Research Article
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Year 2023, Volume: 15 Issue: 2, 1147 - 1156, 29.09.2023
https://doi.org/10.37212/jcnos.1365512

Abstract

References

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Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model

Year 2023, Volume: 15 Issue: 2, 1147 - 1156, 29.09.2023
https://doi.org/10.37212/jcnos.1365512

Abstract

Migraine is a complex neurological problem whose primary symptom is headache and is common in the human population. It is well known that neuroinflammation plays a vital role in the pathogenesis of migraine, with adverse effects on the nervous system, including headache disorders such as migraine. The infusion of the nitric oxide donor glyceryl trinitrate (GTN) is often used in experimental models of migraine because it is the best-known model of migraine provocation. N-(p-amyl cinnamoyl) anthranilic acid (ACA) has been shown to inhibit both TRPM2 and phospholipase A2 (PLA2). Recent research has explored potential interventions to mitigate GTN-induced neurotoxicity. One such candidate is ACA, a compound with anti-inflammatory and antioxidant properties.
Thirty-six C57BL/6j black mice were divided into the control groups of ACA, GTN, and ACA+GTN. Mice in the ACA were treated intraperitoneally with ACA (25 mg/kg) for three days. Mice in the GTN were treated intraperitoneally with a single dose of GTN (10 mg/kg) for migraine induction. After the experimental stages were completed, the mice in all groups were sacrificed, and brain tissue and erythrocyte samples were taken from the mice.
The levels of inflammatory cytokines (TNF α, IL 1β, and IL 6), apoptosis, intracellular ROS, lipid peroxidation, caspase 3-9, and mitochondrial membrane potential increased in the GTN group. However, their levels were decreased in the ACA+GTN group by the injection of ACA. The treatment of ACA regulated the GTN treatment-induced decreases of glutathione levels, glutathione peroxidase activation, and cell viability in the brain and erythrocytes.
In conclusion, GTN plays a role in neurotoxicity caused by increased apoptosis and ROS. We observed that ACA modulated the brain and erythrocyte oxidant, antioxidant parameters, and apoptotic processes. The neuro-protective role of ACA treatment may be explained by its modulating activity against increased apoptosis and oxidative stress.

References

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  • Hou M, Tang Q, Xue Q, Zhang X, Liu Y, Yang S, Chen L, Xu X. (2017). Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine. J Ethnopharmacol. 4;195:231-237. https://doi.org/10.1016/j.jep
  • Ishii M, Iizuka R, Kiuchi Y, Mori Y, Shimizu S. (2011). Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. Mol Cell Biochem 358(1 2):1–11. https://doi.org/10.1007/s11010-011-0913-3
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  • Joshi DC, Bakowska JC. (2011). Determination of mitochondrial membrane potential and reactive oxygen species in live rat cortical neurons. J Vis Exp 23(51):2704. https://doi.org/10.3791/2704
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  • Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL. (2010). Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J 24(7):2533–2545. https://doi.org/10.1096/f.09-149997
  • Li X, Jiang LH. (2019). A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species-induced delayed cell death. J Cell Physiol 234(4):3647–3660. https://doi.org/10.1002/jcp.27134
  • Maniskas ME, Roberts JM, Trueman R, Learoyd AE, Gorman A, Fraser JF, Bix GJ. (2018). Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. J Neurointerv Surg. 10(1):29–33. https://doi.org/10.1136/neurintsurg-2016-012793
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There are 48 citations in total.

Details

Primary Language English
Subjects Neurosciences (Other)
Journal Section Original Articles
Authors

Betül Yazğan 0000-0002-4029-2007

Yener Yazğan 0000-0002-5613-6906

Publication Date September 29, 2023
Published in Issue Year 2023 Volume: 15 Issue: 2

Cite

APA Yazğan, B., & Yazğan, Y. (2023). Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model. Journal of Cellular Neuroscience and Oxidative Stress, 15(2), 1147-1156. https://doi.org/10.37212/jcnos.1365512
AMA Yazğan B, Yazğan Y. Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model. J Cell Neurosci Oxid Stress. September 2023;15(2):1147-1156. doi:10.37212/jcnos.1365512
Chicago Yazğan, Betül, and Yener Yazğan. “Regulatory Role of Phospholipase A2 Inhibitor in Oxidative Stress and Inflammation Induced by an Experimental Mouse Migraine Model”. Journal of Cellular Neuroscience and Oxidative Stress 15, no. 2 (September 2023): 1147-56. https://doi.org/10.37212/jcnos.1365512.
EndNote Yazğan B, Yazğan Y (September 1, 2023) Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model. Journal of Cellular Neuroscience and Oxidative Stress 15 2 1147–1156.
IEEE B. Yazğan and Y. Yazğan, “Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model”, J Cell Neurosci Oxid Stress, vol. 15, no. 2, pp. 1147–1156, 2023, doi: 10.37212/jcnos.1365512.
ISNAD Yazğan, Betül - Yazğan, Yener. “Regulatory Role of Phospholipase A2 Inhibitor in Oxidative Stress and Inflammation Induced by an Experimental Mouse Migraine Model”. Journal of Cellular Neuroscience and Oxidative Stress 15/2 (September 2023), 1147-1156. https://doi.org/10.37212/jcnos.1365512.
JAMA Yazğan B, Yazğan Y. Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model. J Cell Neurosci Oxid Stress. 2023;15:1147–1156.
MLA Yazğan, Betül and Yener Yazğan. “Regulatory Role of Phospholipase A2 Inhibitor in Oxidative Stress and Inflammation Induced by an Experimental Mouse Migraine Model”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 15, no. 2, 2023, pp. 1147-56, doi:10.37212/jcnos.1365512.
Vancouver Yazğan B, Yazğan Y. Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model. J Cell Neurosci Oxid Stress. 2023;15(2):1147-56.