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Effect of perinatal factors on platelet indices in late preterm and term newborns

Year 2021, Volume: 11 Issue: 5, 661 - 665, 17.09.2021
https://doi.org/10.16899/jcm.895718

Abstract

Abstract
Aim: This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions.
Materials and Methods: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life.
Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex and maternal hypertension were significantly related to lower PLT (p<0.001, p=0.001 and p=0.017, respectively). In addition, SGA and male sex were related to lower PCT (p=0.001). In all studied patients, MPV was significantly different between infants with and without prolonged rupture of membrane (PROM) (9.8fL vs. 9.2fL, p=0.001).
Conclusion: The obtained results show that various perinatal features influence the platelet indices in late preterm and term newborns.

References

  • 1. Golebiewska EM, Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev 2015; 29: 153-62.
  • 2. Coban E, Adanir H, Bilgin D. The association of mean platelet volume levels with hypertensive retinopathy. Platelets. 2008; 19(2):115–8
  • 3. Martin JF, Kristensen SD, Mathur A, Grove EL, Choudry FA. The causal role of megakaryocyte-platelet hyperactivity in acute coronary syndromes. Nat Rev Cardiol. 2012; 9(11):658–70.
  • 4. Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol 2009;29: 130–6.
  • 5. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Neonatal Ed. 2003; 88: F359–364
  • 6. Aydemir C, Aydemir H, Kokturk F, Kulah C, Mungan AG. The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis. BMC Pediatr. 2018; 18(1):253
  • 7. Mitsiakos G, Papathanasiou AE, Kyriakidis I, Karagianni P, Tsepis K, Tzimou I, et al. Intraventricular Hemorrhage and Platelet indices in Extremely Premature Neonates. J Pediatr Hematol Oncol. 2016; 38 (7):533–538
  • 8. Go H, Ohto H, Kenneth N, Takano S, Kashiwabara N, Chisiki M, et al. Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study. Front Pediatr.2020; 8:90
  • 9. Loftin RW, Habli M, Snyder CC, et al. Late preterm birth. Rev Obstet Gynecol 2010; 3 :10–19.
  • 10. Meloni A, Antonelli A, Deiana S, et al. Late preterm: obstetric management. J Matern Fetal Neonatal Med 2010;23:113–15.
  • 11. Alicja W, Agnieszka P, Piotr L, Slawomir R, Barbara KW, Milena D, et al. Platelet indices in late preterm newborns. J Matern Fetal Neonatal Med. 2017; 30(14):1699–1703
  • 12. Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ. Maternal preeclampsia and neonatal outcomes. J Pregnancy 2011; 214365
  • 13. Thalor N, Singh K, Pujani M, Chauhan V, Agarwal C, Ahuja R. A correlation between platelet indices and preeclampsia. Hematol Transfus Cell Ther. 2019; 41(2)129–133.
  • 14. Ekin A, Gezer C, Kulhan G, Avci ME, Taner CE. Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes? J Obstet Gynaecol Res. 2015; 41(1):23–28
  • 15. Wasiluk A, Osada J, Dabrowska M, Szczepański M, Jasinska E. Does prematurity affect platelet indices? Adv Med Sci. 2009; 54(2):253–5.
