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Year 2020, Volume: 1 Issue: 1, 1 - 11, 30.04.2020

Abstract

References

  • 1. Atalay D, Selen H, Abant E, et al. Gıda Takviyeleri ve Sağlık Üzerine Etkileri. 2018;4(2):98-111. doi:10.3153/FH18010 2. T.C. Tarım ve Orman Bakanlığı. Türk Gıda Kodeksi Takviye Edici Gıdalar Tebliği (Tebliğ No:2013/49). Türkiye; 2013:4. https://www.resmigazete.gov.tr/eskiler/2013/08/20130816-16.htm. 3. Lange D. Europe’s medicinal and aromatic plants: their use, trade and conservation. Eur Med Aromat plants their use, trade Conserv. 1998. https://www.cabdirect.org/cabdirect/abstract/19980314129. Accessed October 1, 2018. 4. Sharma M, Sharma R. Synergistic Antifungal Activity of Curcumaï¿¿longa (Turmeric) and Zingiberï¿¿officinale (Ginger) Essential Oils Against Dermatophyte Infections. J Essent Oil Bear Plants. 2011;14(1):38-47. doi:10.1080/0972060X.2011.10643899 5. Yasar M. The remember regeneration therapy method: An overview of new therapy protocol to approach diseases. J Complement Med Res. 2019;10(1). doi:10.5455/jcmr.20181229122909 6. Zhao FR, Mao HP, Zhang H, et al. Antagonistic effects of two herbs in Zuojin Wan, a traditional Chinese medicine formula, on catecholamine secretion in bovine adrenal medullary cells. Phytomedicine. 2010;17(8-9):659-668. doi:10.1016/j.phymed.2009.10.010 7. Monga M, Sausville EA. Developmental therapeutics program at the NCI: Molecular target and drug discovery process. Leukemia. 2002;16(4):520-526. doi:10.1038/sj.leu.2402464 8. Anonymous. ISO 10993-11:2017(en), Biological evaluation of medical devices — Part 11: Tests for systemic toxicity. International Organization for Standardization. https://www.iso.org/obp/ui/#iso:std:iso:10993:-11:ed-3:v1:en. Published 2017. Accessed March 30, 2020. 9. Saygı Ş. Deneysel Toksikolojide Toksisite Testleri ve Test Sonuçlarının Önemi. Gülhane Tıp Derg. 2003;45(3):291-298. http://cms.galenos.com.tr/Uploads/Article_32654/GMJ-45-291-En.pdf. Accessed March 31, 2020. 10. Anonymous. ISO 10993-2:2006 Biological evaluation of medical devices — Part 2: Animal welfare requirements. International Organization for Standardization. https://www.iso.org/obp/ui/#iso:std:iso:10993:-2:ed-2:v1:en. Published 2015. Accessed March 30, 2020. 11. Anonymous. ISO 10993-12:2012 Biological evaluation of medical devices — Part 12: Sample preparation and reference materials. International Organization for Standardization. https://www.iso.org/obp/ui/#iso:std:iso:10993:-12:ed-4:v1:en. Published 2012. Accessed March 30, 2020. 12. Kusari S, Lamshöft M, Spiteller M. Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin. J Appl Microbiol. 2009;107(3):1019-1030. doi:10.1111/j.1365-2672.2009.04285.x 13. Fernandez A, Edwin Cock I. The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity. Pharmacogn J. 2016;8(3):273-280. doi:10.5530/pj.2016.3.17 14. Pandey G. Active principles and median lethal dose of Curcuma longa Linn. Artic Int Res J Pharm. 2014;2(5):239-241. 15. Kazeem MI, Akanji MA, Yakubu MT, Omotayo A, Ashafa T. Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinale Roscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats. Evidence-Based Complement Altern Med. 2013;2013. doi:10.1155/2013/935486 16. Zarringhalami R, Hanachi P, Kaya E, Ağan AF, Ağan K, Donmez M. Investigation of total phenolic content of tilia dasystyla and polygonatum orientale desf extracts and their cytotoxic effect on the osteogenic sarcoma (Saos-2) cancer cell line. Int J Cancer Manag. 2020;13(2). doi:10.5812/ijcm.94130 17. Mascolo N, Jain R, Jain SC, Capasso F. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol. 1989;27(1-2):129-140. doi:10.1016/0378-8741(89)90085-8 18. Lim GP, Chu T, Yang F, Beech W, Frautschy S a, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001;21(21):8370-8377. doi:21/21/8370 [pii] 19. Palla AH, Khan NA, Bashir S, ur-Rehman N, Iqbal J, Gilani A-H. Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea. J Ethnopharmacol. 2015;160:61-68. doi:10.1016/J.JEP.2014.11.030 20. Sharma RA, Mclelland HR, Hill KA, et al. Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer 1. 2001;7(July):1894-1900. 21. Jurenka JS, Ascp MT. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-153. 22. Ojewole JAO. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract ofZingiber officinale (roscoe) rhizomes (zingiberaceae) in mice and rats. Phyther Res. 2006;20(9):764-772. doi:10.1002/ptr.1952 23. Bais S, Gill NS, Rana N, Shandil S. A Phytopharmacological Review on a Medicinal Plant: Juniperus communis. Int Sch Res Not. 2014:1-6. doi:10.1155/2014/634723 24. Manel M, Nouzha H, Rim M, et al. Antibacterial and antioxidant activity of Juniperus thurifera L. leaf extracts growing in East of Algeria. Vet World. 2018;11(3):373-378. doi:10.14202/vetworld.2018.373-378 25. Bais S, Gill NS, Rana N. Effect of Juniperus communis Extract on Reserpine Induced Catalepsy. Inven Rapid Ethnopharmacol. 2014;2014(4). 26. Fachini-Queiroz FC, Kummer R, Fernanda Estevão-Silva C, et al. Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Artic ID. 2012;2012. doi:10.1155/2012/657026 27. Taşdemir B. Ratlarda İndometazinle Oluşturulan gastrik Ülser Üzerine Silimarinin Koruyucu Etkilerinin Araştırılması. 2016. http://adudspace.adu.edu.tr:8080/xmlui/bitstream/handle/11607/2904/BARIŞ TAŞDEMİR.pdf?sequence=1&isAllowed=y. Accessed March 31, 2020. 28. Bayram D. Silibinin İn Vitro Ortamda CCL-228-SW 480 Kolon Kanseri Hücre Hattı Üzerine Apoptotik Etkisinin Araştırılması. SDÜ Sağlık Bilim Derg. 2017;8(2):1-1. doi:10.22312/sdusbed.287465 29. Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clin Drug Investig. 2002;22(1):51-65. doi:10.2165/00044011-200222010-00007 30. Oktay M. Kabalcı Şifalı Bitkiler Ansiklopedisi. Vol 4. 2nd ed. İstanbul: Kabalcı Yayınevi; 2016. https://www.kabalci.com.tr/alternatif-tip-sifali-bitkiler/kabalci-sifali-bitkiler-ansiklopedisi/oktay-mete/kabalci-yayinevi. 31. Joshi BC, Mukhija M, Kalia AN. Pharmacognostical review of Urtica dioica L. Int J Green Pharm. 2019;8(4):23-30. 32. Malayoğlu HB. Biberiyenin (Rosmarinus officinalis L.) Antioksidan Etkisi. Hayvansal Üretim. 2010;51(2). 33. Jhala AJ, Hall LM. Flax (Linum usitatissimum L.): Current Uses and Future Applications. Aust J basic Appl Sci. 2010;4(9):4304-4312.

