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Can QT dispersion predict multi-vessel coronary artery disease in patients with acute coronary syndrome?

Year 2016, Volume: 2 Issue: 1, 12 - 15, 04.03.2016
https://doi.org/10.18621/eurj.2016.2.1.12

Abstract

Objective. This study was planned to evaluate relation between QT dispersion (QTd) and multi-vessel coronary artery disease in acute coronary syndrome. Methods. This study included 225 consecutive patients with a diagnosis of non-ST segment elevation acute coronary syndrome. Three groups were defined as single vessel, two vessels, and three vessels. Echocardiographic, biochemical and electrocardiographic parameters of the three groups were compared. Results. QTd, corrected QT dispersion (QTcd) and corrected QT max values significantly increased in patients with three-vessel disease compared to the patients with single-vessel disease group (60±27 vs 45±28 ms, 68±32 vs 50±32 ms and 471±52 vs 443±48 ms; p=0.002, p=0.001 and p=0.001, respectively). In addition, QTd and QTcd were statistically more increased in patients with two-vessels disease than single-vessel disease group (57±29 vs 45±28 ms; p=0.045, and 63±32 vs 50±32 ms; p=0.046, respectively). Conclusion. In patient with acute coronary syndrome and diffuse vessel disease, changes in the myocardial cells due to ischemia cause more of the QT dispersion in the patients with multi-vessel disease than those with single-vessel disease.

References

  • Bebbington P. The World Health Report 2001. Soc Psychiatry Psychiatr Epidemol. 2001 Oct; 36(10):473-4.
  • Basra SS, Virani SS, Paniagua D, Kar B, Jneid H. Acute coronary syndromes: unstable angina and non-ST elevation myocardial infarction. Cardiol Clin. 2014 Aug;32(3):353-70.
  • Rodriguez F, Chavez E, Machin WJ, Alanso A, Gonzalez V. Increased QT interval dispersion in diagnosis of acute coronary syndrome with atypical symptoms and EKG. MEDICC Rev. 2014 Jul-Oct;16(3-4):42-6.
  • Gibson CM, de Lemos JA, Murphy SA, Marble SJ, McCabe CH, Cannon CP, et al; TIMI Study Group. Combination therapy with abciximab reduces angiograhically evident thrombus in acute myocardial infarction: a TIMI 14 substudy. Circulation. 2001 May 29;103(21):2550-4.
  • Bazett HC. An analysis of the time relations of electrocardiograms. Ann Noninvasive Electrocardiol. 1997; Apr;2(2):177-94.
  • Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors : a clinicobiochemical perspective. Angiology. 2007 Oct-Nov;58(5):513-22.
  • Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation 1995 Aug 1;92(3):657-71.
  • Tikiz H, Terzi T, Balbay Y, Demir AD, Soylu M, Keles T, et al. QT dispersion in single coronary artery disease: is there a relation between QT dispersion and the diseased coronary artery or lesion localization? Angiology. 2001 Jan;52(1):43-51.
  • Moss AJ, Schwartz PJ, Crampton RS, Tzinovi D, Locati EH, MacCluer J, et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation. 1991 Sep;84(3):1136-44.
  • Surawicz B, Knoebel SB. Long QT: good, bad or indifferent? J Am Coll Cardiol. 1984 Aug;4(2):398-413.
  • Han J, Moe GK. Nonuniform recovery of excitability in ventricular muscle. Circ Res 1964 Jan;14:44-60.
  • Vassalo JA, Casidy DM, Kindwall KE, Marchlinski FE, Josephson ME. Nonuniform recovery of excitability in the left vetricle. Circulation. 1988 Dec;78(6):1365-72.
  • Surawicz B. Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early after depolarizations? J Am Coll Cardiol. 1989 Jul;14(1):172-84.
  • Alici G, Sahin M, Ozkan B, Acar G, Acar RD, Yazicioglu MV, et al. The comparison in reduction of QT dispersion after primary percutaneous coronary intervention according to existence of thrombectomy in ST-segment elevation myocardial infarction. Clin Cardiol. 2013 May;36(5):276-9.
Year 2016, Volume: 2 Issue: 1, 12 - 15, 04.03.2016
https://doi.org/10.18621/eurj.2016.2.1.12

