Case Report
BibTex RIS Cite
Year 2021, Volume: 12 Issue: 4, 124 - 126, 14.12.2021
https://doi.org/10.33706/jemcr.972191

Abstract

References

  • 1. Zárybnický T, Boušová I, Ambrož M, Skálová L. Hepatotoxicity of monoterpenes and sesquiterpenes. Arch Toxicol 2018; 92(1): 1–13. doi: 10.1007/s00204-017-2062-2. PMID: 28905185.
  • 2. Abou Seif HS. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-Suef Univ J Basic Appl Sci 2016; 5(2): 134–46. doi: 10.1016/j.bjbas.2016.03.004.
  • 3. Chbili C, Maher M, Sawssen M, Mejda S, Hajer B, Hedi K, et al. Evaluation of Impact of Daily Laurus Nobilis Tea Consumption on the Lipid Profile and on the Increased Anti-Oxidant Activity In Healthy Volunteers. Doctoral dissertation, Assiut University. 2020. doi: 10.21203/rs.3.rs-28846/v1.
  • 4. Akcan T, Estévez M, Serdaroğlu M. Antioxidant protection of cooked meatballs during frozen storage by whey protein edible films with phytochemicals from Laurus nobilis L. and Salvia officinalis. LWT 2017; 77: 323–31. doi: 10.1016/j.lwt.2016.11.051.
  • 5. Stournaras E, Tziomalos K. Herbal medicine-related hepatotoxicity. World J Hepatol 2015; 7(19): 2189–93. doi: 10.4254/wjh.v7.i19.2189. PMID: 26380043; PMCID: PMC4561772.
  • 6. Pantano F, Tittarelli R, Mannocchi G, Zaami S, Ricci S, Giorgetti R, et al. Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat. Int J Mol Sci 2016; 17(4): 580. doi: 10.3390/ijms17040580. PMID: 27092496; PMCID: PMC4849036.
  • 7. Amadi CN, Orisakwe OE. Herb-Induced Liver Injuries in Developing Nations: An Update. Toxics 2018; 6(2): 24. doi: 10.3390/toxics6020024. PMID: 29673137; PMCID: PMC6027193.
  • 8. Pantano F, Mannocchi G, Marinelli E, Gentili S, Graziano S, Busardò FP, et al. Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature. Eur Rev Med Pharmacol Sci 2017; 21(1 Suppl): 46–52. PMID: 28379595.
  • 9. Chalasani NP, Hayashi PH, Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ; Practice Parameters Committee of the American College of Gastroenterology. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol 2014; 109(7): 950–66; quiz 967. doi: 10.1038/ajg.2014.131. PMID: 24935270.
  • 10. Zheng EX, Navarro VJ. Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review. J Clin Transl Hepatol 2015; 3(2): 93–8. doi: 10.14218/JCTH.2015.00006. PMID: 26357638; PMCID: PMC4548352.
  • 11. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006; 354(7): 731–9. doi: 10.1056/NEJMra052270. PMID: 16481640.
  • 12. Dey P, Saha MR, Sen A. Hepatotoxicity and the present herbal hepatoprotective scenario. International Journal of Green Pharmacy (IJGP) 2013; 7(4): 265–73. doi: 10.4103/0973-8258.122046.
  • 13. Ozcan B, Esen M, Sangun MK, Coleri A, Caliskan M. Effective antibacterial and antioxidant properties of methanolic extract of Laurus nobilis seed oil. J Environ Biol 2010; 31(5): 637–41. PMID: 21387914.
  • 14. Taban A, Saharkhiz MJ, Niakousari M. Sweet bay (Laurus nobilis L.) essential oil and its chemical composition, antioxidant activity and leaf micromorphology under different extraction methods. Sustainable Chemistry and Pharmacy 2018; 9: 12–8. doi: 10.1016/j.scp.2018.05.001.
  • 15. da Silveira SM, Luciano FB, Fronza N, Cunha Jr A, Scheuermann GN, Vieira CRW. Chemical composition and antibacterial activity of Laurus nobilis essential oil towards foodborne pathogens and its application in fresh Tuscan sausage stored at 7 C. LWT-Food Science and Technology 2014; 59(1): 86–93. doi: 10.1016/j.lwt.2014.05.032.
