Abstract
References
- Beasley R, of Asthma TIS. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The Lancet 1998; 351: 1225-32.
- Şekerel BE, Türktaş H, Bavbek S, Öksüz E, Malhan S. Economic burden of pediatric asthma in Turkey: A Cost of Illness Study from payer perspective. Turk Thorac J 2020; 21: 248.
- D’Amato G, Vitale C, Molino A, et al. Asthma-related deaths. Multidiscip Respir Med 2016; 11: 37.
- Pakhale S, Mulpuru S, Boyd M. Optimal management of severe/refractory asthma. Clin Med Insights Circ Respir Pulm Med 2011; 5: 37-47.
- Adams RJ, Smith BJ, Ruffin RE. Factors associated with hospital admissions and repeat emergency department visits for adults with asthma. Thorax 2000; 55: 566-73.
- Bavbek S, Malhan S, Mungan D, et al. Economic burden of severe asthma in Turkey: a cost of illness study from payer perspective. Eur Ann Allergy Clin Immunol 2021; 53: 128-37.
- Çelik GE, Bavbek S, Paşaoğlu G, et al. Direct medical cost of asthma in Ankara, Turkey. Respiration 2004; 71: 587-93.
- Bavbek S, Mungan D, Türktaş H, et al. A cost-of-illness study estimating the direct cost per asthma exacerbation in Turkey. Respir Med 2011; 105: 541-8.
- Schulman ES. Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders. Am J Respir Crit Care Med 2001; 164: 6-11.
- Lai T, Wang S, Xu Z, et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Sci Rep 2015; 5: 1-10.
- Bousquet J, Cabrera P, Berkman N, et al. The effect of treatment with omalizumab, an anti‐IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma. Allergy 2005; 60: 302-8.
- Chipps B, Buhl R, Beeh K-M, et al. Improvement in quality of life with omalizumab in patients with severe allergic asthma. Curr Med Res Opin 2006; 22: 2201-8.
- Korn S, Thielen A, Seyfried S, et al. Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany. Respir Med 2009; 103: 1725-31.
- Bavbek S, Aydın O, Kepil SÖ, et al. Therapy with omalizumab in patients with severe persistent allergic asthma: a real life data in Turkey. Tuberk Toraks 2010; 58: 425-34.
- Yorgancıoğlu A, Öner Erkekol F, Mungan D, et al. Long-Term omalizumab treatment: a multicenter, real-life, 5-year trial. Int Arch Allergy Immunol 2018; 176: 225-33.
- Tadrous M, Khuu W, Lebovic G, et al. Real-world health care utilization and effectiveness of omalizumab for the treatment of severe asthma. Ann Allergy Asthma Immunol 2018; 120: 59-65.
- Suzuki C, Lopes da Silva N, Kumar P, Pathak P, Ong SH. Cost-effectiveness of omalizumab add-on to standard-of-care therapy in patients with uncontrolled severe allergic asthma in a Brazilian healthcare setting. J Med Econ 2017; 20: 832-9.
- Hochhaus G, Brookman L, Fox H, et al. Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma. Curr Med Res Opin 2003; 19: 491-9.
- Jahnz-Różyk K, Lis J, Warchoł M, Kucharczyk A. Clinical and economic impact of a one-year treatment with omalizumab in patients with severe allergic asthma within a drug programme in Poland. BMC Pulm Med 2018; 18: 48.
- Morishima T, Ikai H, Imanaka Y. Cost-effectiveness analysis of omalizumab for the treatment of severe asthma in Japan and the value of responder prediction methods based on a multinational trial. Value Health Reg Issues 2013; 2: 29-36.
- Wu AC, Paltiel AD, Kuntz KM, Weiss ST, Fuhlbrigge AL. Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy Model. J Allergy Clin Immunol 2007; 120: 1146-52.
- Costello R, Long D, Gaine S, et al. Therapy with omalizumab for patients with severe allergic asthma improves asthma control and reduces overall healthcare costs. Irish J Med Sci 2011; 180: 637-41.
- Dal Negro RW, Tognella S, Pradelli L. A 36-month study on the cost/utility of add-on omalizumab in persistent difficult-to-treat atopic asthma in Italy. J Asthma 2012; 49: 843-8.
- van Nooten F, Stern S, Braunstahl G-J, et al. Cost-effectiveness of omalizumab for uncontrolled allergic asthma in the Netherlands. J Med Econ 2013; 16: 342-8.
- Levy AN, García a Ruiz AJ, García-Agua Soler N, Sanjuan MVH. Cost-effectiveness of omalizumab in severe persistent asthma in Spain: a real-life perspective. J Asthma 2015; 52: 205-10.
- del Carmen Vennera M, Valero A, Uría E, Forné C, Picado C. Cost-effectiveness analysis of omalizumab for the treatment of severe persistent asthma in real clinical practice in Spain. Clin Drug Investig 2016; 36: 567-78.
