Abstract
References
- Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 2006; 12: 6243-9.
- Chin H, Kim J. Bone Metastasis: Concise Overview. Fed Pract 2015; 32: 24-30.
- Jimenez-Andrade JM, Mantyh WG, Bloom AP, et al. Bone cancer pain. Ann N Y Acad Sci 2010; 1198: 173-81.
- Maurizi A, Rucci N. The osteoclast in bone metastasis: player and target. Cancers (Basel) 2018; 10: 218.
- Sabino MA, Mantyh PW. Pathophysiology of bone cancer pain. J Support Oncol 2005; 3: 15-24.
- Chow E, Harris K, Fan G, et al. Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol 2007; 25: 1423-36.
- De Felice F, Piccioli A, Musio D. et al. The role of radiation therapy ın bone metastases management. Oncotarget 2017; 8: 25691-9.
- Fairchild A, Barnes E, Ghosh S. et al. International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice? Int J Radiat Oncol Biol Phys 2009; 75: 1501-10.
- Saito T, Yamaguchi K, Toya R, Oya N. Single-versus multiple-fraction radiation therapy for painful bone metastases: a systematic review and meta-analysis of nonrandomized studies. Adv Radiat Oncol 2019; 4: 706-15.
- Lutz S, Balboni T, Jones J. et al. Palliative radiation therapy for bone metastases: update of an ASTRO evidence-based guideline. Pract Radiat Oncol 2017; 7: 4-12.
- Wu JS, Wong R, Johnston M, et al. Cancer Care Ontario Practice Guidelines Initiative Supportive Care Group. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 2003; 55: 594-605.
- Rinaldi CG, Ippolito E, Greco C, Matteucci P, D'Angelillo RM, Ramella S. Radiotherapy for pain relief from bone metastases during Coronavirus (COVID-19) pandemic. Eur J Pain 2020; 24: 1211-2.
- Thureau S, Faivre JC, Assaker R. et al. Adapting palliative radiation therapy for bone metastases during the Covid-19 pandemic: GEMO position paper. J Bone Oncol 2020; 22: 100291.
- Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singap1994; 23: 129-38.
- Chow E, Hoskin P, Mitera G, et al. International Bone Metastases Consensus Working Party. Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Int J Radiat Oncol Biol Phys 2012; 82: 1730-7.
- Chow E, Hahn CA, Lutz ST. Global reluctance to practice evidence-based medicine continues in the treatment of uncomplicated painful bone metastases despite level 1 evidence and practice guidelines. Int J Radiat Oncol Biol Phys 2012; 83: 1-2.
- McDonald R, Ding K, Brundage M, et al. Effect of radiotherapy on painful bone metastases: a secondary analysis of the NCIC Clinical Trials Group Symptom Control Trial SC. 23. JAMA Oncol 2017; 3: 953-9.
- Szumacher E, Llewellyn-Thomas H, Franssen E, et al. Treatment of bone metastases with palliative radiotherapy: patients' treatment preferences. Int J Radiat Oncol Biol Phys 2005; 61: 1473-81.
- Saito T, Toya R, Semba A, Matsuyama T, Oya N. Influence of the treatment schedule on the physicians' decisions to refer bone metastases patients for palliative radiotherapy: a questionnaire survey of physicians in various specialties. Nagoya J Med Sci 2016; 78: 275-84.
- van den Hout WB, van der Linden YM, Steenland E, et al. Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: cost-utility analysis based on a randomized trial. J Natl Cancer Inst 2003; 95: 222-9.
- Steenland E, Leer JW, van Houwelingen H, et al. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol 1999; 52: 101-9.
- Wu JS, Wong RK, Lloyd NS, et al. Supportive Care Guidelines Group of Cancer Care Ontario. Radiotherapy fractionation for the palliation of uncomplicated painful bone metastases - an evidence-based practice guideline. BMC Cancer 2004; 4: 71.
- Hoskin P, Rojas A, Fidarova E, et al. IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone metastases. Radiother Oncol 2015; 116: 10-4.
- Jaffray D, Kupelian P, Djemil T, Macklis RM. Review of image-guided radiation therapy. Expert Rev Anticancer Ther 2007; 7: 89-103.
- Johnstone C, Lutz ST. External beam radiotherapy and bone metastases. Ann Palliat Med 2014; 3: 114-22.
- Rief H, Habermehl D, Schubert K, Debus J, Combs SE. Time evaluation of image-guided radiotherapy in patients with spinal bone metastases. A single-center study. Strahlenther Onkol 2014; 190: 287-92.
Single fraction image guided radiation therapy for management of bone metastases during the COVID-19 pandemic
Abstract
Aim: Radiation therapy (RT) plays a major role in management of bone metastases, however, various dose-fractionation schemes are utilized taking into account patient, tumor, and treatment characteristics. The aim of this study was to assess Image Guided Single Fraction Radiation Therapy (IG-SFRT) for management of painful bone metastases during the COVID-19 pandemic.
Material and Method: Patients receiving IG-SFRT for painful bone metastases were assessed for age, gender, primary cancer diagnosis, location of metastases, performance status, analgesic intake, pain relief, and overall treatment efficacy in this study.
Results: Out of the total 65 patients treated with IG-SFRT during the course of COVID-19 pandemic at our department, 54 patients were evaluable for overall treatment efficacy analysis. Based on the international consensus on palliative RT endpoints, rates of complete response (CR), partial response (PR), pain progression (PP), and indeterminate response (IR) were 16.67%, 59.26%, 9.26%, 14.81%, respectively corresponding to an overall response rate of 75.93%. IG-SFRT was well tolerated by all patients without toxicity.