  • 16. Rolim ACB, Lambert MA, Borges JPG, Abbas SA, Bordin, JO, Junior DAL et al. Blood Cells Profile In Umbilical Cord Of Late Preterm And Term Newborns. Revista Paulista de Pediatria, 2019; 37(3), 264-274
  • 17. Christensen RD, Baer VL, Henry E, Snow GL, Butler A, Sola-Visner MC. Thrombocytopenia in Small for- Gestational-Age Infants. Pediatrics. 2015; 135(2):e361–70.
  • 18. Fustolo-Gunnink SF, Vlug RD, Smits-Wintjens VE, Heckman EJ, Te Pas AB, Fijnvandaraat K, et al. Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A retrospective Cohort Study. PLoS One. 2016; 11(5):e0154853.
  • 19. Lee E, Lim Z, Malhotra A. Thrombocytopenia in well small for gestational age neonates. Blood Coagul Fibrinolysis. 2019. 30(3):104–110.
  • 20. Wasiluk A, Mantur M, Kemona H, Szczepański M, Jasińska E, Milewski R. Thrombopoiesis in small for gestational age newborns. Platelets. 2009; 20(7):520–524
  • 21. Liu Z-J, Sola-Visner M. Neonatal and adult megakaryopoiesis. Curr Opin Hematol 2011;18:330–7.
  • 22. Hiett AK, Britton KA, Hague NL, Brown HL, Stehman FB, Broxmeyer HE. Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age Transfusion. 1995; 35 (7) pp. 587-591
  • 23. Brazy J. E., Grimm J. K., and Little V. A. Neonatal manifestations of severe maternal hypertension occurring before the thirty-sixth week of pregnancy. J Pediatr. 1982; 100(2):265–271
  • 24. Weiner C. P. and Williamson R. A. Evaluation of severe growth retardation using cordocentesis—hematologic and metabolic alterations by etiology. Obstet Gynecol.1989; 73(2): 225–229
  • 25. Chen CY, Essien MD, Johnson AJ, Lee GT, Chou FS. Use of mean platelet volume in the assessment of intrauterine infection in newborns with thrombocytopenia and leukopenia at birth. J Matern Fetal Neonatal Med. 2019; 1–7
  • 26. Cekmez F, Tanju IA, Canpolat FE, et al. Mean platelet volume in very preterm infants: a predictor of morbidities? Eur Rev Med Pharmacol Sci 2013;17:134–7
  • 27. Patrick CH, Lazarick J. The effect of bacteremia on automated platelet measurements in neonates. Am J Clin Pathol 1990; 93: 391–4.
  • 28. Wasiluk A. Thrombocytopoiesis in healthy term newborns. J Perinat Med. 2005;33(3):252-4.
  • 29. Saxonhouse MA, Rimsza LM, Stevens G, Jouei N, Christensen RD, Sola MC. Effects of hypoxia on megakaryocyte progenitors obtained from the umbilical cord blood of term and preterm neonates. Biol Neonate. 2006;89(2):104–108pmid:16192692
  • 30. Nadkarni J, Patne SK, Kispotta R. Hypoxia as a predisposing factor for the development of early onset neonatal thrombocytopenia. J Clin Neonatol. 2012; 1(3):131–134.
  • 31. Beiner ME, Simchen MJ, Sivan E, Chetrit A, Kuint J, Schiff E. Risk factors for neonatal thrombocytopenia in preterm infants. Am J Perinatol. 2003; 20(1):49–54.
  • 32. Castle V, Coates G, Mitchell LG, O’Brodovich H, Andrew M. The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbits. Thromb Haemost. 1988; 59(1):45–48.

