Abstract
Thyroid dysfunctions significantly impact various physiological processes, extending their influence on hemorheological properties and microcirculation. This comprehensive review explores the intricate relationship between thyroid disorders and hemorheology, emphasizing the substantial effects on blood flow dynamics and tissue perfusion. Examining the alterations in blood viscosity, erythrocyte behavior, and microvascular circulation in both hypothyroidism and hyperthyroidism reveals crucial insights into the pathophysiology of these conditions. Furthermore, elucidating the hemorheological changes associated with thyroid dysfunctions offers potential avenues for improved clinical management strategies. This review synthesizes current research findings, highlighting the importance of considering hemorheological aspects in understanding the complexities of thyroid-related complications and advancing patient care paradigms.
Keywords
Hemorheology thyroid dysfunction hypothyroidism hyperthyroidism erythrocyte deformability erythrocyte aggregation blood viscosity plasma viscosity
References
- Katznelson L, Atkinson J, Cook D, Ezzat S, Hamrahian A, Miller K. AACE Guidelines. Endocr Pract. 2011;17(4):1-44.
- Kravets I. Hyperthyroidism: diagnosis and treatment. Am Fam Physician. 2016;93(5):363-370.
- Bahn RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593-646.
- Sari O, Tanoglu A, Aydogan U, et al. Serum visfatin levels before and after levothyroxin treatment in cases with hypothyroidism and subclinical hypothyroidism and their relationships between the lipid levels. Biomed Res. 2012;23(1):55-59.
- Cho Y Il, Cho DJ. Hemorheology and microvascular disorders. Korean Circ J. 2011;41(6):287-295.
- Popel AS, Johnson PC. Microcirculation and hemorheology. Platelets. 2005;37:43-69. doi.org/10.1146/annurev.fluid.37.042604.133933
- Kawa MP, Grymuła K, Paczkowska E, et al. Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies. Eur J Endocrinol. 2010;162(2):295-305.
- Baskurt OK, Meiselman HJ. Blood rheology and hemodynamics. Semin Thromb Hemost. 2003;29(5):435-450.
- Somer T, Meiselman HJ. Disorders of blood viscosity. Ann Med. 1993;25(1):31-39.
- Renoux C, Faivre M, Bessaa A, et al. Impact of surface-area-to-volume ratio, internal viscosity and membrane viscoelasticity on red blood cell deformability measured in isotonic condition. Sci Rep. 2019;9(1):1-7.
- Chasis JA, Mohandas N. Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations. J Cell Biol. 1986;103(2):343-350.
- Kim J, Lee H, Shin S. Advances in the measurement of red blood cell deformability: a brief review. J Cell Biotechnol. 2015;1(1):63-79.
- Tomaiuolo G. Biomechanical properties of red blood cells in health and disease towards microfluidics. Biomicrofluidics. 2014;8(5):1-19. doi.org/10.1063/1.4895755
- Baskurt OK, Meiselman HJ. Erythrocyte aggregation: basic aspects and clinical importance. Clin Hemorheol Microcirc. 2013;53(1–2):23-37.
- Connes P, Dufour S, Pichon A, Favret F. Blood Rheology, Blood Flow, and Human Health. In: Bagchi D, Nair S, Sen CK, eds. Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. 2nd Edition. Elsevier Inc.: 2018: 359-369. doi.org/10.1016/B978-0-12-813922-6.00030-8
- Baskurt OK, Meiselman HJ. Red blood cell “aggregability.” Clin Hemorheol Microcirc. 2009;43(4):353-354.
- Neu B, Meiselman HJ. Depletion-mediated red blood cell aggregation in polymer solutions. Biophys J. 2002;83(5):2482-2490.
- Flormann DAD. Physical charaterization of red blood cell aggregation (Doctoral dissertation, Universität des Saarlandes). 2017.
- Baskurt OK, Boynard M, Cokelet GC, et al. New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc. 2009;42(2):75-97.
- Panagoulis C, Halapas A, Chariatis E, Driva P, Matsakas E. Hyperthyroidism and the heart. Hell J Cardiol. 2008;49(3):169-175.
- Mejia Osuna P, Udovcic M, Sharma MD. Hyperthyroidism and the heart. Methodist Debakey Cardiovasc J. 2017;13(2):60-63.
- Elblbesy MA, Shawki MM. Dependency of whole blood viscosity and plasma viscosity on electrolytes and lipids-an in vitro study. Int J Basic Appl Sci IJBAS-IJENS. 2016;16(03):168003–9494.