Systemic Investigation of Acute Toxicity of Some Food Supplements on The Market in Turkey

Year 2020, Volume: 1 Issue: 1, 1 - 11, 30.04.2020

Abstract

Objective: Along with changing living and working conditions in recent years, changes have occurred in eating habits. People are turning to supplements for many purposes such as supplementing normal nutrition, feeling more energetic, enhancing the immune system by taking vitamins and minerals that they think they do not get enough, and meeting their body's needs when they cannot eat a balanced and healthy diet. Supplements are prepared in various forms using nutrients such as vitamins, minerals, proteins, amino acids, plants, enzymes, fiber and fatty acids. These supplement foods are not intended to treat or prevent any disease. In general, supplement foods; it is not a substitute for natural nutrition, but it is intended to complement its deficiencies. They cannot be recommended and sold instead of medicines. Because of many of these products have natural content, they can be placed on the market without toxicity tests. In the current study, it is planned to observe the effects of acute systemic toxicity of supplements that are used in remember regeneration therapy method (RTM) and sold in the markets with the brands’ name of IST-ARD®, ARD-REM®, DVD-ARD®, KT-REM®, ARDZ-REM®, IST-GLIO®, IST-REM®, ROMX®, and REGULIN®. 
Material-Method: In the experimental design, there were 10 groups (1 control and 9 application groups) male mice. To observe acute toxicity, clinical observation was performed for 72 hours and the biochemical and histopathological parameters of the animals were evaluated at the end of the application. 
Results: According to the results obtained from the study, there were not found significant differences in biochemical and histopathological evaluations between the control and the application groups. 
Conclusion: The acute toxicity effect of the food supplements was not determined. May be further studies with bigger numbers of samples investigating the nephrotoxic effects of these products lighten this matter.