Geç preterm ve term yenidoğanlarda perinatal faktörlerin trombosit indeksleri üzerindeki etkileri

Year 2021, Volume: 11 Issue: 5, 661 - 665, 17.09.2021
https://doi.org/10.16899/jcm.895718

Abstract

Amaç: Bu çalışmanın amacı geç preterm yenidoğanlar ve term yenidoğanlarda trombosit indekslerini karşılaştırmak ve perinatal faktörlerle ilişkisini incelemektir.
Gereç ve Yöntemler: 2018-2020 yılları arasında akademik bir merkezin Yenidoğan Yoğun Bakım Ünitesine kabul edilen 98 geç preterm ve 102 term yenidoğan retrospektif olarak değerlendirildi. Yaşamın ilk gününde alınan kan örneklerinde trombosit sayısı (PLT), ortalama trombosit hacmi (MPV), plateletkrit (PCT) ve trombosit dağılım genişliği (PDW) dahil olmak üzere trombosit indeksleri ölçüldü.
Bulgular: Geç prematüre ve term yenidoğanlar arasında PLT, MPV, PCT ve PDW değerleri açısından anlamlı fark yoktu. Geç prematüre yenidoğanlarda, çok değişkenli analiz, maternal hipertansiyonun düşük PLT ile anlamlı şekilde ilişkili olduğunu gösterdi (p=0.001). Term yenidoğanlarda, çok değişkenli analiz, gebelik yaşına küçük (SGA) olmak, erkek cinsiyet ve maternal hipertansiyonun düşük PLT ile anlamlı şekilde ilişkili olduğunu gösterdi (sırasıyla p<0.001, p=0.001 ve p=0.017). Ayrıca, SGA ve erkek cinsiyet daha düşük PCT ile ilişkiliydi (p = 0.001). Çalışılan tüm hastalarda, MPV, uzamış membran rüptürü (PROM) olan ve olmayan bebekler arasında önemli ölçüde farklıydı (9.8fL ve 9.2fL, p = 0.001).
Tartışma ve Sonuç: Elde edilen sonuçlar, çeşitli perinatal özelliklerin geç preterm ve term yenidoğanların trombosit indekslerini etkilediğini göstermektedir.

