Abstract
ABSTRACT
Objective: We aimed to show the clinical characteristics of children with influenza infection and the relationship between influenza infections and hemogram parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), and mean platelet volume (MPV).
Methods: The data of patients who applied to Necmettin Erbakan University Meram Medical Faculty Pediatrics outpatient clinics and had positive rapid influenza test were scanned through the hospital information system.
Results: The median age and neutrophil value in the influenza A group were significantly lower than in the influenza B group (p=.002, p=.008). The median MPV and monocyte value in the influenza A group were significantly higher than in influenza B (p<.00, p=.005). The mean WBC count was found to be significantly higher in hospitalized patients compared to outpatients. (p = .039). There were no significant difference between the groups in terms of NLR, PLR, NMR. Bacteremia was detected significantly more in hospitalized patients compared to outpatients. Underlying chronic diseases were significantly lower in outpatients than in inpatients.(p<.001)
Conclusion: There were no difference in the severity of clinical severity between infleunza A and B subgroups and no significant difference was found in terms of hemogram parameters.
Keywords
Influenza A Influenza B hemogram parameters Neutrophil/lymphocyte ratio hospitalization children
References
- REFERENCES 1. Zhu R, Chen C, Wang Q et al. Routine blood parameters are helpful for early identification of influenza infection in children. BMC Infect. Dis. 2020;20(1):864.
- 2. Principi N, Esposito S. Severe influenza in children: incidence and risk factors. Expert Rev. Anti. Infect. Ther. 2016;14(10):961–968.
- 3. Kondrich J, Rosenthal M. Influenza in children. Curr. Opin. Pediatr. 2017;29(3):297–302.
- 4. Paksu MS, Aslan K, Kendirli T et al. Neuroinfluenza: evaluation of seasonal influenza associated severe neurological complications in children (a multicenter study). Child’s Nerv. Syst. ChNS Off. J. Int. Soc. Pediatr. Neurosurg. 2018;34(2):335–347.
- 5. Uyeki TM, Bernstein HH, Bradley JS et al. Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa. Clin. Infect. Dis. an Off. Publ. Infect. Dis. Soc. Am. 2019;68(6):895–902.
- 6. Yorulmaz A, Ağır MA, Arslan Ş. Benign Acute Childhood Myositis Associated with Influenza A (H1N1) Virus Infection: Evaluation of 22 Cases. J. Pediatr. Infect. Dis. 2019;14(03):127–132.
- 7. Fei Y, Zhang H, Zhang C. The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children. J. Clin. Lab. Anal. 2019;33(9):e22995.
- 8. Esposito S, Molteni CG, Daleno C et al. Clinical and socioeconomic impact of different types and subtypes of seasonal influenza viruses in children during influenza seasons 2007/2008 and 2008/2009. BMC Infect. Dis. 2011;11:271.
- 9. Li-Kim-Moy J, Yin JK, Blyth CC et al. Influenza hospitalizations in Australian children. Epidemiol. Infect. 2017;145(7):1451–1460.
- 10. Chu SG, Becker RC, Berger PB et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J. Thromb. Haemost. 2010;8(1):148–156.
- 11. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019;2019:9213074.
- 12. Uzun N, Akıncı MA. Hemogram parameters in childhood anxiety disorders: Could anxiety disorders be related with inflammation? Med. Hypotheses 2021;146:110440.
- 13. Akinci MA, Uzun N. Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder. Bratisl. Lek. Listy 2021;122(4):256–262.
- 14. Varman, Alkan, Alper S. Evaluation of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume, and neutrophil/monocyte ratio in patients with benign breast lesions. Bratisl. Lek. Listy 2021;122(7):489–492.
- 15. Jain VK, Rivera L, Zaman K et al. Vaccine for prevention of mild and moderate-to-severe influenza in children. N. Engl. J. Med. 2013;369(26):2481–2491.
- 16. Paules C, Subbarao K. Influenza. Lancet (London, England) 2017;390(10095):697–708.
- 17. Wada T, Morishima T, Okumura A et al. Differences in clinical manifestations of influenza-associated encephalopathy by age. Microbiol. Immunol. 2009;53(2):83–88.
- 18. Teutsch SM, Zurynski YA, Nunez C et al. Ten Years of National Seasonal Surveillance for Severe Complications of Influenza in Australian Children. Pediatr. Infect. Dis. J. 2021;40(3):191–198.
- 19. Han SB, Rhim J-W, Kang JH, Lee K-Y. Clinical features and outcomes of influenza by virus type/subtype/lineage in pediatric patients. Transl. Pediatr. 2021;10(1):54–63.
- 20. Livingston RA, Bernstein HH. Prevention of Influenza in Children. Infect. Dis. Clin. North Am. 2015;29(4):597–615.
- 21. Choe YJ, Park S, Michelow IC. Co-seasonality and co-detection of respiratory viruses and bacteraemia in children: a retrospective analysis. Clin. Microbiol. Infect. Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis. 2020;26(12):1690.e5-1690.e8.
- 22. Tavares LP, Garcia CC, Machado MG et al. CXCR1/2 Antagonism Is Protective during Influenza and Post-Influenza Pneumococcal Infection. Front. Immunol. 2017;8:1799.
Abstract
ÖZ
Amaç: Bu çalışmada influenza enfeksiyonu olan çocukların klinik özelliklerini ve nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR), nötrofil/monosit (NMR), ortalama trombosit hacmi (MPV) gibi laboratuvar bulgularını göstermeyi amaçladık.