References

  • 1. Atalay D, Selen H, Abant E, et al. Gıda Takviyeleri ve Sağlık Üzerine Etkileri. 2018;4(2):98-111. doi:10.3153/FH18010 2. T.C. Tarım ve Orman Bakanlığı. Türk Gıda Kodeksi Takviye Edici Gıdalar Tebliği (Tebliğ No:2013/49). Türkiye; 2013:4. https://www.resmigazete.gov.tr/eskiler/2013/08/20130816-16.htm. 3. Lange D. Europe’s medicinal and aromatic plants: their use, trade and conservation. Eur Med Aromat plants their use, trade Conserv. 1998. https://www.cabdirect.org/cabdirect/abstract/19980314129. Accessed October 1, 2018. 4. Sharma M, Sharma R. Synergistic Antifungal Activity of Curcumaï¿¿longa (Turmeric) and Zingiberï¿¿officinale (Ginger) Essential Oils Against Dermatophyte Infections. J Essent Oil Bear Plants. 2011;14(1):38-47. doi:10.1080/0972060X.2011.10643899 5. Yasar M. The remember regeneration therapy method: An overview of new therapy protocol to approach diseases. J Complement Med Res. 2019;10(1). doi:10.5455/jcmr.20181229122909 6. Zhao FR, Mao HP, Zhang H, et al. Antagonistic effects of two herbs in Zuojin Wan, a traditional Chinese medicine formula, on catecholamine secretion in bovine adrenal medullary cells. Phytomedicine. 2010;17(8-9):659-668. doi:10.1016/j.phymed.2009.10.010 7. Monga M, Sausville EA. Developmental therapeutics program at the NCI: Molecular target and drug discovery process. Leukemia. 2002;16(4):520-526. doi:10.1038/sj.leu.2402464 8. Anonymous. ISO 10993-11:2017(en), Biological evaluation of medical devices — Part 11: Tests for systemic toxicity. International Organization for Standardization. https://www.iso.org/obp/ui/#iso:std:iso:10993:-11:ed-3:v1:en. Published 2017. Accessed March 30, 2020. 9. Saygı Ş. Deneysel Toksikolojide Toksisite Testleri ve Test Sonuçlarının Önemi. Gülhane Tıp Derg. 2003;45(3):291-298. http://cms.galenos.com.tr/Uploads/Article_32654/GMJ-45-291-En.pdf. Accessed March 31, 2020. 10. Anonymous. ISO 10993-2:2006 Biological evaluation of medical devices — Part 2: Animal welfare requirements. International Organization for Standardization. https://www.iso.org/obp/ui/#iso:std:iso:10993:-2:ed-2:v1:en. Published 2015. Accessed March 30, 2020. 11. Anonymous. ISO 10993-12:2012 Biological evaluation of medical devices — Part 12: Sample preparation and reference materials. International Organization for Standardization. https://www.iso.org/obp/ui/#iso:std:iso:10993:-12:ed-4:v1:en. Published 2012. Accessed March 30, 2020. 12. Kusari S, Lamshöft M, Spiteller M. Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin. J Appl Microbiol. 2009;107(3):1019-1030. doi:10.1111/j.1365-2672.2009.04285.x 13. Fernandez A, Edwin Cock I. The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity. Pharmacogn J. 2016;8(3):273-280. doi:10.5530/pj.2016.3.17 14. Pandey G. Active principles and median lethal dose of Curcuma longa Linn. Artic Int Res J Pharm. 2014;2(5):239-241. 15. Kazeem MI, Akanji MA, Yakubu MT, Omotayo A, Ashafa T. Protective Effect of Free and Bound Polyphenol Extracts from Ginger (Zingiber officinale Roscoe) on the Hepatic Antioxidant and Some Carbohydrate Metabolizing Enzymes of Streptozotocin-Induced Diabetic Rats. Evidence-Based Complement Altern Med. 2013;2013. doi:10.1155/2013/935486 16. Zarringhalami R, Hanachi P, Kaya E, Ağan AF, Ağan K, Donmez M. Investigation of total phenolic content of tilia dasystyla and polygonatum orientale desf extracts and their cytotoxic effect on the osteogenic sarcoma (Saos-2) cancer cell line. Int J Cancer Manag. 2020;13(2). doi:10.5812/ijcm.94130 17. Mascolo N, Jain R, Jain SC, Capasso F. