Review
BibTex RIS Cite

COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ

Year 2020, Volume: 5 Issue: 3, 1 - 7, 31.12.2020

Cemile Merve Seymen

Abstract

Tüm dünyayı tehdit eden ve küresel pandemi ilan edilen Koronavirüs Hastalığı-19 (COVID-19) hakkında literatürde bulunan veriler; bu hastalığın sadece solunum sistemini değil, aynı zamanda genital sistemin de arasında bulunduğu pekçok sistemi ve buna bağlı organları tehdit ettiğini ortaya koymuştur. Virüsün bu kadar geniş bir aralıkta etki göstermesinin temel nedeni ise, hücre içerisine girişte kullandığı ACE 2’yi eksprese eden pekçok organ bulunmasıdır. COVID-19’un kadın üreme sağlığı üzerindeki etkilerinin yer aldığı araştırma sayısı fazla olmamakla birlikte, olası etkileri hipotez aşamasında kalmış durumdadır. Bu derleme; COVID-19’un ovaryum, uterus, serviks dokuları ile vajinal sıvı üzerindeki olası etkileri ve bu etkilere sebep olan mekanizmaları ortaya koymayı hedeflemektedir.

Keywords

ACE 2 COVID-19 KADIN FERTİLİTESİ SARS-CoV-2 OVARYUM UTERUS

References

  • 1. Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, et al. Potential influence of COVID-19/ACE2 on the female reproductive system. Molecular Human Reproduction. 2020; gaaa030. Doi: 10.1093/molehr/gaaa030.
  • 2. Huang H, Wang P, Yang Y, Chou S, et al. A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system. Journal of the Chinese Medical Association. 2020; 83(10): 895-97. Doi: 10.1097/JCMA.0000000000000388.
  • 3. Chen J, Jiang Q, Xi X, Liu K, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020; 19(7): e13168. Doi: 10.1111/acel.13168.
  • 4. Iliano E, Trama F, Costantini E. Could COVID-19 have an impact on male fertility? Andrologia. 2020; 00: e13654. Doi: 10.1111/and.13654.
  • 5. Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, et al. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host & Microbe. 2020; 27(3): 325-28. Doi: 10.1016/j.chom.2020.02.001.
  • 6. Ge X-Y, Li J-L, Yang X-L, Chmura AA, Zhu G, Epstein JH, et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013; 503:535-8. Doi: 10.1038/nature12711.
  • 7. Atlas SA. The renin-angiotensin-aldosterone system: Patophysiological role and pharmacologic inhibition. Journal of Managed Care & Specialty Pharmacy. 2007; 13: 9-20. Doi: 10.18553/jmcp.2007.
  • 8. Fu J, Zhou B, Zhang L, Balaji KS, et al. Expressions and significances of the angiotensin‑converting enzyme 2 gene, the receptor of SARS‑CoV‑2 for COVID‑19. Molecular Biology Reports. 2020; 14: 1-10. Doi: 10.1007/s11033-020-05478-4.
  • 9. Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus disease-19 and fertility: Viral host entry protein expression in male and female reproductive tissues. Fertility and Sterility. 2020; 114(1): 33-43. Doi: 10.1016/j.fertnstert.2020.05.001.
  • 10. Naik GO. COVID-19 and the renin-angiotensin-aldosterone system. Clinical Infectious Diseases. 2020; 81: 63-7. Doi: 10.1016/j.ando.2020.04.005.
  • 11. Sun J. The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy. Medical Hypotheses. 2020; 143: 110083. Doi: 10.1016/j.mehy.2020.110083.
  • 12. Singh B, Gornet M, Sims H, Kisanga E, et al. Severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) and its effect on gametogenesis and early pregnancy. American Journal of Reproductive Immunology. 2020; e13351. Doi: 10.1111/aji.13351.
  • 13. Mohammadi S, Abouzaripour M, Shariati NH, Shariati MBH. Ovarian vein thrombosis after coronavirus disease (COVID‑19) infection in a pregnant woman: Case report. Journal of Thrombosis and Thrombolysis. 2020; 8: 1-4. Doi: 10.1007/s11239-020-02177-6.
  • 14. Moin AS, Sathyapalan T, Atkin SL, Butler AE. Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? Metabolism Open. 2020; 7: 100052. Doi: 10.1016/j.metop.2020.100052.
  • 15. Kyrou I, Karteris E, Robbins T, Chatha K, et al. Polycystic ovary syndrome (PCOS) and COVID-19: An overlooked female patient population at potentially higher risk during the COVID-19 pandemic. BMC Medicine. 2020; 18: 220. Doi: 10.1186/s12916-020-01697-5.
  • 16. Vaz-Silva J, Carneiro MM, Ferreira MC, Pinheiro SV, et al. The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. Reproductive Sciences. 2009; 6: 247-56. Doi: 10.1177/1933719108327593.
  • 17. Henarejos-Castillo I, Sebastian-Leon P, Devesa-Peiro A, Pellicer A, et al. SARS-CoV-2 infection risk assessment in the endometrium: Viral infection-related gene expression across the menstrual cycle. Fertility and Sterility. 2020; 114(2): 223-32. Doi: 10.1016/j.fertnstert.2020.06.026.
  • 18. Vavoulidis E, Margioula-Siarkou C, Petousis S, Dinas K. SARS‐CoV‐2 infection and impact on female genital tract: An untested hypothesis. Medical Hypotheses. 2020; 114: 110162. Doi: 10.1016/j.mehy.2020.110162.
  • 19. Cui P, Chen Z, Wang T, Dai J, et al. Severe acute respiratory syndrome coronavirus 2 detection in the female lower genital tract. American Journal of Obstetrics and Gynaecology. 2020; 223(1): 131-34. Doi: 10.1016/j.ajog.2020.04.038.
  • 20. Qui L, Liu X, Xiao M, Xie J, et al. SARS CoV 2 is not detectable in the vaginal fluid of women with severe COVID 19 infection. Clinical Infectious Diseases. 2020; 71(15): 813-17. Doi: 10.1093/cid/ciaa375.

