancy and preeclampsia. Hypertens Pregnancy 2008; 27:159-167.
- Rossi A, Bortolotti N, Vescovo S, et al. Ischemia-modified albumin in pregnancy. Eur J Obstet Gynecol Reprod Biol 2013; 170:348-351.
- Vyakaranam S, Bhongir AV, Patlolla D, Chintapally R. Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot study. Int J Reprod Contracept Obstet Gynecol 2015; 4:611-616.
- Özdemir S, Kıyıcı A, Balci O, Göktepe H, Çiçekler H, Çelik Ç. Assessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimester. Eur J Obstet Gynecol Reprod Biol 2011; 155:209-212.
- Vlachos GD, Bartzeliotou A, Schulpis KH, et al. Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. Clin Biochem 2006; 39:923-928.
- Noh EJ, Kim YH, Cho MK, et al. Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery. Obstet Gynecol Sci 2014; 57:109-114.
Abstract
Amaç: Serum albumini iskemik olaylara yanıt olarak değişir ve N-terminalinin kobalt metaline afinitesi azalır. Bu modifikasyon sonucu iskemi modifiye albümin (IMA) oluşur. IMA, iskemik olaydan hemen sonra yükselir ve iskeminin sonlanmasından sonra birkaç saat yüksek kalır. Bu çalışmanın amacı, doğum şeklinin annelerde ve term bebeklerde İMA düzeylerine etkisini araştırmak ve hangi doğum şeklinin daha fazla oksidatif strese neden olduğunu belirlemektir.
Gereç ve Yöntem: Vakalar doğum şekline göre vajinal doğum grubu (VD, n=40) ve sezaryen grubu (C/S, n=40) olarak gruplandırıldı. Annelerden doğum öncesi, kordon kanından ve bebeklerden doğumdan sonraki 24. saatte serum örnekleri belirlenen kriterlere uyan vakalardan alındı; (1) tekil canlı doğum, (2) gebelik yaşı 37-41 6/7 hafta arası, (3) 2500 ve 4000 gr doğum ağırlığı ve (4) 5. dakikada Apgar skoru ≥ 8. Her iki grubun İMA düzeyleri karşılaştırıldı.
Bulgular: Doğum öncesi serum IMA seviyeleri iki grup arasında benzerdi. Kordon kanı IMA düzeyleri C/S grubunda VD grubuna göre anlamlı olarak yüksekti (0,694±0,113’e vs 0,642±0,084, p=0,021). C/S ile doğan bebeklerde serum IMA seviyeleri, VD ile doğan bebeklere göre daha yüksekti, ancak sonuç istatistiksel olarak anlamlı değildi.
Sonuç: Bulgularımız bebeklerde ve kord kanında IMA düzeylerinin doğum şeklinden etkilenebileceğini ve VD ile doğan bebeklerde oksidatif stresin azaldığını desteklemektedir.
References
- Hussain T, Murtaza G, Metwally E, et al. The Role of Oxidative Stress and Antioxidant Balance in Pregnancy. Mediators Inflamm 2021:27;2021: 9962860.
- Ozsurekci Y, Aykac K. Oxidative Stress Related Diseases in Newborns. Oxid Med Cell Longev 2016; 2016:2768365.
- Adekanle DA, Oparinde DP, Atiba AS, et al. Effect of different modes of delivery on cord blood oxidative stress markers. Int J Biomed Sci 2013; 9:249-254.
- Wilinska M, Borszewska-Kornacka MK, Niemiec T, Jakiel G. Oxidative stress and total antioxidant status in term newborns and their mothers. Ann Agric Environ Med 2015; 22:736-740.
- Nejad RK, Goodarzi MT, Shfiee G, Pezeshki N, Sohrabi M. Comparison of Oxidative Stress Markers and Serum Cortisol between Normal Labor and Selective Cesarean Section Born Neonates. J Clin Diagn Res 2016;10: BC01-03.
- Mutlu B, Aksoy N, Cakir H, Celİk H, Erel O. The effects of the mode of delivery on oxidative-antioxidative balance. J Matern Fetal Neonatal Med 2011; 24:1367-1370.
