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The role of the ratio of first trimester CRL (crown rump length) measurement to NT (nuchal translucency) measurements in predicting early-onset fetal growth restriction (FGR)

Year 2024, Volume: 21 Issue: 1, 28 - 32, 01.04.2024
https://doi.org/10.38136/jgon.1397142

Abstract

Objective: Our aim is to evaluate the role of the ratio of first-trimester CRL (crown rump length) measurement to NT (nuchal translucency) measurements in predicting early-onset fetal growth restriction (FGR) and to contribute to the existing literature.
Methods: In the present case-control study, fetuses with early-onset FGR were compared to a frequency matched low risk control group. This study was conducted in the perinatology clinic of Ankara Bilkent City Hospital between 2020 and 2023. Maternal age, gravidity, parity, crown-rump length (CRL), and nuchal translucency (NT) measurements were compared between pregnant women with early onset FGR (n=39) and pregnant women without FGR (n=50).
Results: The mean age of pregnant women with FGR who participated in the study was 27.1±0.8, and the mean age of pregnant women without FGR was 26.3±0.6, and no statistically significant difference was found between the two groups (p=0.4)). Mean CRL was 54.98±1.08 mm in the group with FGR and 56.99±1.11 mm in the group without FGR; there was no significant difference between the two groups (p=0.2). The NT value was 1.11 ± 0.04 mm in the FGR group and 1.13 ± 0.02 mm in the without FGR group, there was no significant difference between the two groups (p=0.73). The mean CRL/NT ratio was 52.00±2.33 in the group with early onset FGR and 51.46±1.48 in the group without FGR and there was no statistically significant difference between the two groups (p=0.83).
When the early developing FGR group is evaluated within itself, the mean age at diagnosis was 31.7±0.3 weeks. EFW mean percentile at diagnosis was 4.5±0.6 and ac percentile was 2.9±0.4. The mean umbilical artery systole/diastole ratio (UA-SD) was 2.9±0.16 and the mean umbilical artery pulsatility index (UA-PI) was 1.02±0.05.
Conclusion: Crown-rump length to nuchal translucency ratio is not clinically useful to predict early-onset FGR.

References

  • 1. Gardosi J, Chang A, Kalyan B, Sahota D, Symon- ds E. Customised antenatal growth charts. The Lancet. 1992;339(8788):283-7. 2. Tudehope D, Vento M, Bhutta Z, Pachi P. Nut- ritional requirements and feeding recommendations for small for gestational age infants. The Journal of Pediatrics. 2013;162(3):S81-S9. 3. Lapillonne A, Braillon P, Claris O, Chatelain P, Delmas P, Salle B. Body composition in appropriate and in small for gestational age infants. Acta Paediatrica. 1997;86(2):196-200.

Erken başlangıçlı fetal büyüme kısıtlamasını (FGR) öngörmede ilk trimester CRL (baş popo mesafesi) ölçümünün NT (ense saydımlığı) ölçümlerine oranının rolü

Year 2024, Volume: 21 Issue: 1, 28 - 32, 01.04.2024
https://doi.org/10.38136/jgon.1397142

Abstract

Amaç: Amacımız, ilk trimester CRL (baş popo mesafesi) ölçümünün NT (ense saydamlığı) ölçümlerine oranının erken başlangıçlı fetal büyüme kısıtlamasını (FBK) öngörmedeki rolünü değerlendirmek ve mevcut literatüre katkıda bulunmaktır.
Yöntemler: Mevcut vaka-kontrol çalışmasında, erken başlangıçlı FBK'lı fetüsler, frekans eşleştirilmiş düşük riskli kontrol grubuyla karşılaştırıldı. Bu çalışma, 2020-2023 yılları arasında Ankara Bilkent Şehir Hastanesi Perinatoloji kliniğinde gerçekleştirildi. Erken başlangıçlı FBK'lı gebe kadınlar ( n=39) ve FBK'sı olmayan hamile kadınlar (n=50) arasında anne yaşı, gravida , parite, baş popo mesafesi (CRL) ve ense saydamlığı (NT) ölçümleri karşılaştırıldı.
Bulgular: Çalışmaya katılan FBK'lı gebelerin yaş ortalaması 27,1±0,8, FBK olmayan gebelerin yaş ortalaması 26,3±0,6 olup iki grup arasında istatistiksel olarak anlamlı fark saptanmadı (p=0,4) ). Ortalama CRL FBK'lı grupta 54,98±1,08 mm, FBK’sız grupta ise 56,99±1,11 mm idi; iki grup arasında anlamlı fark yoktu (p=0,2). NT değeri FBK grubunda 1,11±0,04 mm, FBK olmayan grupta 1,13±0,02 mm olup iki grup arasında anlamlı fark yoktu (p=0,73). Erken başlangıçlı FBK'lı grupta ortalama CRL/NT oranı 52,00±2,33, FBK'sız grupta ise 51,46±1,48 olup iki grup arasında istatistiksel olarak anlamlı fark yoktu (p=0,83).
Erken gelişen FBK grubu kendi içinde değerlendirildiğinde ortalama tanı yaşı 31,7±0,3 hafta idi. Tanı anındaki EFW ortalama persantil 4,5±0,6 ve AC persantil 2,9±0,4 idi. Ortalama umbilikal arter sistol/diyastol oranı (UA-SD) 2,9±0,16 ve ortalama umbilikal arter pulsatilite indeksi (UA-PI) 1,02±0,05 idi.
Sonuç: baş popo mesafesi/ense saydamlığı oranı, erken başlangıçlı FBK'yı tahmin etmede klinik olarak yararlı değildir.

References

  • 1. Gardosi J, Chang A, Kalyan B, Sahota D, Symon- ds E. Customised antenatal growth charts. The Lancet. 1992;339(8788):283-7. 2. Tudehope D, Vento M, Bhutta Z, Pachi P. Nut- ritional requirements and feeding recommendations for small for gestational age infants. The Journal of Pediatrics. 2013;162(3):S81-S9. 3. Lapillonne A, Braillon P, Claris O, Chatelain P, Delmas P, Salle B. Body composition in appropriate and in small for gestational age infants. Acta Paediatrica. 1997;86(2):196-200.
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Details

Primary Language English
Subjects Obstetrics and Gynaecology
Journal Section Research Articles
Authors

Refaettin Şahin 0000-0002-5866-1798

Atakan Tanacan 0000-0001-8209-8248

Hakkı Şerbetçi 0000-0001-6536-8138

Osman Onur Özkavak 0000-0001-9259-7825

Murat Haksever 0000-0002-9526-3828

Mehmet Utku Başarır 0009-0000-5741-3875

Özgür Kara 0000-0002-4204-0014

Dilek Sahin 0000-0001-8567-9048

Publication Date April 1, 2024
Submission Date November 29, 2023
Acceptance Date January 25, 2024
Published in Issue Year 2024 Volume: 21 Issue: 1

Cite

Vancouver Şahin R, Tanacan A, Şerbetçi H, Özkavak OO, Haksever M, Başarır MU, Kara Ö, Sahin D. The role of the ratio of first trimester CRL (crown rump length) measurement to NT (nuchal translucency) measurements in predicting early-onset fetal growth restriction (FGR). JGON. 2024;21(1):28-32.