- Dörr M, Robinson DM, Wallaschofski H, et al. Brief report: low serum thyrotropin is associated with high plasma fibrinogen. J Clin Endocrinol Metab. 2006;91(2):530-534.
- Shih CH, Chen SL, Yen CC, et al. Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins. Endocrinol. 2004;145(6):2804-2814.
- Erol-Yilmaz A, Atasever B, Mathura K, et al. Cardiac resynchronization improves microcirculation. J Card Fail. 2007;13(2):95-99.
- Elbers PWG, Prins WB, Plokker HWM, Van Dongen EPA, Van Iterson M, Ince C. Electrical cardioversion for atrial fibrillation improves microvascular flow independent of blood pressure changes. J Cardiothorac Vasc Anesth. 2012;26(5):799-803. doi.org/10.1053/j.jvca.2012.04.016
- Vayá A, Giménez C, Sarnago A, et al. Subclinical hypothyroidism and cardiovascular risk. Clin Hemorheol Microcirc. 2014;58(1):1-7.
- Dintenfass L, Forbes CD, McDougall IR. Blood viscosity in hyperthyroid and hypothyroid patients. Pathophysiol Haemost Thromb. 1974;3(5-6):348-352.
- Franchini M. Hemostasis and thyroid diseases revisited. J Endocrinol Invest. 2004;27(9):886-892.
- Akin MA, Aydogan S, Gunes T, Artis AS, Karakukcu M, Kurtoglu S. Changes of red blood cell rheology in newborns with congenital hypothyroidism during treatment. J Matern Neonatal Med. 2013;26(15):1532-1536.
Abstract
Tiroid disfonksiyonları çeşitli fizyolojik süreçleri önemli ölçüde etkilemekte, bu etki kan akışı özelliklerine ve mikrodolaşım sistemine kadar uzanmaktadır. Bu kapsamlı derleme, tiroid bozuklukları ile hemoreoloji arasındaki kompleks ilişkiyi inceleyerek, kan akışı dinamikleri ve doku perfüzyonu üzerindeki önemli etkilerine vurgu yapmaktadır. Hipotiroidi ve hipertiroidi durumlarında kan viskozitesi, eritrosit davranışı ve mikrovasküler dolaşım üzerindeki değişikliklerin incelenmesi, bu durumların patofizyolojisine ilişkin önemli ipuçları sunmaktadır. Ayrıca, tiroid disfonksiyonları ile ilişkilendirilen hemoreolojik değişikliklerin aydınlatılması, klinik yönetim stratejilerinin geliştirilmesi için potansiyel olanaklar sunmaktadır. Bu derleme, mevcut araştırma bulgularını sentezleyerek, tiroidle ilişkili komplikasyonların karmaşıklığını anlamak için hemoreolojik yönlerin dikkate alınmasının önemini vurgulamaktadır ve tiroid disfonksiyonlarına yaklaşımda alternatif bakış açıları sunma potansiyeline sahiptir.
Keywords
hemoreoloji eritrosit deformabilitesi eritrosit agregasyonu hipertiroidi hipotiroidi tiroid disfonksiyonu kan viskozitesi
References
- Katznelson L, Atkinson J, Cook D, Ezzat S, Hamrahian A, Miller K. AACE Guidelines. Endocr Pract. 2011;17(4):1-44.
- Kravets I. Hyperthyroidism: diagnosis and treatment. Am Fam Physician. 2016;93(5):363-370.
- Bahn RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593-646.
- Sari O, Tanoglu A, Aydogan U, et al. Serum visfatin levels before and after levothyroxin treatment in cases with hypothyroidism and subclinical hypothyroidism and their relationships between the lipid levels. Biomed Res. 2012;23(1):55-59.
- Cho Y Il, Cho DJ. Hemorheology and microvascular disorders. Korean Circ J. 2011;41(6):287-295.
- Popel AS, Johnson PC. Microcirculation and hemorheology. Platelets. 2005;37:43-69. doi.org/10.1146/annurev.fluid.37.042604.133933
- Kawa MP, Grymuła K, Paczkowska E, et al. Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies. Eur J Endocrinol. 2010;162(2):295-305.
- Baskurt OK, Meiselman HJ. Blood rheology and hemodynamics. Semin Thromb Hemost. 2003;29(5):435-450.