- Dominguez-Rodriguez A, Abreu-Gonzalez P. Current role of ischemia-modified albumin in routine clinical practice. Biomarkers 2010; 15:655-662.
- Sinha MK, Roy D, Gaze DC, Collinson PO, Kaski JC. Role of “Ischemia modified albumin”, a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes. Emerg Med J 2004; 21:29-34.
- Bilgi M, Keser A, Katlandur H et al. Evaluation of the Relationship Between Microalbuminuria and Urine Ischemia-Modified Albumin Levels in Patients with Diabetic Nephropathy. J Clin Lab Anal 2017;31: e22058.
- Kaefer M, Piva SJ, De Carvalho JA et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem 2010; 43:450-454.
- Talat MA, Saleh RM, Shehab MM, Khalifa NA, Sakr MMH, Elmesalamy WM. Evaluation of the role of ischemia modified albumin in neonatal hypoxic-ischemic encephalopathy. Clin Exp Pediatr 2020; 63: 329-334.
- Iacovidou N, Briana DD, Boutsikou M, et al. Cord blood ischemia-modified albumin levels in normal and intrauterine growth restricted pregnancies. Mediators Inflamm 2008:523081.
- Caglar GS, Tasci Y, Goktolga U, et al. Maternal and umbilical cord ischemia-modified albumin levels in nonreassuring fetal heart rate tracings regarding the mode of delivery. J Matern Fetal Neonatal Med 2013; 26:528-531.
- Özdemir ÖM, Özdemir E, Enli Y, Öztekin Ö, Ergin H. Ischemia-modified albumin in preterm infants born to mothers with pre-eclampsia. Pediatr Int 2018; 60:553-559.
- Oztekın O, Kalay S, Tayman C, Namuslu M, Celık HT. Levels of ischemia-modified albumin in transient tachypnea of the newborn. Am J Perinatol 2015; 30:193-198.
- Wang K, Tao G, Sun Z, Sylvester KG. Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis. Gastroenterol Res Pract 2019; 2019: 8413698.
- Erol S, Unal S, Demirel N, et al. Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. J Matern Fetal Neonatal Med 2018; 31:3133-3138.
- Kahveci H, Tayman C, Laloğlu F, et al. Relationship Between Hemodynamically Significant Ductus Arteriosus and Ischemia-Modified Albumin in Premature Infants. Indian J Clin Biochem 2016; 31:231-236.
- Ulubas Isik D, Akdaş Reis Y, Bas AY, et al. The effect of the modes of delivery on the maternal and neonatal dynamic thiol-disulfide homeostasis. J Matern Fetal Neonatal Med 2019; 32:3993-3997.
- Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med 2000; 19:311-315.
- Shevtsova A, Gordiienko I, Tkachenko V, Ushakova G. Ischemia-Modified Albumin: Origins and Clinical Implications. Dis Markers 2021; 2021: 9945424.
- van Rijn BB, Franx A, Sikkema JM, van Rijn HJ, Bruinse HW, Voorbij HA. Ischemia modified albumin in normal pregnancy and preeclampsia. Hypertens Pregnancy 2008; 27:159-167.
- Rossi A, Bortolotti N, Vescovo S, et al. Ischemia-modified albumin in pregnancy. Eur J Obstet Gynecol Reprod Biol 2013; 170:348-351.
- Vyakaranam S, Bhongir AV, Patlolla D, Chintapally R. Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy: a pilot study. Int J Reprod Contracept Obstet Gynecol 2015; 4:611-616.
- Özdemir S, Kıyıcı A, Balci O, Göktepe H, Çiçekler H, Çelik Ç. Assessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimester. Eur J Obstet Gynecol Reprod Biol 2011; 155:209-212.
- Vlachos GD, Bartzeliotou A, Schulpis KH, et al. Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. Clin Biochem 2006; 39:923-928.
- Noh EJ, Kim YH, Cho MK, et al. Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery. Obstet Gynecol Sci 2014; 57:109-114.
Details
| Primary Language | English |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | July 4, 2023 |
| Acceptance Date | July 3, 2023 |
| Published in Issue | Year 2023 Volume: 5 Issue: 2 |