  • 16. Ramos C, Teixeira B, Batista I, Matos O, Serrano C, Neng NR, et al. Antioxidant and antibacterial activity of essential oil and extracts of bay laurel Laurus nobilis Linnaeus (Lauraceae) from Portugal. Nat Prod Res 2012; 26(6): 518–29. doi: 10.1080/14786419.2010.531478. PMID: 21756182.
  • 17. Hafizoǧlu H, Reunanen M. Studies on the components of Lauras nobilis from Turkey with special reference to Laurel berry fat. Eur J Lipid Sci Technol 1993; 95(8): 304–8. doi: 10.1002/lipi.19930950806.
  • 18. Stickel F, Patsenker E, Schuppan D. Herbal hepatotoxicity. J Hepatol 2005; 43(5): 901–10. doi: 10.1016/j.jhep.2005.08.002. PMID: 16171893.
  • 19. Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis 2007; 39(4): 293–304. doi: 10.1016/j.dld.2006.11.004. PMID: 17331820.
  • 20. Favreau JT, Ryu ML, Braunstein G, Orshansky G, Park SS, Coody GL, et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med 2002; 136(8): 590–5. doi: 10.7326/0003-4819-136-8-200204160-00008. PMID: 11955027.
  • 21. De Smet PA. Herbal remedies. N Engl J Med 2002; 347(25): 2046–56. doi: 10.1056/NEJMra020398. PMID: 12490687.
  • 22. Schoepfer AM, Engel A, Fattinger K, Marbet UA, Criblez D, Reichen J, et al. Herbal does not mean innocuous: ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife products. J Hepatol 2007; 47(4): 521–6. doi: 10.1016/j.jhep.2007.06.014. PMID: 17692989.
  • 23. Maddrey WC. Drug-induced hepatotoxicity: 2005. J Clin Gastroenterol 2005; 39(4): S83–S89. doi: 10.1097/01.mcg.0000155548.91524.6e.
  • 24. Seeff LB, Bonkovsky HL, Navarro VJ, Wang G. Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology 2015; 148(3): 517–32.e3. doi: 10.1053/j.gastro.2014.12.004. PMID: 25500423.
  • 25. Stickel F, Droz S, Patsenker E, Bögli-Stuber K, Aebi B, Leib SL. Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis. J Hepatol 2009; 50(1): 111–7. doi: 10.1016/j.jhep.2008.08.017. PMID: 19010564.
  • 26. Rossi S, Navarro VJ. Herbs and liver injury: a clinical perspective. Clin Gastroenterol Hepatol 2014; 12(7): 1069–76. doi: 10.1016/j.cgh.2013.07.030. PMID: 23924877.
  • 27. Nadir A, Reddy D, Van Thiel DH. Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000; 95(12): 3634–7. doi: 10.1016/S0002-9270(00)02179-1.
  • 28. Yahya F, Mamat SS, Kamarolzaman MF, Seyedan AA, Jakius KF, Mahmood ND, et al. Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats. Evid Based Complement Alternat Med 2013; 2013: 636580. doi: 10.1155/2013/636580. PMID: 23853662; PMCID: PMC3703353.
  • 29. Vardapetyan H, Tiratsuyan S, Hovhannisyan A. Hepatoprotective activity of leaf extract of Laurus nobilis L. against CCl4 induced hepatotoxicity in rats. In 3rd International Conference on Nanotechnologies and Biomedical Engineering. 2016. pp:419–23. Springer, Singapore.
  • 30. Gasparyan G, Tiratsuyan S, Kazaryan S, Vardapetyan H. Effect of Laurus nobilis extract on the functioning of liver against CCl4 induced toxicity. Journal of Experimental Biology and Agricultural Sciences 2015; 3(2): 174–83. doi: 10.18006/2015.3(2).174.183.
  • 31. Gulfraz M, Ahamd D, Ahmad MS, Qureshi R, Mahmood RT, Jabeen N, et al. Effect of leaf extracts of Taraxacum officinale on CCl4 induced hepatotoxicity in rats, in vivo study. Pak J Pharm Sci 2014; 27(4): 825–9. PMID: 25015447.
  • 32. Colle D, Arantes LP, Gubert P, da Luz SC, Athayde ML, Teixeira Rocha JB, et al. Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice. J Med Food 2012; 15(6): 549–56. doi: 10.1089/jmf.2011.0282. PMID: 22424457.
  • 33. Mohammed RR, Omer AK, Yener Z, Uyar A, Ahmed AK. Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research. Ann Med Surg (Lond) 2020; 61: 188–97. doi: 10.1016/j.amsu.2020.11.051. PMID: 33520200; PMCID: PMC7817776.

Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report

Year 2021, Volume: 12 Issue: 4, 124 - 126, 14.12.2021
https://doi.org/10.33706/jemcr.972191

Abstract

Introduction: In recent years, an increase in the use of herbal supplements, natural products, and traditional medicines has been observed. These herbs and herbal products have been associated with complications, such as liver injury, causing high mortality and morbidity.
Case Report: A 51-year-old female presented to the emergency department with a 2-week history of abdominal pain, vomiting, and nascent jaundice. In the detailed history of the patient, the daily consumption of Laurus nobilis tea was reported for 1 month at home. On physical examination, she was icteric and ill-looking. Mild right upper quadrant discomfort with tenderness was noted, but no rash or hepatosplenomegaly was observed. The laboratory tests results were as follows: serum AST/ALT ratio 1.2 (908/744 U/L), gamma-glutamyl transferase 63 U/L, ALP 124 U/L, bilirubin (total/direct) 27.0/14.0 mg/dL, and lactate dehydrogenase 420 U/L. Prothrombin time international normalized ratio was 2.77. The gastroenterology department considered fulminant hepatitis in the patient and recommended liver transplantation. The patient died while preparations for the transplant were ongoing.
Conclusion: Many herbal products are known to be hepatotoxic. Laurus nobilis is a commonly consumed herbal product, and the potential of this herb to cause hepatotoxicity should be considered.