Year 2020, Volume: 5 Issue: 3, 1 - 7, 31.12.2020

Cemile Merve Seymen

Abstract

References

  • 1. Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, et al. Potential influence of COVID-19/ACE2 on the female reproductive system. Molecular Human Reproduction. 2020; gaaa030. Doi: 10.1093/molehr/gaaa030.
  • 2. Huang H, Wang P, Yang Y, Chou S, et al. A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system. Journal of the Chinese Medical Association. 2020; 83(10): 895-97. Doi: 10.1097/JCMA.0000000000000388.
  • 3. Chen J, Jiang Q, Xi X, Liu K, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell. 2020; 19(7): e13168. Doi: 10.1111/acel.13168.
  • 4. Iliano E, Trama F, Costantini E. Could COVID-19 have an impact on male fertility? Andrologia. 2020; 00: e13654. Doi: 10.1111/and.13654.
  • 5. Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, et al. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host & Microbe. 2020; 27(3): 325-28. Doi: 10.1016/j.chom.2020.02.001.
  • 6. Ge X-Y, Li J-L, Yang X-L, Chmura AA, Zhu G, Epstein JH, et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013; 503:535-8. Doi: 10.1038/nature12711.
  • 7. Atlas SA. The renin-angiotensin-aldosterone system: Patophysiological role and pharmacologic inhibition. Journal of Managed Care & Specialty Pharmacy. 2007; 13: 9-20. Doi: 10.18553/jmcp.2007.
  • 8. Fu J, Zhou B, Zhang L, Balaji KS, et al. Expressions and significances of the angiotensin‑converting enzyme 2 gene, the receptor of SARS‑CoV‑2 for COVID‑19. Molecular Biology Reports. 2020; 14: 1-10. Doi: 10.1007/s11033-020-05478-4.
  • 9. Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus disease-19 and fertility: Viral host entry protein expression in male and female reproductive tissues. Fertility and Sterility. 2020; 114(1): 33-43. Doi: 10.1016/j.fertnstert.2020.05.001.
  • 10. Naik GO. COVID-19 and the renin-angiotensin-aldosterone system. Clinical Infectious Diseases. 2020; 81: 63-7. Doi: 10.1016/j.ando.2020.04.005.
  • 11. Sun J. The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy. Medical Hypotheses. 2020; 143: 110083. Doi: 10.1016/j.mehy.2020.110083.
  • 12. Singh B, Gornet M, Sims H, Kisanga E, et al. Severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) and its effect on gametogenesis and early pregnancy. American Journal of Reproductive Immunology. 2020; e13351. Doi: 10.1111/aji.13351.
  • 13. Mohammadi S, Abouzaripour M, Shariati NH, Shariati MBH. Ovarian vein thrombosis after coronavirus disease (COVID‑19) infection in a pregnant woman: Case report. Journal of Thrombosis and Thrombolysis. 2020; 8: 1-4. Doi: 10.1007/s11239-020-02177-6.
  • 14. Moin AS, Sathyapalan T, Atkin SL, Butler AE. Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? Metabolism Open. 2020; 7: 100052. Doi: 10.1016/j.metop.2020.100052.