- Campbell J, Spackman D, Sullivan S. The costs and consequences of omalizumab in uncontrolled asthma from a USA payer perspective. Allergy 2010; 65: 1141-8.
- Faria R, McKenna C, Palmer S. Optimizing the position and use of omalizumab for severe persistent allergic asthma using cost-effectiveness analysis. Value Health 2014; 17 : 772-82.
- Oba Y, Salzman GA. Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma. J Allergy Clin Immunol 2004; 114: 265-9.
Abstract
Aim: The present study aims to reveal direct cost analysis of patients with severe allergic asthma receiving omalizumab treatment.
Material and Methods: Twenty-two adults with severe allergic asthma who were treated with omalizumab and were routinely checked on the 16th week, 1st year, and 3rd year of treatment were included in the study. Clinical and demographic features of subjects were retrospectively documented before and after omalizumab treatment as well as pharmaceutical, emergency and hospital costs.
Results: The monthly treatment cost per patient was higher during the 16th week, 1st year, and 3rd year (€411.80±190.84, €409.7±211.57, €404.2±157.30 respectively) when compared with the pre-treatment period (€107.91±48.62) (p<0.001). Similarly monthly emergency visit cost per patient at 16th week, 1st year, and 3rd year of omalizumab treatment (€0.03±0.13, €0.19±0.51, €0.56±0.41 respectively) as well as the monthly hospitalization cost per patient at 16th week, 1st year, and 3rd year of omalizumab treatment (€1.44±5.57, €1.50±5.27, €16.3±13.8 respectively ) were both lower compared to pre-treatment period (€1.82±1.23 and €17.69±10.84 respectively) (p<0.001 for both). Statistically significant drop was observed in the frequency of asthma exacerbations as well as emergency visits, hospitalizations and number of patients receiving systemic corticosteroid with omalizumab treatment. An improvement was also detected in asthma control test scores, forced expiratory volume in 1 second, and peak expiratory flow values of patients compared to the baseline values.
Conclusion: Omalizumab treatment is clinically effective and although it adds an extra pharmaceutical cost to the patients’ management it reduces the emergency and hospital costs.
References
- Beasley R, of Asthma TIS. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The Lancet 1998; 351: 1225-32.
- Şekerel BE, Türktaş H, Bavbek S, Öksüz E, Malhan S. Economic burden of pediatric asthma in Turkey: A Cost of Illness Study from payer perspective. Turk Thorac J 2020; 21: 248.
- D’Amato G, Vitale C, Molino A, et al. Asthma-related deaths. Multidiscip Respir Med 2016; 11: 37.
- Pakhale S, Mulpuru S, Boyd M. Optimal management of severe/refractory asthma. Clin Med Insights Circ Respir Pulm Med 2011; 5: 37-47.
- Adams RJ, Smith BJ, Ruffin RE. Factors associated with hospital admissions and repeat emergency department visits for adults with asthma. Thorax 2000; 55: 566-73.
- Bavbek S, Malhan S, Mungan D, et al. Economic burden of severe asthma in Turkey: a cost of illness study from payer perspective. Eur Ann Allergy Clin Immunol 2021; 53: 128-37.
- Çelik GE, Bavbek S, Paşaoğlu G, et al. Direct medical cost of asthma in Ankara, Turkey. Respiration 2004; 71: 587-93.
- Bavbek S, Mungan D, Türktaş H, et al. A cost-of-illness study estimating the direct cost per asthma exacerbation in Turkey. Respir Med 2011; 105: 541-8.
- Schulman ES. Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders. Am J Respir Crit Care Med 2001; 164: 6-11.
- Lai T, Wang S, Xu Z, et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Sci Rep 2015; 5: 1-10.
- Bousquet J, Cabrera P, Berkman N, et al. The effect of treatment with omalizumab, an anti‐IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma. Allergy 2005; 60: 302-8.
- Chipps B, Buhl R, Beeh K-M, et al. Improvement in quality of life with omalizumab in patients with severe allergic asthma. Curr Med Res Opin 2006; 22: 2201-8.
- Korn S, Thielen A, Seyfried S, et al. Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany. Respir Med 2009; 103: 1725-31.
- Bavbek S, Aydın O, Kepil SÖ, et al. Therapy with omalizumab in patients with severe persistent allergic asthma: a real life data in Turkey. Tuberk Toraks 2010; 58: 425-34.
- Yorgancıoğlu A, Öner Erkekol F, Mungan D, et al. Long-Term omalizumab treatment: a multicenter, real-life, 5-year trial. Int Arch Allergy Immunol 2018; 176: 225-33.
- Tadrous M, Khuu W, Lebovic G, et al. Real-world health care utilization and effectiveness of omalizumab for the treatment of severe asthma. Ann Allergy Asthma Immunol 2018; 120: 59-65.