References

  • 1. Zárybnický T, Boušová I, Ambrož M, Skálová L. Hepatotoxicity of monoterpenes and sesquiterpenes. Arch Toxicol 2018; 92(1): 1–13. doi: 10.1007/s00204-017-2062-2. PMID: 28905185.
  • 2. Abou Seif HS. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-Suef Univ J Basic Appl Sci 2016; 5(2): 134–46. doi: 10.1016/j.bjbas.2016.03.004.
  • 3. Chbili C, Maher M, Sawssen M, Mejda S, Hajer B, Hedi K, et al. Evaluation of Impact of Daily Laurus Nobilis Tea Consumption on the Lipid Profile and on the Increased Anti-Oxidant Activity In Healthy Volunteers. Doctoral dissertation, Assiut University. 2020. doi: 10.21203/rs.3.rs-28846/v1.
  • 4. Akcan T, Estévez M, Serdaroğlu M. Antioxidant protection of cooked meatballs during frozen storage by whey protein edible films with phytochemicals from Laurus nobilis L. and Salvia officinalis. LWT 2017; 77: 323–31. doi: 10.1016/j.lwt.2016.11.051.
  • 5. Stournaras E, Tziomalos K. Herbal medicine-related hepatotoxicity. World J Hepatol 2015; 7(19): 2189–93. doi: 10.4254/wjh.v7.i19.2189. PMID: 26380043; PMCID: PMC4561772.
  • 6. Pantano F, Tittarelli R, Mannocchi G, Zaami S, Ricci S, Giorgetti R, et al. Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat. Int J Mol Sci 2016; 17(4): 580. doi: 10.3390/ijms17040580. PMID: 27092496; PMCID: PMC4849036.
  • 7. Amadi CN, Orisakwe OE. Herb-Induced Liver Injuries in Developing Nations: An Update. Toxics 2018; 6(2): 24. doi: 10.3390/toxics6020024. PMID: 29673137; PMCID: PMC6027193.
  • 8. Pantano F, Mannocchi G, Marinelli E, Gentili S, Graziano S, Busardò FP, et al. Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature. Eur Rev Med Pharmacol Sci 2017; 21(1 Suppl): 46–52. PMID: 28379595.
  • 9. Chalasani NP, Hayashi PH, Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ; Practice Parameters Committee of the American College of Gastroenterology. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol 2014; 109(7): 950–66; quiz 967. doi: 10.1038/ajg.2014.131. PMID: 24935270.
  • 10. Zheng EX, Navarro VJ. Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review. J Clin Transl Hepatol 2015; 3(2): 93–8. doi: 10.14218/JCTH.2015.00006. PMID: 26357638; PMCID: PMC4548352.
  • 11. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006; 354(7): 731–9. doi: 10.1056/NEJMra052270. PMID: 16481640.
  • 12. Dey P, Saha MR, Sen A. Hepatotoxicity and the present herbal hepatoprotective scenario. International Journal of Green Pharmacy (IJGP) 2013; 7(4): 265–73. doi: 10.4103/0973-8258.122046.
  • 13. Ozcan B, Esen M, Sangun MK, Coleri A, Caliskan M. Effective antibacterial and antioxidant properties of methanolic extract of Laurus nobilis seed oil. J Environ Biol 2010; 31(5): 637–41. PMID: 21387914.
  • 14. Taban A, Saharkhiz MJ, Niakousari M. Sweet bay (Laurus nobilis L.) essential oil and its chemical composition, antioxidant activity and leaf micromorphology under different extraction methods. Sustainable Chemistry and Pharmacy 2018; 9: 12–8. doi: 10.1016/j.scp.2018.05.001.
  • 15. da Silveira SM, Luciano FB, Fronza N, Cunha Jr A, Scheuermann GN, Vieira CRW. Chemical composition and antibacterial activity of Laurus nobilis essential oil towards foodborne pathogens and its application in fresh Tuscan sausage stored at 7 C. LWT-Food Science and Technology 2014; 59(1): 86–93. doi: 10.1016/j.lwt.2014.05.032.
  • 16. Ramos C, Teixeira B, Batista I, Matos O, Serrano C, Neng NR, et al. Antioxidant and antibacterial activity of essential oil and extracts of bay laurel Laurus nobilis Linnaeus (Lauraceae) from Portugal. Nat Prod Res 2012; 26(6): 518–29. doi: 10.1080/14786419.2010.531478. PMID: 21756182.
  • 17. Hafizoǧlu H, Reunanen M. Studies on the components of Lauras nobilis from Turkey with special reference to Laurel berry fat. Eur J Lipid Sci Technol 1993; 95(8): 304–8. doi: 10.1002/lipi.19930950806.
  • 18. Stickel F, Patsenker E, Schuppan D. Herbal hepatotoxicity. J Hepatol 2005; 43(5): 901–10. doi: 10.1016/j.jhep.2005.08.002. PMID: 16171893.
  • 19. Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis 2007; 39(4): 293–304. doi: 10.1016/j.dld.2006.11.004. PMID: 17331820.
  • 20. Favreau JT, Ryu ML, Braunstein G, Orshansky G, Park SS, Coody GL, et al. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann Intern Med 2002; 136(8): 590–5. doi: 10.7326/0003-4819-136-8-200204160-00008. PMID: 11955027.
  • 21. De Smet PA. Herbal remedies. N Engl J Med 2002; 347(25): 2046–56. doi: 10.1056/NEJMra020398. PMID: 12490687.
  • 22. Schoepfer AM, Engel A, Fattinger K, Marbet UA, Criblez D, Reichen J, et al. Herbal does not mean innocuous: ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife products. J Hepatol 2007; 47(4): 521–6. doi: 10.1016/j.jhep.2007.06.014. PMID: 17692989.
  • 23. Maddrey WC. Drug-induced hepatotoxicity: 2005. J Clin Gastroenterol 2005; 39(4): S83–S89. doi: 10.1097/01.mcg.0000155548.91524.6e.
  • 24. Seeff LB, Bonkovsky HL, Navarro VJ, Wang G. Herbal products and the liver: a review of adverse effects and mechanisms. Gastroenterology 2015; 148(3): 517–32.e3. doi: 10.1053/j.gastro.2014.12.004. PMID: 25500423.
  • 25. Stickel F, Droz S, Patsenker E, Bögli-Stuber K, Aebi B, Leib SL. Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with Bacillus subtilis. J Hepatol 2009; 50(1): 111–7. doi: 10.1016/j.jhep.2008.08.017. PMID: 19010564.
  • 26. Rossi S, Navarro VJ. Herbs and liver injury: a clinical perspective. Clin Gastroenterol Hepatol 2014; 12(7): 1069–76. doi: 10.1016/j.cgh.2013.07.030. PMID: 23924877.
  • 27. Nadir A, Reddy D, Van Thiel DH. Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000; 95(12): 3634–7. doi: 10.1016/S0002-9270(00)02179-1.
  • 28. Yahya F, Mamat SS, Kamarolzaman MF, Seyedan AA, Jakius KF, Mahmood ND, et al. Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats. Evid Based Complement Alternat Med 2013; 2013: 636580. doi: 10.1155/2013/636580. PMID: 23853662; PMCID: PMC3703353.
  • 29. Vardapetyan H, Tiratsuyan S, Hovhannisyan A. Hepatoprotective activity of leaf extract of Laurus nobilis L. against CCl4 induced hepatotoxicity in rats. In 3rd International Conference on Nanotechnologies and Biomedical Engineering. 2016. pp:419–23. Springer, Singapore.
  • 30. Gasparyan G, Tiratsuyan S, Kazaryan S, Vardapetyan H. Effect of Laurus nobilis extract on the functioning of liver against CCl4 induced toxicity. Journal of Experimental Biology and Agricultural Sciences 2015; 3(2): 174–83. doi: 10.18006/2015.3(2).174.183.
  • 31. Gulfraz M, Ahamd D, Ahmad MS, Qureshi R, Mahmood RT, Jabeen N, et al. Effect of leaf extracts of Taraxacum officinale on CCl4 induced hepatotoxicity in rats, in vivo study. Pak J Pharm Sci 2014; 27(4): 825–9. PMID: 25015447.
  • 32. Colle D, Arantes LP, Gubert P, da Luz SC, Athayde ML, Teixeira Rocha JB, et al. Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice. J Med Food 2012; 15(6): 549–56. doi: 10.1089/jmf.2011.0282. PMID: 22424457.
  • 33. Mohammed RR, Omer AK, Yener Z, Uyar A, Ahmed AK. Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research. Ann Med Surg (Lond) 2020; 61: 188–97. doi: 10.1016/j.amsu.2020.11.051. PMID: 33520200; PMCID: PMC7817776.
There are 33 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Hasan Kara 0000-0002-3839-7651

