Research Article
Year 2022,
Volume: 8 Issue: 2, 202 - 209, 04.03.2022
Abstract
References
- 1. Eisner F, Hermann D, Bajaeifer K, Glatzle J, Königsrainer A, Küper MA. Gastric ulcer complications after the introduction of proton pump inhibitors into clinical routine: 20-year experience. Visc Med 2017;33:221-6.
- 2. Dutta AK, Chacko A, Balekuduru A, Sahu MK, Gangadharan SK. Time trends in epidemiology of peptic ulcer disease in India over two decades. Indian J Gastroenterol 2012;31:111-5.
- 3. Tarasconi A, Coccolini F, Biffl WL, Tomasoni M, Ansaloni L, Picetti E, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg 2020;15:1-24.
- 4. Svanes C. Trends in perforated peptic ulcer: incidence, etiology, treatment, and prognosis. World J Surg 2000;24:277-83.
- 5. Thorsen K, Glomsaker TB, von Meer A, Søreide K, Søreide JA. Trends in diagnosis and surgical management of patients with perforated peptic ulcer. J Gastrointest Surg 2011;15:1329-35.
- 6. Byrne BE, Bassett M, Rogers CA, Anderson ID, Beckingham I, Blazeby JM. Short-term outcomes after emergency surgery for complicated peptic ulcer disease from the UK National Emergency Laparotomy Audit: a cohort study. BMJ Open 2018;8:e023721.
- 7. Sommer T, Elbroend H, Friis-Andersen H. Laparoscopic repair of perforated ulcer in Western Denmark--a retrospective study. Scand J Surg 2010;99:119-21.
- 8. Özkan E, Dulundu E, Özel Y, Yıldız MK, Yardımcı S, Topaloğlu. [Size determines morbidity, older age and ASA score determines mortality in peptic ulcus perforation]. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi 2008;48:222-8. [Article in Turkish]
- 9. Kamani F, Moghimi M, Marashi SA, Peyrovi H, Sheikhvatan M. Perforated peptic ulcer disease: mid-term outcome among Iranian population. Turk J Gastroenterol 2010;21:125-8.
- 10. Kocer B, Surmeli S, Solak C, Unal B, Bozkurt B, Yildirim O, et al. Factors affecting mortality and morbidity in patients with peptic ulcer perforation. J Gastroenterol Hepatol 2007;22:565-70.
- 11. Bas G, Eryilmaz R, Okan I, Sahin M. Risk factors of morbidity and mortality in patients with perforated peptic ulcer. Acta Chir Belg 2008;108:424-7.
- 12. Kim HC, Kim SW, Park SJ. Gastrointestinal tract perforation: evaluation of MDCT according to perforation site and elapsed time. Eur Radiol 2014;24:1386-93.
- 13. Yıldırım M, Engin Ö, İlhan E, Coşkun A. Risk factors and Mannheim Peritonitis Index for the prediction of morbidity and mortality in patients with peptic ulcer perforation. Nobel Med 2009;5:74-81.
- 14. Agarwal A, Jain S, Meena L, Jain SA, Agarwal L. Validation of Boey’s score in predicting morbidity and mortality in peptic perforation peritonitis in Northwestern India. Trop Gastroenterol 2016;36:256-60.
- 15. Andersen IB, Jørgensen T, Bonnevie O, Grønbæk M, Sørensen TI. Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: a population-based cohort study. Epidemiology 2000;11:434-9.
- 16. Testini M, Portincasa P, Piccinni G, Lissidini G, Pellegrini F, Greco L. Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer. World J Gastroenterol 2003;9:2338-40.
- 17. Chan W, Wong W, Khin L, Soo K. Adverse operative risk factors for perforated peptic ulcer. Ann Acad Med Singap 2000;29:164-7.
- 18. Taş İ, Ülger BV, Önder A, Kapan M, Bozdağ Z. Risk factors influencing morbidity and mortality in perforated peptic ulcer disease. Ulusal Cerr Derg 2015;31:20-5.
- 19. Arıcı C, Dinçkan A, Erdoğan O, Bozan H, Çolak T. [Peptic ulcer perforation: an analysis of risk factors affect on operative mortality]. Ulusal Travma Acil Cerrahi Derg 2002;8:142-6. [Article in Turkish]
- 20. Yamamoto K, Takahashi O, Arioka H, Kobayashi D. Evaluation of risk factors for perforated peptic ulcer. BMC Gastroenterol 2018;18:1-8.