References

  • 1. Golebiewska EM, Poole AW. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev 2015; 29: 153-62.
  • 2. Coban E, Adanir H, Bilgin D. The association of mean platelet volume levels with hypertensive retinopathy. Platelets. 2008; 19(2):115–8
  • 3. Martin JF, Kristensen SD, Mathur A, Grove EL, Choudry FA. The causal role of megakaryocyte-platelet hyperactivity in acute coronary syndromes. Nat Rev Cardiol. 2012; 9(11):658–70.
  • 4. Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol 2009;29: 130–6.
  • 5. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Neonatal Ed. 2003; 88: F359–364
  • 6. Aydemir C, Aydemir H, Kokturk F, Kulah C, Mungan AG. The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis. BMC Pediatr. 2018; 18(1):253
  • 7. Mitsiakos G, Papathanasiou AE, Kyriakidis I, Karagianni P, Tsepis K, Tzimou I, et al. Intraventricular Hemorrhage and Platelet indices in Extremely Premature Neonates. J Pediatr Hematol Oncol. 2016; 38 (7):533–538
  • 8. Go H, Ohto H, Kenneth N, Takano S, Kashiwabara N, Chisiki M, et al. Using Platelet Parameters to Anticipate Morbidity and Mortality Among Preterm Neonates: A Retrospective Study. Front Pediatr.2020; 8:90
  • 9. Loftin RW, Habli M, Snyder CC, et al. Late preterm birth. Rev Obstet Gynecol 2010; 3 :10–19.
  • 10. Meloni A, Antonelli A, Deiana S, et al. Late preterm: obstetric management. J Matern Fetal Neonatal Med 2010;23:113–15.
  • 11. Alicja W, Agnieszka P, Piotr L, Slawomir R, Barbara KW, Milena D, et al. Platelet indices in late preterm newborns. J Matern Fetal Neonatal Med. 2017; 30(14):1699–1703
  • 12. Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ. Maternal preeclampsia and neonatal outcomes. J Pregnancy 2011; 214365
  • 13. Thalor N, Singh K, Pujani M, Chauhan V, Agarwal C, Ahuja R. A correlation between platelet indices and preeclampsia. Hematol Transfus Cell Ther. 2019; 41(2)129–133.
  • 14. Ekin A, Gezer C, Kulhan G, Avci ME, Taner CE. Can platelet count and mean platelet volume during the first trimester of pregnancy predict preterm premature rupture of membranes? J Obstet Gynaecol Res. 2015; 41(1):23–28
  • 15. Wasiluk A, Osada J, Dabrowska M, Szczepański M, Jasinska E. Does prematurity affect platelet indices? Adv Med Sci. 2009; 54(2):253–5.
  • 16. Rolim ACB, Lambert MA, Borges JPG, Abbas SA, Bordin, JO, Junior DAL et al. Blood Cells Profile In Umbilical Cord Of Late Preterm And Term Newborns. Revista Paulista de Pediatria, 2019; 37(3), 264-274
  • 17. Christensen RD, Baer VL, Henry E, Snow GL, Butler A, Sola-Visner MC. Thrombocytopenia in Small for- Gestational-Age Infants. Pediatrics. 2015; 135(2):e361–70.
  • 18. Fustolo-Gunnink SF, Vlug RD, Smits-Wintjens VE, Heckman EJ, Te Pas AB, Fijnvandaraat K, et al. Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A retrospective Cohort Study. PLoS One. 2016; 11(5):e0154853.
  • 19. Lee E, Lim Z, Malhotra A. Thrombocytopenia in well small for gestational age neonates. Blood Coagul Fibrinolysis. 2019. 30(3):104–110.
  • 20. Wasiluk A, Mantur M, Kemona H, Szczepański M, Jasińska E, Milewski R. Thrombopoiesis in small for gestational age newborns. Platelets. 2009; 20(7):520–524
  • 21. Liu Z-J, Sola-Visner M. Neonatal and adult megakaryopoiesis. Curr Opin Hematol 2011;18:330–7.
  • 22. Hiett AK, Britton KA, Hague NL, Brown HL, Stehman FB, Broxmeyer HE. Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age Transfusion. 1995; 35 (7) pp. 587-591
  • 23. Brazy J. E., Grimm J. K., and Little V. A. Neonatal manifestations of severe maternal hypertension occurring before the thirty-sixth week of pregnancy. J Pediatr. 1982; 100(2):265–271
  • 24. Weiner C. P. and Williamson R. A. Evaluation of severe growth retardation using cordocentesis—hematologic and metabolic alterations by etiology. Obstet Gynecol.1989; 73(2): 225–229
  • 25. Chen CY, Essien MD, Johnson AJ, Lee GT, Chou FS. Use of mean platelet volume in the assessment of intrauterine infection in newborns with thrombocytopenia and leukopenia at birth. J Matern Fetal Neonatal Med. 2019; 1–7
  • 26. Cekmez F, Tanju IA, Canpolat FE, et al. Mean platelet volume in very preterm infants: a predictor of morbidities? Eur Rev Med Pharmacol Sci 2013;17:134–7
  • 27. Patrick CH, Lazarick J. The effect of bacteremia on automated platelet measurements in neonates. Am J Clin Pathol 1990; 93: 391–4.
  • 28. Wasiluk A. Thrombocytopoiesis in healthy term newborns. J Perinat Med. 2005;33(3):252-4.
  • 29. Saxonhouse MA, Rimsza LM, Stevens G, Jouei N, Christensen RD, Sola MC. Effects of hypoxia on megakaryocyte progenitors obtained from the umbilical cord blood of term and preterm neonates. Biol Neonate. 2006;89(2):104–108pmid:16192692
  • 30. Nadkarni J, Patne SK, Kispotta R. Hypoxia as a predisposing factor for the development of early onset neonatal thrombocytopenia. J Clin Neonatol. 2012; 1(3):131–134.
  • 31. Beiner ME, Simchen MJ, Sivan E, Chetrit A, Kuint J, Schiff E. Risk factors for neonatal thrombocytopenia in preterm infants. Am J Perinatol. 2003; 20(1):49–54.
  • 32. Castle V, Coates G, Mitchell LG, O’Brodovich H, Andrew M. The effect of hypoxia on platelet survival and site of sequestration in the newborn rabbits. Thromb Haemost. 1988; 59(1):45–48.
There are 32 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Nuran Üstün 0000-0003-1680-1825

Publication Date September 17, 2021
Acceptance Date May 26, 2021
Published in Issue Year 2021 Volume: 11 Issue: 5

Cite

AMA Üstün N. Effect of perinatal factors on platelet indices in late preterm and term newborns. J Contemp Med. September 2021;11(5):661-665. doi:10.16899/jcm.895718