- Somer T, Meiselman HJ. Disorders of blood viscosity. Ann Med. 1993;25(1):31-39.
- Renoux C, Faivre M, Bessaa A, et al. Impact of surface-area-to-volume ratio, internal viscosity and membrane viscoelasticity on red blood cell deformability measured in isotonic condition. Sci Rep. 2019;9(1):1-7.
- Chasis JA, Mohandas N. Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations. J Cell Biol. 1986;103(2):343-350.
- Kim J, Lee H, Shin S. Advances in the measurement of red blood cell deformability: a brief review. J Cell Biotechnol. 2015;1(1):63-79.
- Tomaiuolo G. Biomechanical properties of red blood cells in health and disease towards microfluidics. Biomicrofluidics. 2014;8(5):1-19. doi.org/10.1063/1.4895755
- Baskurt OK, Meiselman HJ. Erythrocyte aggregation: basic aspects and clinical importance. Clin Hemorheol Microcirc. 2013;53(1–2):23-37.
- Connes P, Dufour S, Pichon A, Favret F. Blood Rheology, Blood Flow, and Human Health. In: Bagchi D, Nair S, Sen CK, eds. Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. 2nd Edition. Elsevier Inc.: 2018: 359-369. doi.org/10.1016/B978-0-12-813922-6.00030-8
- Baskurt OK, Meiselman HJ. Red blood cell “aggregability.” Clin Hemorheol Microcirc. 2009;43(4):353-354.
- Neu B, Meiselman HJ. Depletion-mediated red blood cell aggregation in polymer solutions. Biophys J. 2002;83(5):2482-2490.
- Flormann DAD. Physical charaterization of red blood cell aggregation (Doctoral dissertation, Universität des Saarlandes). 2017.
- Baskurt OK, Boynard M, Cokelet GC, et al. New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc. 2009;42(2):75-97.
- Panagoulis C, Halapas A, Chariatis E, Driva P, Matsakas E. Hyperthyroidism and the heart. Hell J Cardiol. 2008;49(3):169-175.
- Mejia Osuna P, Udovcic M, Sharma MD. Hyperthyroidism and the heart. Methodist Debakey Cardiovasc J. 2017;13(2):60-63.
- Elblbesy MA, Shawki MM. Dependency of whole blood viscosity and plasma viscosity on electrolytes and lipids-an in vitro study. Int J Basic Appl Sci IJBAS-IJENS. 2016;16(03):168003–9494.
- Dörr M, Robinson DM, Wallaschofski H, et al. Brief report: low serum thyrotropin is associated with high plasma fibrinogen. J Clin Endocrinol Metab. 2006;91(2):530-534.
- Shih CH, Chen SL, Yen CC, et al. Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins. Endocrinol. 2004;145(6):2804-2814.
- Erol-Yilmaz A, Atasever B, Mathura K, et al. Cardiac resynchronization improves microcirculation. J Card Fail. 2007;13(2):95-99.
- Elbers PWG, Prins WB, Plokker HWM, Van Dongen EPA, Van Iterson M, Ince C. Electrical cardioversion for atrial fibrillation improves microvascular flow independent of blood pressure changes. J Cardiothorac Vasc Anesth. 2012;26(5):799-803. doi.org/10.1053/j.jvca.2012.04.016
- Vayá A, Giménez C, Sarnago A, et al. Subclinical hypothyroidism and cardiovascular risk. Clin Hemorheol Microcirc. 2014;58(1):1-7.
- Dintenfass L, Forbes CD, McDougall IR. Blood viscosity in hyperthyroid and hypothyroid patients. Pathophysiol Haemost Thromb. 1974;3(5-6):348-352.
- Franchini M. Hemostasis and thyroid diseases revisited. J Endocrinol Invest. 2004;27(9):886-892.
- Akin MA, Aydogan S, Gunes T, Artis AS, Karakukcu M, Kurtoglu S. Changes of red blood cell rheology in newborns with congenital hypothyroidism during treatment. J Matern Neonatal Med. 2013;26(15):1532-1536.
Details
| Primary Language | English |
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| Subjects | Haematology, Medical Physiology (Other) |
| Journal Section | Review [en] Derleme [tr] |
| Authors | |
| Publication Date | December 31, 2023 |
| Submission Date | November 30, 2023 |
| Acceptance Date | December 17, 2023 |
| Published in Issue | Year 2023 Volume: 4 Issue: 6 |
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