Yöntemler: Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı polikliniklerine başvuran ve hızlı influenza testi pozitif çıkan hastaların verileri hastane bilgi sistemi üzerinden tarandı.
Bulgular: İnfluenza A grubunda ortanca yaş ve nötrofil değeri influenza B grubuna göre anlamlı derecede düşüktü (p=.002, p=.008). İnfluenza A grubunda ortanca MPV ve monosit değeri influenza B'ye göre anlamlı derecede yüksekti (p<.00, p=.005). Hastanede yatan hastalarda ortalama WBC sayısı ayaktan hastalara göre anlamlı derecede yüksek bulundu. (p = .039). NLR, PLR, NMR açısından gruplar arasında anlamlı fark yoktu. Hastanede yatan hastalarda ayaktan hastalara göre anlamlı derecede daha fazla bakteriyemi saptandı. Altta yatan kronik hastalıklar ayaktan hastalarda yatan hastalara göre anlamlı derecede düşüktü.(p<.001)
Sonuç: İnfluenza A ve B alt grupları arasında klinik şiddet şiddeti açısından fark bulunmadı ve
hemogram parametreleri açısından anlamlı fark bulunmadı.
Keywords
: İnfluenza A İnfluenza B kan sayımı parametreleri Nötrofil/lenfosit oranı hastaneye yatış çocuklar
References
- REFERENCES 1. Zhu R, Chen C, Wang Q et al. Routine blood parameters are helpful for early identification of influenza infection in children. BMC Infect. Dis. 2020;20(1):864.
- 2. Principi N, Esposito S. Severe influenza in children: incidence and risk factors. Expert Rev. Anti. Infect. Ther. 2016;14(10):961–968.
- 3. Kondrich J, Rosenthal M. Influenza in children. Curr. Opin. Pediatr. 2017;29(3):297–302.
- 4. Paksu MS, Aslan K, Kendirli T et al. Neuroinfluenza: evaluation of seasonal influenza associated severe neurological complications in children (a multicenter study). Child’s Nerv. Syst. ChNS Off. J. Int. Soc. Pediatr. Neurosurg. 2018;34(2):335–347.
- 5. Uyeki TM, Bernstein HH, Bradley JS et al. Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa. Clin. Infect. Dis. an Off. Publ. Infect. Dis. Soc. Am. 2019;68(6):895–902.
- 6. Yorulmaz A, Ağır MA, Arslan Ş. Benign Acute Childhood Myositis Associated with Influenza A (H1N1) Virus Infection: Evaluation of 22 Cases. J. Pediatr. Infect. Dis. 2019;14(03):127–132.
- 7. Fei Y, Zhang H, Zhang C. The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children. J. Clin. Lab. Anal. 2019;33(9):e22995.
- 8. Esposito S, Molteni CG, Daleno C et al. Clinical and socioeconomic impact of different types and subtypes of seasonal influenza viruses in children during influenza seasons 2007/2008 and 2008/2009. BMC Infect. Dis. 2011;11:271.
- 9. Li-Kim-Moy J, Yin JK, Blyth CC et al. Influenza hospitalizations in Australian children. Epidemiol. Infect. 2017;145(7):1451–1460.
- 10. Chu SG, Becker RC, Berger PB et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J. Thromb. Haemost. 2010;8(1):148–156.
- 11. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019;2019:9213074.
- 12. Uzun N, Akıncı MA. Hemogram parameters in childhood anxiety disorders: Could anxiety disorders be related with inflammation? Med. Hypotheses 2021;146:110440.
- 13. Akinci MA, Uzun N. Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder. Bratisl. Lek. Listy 2021;122(4):256–262.
- 14. Varman, Alkan, Alper S. Evaluation of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume, and neutrophil/monocyte ratio in patients with benign breast lesions. Bratisl. Lek. Listy 2021;122(7):489–492.
- 15. Jain VK, Rivera L, Zaman K et al. Vaccine for prevention of mild and moderate-to-severe influenza in children. N. Engl. J. Med. 2013;369(26):2481–2491.
- 16. Paules C, Subbarao K. Influenza. Lancet (London, England) 2017;390(10095):697–708.
- 17. Wada T, Morishima T, Okumura A et al. Differences in clinical manifestations of influenza-associated encephalopathy by age. Microbiol. Immunol. 2009;53(2):83–88.
- 18. Teutsch SM, Zurynski YA, Nunez C et al. Ten Years of National Seasonal Surveillance for Severe Complications of Influenza in Australian Children. Pediatr. Infect. Dis. J. 2021;40(3):191–198.
- 19. Han SB, Rhim J-W, Kang JH, Lee K-Y. Clinical features and outcomes of influenza by virus type/subtype/lineage in pediatric patients. Transl. Pediatr. 2021;10(1):54–63.
- 20. Livingston RA, Bernstein HH. Prevention of Influenza in Children. Infect. Dis. Clin. North Am. 2015;29(4):597–615.
- 21. Choe YJ, Park S, Michelow IC. Co-seasonality and co-detection of respiratory viruses and bacteraemia in children: a retrospective analysis. Clin. Microbiol. Infect. Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis. 2020;26(12):1690.e5-1690.e8.
- 22. Tavares LP, Garcia CC, Machado MG et al. CXCR1/2 Antagonism Is Protective during Influenza and Post-Influenza Pneumococcal Infection. Front. Immunol. 2017;8:1799.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research |
| Authors | |
| Publication Date | January 15, 2022 |
| Acceptance Date | November 10, 2021 |
| Published in Issue | Year 2022 Volume: 12 Issue: 1 |
