Research Article
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Major depresyon hastalarında iskemi modifiye albumin seviyelerinin değerlendirilmesi

Year 2019, Volume: 3 Issue: 8, 557 - 560, 01.08.2019
https://doi.org/10.28982/josam.598200

Abstract

Amaç: Depresyon, önemli bir halk sağlığı sorunudur. Depresyonun antioksidan savunma sistemi ile ilişkisi olduğu bildirilmiştir. İskemi modifiye albümin (IMA), iskemi varlığını değerlendiren yeni bir biyobelirteçtir. Bu çalışmada Major depresif bozukluğu (MDB) olan hastalarda oksidatif stres ile ilgili yeni bir parametre olan IMA düzeylerinin değerlendirilmesi amaçlanmıştır.

Yöntemler: Bu kesitsel vaka-kontrol çalışmasına Haziran 2018-Aralık 2018 tarihleri arasında psikiyatri polikliniğimize başvuran 18-65 yaş arasında, MDB tanısı almış, psikotrop ilaç kullanmayan toplam 59 hasta ve 59 sağlıklı kontrol dahil edildi. Hasta ve kontrol grubundan alınan kan örneklerinde serum İMA ve albumin düzeyleri değerlendirildi. Depresyon seviyesini değerlendirmek için deneklere Hamilton Depresyon Derecelendirme Ölçeği (HDRS) uygulandı.

Bulgular: Depresyonlu hastaların 27'si (% 45,8) erkek, 32'si (% 54,2) kadın, kontrol grubunun 29'u (%49) erkek, 30'u (%51) kadındı. MDD grubunun yaş ortalaması 39,40 (12,20) yıl, kontrol grubununki 38,67 (9,29) yıldı. Hasta grubu ile kontrol grubu arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı fark bulunmadı (sırasıyla P=0,942 ve P=0,714). MDD ve control gruplarının ortalama İMA düzeyleri sırasıyla 0,84 (0,39) ve 0,82 (0,30) olup, aradaki fark istatistiksel olarak anlamlıydı (P<0,001). Ek olarak, iki grubun ortalama albümin seviyeleri arasındaki fark da istatistiksel olarak anlamlı bulundu (P=0,01). Korelasyon analizinde serum IMA düzeyleri ile HDRS skorları arasında pozitif korelasyon tespit edildi (r=0,235, P=0,008).

Sonuç: Çalışmamızda depresyon hastalarının İMA değerlerinin sağlıklı kontrollerden istatistiksel olarak anlamlı biçimde yüksek olduğu tespit edildi. Bu sonuç, depresyonu olan hastalarda artmış oksidatif stresin bir göstergesi olabilir. Literatürde psikiyatrik hastalıklarda İMA düzeylerini değerlendiren nadir veri bulunmaktadır.

References

  • 1. Kessler RC, Demler O, Frank RG, Olfson M, Pincus HA, Walters EE, et al. Prevalence and treatment of mental disorders, 1990 to 2003. New England Journal of Medicine. 2005;352(24):2515-23.
  • 2. Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology. 2011;36(12):2375-94.
  • 3. Sözeri Varma G. Major Depresif Bozuklukta Nöroinflamatuvar Hipotez. Psikiyatride Güncel Yaklaşımlar. 2014;6(1):1-9.
  • 4. Çelik Helvacı F, Hocaoğlu Ç. Major depresif bozukluk tanımı, etyolojisi ve epidemiyolojisi: bir gözden geçirme. Çağdaş Tıp Dergisi. 2016;6(1):51-66.
  • 5. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med. 2011;49(2):177-84.
  • 6. Gulpamuk B, Tekin K, Sonmez K, Inanc M, Neselioglu S, Erel O, Yilmazbas P. The significance of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in patients with different stages of diabetes mellitus. Scandinavian journal of clinical and laboratory investigation. 2018;78(1-2):136-42.
  • 7. Çevik M. U, Yücel Y, Arıkanoğlu A, Varol S, Akıl E, Yüksel H, et al. Multipl sklerozlu hastalarda serum prolidaz ve iskemi modifiye albümin düzeyleri. Journal of Clinical and Experimental Investigations. 2012;3(4):518-20.
  • 8. Ustun Y, Ustun YE, Ozturk O, Alanbay I, Yaman H. Ischemia-modified albumin as an oxidative stress marker in preeclampsia. The Journal of Maternal-Fetal and Neonatal Medicine. 2011;24(3):418–21.
  • 9. Marta MMF, Duarte A, João BT, Rocha AB, Rafael N, Moresco C, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clinical Biochemistry. 2009;42:666-71.
  • 10. Kaefer Michelle K, Sílvia JP, José AM De Carvalho, Dievan B Da Silva, Aline MB, et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clinical Biochemistry. 2010;43:450-4.
  • 11. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia: a preliminary report. J Emerg Med. 2000;19:311–5.
  • 12. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Archiv General Psychiatr. 1988;45:742-7.
  • 13. Akdemir A, Örsel SD, Dağ İ, Türkçapar H, İşcan N, Özbay H. Hamilton depresyon derecelendirme ölçeğinin geçerliliği-güvenilirliği ve klinikte kullanımı. Psikiyatri, Psikoloji ve Psikofarmakoloji Dergisi. 1996;4:251-9.
  • 14. Vavakova M, Durackova Z, Trebaticka J. Markers of oxidative stress and neuroprogression in depression disorder. Oxid Med Cell Longev. 2015;2015:898393.
  • 15. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008;11:851–6.
  • 16. Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:201–17.
  • 17. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446–7.
  • 18. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71:171–86.
  • 19. Lippi G, Montagnana M, Guidi GC. Albumin cobalt binding and ischemia modified albumin generation: an endogenous response to ischemia? International journal of cardiology. 2006;108(3):410-1.
  • 20. Peacock F, Morris DL, Anwaruddin S, Christenson RH, Collinson PO, Goodacre SW, et al. Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department. American heart journal. 2006;152(2):253-62.
  • 21. Dahiya K, Aggarwal K, Seth S, Singh V, Sharma TK. Type 2 diabetes mellitus without vascular complications and ischemia modified albumin. Clin Lab. 2010;56:187-90.
  • 22. Unal K, Topcuoglu C, Cingi Yirun C. Serum ischemia modified albumin (IMA) levels of patients with bipolar disorder in remission and healthy controls. Biomedical Research. 2018; 29(12):2672-5.
  • 23. Tunç S, Atagün Mİ, Neşelioğlu S, Bilgin YY, Başbuğ HS, Erel Ö. Ischemia-modified albumin: a unique marker of global metabolic risk in schizophrenia and mood disorders. Psychiatry and Clinical Psychopharmacology. 2019;29(2):123-9.