  • 15. Kyrou I, Karteris E, Robbins T, Chatha K, et al. Polycystic ovary syndrome (PCOS) and COVID-19: An overlooked female patient population at potentially higher risk during the COVID-19 pandemic. BMC Medicine. 2020; 18: 220. Doi: 10.1186/s12916-020-01697-5.
  • 16. Vaz-Silva J, Carneiro MM, Ferreira MC, Pinheiro SV, et al. The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium. Reproductive Sciences. 2009; 6: 247-56. Doi: 10.1177/1933719108327593.
  • 17. Henarejos-Castillo I, Sebastian-Leon P, Devesa-Peiro A, Pellicer A, et al. SARS-CoV-2 infection risk assessment in the endometrium: Viral infection-related gene expression across the menstrual cycle. Fertility and Sterility. 2020; 114(2): 223-32. Doi: 10.1016/j.fertnstert.2020.06.026.
  • 18. Vavoulidis E, Margioula-Siarkou C, Petousis S, Dinas K. SARS‐CoV‐2 infection and impact on female genital tract: An untested hypothesis. Medical Hypotheses. 2020; 114: 110162. Doi: 10.1016/j.mehy.2020.110162.
  • 19. Cui P, Chen Z, Wang T, Dai J, et al. Severe acute respiratory syndrome coronavirus 2 detection in the female lower genital tract. American Journal of Obstetrics and Gynaecology. 2020; 223(1): 131-34. Doi: 10.1016/j.ajog.2020.04.038.
  • 20. Qui L, Liu X, Xiao M, Xie J, et al. SARS CoV 2 is not detectable in the vaginal fluid of women with severe COVID 19 infection. Clinical Infectious Diseases. 2020; 71(15): 813-17. Doi: 10.1093/cid/ciaa375.
There are 20 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Makaleler
Authors

Cemile Merve Seymen 0000-0002-8945-3801

Publication Date December 31, 2020
Submission Date October 24, 2020
Acceptance Date January 4, 2021
Published in Issue Year 2020 Volume: 5 Issue: 3

Cite

APA Seymen, C. M. (2020). COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ. Gazi Sağlık Bilimleri Dergisi, 5(3), 1-7.
AMA Seymen CM. COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ. Gazi sağlık bilim. derg. December 2020;5(3):1-7.
Chicago Seymen, Cemile Merve. “COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ”. Gazi Sağlık Bilimleri Dergisi 5, no. 3 (December 2020): 1-7.
EndNote Seymen CM (December 1, 2020) COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ. Gazi Sağlık Bilimleri Dergisi 5 3 1–7.
IEEE C. M. Seymen, “COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ”, Gazi sağlık bilim. derg, vol. 5, no. 3, pp. 1–7, 2020.
ISNAD Seymen, Cemile Merve. “COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ”. Gazi Sağlık Bilimleri Dergisi 5/3 (December 2020), 1-7.
JAMA Seymen CM. COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ. Gazi sağlık bilim. derg. 2020;5:1–7.
MLA Seymen, Cemile Merve. “COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ”. Gazi Sağlık Bilimleri Dergisi, vol. 5, no. 3, 2020, pp. 1-7.
Vancouver Seymen CM. COVID-19 PANDEMİSİNİN KADIN FERTİLİTESİ ÜZERİNE ETKİLERİ. Gazi sağlık bilim. derg. 2020;5(3):1-7.