Case Report
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Year 2023, Volume: 9 Issue: 4, 823 - 827, 04.07.2023
https://doi.org/10.18621/eurj.1032176

Abstract

References

  • 1. Patnayak R, Preetam P, Jena A, Subramanian S, Lakshmi AY. Space occupying lesion (paraganglioma) of the urinary bladder in a young male: a case report and brief review of the literature. J Cancer Res Ther 2015;11:1039.
  • 2. Zhou M, Epstein JI, Young RH. Paraganglioma of the urinary bladder: a lesion that may be misdiagnosed as urothelial carcinoma in transurethral resection specimens. Am J Surg Pathol 2004;28:94-100.
  • 3. Albores‐Saavedra J, Maldonado ME, Ibarra J, Rodriguez HA. Pheochromocytoma of the urinary bladder. Cancer 1969;23:1110-8.
  • 4. Feng N, Li X, Gao H-D, Liu Z-L, Shi L-J, Liu W-Z. Urinary bladder malignant paraganglioma with vertebral metastasis: a case report with literature review. Chin J Cancer 2013;32:624-8.
  • 5. Murphy WM, Deana DG. The nested variant of transitional cell carcinoma: a neoplasm resembling proliferation of Brunn's nests. Mod Pathol 1992;5:240-3.
  • 6. Rosenbaum JN, Guo Z, Baus RM, Werner H, Rehrauer WM, Lloyd RV. INSM1: a novel immunohistochemical and molecular marker for neuroendocrine and neuroepithelial neoplasms. Am J Clin Pathol 2015;144:579-91.
  • 7. So JS, Epstein JI. GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma. Mod Pathol 2013;26:1365-70.
  • 8. Grouzmann E, Tschopp O, Triponez F, Matter M, Bilz S, Brandle M, et al. Catecholamine metabolism in paraganglioma and pheochromocytoma: similar tumors in different sites? PLoS One 2015;10:e0125426.
  • 9. Asa SL, Ezzat S, Mete O. The diagnosis and clinical significance of paragangliomas in unusual locations. J Clin Med 2018;7:280.
  • 10. Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi M, et al. Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma. Endocr Relat Cancer 2014;21:405-14.
  • 11. Gupta S, Zhang J, Rivera M, Erickson L A. Urinary bladder paragangliomas: analysis of succinate dehydrogenase and outcome. Endocr Pathol 2016;27:243-52.
  • 12. Kimura N, Capella C, DeLellis RA, Epstein JI, Gill A, Kawashima A, et al. Extra-adrenal paragangliomas. In: WHO Classification of Tumours of Endocrine Organs. Lloyd RV, Osamura RY, Kloeppel G, Rosai J, eds., 4th ed., International Agency for Research on Cancer: Lyon, France, 2017;10: pp.190-5.
  • 13. Hanji AM, Rohan VS, Patel JJ, Tankshali RA. Pheochromocytoma of the urinary bladder: a rare cause of severe hypertension. Saudi J Kidney Dis Transpl 2012;23:813-6.

Paraganglioma of the urinary bladder mimicking a urothelial carcinoma: a case report

Year 2023, Volume: 9 Issue: 4, 823 - 827, 04.07.2023
https://doi.org/10.18621/eurj.1032176

Abstract

Paragangliomas of the urinary bladder are rare tumors and can mimic urothelial carcinomas due to some features and can be misdiagnosed. A 71-year-old female was seen for hematuria and there was a solid lesion that measured 3 cm on the urinary bladder at cystoscopy. Treatment approaches for paraganglioma and urothelial carcinoma are very different from each other; therefore differential diagnoses should be made carefully. Although immunohistochemical studies are helpful in differential diagnosis, they may cause misdiagnosis in some cases. In this article, we will discuss the clinical, histomorphological, and immunohistochemical differences between paraganglioma and urothelial carcinomas under their differential diagnosis.

References

  • 1. Patnayak R, Preetam P, Jena A, Subramanian S, Lakshmi AY. Space occupying lesion (paraganglioma) of the urinary bladder in a young male: a case report and brief review of the literature. J Cancer Res Ther 2015;11:1039.
  • 2. Zhou M, Epstein JI, Young RH. Paraganglioma of the urinary bladder: a lesion that may be misdiagnosed as urothelial carcinoma in transurethral resection specimens. Am J Surg Pathol 2004;28:94-100.
  • 3. Albores‐Saavedra J, Maldonado ME, Ibarra J, Rodriguez HA. Pheochromocytoma of the urinary bladder. Cancer 1969;23:1110-8.
  • 4. Feng N, Li X, Gao H-D, Liu Z-L, Shi L-J, Liu W-Z. Urinary bladder malignant paraganglioma with vertebral metastasis: a case report with literature review. Chin J Cancer 2013;32:624-8.
  • 5. Murphy WM, Deana DG. The nested variant of transitional cell carcinoma: a neoplasm resembling proliferation of Brunn's nests. Mod Pathol 1992;5:240-3.
  • 6. Rosenbaum JN, Guo Z, Baus RM, Werner H, Rehrauer WM, Lloyd RV. INSM1: a novel immunohistochemical and molecular marker for neuroendocrine and neuroepithelial neoplasms. Am J Clin Pathol 2015;144:579-91.
  • 7. So JS, Epstein JI. GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma. Mod Pathol 2013;26:1365-70.
  • 8. Grouzmann E, Tschopp O, Triponez F, Matter M, Bilz S, Brandle M, et al. Catecholamine metabolism in paraganglioma and pheochromocytoma: similar tumors in different sites? PLoS One 2015;10:e0125426.
  • 9. Asa SL, Ezzat S, Mete O. The diagnosis and clinical significance of paragangliomas in unusual locations. J Clin Med 2018;7:280.
  • 10. Kimura N, Takayanagi R, Takizawa N, Itagaki E, Katabami T, Kakoi M, et al. Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma. Endocr Relat Cancer 2014;21:405-14.
  • 11. Gupta S, Zhang J, Rivera M, Erickson L A. Urinary bladder paragangliomas: analysis of succinate dehydrogenase and outcome. Endocr Pathol 2016;27:243-52.
  • 12. Kimura N, Capella C, DeLellis RA, Epstein JI, Gill A, Kawashima A, et al. Extra-adrenal paragangliomas. In: WHO Classification of Tumours of Endocrine Organs. Lloyd RV, Osamura RY, Kloeppel G, Rosai J, eds., 4th ed., International Agency for Research on Cancer: Lyon, France, 2017;10: pp.190-5.
  • 13. Hanji AM, Rohan VS, Patel JJ, Tankshali RA. Pheochromocytoma of the urinary bladder: a rare cause of severe hypertension. Saudi J Kidney Dis Transpl 2012;23:813-6.
There are 13 citations in total.

Details

Primary Language English
Subjects Pathology
Journal Section Case Reports
Authors

Çiğdem Öztürk 0000-0003-2587-214X

Hasan Güçer This is me 0000-0002-9122-379X

Seher Çetinkaya Altuntaş 0000-0002-9733-9443

Oğuzhan Okcu 0000-0001-7481-4718

Early Pub Date June 1, 2023
Publication Date July 4, 2023
Submission Date December 3, 2021
Acceptance Date August 24, 2022
Published in Issue Year 2023 Volume: 9 Issue: 4

Cite

AMA Öztürk Ç, Güçer H, Çetinkaya Altuntaş S, Okcu O. Paraganglioma of the urinary bladder mimicking a urothelial carcinoma: a case report. Eur Res J. July 2023;9(4):823-827. doi:10.18621/eurj.1032176

e-ISSN: 2149-3189 


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