Evaluation of ischemia modified albumin levels in major depression patients

Year 2019, Volume: 3 Issue: 8, 557 - 560, 01.08.2019
https://doi.org/10.28982/josam.598200

Abstract

Aim: Depression is an important public health problem, which has been associated with an antioxidant defense system. Ischemia-modified albumin (IMA) is a new biomarker that measures ischemia. The aim of this study was to evaluate IMA levels as a new parameter related to oxidative stress in patients with major depressive disorder (MDD).

Methods: This cross-sectional case-control study included 59 patients aged between 18-65 years who were admitted to our psychiatry outpatient clinic between June 2018-December 2018, diagnosed with MDD and had not used psychotropic drugs for 3 months. In addition, 59 age and sex matched healthy controls were included in the study. Serum IMA and albumin levels were measured in blood samples taken from each patient and from control groups. Hamilton Depression Rating Scale (HDRS) was applied to the subjects to evaluate the depression level. 

Results: Among the MDD group, 27 patients (45.8%) were male and 32 (54.2%) were female. The number of males and females in the control group were 29 (49%) and 30 (51%). Mean ages of the patients in MDD and control groups were 39.40 (12.20) and 38.67 (9.29) years, respectively. No statistically significant difference was found between the groups in terms of age and gender (P=0.942 and P=0.714, respectively). The mean IMA level of MDD and control group patients were 0.84 (0.39) and 0.82 (0.30), respectively; the difference was statistically significant (P<0.001). There was also a statistically significant difference between the albumin levels of the two groups (P=0.01). Correlation analysis showed a positive correlation between serum IMA levels and HDRS scores (r=0.235, P=0.008).

Conclusion: In our study, IMA levels of MDD patients were significantly higher than that of the control group. This result may be an indicator of increased oxidative stress in patients with depression. There is little data in the literature evaluating IMA levels in psychiatric disorders.