Abstract

References

  • Bebbington P. The World Health Report 2001. Soc Psychiatry Psychiatr Epidemol. 2001 Oct; 36(10):473-4.
  • Basra SS, Virani SS, Paniagua D, Kar B, Jneid H. Acute coronary syndromes: unstable angina and non-ST elevation myocardial infarction. Cardiol Clin. 2014 Aug;32(3):353-70.
  • Rodriguez F, Chavez E, Machin WJ, Alanso A, Gonzalez V. Increased QT interval dispersion in diagnosis of acute coronary syndrome with atypical symptoms and EKG. MEDICC Rev. 2014 Jul-Oct;16(3-4):42-6.
  • Gibson CM, de Lemos JA, Murphy SA, Marble SJ, McCabe CH, Cannon CP, et al; TIMI Study Group. Combination therapy with abciximab reduces angiograhically evident thrombus in acute myocardial infarction: a TIMI 14 substudy. Circulation. 2001 May 29;103(21):2550-4.
  • Bazett HC. An analysis of the time relations of electrocardiograms. Ann Noninvasive Electrocardiol. 1997; Apr;2(2):177-94.
  • Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors : a clinicobiochemical perspective. Angiology. 2007 Oct-Nov;58(5):513-22.
  • Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation 1995 Aug 1;92(3):657-71.
  • Tikiz H, Terzi T, Balbay Y, Demir AD, Soylu M, Keles T, et al. QT dispersion in single coronary artery disease: is there a relation between QT dispersion and the diseased coronary artery or lesion localization? Angiology. 2001 Jan;52(1):43-51.
  • Moss AJ, Schwartz PJ, Crampton RS, Tzinovi D, Locati EH, MacCluer J, et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation. 1991 Sep;84(3):1136-44.
  • Surawicz B, Knoebel SB. Long QT: good, bad or indifferent? J Am Coll Cardiol. 1984 Aug;4(2):398-413.
  • Han J, Moe GK. Nonuniform recovery of excitability in ventricular muscle. Circ Res 1964 Jan;14:44-60.
  • Vassalo JA, Casidy DM, Kindwall KE, Marchlinski FE, Josephson ME. Nonuniform recovery of excitability in the left vetricle. Circulation. 1988 Dec;78(6):1365-72.
  • Surawicz B. Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early after depolarizations? J Am Coll Cardiol. 1989 Jul;14(1):172-84.
  • Alici G, Sahin M, Ozkan B, Acar G, Acar RD, Yazicioglu MV, et al. The comparison in reduction of QT dispersion after primary percutaneous coronary intervention according to existence of thrombectomy in ST-segment elevation myocardial infarction. Clin Cardiol. 2013 May;36(5):276-9.
There are 14 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Alkame Akgumus This is me

Kemal Karaagac

Tezcan Peker This is me

Omur Aydin This is me

Ozlem Arican Ozluk

Erhan Tenekecioglu

Fahriye Vatansever

Bedrettin Boyraz This is me

Mustafa Yilmaz This is me

Publication Date March 4, 2016
Submission Date March 13, 2015
Acceptance Date November 24, 2015
Published in Issue Year 2016 Volume: 2 Issue: 1

Cite

AMA Akgumus A, Karaagac K, Peker T, Aydin O, Arican Ozluk O, Tenekecioglu E, Vatansever F, Boyraz B, Yilmaz M. Can QT dispersion predict multi-vessel coronary artery disease in patients with acute coronary syndrome?. Eur Res J. March 2016;2(1):12-15. doi:10.18621/eurj.2016.2.1.12

e-ISSN: 2149-3189 


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