Aysegül Bayır 0000-0002-5680-031X

Huseyin Korkmaz 0000-0002-0571-0402

Fatma Talay This is me 0000-0002-1724-4189

Ahmet Ak 0000-0002-9617-8772

Publication Date December 14, 2021
Submission Date July 16, 2021
Published in Issue Year 2021 Volume: 12 Issue: 4

Cite

APA Kara, H., Bayır, A., Korkmaz, H., Talay, F., et al. (2021). Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report. Journal of Emergency Medicine Case Reports, 12(4), 124-126. https://doi.org/10.33706/jemcr.972191
AMA Kara H, Bayır A, Korkmaz H, Talay F, Ak A. Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report. Journal of Emergency Medicine Case Reports. December 2021;12(4):124-126. doi:10.33706/jemcr.972191
Chicago Kara, Hasan, Aysegül Bayır, Huseyin Korkmaz, Fatma Talay, and Ahmet Ak. “Hepatotoxicity Caused by Bay Leaf (Laurus nobilis): A Case Report”. Journal of Emergency Medicine Case Reports 12, no. 4 (December 2021): 124-26. https://doi.org/10.33706/jemcr.972191.
EndNote Kara H, Bayır A, Korkmaz H, Talay F, Ak A (December 1, 2021) Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report. Journal of Emergency Medicine Case Reports 12 4 124–126.
IEEE H. Kara, A. Bayır, H. Korkmaz, F. Talay, and A. Ak, “Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report”, Journal of Emergency Medicine Case Reports, vol. 12, no. 4, pp. 124–126, 2021, doi: 10.33706/jemcr.972191.
ISNAD Kara, Hasan et al. “Hepatotoxicity Caused by Bay Leaf (Laurus nobilis): A Case Report”. Journal of Emergency Medicine Case Reports 12/4 (December 2021), 124-126. https://doi.org/10.33706/jemcr.972191.
JAMA Kara H, Bayır A, Korkmaz H, Talay F, Ak A. Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report. Journal of Emergency Medicine Case Reports. 2021;12:124–126.
MLA Kara, Hasan et al. “Hepatotoxicity Caused by Bay Leaf (Laurus nobilis): A Case Report”. Journal of Emergency Medicine Case Reports, vol. 12, no. 4, 2021, pp. 124-6, doi:10.33706/jemcr.972191.
Vancouver Kara H, Bayır A, Korkmaz H, Talay F, Ak A. Hepatotoxicity caused by bay leaf (Laurus nobilis): A case report. Journal of Emergency Medicine Case Reports. 2021;12(4):124-6.