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol. 1989;27(1-2):129-140. doi:10.1016/0378-8741(89)90085-8 18. Lim GP, Chu T, Yang F, Beech W, Frautschy S a, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001;21(21):8370-8377. doi:21/21/8370 [pii] 19. Palla AH, Khan NA, Bashir S, ur-Rehman N, Iqbal J, Gilani A-H. Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea. J Ethnopharmacol. 2015;160:61-68. doi:10.1016/J.JEP.2014.11.030 20. Sharma RA, Mclelland HR, Hill KA, et al. Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer 1. 2001;7(July):1894-1900. 21. Jurenka JS, Ascp MT. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-153. 22. Ojewole JAO. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract ofZingiber officinale (roscoe) rhizomes (zingiberaceae) in mice and rats. Phyther Res. 2006;20(9):764-772. doi:10.1002/ptr.1952 23. Bais S, Gill NS, Rana N, Shandil S. A Phytopharmacological Review on a Medicinal Plant: Juniperus communis. Int Sch Res Not. 2014:1-6. doi:10.1155/2014/634723 24. Manel M, Nouzha H, Rim M, et al. Antibacterial and antioxidant activity of Juniperus thurifera L. leaf extracts growing in East of Algeria. Vet World. 2018;11(3):373-378. doi:10.14202/vetworld.2018.373-378 25. Bais S, Gill NS, Rana N. Effect of Juniperus communis Extract on Reserpine Induced Catalepsy. Inven Rapid Ethnopharmacol. 2014;2014(4). 26. Fachini-Queiroz FC, Kummer R, Fernanda Estevão-Silva C, et al. Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Artic ID. 2012;2012. doi:10.1155/2012/657026 27. Taşdemir B. Ratlarda İndometazinle Oluşturulan gastrik Ülser Üzerine Silimarinin Koruyucu Etkilerinin Araştırılması. 2016. http://adudspace.adu.edu.tr:8080/xmlui/bitstream/handle/11607/2904/BARIŞ TAŞDEMİR.pdf?sequence=1&isAllowed=y. Accessed March 31, 2020. 28. Bayram D. Silibinin İn Vitro Ortamda CCL-228-SW 480 Kolon Kanseri Hücre Hattı Üzerine Apoptotik Etkisinin Araştırılması. SDÜ Sağlık Bilim Derg. 2017;8(2):1-1. doi:10.22312/sdusbed.287465 29. Fraschini F, Demartini G, Esposti D. Pharmacology of silymarin. Clin Drug Investig. 2002;22(1):51-65. doi:10.2165/00044011-200222010-00007 30. Oktay M. Kabalcı Şifalı Bitkiler Ansiklopedisi. Vol 4. 2nd ed. İstanbul: Kabalcı Yayınevi; 2016. https://www.kabalci.com.tr/alternatif-tip-sifali-bitkiler/kabalci-sifali-bitkiler-ansiklopedisi/oktay-mete/kabalci-yayinevi. 31. Joshi BC, Mukhija M, Kalia AN. Pharmacognostical review of Urtica dioica L. Int J Green Pharm. 2019;8(4):23-30. 32. Malayoğlu HB. Biberiyenin (Rosmarinus officinalis L.) Antioksidan Etkisi. Hayvansal Üretim. 2010;51(2). 33. Jhala AJ, Hall LM. Flax (Linum usitatissimum L.): Current Uses and Future Applications. Aust J basic Appl Sci. 2010;4(9):4304-4312.
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Details

Primary Language English
Subjects Traditional, Complementary and Integrative Medicine
Journal Section Research Articles
Authors

Mustafa Yaşar This is me 0000-0002-3746-5042

Oğuzhan Şenoğul This is me 0000-0003-0296-5634

Ali Gök 0000-0003-4103-9537

Kağan Ağan 0000-0003-1472-570X

Aydan Fülden Ağan 0000-0002-4319-6264

Ersin Beyazçiçek 0000-0002-6817-4512

Sinem Kantarcıoğlu Coşkun 0000-0002-8133-8665

Publication Date April 30, 2020
Submission Date April 16, 2020
Published in Issue Year 2020 Volume: 1 Issue: 1

Cite

APA Yaşar, M., Şenoğul, O., Gök, A., Ağan, K., et al. (2020). Systemic Investigation of Acute Toxicity of Some Food Supplements on The Market in Turkey. International Journal of Traditional and Complementary Medicine Research, 1(1), 1-11.

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