- 21. Manglik R, Gopal KV. Correlation of serum amylase and peritoneal fluid amylase with, perforated peptic ulcer and its complications. J Evolution Med Dent Sci 2019;8:2897-902.
- 22. Lemaitre J, Founas WE, Simoens C, Ngongang C, Smets D, da Costa PM. Surgical management of acute perforation of peptic ulcers. A single centre experience. Acta Chir Belg 2005;105:588-91.
- 23. Grassi R, Romano S, Pinto A, Romano L. Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients. Eur J Radiol 2004;50:30-6.
- 24. Mäkelä JT, Kiviniemi H, Ohtonen P, Laitinen SO. Factors that predict morbidity and mortality in patients with perforated peptic ulcers. Eur J Surg 2002;168:446-51.
- 25. Imhof M, Epstein S, Ohmann C, Röher H-D. Duration of survival after peptic ulcer perforation. World J Surg 2008;32:408-12.
- 26. Çakır M, Küçükkartallar T, Tekin A. [Changing surgical methods in peptic ulcer perforation]. Selçuk Üniv Tıp Derg 2011;27:160-1. [Article in Turkish]
Evaluation of clinico-radiological factors affecting morbidity and mortality in peptic ulcer perforation surgery
Abstract
Objectives: Peptic ulcer perforation (PUP) remains a surgical emergency with high early period morbidity and mortality. In this study, it was aimed to evaluate clinico-radiological factors affecting morbidity and mortality in peptic ulcer perforation surgery.
Methods: Patients who were operated for PUP at Erzurum Regional Training and Research Hospital General Surgery Clinic, Erzurum, Turkey between 2010 and 2020 were selected retrospectively. The patients’ clinical and radiological parameters were retrieved from their medical records. Patients who developed complications in the 30 days after surgery were considered the morbidity-positive group, and the patients who developed mortality in the 30 days after surgery were considered the mortality-positive group. The relationship between investigated factors and morbidity and mortality was investigated with suitable statistical tests. A p value < 0.05 was considered statistically significant.
Results: The study included 81 patients and, 74 (91.4%) patients were males. Complications were observed in 15 (18.5%) patients and mortality was seen in 3 (3.7%) patients in the first 30 days postoperatively. Preoperative comorbidity, low systolic blood pressure, high Boey score had negative effect on both morbidity and mortality. In addition, lower amylase levels played a protective role in both morbidity (p = 0.011) and mortality (p = 0.018). Mortality increased significantly with increasing age. However, no radiological factor affected either morbidity or mortality.
Conclusions: Both morbidity and mortality increased in cases with poor clinical condition at the time of diagnosis. In addition, the mortality rate was higher in patients with comorbidities and postoperative complications.
References
- 1. Eisner F, Hermann D, Bajaeifer K, Glatzle J, Königsrainer A, Küper MA. Gastric ulcer complications after the introduction of proton pump inhibitors into clinical routine: 20-year experience. Visc Med 2017;33:221-6.
- 2. Dutta AK, Chacko A, Balekuduru A, Sahu MK, Gangadharan SK. Time trends in epidemiology of peptic ulcer disease in India over two decades. Indian J Gastroenterol 2012;31:111-5.
- 3. Tarasconi A, Coccolini F, Biffl WL, Tomasoni M, Ansaloni L, Picetti E, et al. Perforated and bleeding peptic ulcer: WSES guidelines. World J Emerg Surg 2020;15:1-24.
- 4. Svanes C. Trends in perforated peptic ulcer: incidence, etiology, treatment, and prognosis. World J Surg 2000;24:277-83.
- 5. Thorsen K, Glomsaker TB, von Meer A, Søreide K, Søreide JA. Trends in diagnosis and surgical management of patients with perforated peptic ulcer. J Gastrointest Surg 2011;15:1329-35.
- 6. Byrne BE, Bassett M, Rogers CA, Anderson ID, Beckingham I, Blazeby JM. Short-term outcomes after emergency surgery for complicated peptic ulcer disease from the UK National Emergency Laparotomy Audit: a cohort study. BMJ Open 2018;8:e023721.
- 7. Sommer T, Elbroend H, Friis-Andersen H. Laparoscopic repair of perforated ulcer in Western Denmark--a retrospective study. Scand J Surg 2010;99:119-21.
