Abstract
Giriş: Granülositik sarkom (GS) granülositik prekürsör hücrelerin ekstramedüller yayılımından kaynaklanan lokalize bir tümördür ve literatürde; chloroma, monositik sarkom, myeloid sarkom, myeloblastom, ekstramedüller myeloid hücreli tümör olarak da adlandırılmaktadır. Genellikle kemik, periost, yumuşak doku, lenf nodları veya deride lokalize olur. En yaygın paranazal sinüsler ve orbita etkilenir. GS ayrıca akut miyeloid löseminin nadir bir başlangıç prezentasyonudur.
Olgu: Bu olgumuzda bacak ağrısı ve üst solunum yolu enfeksiyonu bulgularıyla başvuran 2 yaş 10 aylık kız hasta sunulmaktadır. Hastamıza yapılan periferik kandan parmak ucu yaymasında ve kemik iliği aspirasyonunda blast görülmemesi nedeniyle akut miyeloid lösemi (AML) düşünülmeyip gecikerek GS tanısı alan, daha sonra yoğun kemoterapi ile başarılı şekilde tedavisi devam eden bir olgu sunulmaktadır.
Sonuç: Çocuklarda ekstramedüller kitle varlığında ayrıntılı muayene ve görüntüleme yöntemleri ile araştırılmalıdır. Akut lösemi tablosu ihtimali de akılda tutulmalıdır. Bu olgu sunumunda, torasik kostada destrüksiyona neden olan nadir bir granülositik sarkom olgusu sunulmuştur.
References
- Reinhardt D, Creutzig U. Isolated myelosarcoma in children--update and review, Leukemia & lymphoma. 2002;43(3):565-74.
- Atay D, Türkkan E, Terzi Ö, Barış S, Adal SE. Ekstra-ve intrakranial kitleler ile başvuran granülositik sarkom, Okmeydanı Tıp Dergisi. 2012;28(1):45-8.
- Yilmaz AF, Saydam G, Sahin F, Baran Y. Granulocytic sarcoma: a systematic review, American journal of blood research. 2013;3(4):265.
- Binder C, Tiemann M, Haase D, Humpe A, Kneba M. Isolated meningeal chloroma (granulocytic sarcoma)–a case report and review of the literature, Annals of hematology. 2000;79:459-62.
- Ceren E, Gökdemir G, Yıldırmak ZY, Köşlü A. Akut lösemili çocuklarda sık görülen deri bulguları, Şişli Etfal Tıp Bülteni. 2010;44(3):100-5.
- Byrd JC, Edenfield WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review, Journal of Clinical Oncology. 1995;13(7):1800-16.
- Reinhardt D, Pekrun A, Lakomek M, Zimmermann M, Ritter J, Creutzig U. Primary myelosarcomas are associated with a high rate of relapse: report on 34 children from the acute myeloid leukaemia–Berlin–Frankfurt–Münster studies, British journal of haematology. 2000;110(4):863-6.
- Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases, Cancer. 1981;48(6):1426-37.
- Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature, Leukemia & lymphoma. 2006;47(12):2527-41.
- Byrd JC, Weiss RB, Arthur DC, Lawrence D, Baer MR, Davey F, et al. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t (8; 21)(q22; q22): results from Cancer and Leukemia Group B 8461, Journal of Clinical Oncology. 1997;15(2):466-75.
- Dusenbery KE, Howells WB, Arthur DC, Alonzo T, Lee JW, Kobrinsky N, et al. Extramedullary leukemia in children with newly diagnosed acute myeloid leukemia: a report from the Children's Cancer Group, Journal of pediatric hematology/oncology. 2003;25(10):760-8.
Abstract
Introduction: Granulocytic sarcoma (GS) is a localized tumor arising from extramedullary invasion of granulocytic precursor cells and is also called chloroma, monocytic sarcoma, myeloid sarcoma, myeloblastoma, extramedullary myeloid cell tumor in the literature. It is usually localized in bone, periosteum, soft tissue, lymph nodes or skin. The paranasal sinuses and orbit are most commonly affected.GS is also a rare initial presentation of acute myeloid leukemia.
Case report: In this case, we report a 2 years and 10 months old female patient who presented with leg pain and upper respiratory tract infection. Because of the absence of blasts in the peripheral blood fingertip smear and bone marrow aspiration, AML was not considered and GS was diagnosed with a delayed delay, which was then successfully treated with intensive chemotherapy.
Conclusion: In the presence of extramedullary mass in children, should be investigated with detailed examination and imaging methods. The possibility of acute leukemia should also be kept in mind. In this case report, we present a rare case of granulocytic sarcoma causing destriction of the thoracic costa.
References
- Reinhardt D, Creutzig U. Isolated myelosarcoma in children--update and review, Leukemia & lymphoma. 2002;43(3):565-74.
- Atay D, Türkkan E, Terzi Ö, Barış S, Adal SE. Ekstra-ve intrakranial kitleler ile başvuran granülositik sarkom, Okmeydanı Tıp Dergisi. 2012;28(1):45-8.
- Yilmaz AF, Saydam G, Sahin F, Baran Y. Granulocytic sarcoma: a systematic review, American journal of blood research. 2013;3(4):265.
- Binder C, Tiemann M, Haase D, Humpe A, Kneba M. Isolated meningeal chloroma (granulocytic sarcoma)–a case report and review of the literature, Annals of hematology. 2000;79:459-62.
- Ceren E, Gökdemir G, Yıldırmak ZY, Köşlü A. Akut lösemili çocuklarda sık görülen deri bulguları, Şişli Etfal Tıp Bülteni. 2010;44(3):100-5.
- Byrd JC, Edenfield WJ, Shields DJ, Dawson NA. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review, Journal of Clinical Oncology. 1995;13(7):1800-16.
- Reinhardt D, Pekrun A, Lakomek M, Zimmermann M, Ritter J, Creutzig U. Primary myelosarcomas are associated with a high rate of relapse: report on 34 children from the acute myeloid leukaemia–Berlin–Frankfurt–Münster studies, British journal of haematology. 2000;110(4):863-6.
- Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases, Cancer. 1981;48(6):1426-37.
- Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature, Leukemia & lymphoma. 2006;47(12):2527-41.
- Byrd JC, Weiss RB, Arthur DC, Lawrence D, Baer MR, Davey F, et al. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t (8; 21)(q22; q22): results from Cancer and Leukemia Group B 8461, Journal of Clinical Oncology. 1997;15(2):466-75.
- Dusenbery KE, Howells WB, Arthur DC, Alonzo T, Lee JW, Kobrinsky N, et al. Extramedullary leukemia in children with newly diagnosed acute myeloid leukemia: a report from the Children's Cancer Group, Journal of pediatric hematology/oncology. 2003;25(10):760-8.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Oncologic Surgery |
| Journal Section | Book Reviews |
| Authors | |
| Publication Date | December 30, 2023 |
| Submission Date | October 12, 2023 |
| Acceptance Date | November 2, 2023 |
| Published in Issue | Year 2023 Volume: 2 Issue: 3 |