- Suzuki C, Lopes da Silva N, Kumar P, Pathak P, Ong SH. Cost-effectiveness of omalizumab add-on to standard-of-care therapy in patients with uncontrolled severe allergic asthma in a Brazilian healthcare setting. J Med Econ 2017; 20: 832-9.
- Hochhaus G, Brookman L, Fox H, et al. Pharmacodynamics of omalizumab: implications for optimised dosing strategies and clinical efficacy in the treatment of allergic asthma. Curr Med Res Opin 2003; 19: 491-9.
- Jahnz-Różyk K, Lis J, Warchoł M, Kucharczyk A. Clinical and economic impact of a one-year treatment with omalizumab in patients with severe allergic asthma within a drug programme in Poland. BMC Pulm Med 2018; 18: 48.
- Morishima T, Ikai H, Imanaka Y. Cost-effectiveness analysis of omalizumab for the treatment of severe asthma in Japan and the value of responder prediction methods based on a multinational trial. Value Health Reg Issues 2013; 2: 29-36.
- Wu AC, Paltiel AD, Kuntz KM, Weiss ST, Fuhlbrigge AL. Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy Model. J Allergy Clin Immunol 2007; 120: 1146-52.
- Costello R, Long D, Gaine S, et al. Therapy with omalizumab for patients with severe allergic asthma improves asthma control and reduces overall healthcare costs. Irish J Med Sci 2011; 180: 637-41.
- Dal Negro RW, Tognella S, Pradelli L. A 36-month study on the cost/utility of add-on omalizumab in persistent difficult-to-treat atopic asthma in Italy. J Asthma 2012; 49: 843-8.
- van Nooten F, Stern S, Braunstahl G-J, et al. Cost-effectiveness of omalizumab for uncontrolled allergic asthma in the Netherlands. J Med Econ 2013; 16: 342-8.
- Levy AN, García a Ruiz AJ, García-Agua Soler N, Sanjuan MVH. Cost-effectiveness of omalizumab in severe persistent asthma in Spain: a real-life perspective. J Asthma 2015; 52: 205-10.
- del Carmen Vennera M, Valero A, Uría E, Forné C, Picado C. Cost-effectiveness analysis of omalizumab for the treatment of severe persistent asthma in real clinical practice in Spain. Clin Drug Investig 2016; 36: 567-78.
- Campbell J, Spackman D, Sullivan S. The costs and consequences of omalizumab in uncontrolled asthma from a USA payer perspective. Allergy 2010; 65: 1141-8.
- Faria R, McKenna C, Palmer S. Optimizing the position and use of omalizumab for severe persistent allergic asthma using cost-effectiveness analysis. Value Health 2014; 17 : 772-82.
- Oba Y, Salzman GA. Cost-effectiveness analysis of omalizumab in adults and adolescents with moderate-to-severe allergic asthma. J Allergy Clin Immunol 2004; 114: 265-9.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Article |
| Authors | |
| Publication Date | September 5, 2021 |
| Published in Issue | Year 2021 Volume: 4 Issue: 5 |
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS].
The Directories (indexes) and Platforms we are included in are at the bottom of the page.
Note: Our journal is not WOS indexed and therefore is not classified as Q.
You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/2316/file/4905/show
The indexes of the journal are ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, etc.
|
|
|
| |
|
|
|
|
The platforms of the journal are Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons, etc.
|
|
|
|
|
|
Our Journal using the DergiPark system indexed are;
Ulakbim TR Dizin, Index Copernicus, ICI World of Journals, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, OpenAIRE, MIAR, EuroPub, WorldCat (OCLC), DOAJ, Türkiye Citation Index, Türk Medline Index, InfoBase Index
Our Journal using the DergiPark system platforms are;
Journal articles are evaluated as "Double-Blind Peer Review".
Our journal has adopted the Open Access Policy and articles in JHSM are Open Access and fully comply with Open Access instructions. All articles in the system can be accessed and read without a journal user. https//dergipark.org.tr/tr/pub/jhsm/page/9535
Journal charge policy https://dergipark.org.tr/tr/pub/jhsm/page/10912
Editor List for 2022
Assoc. Prof. Alpaslan TANOĞLU (MD)
Prof. Aydın ÇİFCİ (MD)
Prof. İbrahim Celalaettin HAZNEDAROĞLU (MD)
Prof. Murat KEKİLLİ (MD)
Prof. Yavuz BEYAZIT (MD)
Prof. Ekrem ÜNAL (MD)
Prof. Ahmet EKEN (MD)
Assoc. Prof. Ercan YUVANÇ (MD)
Assoc. Prof. Bekir UÇAN (MD)
Assoc. Prof. Mehmet Sinan DAL (MD)
Our journal has been indexed in DOAJ as of May 18, 2020.
Our journal has been indexed in TR-Dizin as of March 12, 2021.
Articles published in the Journal of Health Sciences and Medicine have open access and are licensed under the Creative Commons CC BY-NC-ND 4.0 International License.