- 8. Özkan E, Dulundu E, Özel Y, Yıldız MK, Yardımcı S, Topaloğlu. [Size determines morbidity, older age and ASA score determines mortality in peptic ulcus perforation]. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi 2008;48:222-8. [Article in Turkish]
- 9. Kamani F, Moghimi M, Marashi SA, Peyrovi H, Sheikhvatan M. Perforated peptic ulcer disease: mid-term outcome among Iranian population. Turk J Gastroenterol 2010;21:125-8.
- 10. Kocer B, Surmeli S, Solak C, Unal B, Bozkurt B, Yildirim O, et al. Factors affecting mortality and morbidity in patients with peptic ulcer perforation. J Gastroenterol Hepatol 2007;22:565-70.
- 11. Bas G, Eryilmaz R, Okan I, Sahin M. Risk factors of morbidity and mortality in patients with perforated peptic ulcer. Acta Chir Belg 2008;108:424-7.
- 12. Kim HC, Kim SW, Park SJ. Gastrointestinal tract perforation: evaluation of MDCT according to perforation site and elapsed time. Eur Radiol 2014;24:1386-93.
- 13. Yıldırım M, Engin Ö, İlhan E, Coşkun A. Risk factors and Mannheim Peritonitis Index for the prediction of morbidity and mortality in patients with peptic ulcer perforation. Nobel Med 2009;5:74-81.
- 14. Agarwal A, Jain S, Meena L, Jain SA, Agarwal L. Validation of Boey’s score in predicting morbidity and mortality in peptic perforation peritonitis in Northwestern India. Trop Gastroenterol 2016;36:256-60.
- 15. Andersen IB, Jørgensen T, Bonnevie O, Grønbæk M, Sørensen TI. Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: a population-based cohort study. Epidemiology 2000;11:434-9.
- 16. Testini M, Portincasa P, Piccinni G, Lissidini G, Pellegrini F, Greco L. Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer. World J Gastroenterol 2003;9:2338-40.
- 17. Chan W, Wong W, Khin L, Soo K. Adverse operative risk factors for perforated peptic ulcer. Ann Acad Med Singap 2000;29:164-7.
- 18. Taş İ, Ülger BV, Önder A, Kapan M, Bozdağ Z. Risk factors influencing morbidity and mortality in perforated peptic ulcer disease. Ulusal Cerr Derg 2015;31:20-5.
- 19. Arıcı C, Dinçkan A, Erdoğan O, Bozan H, Çolak T. [Peptic ulcer perforation: an analysis of risk factors affect on operative mortality]. Ulusal Travma Acil Cerrahi Derg 2002;8:142-6. [Article in Turkish]
- 20. Yamamoto K, Takahashi O, Arioka H, Kobayashi D. Evaluation of risk factors for perforated peptic ulcer. BMC Gastroenterol 2018;18:1-8.
- 21. Manglik R, Gopal KV. Correlation of serum amylase and peritoneal fluid amylase with, perforated peptic ulcer and its complications. J Evolution Med Dent Sci 2019;8:2897-902.
- 22. Lemaitre J, Founas WE, Simoens C, Ngongang C, Smets D, da Costa PM. Surgical management of acute perforation of peptic ulcers. A single centre experience. Acta Chir Belg 2005;105:588-91.
- 23. Grassi R, Romano S, Pinto A, Romano L. Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients. Eur J Radiol 2004;50:30-6.
- 24. Mäkelä JT, Kiviniemi H, Ohtonen P, Laitinen SO. Factors that predict morbidity and mortality in patients with perforated peptic ulcers. Eur J Surg 2002;168:446-51.
- 25. Imhof M, Epstein S, Ohmann C, Röher H-D. Duration of survival after peptic ulcer perforation. World J Surg 2008;32:408-12.
- 26. Çakır M, Küçükkartallar T, Tekin A. [Changing surgical methods in peptic ulcer perforation]. Selçuk Üniv Tıp Derg 2011;27:160-1. [Article in Turkish]
There are 26 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Surgery |
| Journal Section | Original Articles |
| Authors | |
| Publication Date | March 4, 2022 |
| Submission Date | May 16, 2021 |
| Acceptance Date | October 3, 2021 |
| Published in Issue | Year 2022 Volume: 8 Issue: 2 |
e-ISSN: 2149-3189
The European Research Journal, hosted by Turkish JournalPark ACADEMIC, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
2024