References

  • 1. Kessler RC, Demler O, Frank RG, Olfson M, Pincus HA, Walters EE, et al. Prevalence and treatment of mental disorders, 1990 to 2003. New England Journal of Medicine. 2005;352(24):2515-23.
  • 2. Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology. 2011;36(12):2375-94.
  • 3. Sözeri Varma G. Major Depresif Bozuklukta Nöroinflamatuvar Hipotez. Psikiyatride Güncel Yaklaşımlar. 2014;6(1):1-9.
  • 4. Çelik Helvacı F, Hocaoğlu Ç. Major depresif bozukluk tanımı, etyolojisi ve epidemiyolojisi: bir gözden geçirme. Çağdaş Tıp Dergisi. 2016;6(1):51-66.
  • 5. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med. 2011;49(2):177-84.
  • 6. Gulpamuk B, Tekin K, Sonmez K, Inanc M, Neselioglu S, Erel O, Yilmazbas P. The significance of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in patients with different stages of diabetes mellitus. Scandinavian journal of clinical and laboratory investigation. 2018;78(1-2):136-42.
  • 7. Çevik M. U, Yücel Y, Arıkanoğlu A, Varol S, Akıl E, Yüksel H, et al. Multipl sklerozlu hastalarda serum prolidaz ve iskemi modifiye albümin düzeyleri. Journal of Clinical and Experimental Investigations. 2012;3(4):518-20.
  • 8. Ustun Y, Ustun YE, Ozturk O, Alanbay I, Yaman H. Ischemia-modified albumin as an oxidative stress marker in preeclampsia. The Journal of Maternal-Fetal and Neonatal Medicine. 2011;24(3):418–21.
  • 9. Marta MMF, Duarte A, João BT, Rocha AB, Rafael N, Moresco C, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clinical Biochemistry. 2009;42:666-71.
  • 10. Kaefer Michelle K, Sílvia JP, José AM De Carvalho, Dievan B Da Silva, Aline MB, et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clinical Biochemistry. 2010;43:450-4.
  • 11. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia: a preliminary report. J Emerg Med. 2000;19:311–5.
  • 12. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Archiv General Psychiatr. 1988;45:742-7.
  • 13. Akdemir A, Örsel SD, Dağ İ, Türkçapar H, İşcan N, Özbay H. Hamilton depresyon derecelendirme ölçeğinin geçerliliği-güvenilirliği ve klinikte kullanımı. Psikiyatri, Psikoloji ve Psikofarmakoloji Dergisi. 1996;4:251-9.
  • 14. Vavakova M, Durackova Z, Trebaticka J. Markers of oxidative stress and neuroprogression in depression disorder. Oxid Med Cell Longev. 2015;2015:898393.
  • 15. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol. 2008;11:851–6.
  • 16. Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:201–17.
  • 17. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446–7.
  • 18. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71:171–86.
  • 19. Lippi G, Montagnana M, Guidi GC. Albumin cobalt binding and ischemia modified albumin generation: an endogenous response to ischemia? International journal of cardiology. 2006;108(3):410-1.
  • 20. Peacock F, Morris DL, Anwaruddin S, Christenson RH, Collinson PO, Goodacre SW, et al. Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department. American heart journal. 2006;152(2):253-62.
  • 21. Dahiya K, Aggarwal K, Seth S, Singh V, Sharma TK. Type 2 diabetes mellitus without vascular complications and ischemia modified albumin. Clin Lab. 2010;56:187-90.
  • 22. Unal K, Topcuoglu C, Cingi Yirun C. Serum ischemia modified albumin (IMA) levels of patients with bipolar disorder in remission and healthy controls. Biomedical Research. 2018; 29(12):2672-5.
  • 23. Tunç S, Atagün Mİ, Neşelioğlu S, Bilgin YY, Başbuğ HS, Erel Ö. Ischemia-modified albumin: a unique marker of global metabolic risk in schizophrenia and mood disorders. Psychiatry and Clinical Psychopharmacology. 2019;29(2):123-9.
There are 23 citations in total.

Details

Primary Language English
Subjects Psychiatry
Journal Section Research article
Authors

Özgül Karaaslan 0000-0003-0829-5088

Yunus Hacımusalar 0000-0002-1777-2707

Özge Ceren Amuk This is me 0000-0002-1589-3193

Ceylan Bal This is me 0000-0002-1678-1281

Publication Date August 1, 2019
Published in Issue Year 2019 Volume: 3 Issue: 8

Cite

APA Karaaslan, Ö., Hacımusalar, Y., Amuk, Ö. C., Bal, C. (2019). Evaluation of ischemia modified albumin levels in major depression patients. Journal of Surgery and Medicine, 3(8), 557-560. https://doi.org/10.28982/josam.598200
AMA Karaaslan Ö, Hacımusalar Y, Amuk ÖC, Bal C. Evaluation of ischemia modified albumin levels in major depression patients. J Surg Med. August 2019;3(8):557-560. doi:10.28982/josam.598200
Chicago Karaaslan, Özgül, Yunus Hacımusalar, Özge Ceren Amuk, and Ceylan Bal. “Evaluation of Ischemia Modified Albumin Levels in Major Depression Patients”. Journal of Surgery and Medicine 3, no. 8 (August 2019): 557-60. https://doi.org/10.28982/josam.598200.
EndNote Karaaslan Ö, Hacımusalar Y, Amuk ÖC, Bal C (August 1, 2019) Evaluation of ischemia modified albumin levels in major depression patients. Journal of Surgery and Medicine 3 8 557–560.
IEEE Ö. Karaaslan, Y. Hacımusalar, Ö. C. Amuk, and C. Bal, “Evaluation of ischemia modified albumin levels in major depression patients”, J Surg Med, vol. 3, no. 8, pp. 557–560, 2019, doi: 10.28982/josam.598200.
ISNAD Karaaslan, Özgül et al. “Evaluation of Ischemia Modified Albumin Levels in Major Depression Patients”. Journal of Surgery and Medicine 3/8 (August 2019), 557-560. https://doi.org/10.28982/josam.598200.
JAMA Karaaslan Ö, Hacımusalar Y, Amuk ÖC, Bal C. Evaluation of ischemia modified albumin levels in major depression patients. J Surg Med. 2019;3:557–560.
MLA Karaaslan, Özgül et al. “Evaluation of Ischemia Modified Albumin Levels in Major Depression Patients”. Journal of Surgery and Medicine, vol. 3, no. 8, 2019, pp. 557-60, doi:10.28982/josam.598200.
Vancouver Karaaslan Ö, Hacımusalar Y, Amuk ÖC, Bal C. Evaluation of ischemia modified albumin levels in major depression patients. J Surg Med. 2019;3(8):557-60.