Conclusion: For patients with bone metastases, pain palliation is a critical aspect of management. In view of the high rate of overall treatment efficacy achieved with IG-SFRT in our study, we suggest routine utilization of this image guided radiotherapeutic approach for management of painful bone metastases which additionally allows for minimization of treatment visits thereby improving patient and treatment facility convenience under the special circumstances of the recent COVID-19 pandemic.
Keywords
Radiation therapy (RT) image guided radiation therapy (IGRT) bone metastasis COVID-19 pandemic
References
- Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res 2006; 12: 6243-9.
- Chin H, Kim J. Bone Metastasis: Concise Overview. Fed Pract 2015; 32: 24-30.
- Jimenez-Andrade JM, Mantyh WG, Bloom AP, et al. Bone cancer pain. Ann N Y Acad Sci 2010; 1198: 173-81.
- Maurizi A, Rucci N. The osteoclast in bone metastasis: player and target. Cancers (Basel) 2018; 10: 218.
- Sabino MA, Mantyh PW. Pathophysiology of bone cancer pain. J Support Oncol 2005; 3: 15-24.
- Chow E, Harris K, Fan G, et al. Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol 2007; 25: 1423-36.
- De Felice F, Piccioli A, Musio D. et al. The role of radiation therapy ın bone metastases management. Oncotarget 2017; 8: 25691-9.
- Fairchild A, Barnes E, Ghosh S. et al. International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice? Int J Radiat Oncol Biol Phys 2009; 75: 1501-10.
- Saito T, Yamaguchi K, Toya R, Oya N. Single-versus multiple-fraction radiation therapy for painful bone metastases: a systematic review and meta-analysis of nonrandomized studies. Adv Radiat Oncol 2019; 4: 706-15.
- Lutz S, Balboni T, Jones J. et al. Palliative radiation therapy for bone metastases: update of an ASTRO evidence-based guideline. Pract Radiat Oncol 2017; 7: 4-12.
- Wu JS, Wong R, Johnston M, et al. Cancer Care Ontario Practice Guidelines Initiative Supportive Care Group. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 2003; 55: 594-605.
- Rinaldi CG, Ippolito E, Greco C, Matteucci P, D'Angelillo RM, Ramella S. Radiotherapy for pain relief from bone metastases during Coronavirus (COVID-19) pandemic. Eur J Pain 2020; 24: 1211-2.
- Thureau S, Faivre JC, Assaker R. et al. Adapting palliative radiation therapy for bone metastases during the Covid-19 pandemic: GEMO position paper. J Bone Oncol 2020; 22: 100291.
- Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singap1994; 23: 129-38.
- Chow E, Hoskin P, Mitera G, et al. International Bone Metastases Consensus Working Party. Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Int J Radiat Oncol Biol Phys 2012; 82: 1730-7.
- Chow E, Hahn CA, Lutz ST. Global reluctance to practice evidence-based medicine continues in the treatment of uncomplicated painful bone metastases despite level 1 evidence and practice guidelines. Int J Radiat Oncol Biol Phys 2012; 83: 1-2.
- McDonald R, Ding K, Brundage M, et al. Effect of radiotherapy on painful bone metastases: a secondary analysis of the NCIC Clinical Trials Group Symptom Control Trial SC. 23. JAMA Oncol 2017; 3: 953-9.
- Szumacher E, Llewellyn-Thomas H, Franssen E, et al. Treatment of bone metastases with palliative radiotherapy: patients' treatment preferences. Int J Radiat Oncol Biol Phys 2005; 61: 1473-81.
- Saito T, Toya R, Semba A, Matsuyama T, Oya N. Influence of the treatment schedule on the physicians' decisions to refer bone metastases patients for palliative radiotherapy: a questionnaire survey of physicians in various specialties. Nagoya J Med Sci 2016; 78: 275-84.
- van den Hout WB, van der Linden YM, Steenland E, et al. Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: cost-utility analysis based on a randomized trial. J Natl Cancer Inst 2003; 95: 222-9.
- Steenland E, Leer JW, van Houwelingen H, et al. The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study. Radiother Oncol 1999; 52: 101-9.
- Wu JS, Wong RK, Lloyd NS, et al. Supportive Care Guidelines Group of Cancer Care Ontario. Radiotherapy fractionation for the palliation of uncomplicated painful bone metastases - an evidence-based practice guideline. BMC Cancer 2004; 4: 71.
- Hoskin P, Rojas A, Fidarova E, et al. IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone metastases. Radiother Oncol 2015; 116: 10-4.
- Jaffray D, Kupelian P, Djemil T, Macklis RM. Review of image-guided radiation therapy. Expert Rev Anticancer Ther 2007; 7: 89-103.
- Johnstone C, Lutz ST. External beam radiotherapy and bone metastases. Ann Palliat Med 2014; 3: 114-22.
- Rief H, Habermehl D, Schubert K, Debus J, Combs SE. Time evaluation of image-guided radiotherapy in patients with spinal bone metastases. A single-center study. Strahlenther Onkol 2014; 190: 287-92.
Details
| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Original Article |
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| Publication Date | July 20, 2022 |
| Published in Issue | Year 2022 Volume: 5 Issue: 4 |
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