Research Article
Year 2020,
Volume: 12 Issue: 1, 131 - 136, 02.03.2020
Abstract
References
- REFERENCES 1. Attard JA, MacLean AR. Adhesive small bowel obstruction: epidemiology, biology and prevention. Can J Surg. 2007;50:291–300. 2. Wilson MS, Hawkswell J, McCloy RF. Natural history of adhesional small bowel obstruction: counting the cost. Br J Surg 1998; 85: 1294–1298. 3. K. Erol, Adhesiv Ince Bağırsak Obstrüksiyonlarının Görülme Sıklıgı Van Tıp Dergisi: 2004,11 (1):13–16 4. Beck DE, Cohen Z, Fleshman JW, et al. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum 2003;46:1310-9. 5. Gago LA, Saed GM, Chauhan S, Elhammady EF, Diamond MP: Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier. Fertil Steril 2003, 80:612-616. 6. Bahar Uslu, Serap Arbak, Doku Mühendisliğinde Kitozanın Kullanım AlanlarıAcıbadem Üniversitesi Sağlık Bilimleri Dergisi Temmuz 2010 Cilt: 1 Sayı: 3 Sayfa: 129 7. Sahin M, Çakir M, Avsar FM, Tekin A, Küçükkartallar T, Aköz M. Comparıson of antı-adhesıon materıals ın preventıng postsurgıcal adhesıon ın abdomınal cavıty Selçuk Tıp Dergisi 2007:23:4:189–195 8. Tokmak H, Tibet HB, Balkanli M, Oner K, Aydin R. The synergıstıc effects of vıtamın e on the preventıon of postoperatıve adhesıons. Turk J Surg 1995,11:3 162–167 9. Gunal 0, Ghandour s, Deniz M, Aslaner A. Intestinal blood flow alterations in postoperative intraabdominal adhesion formation and the role of Endothelin-1 blockade. Ulus Travma Acil Cerrahi Derg. 2006; 12(2): 101-106. 10. Cheung Et Al. Adjuvant Therapy For The Reduction Of Postoperative Intra-Abdominal Adhesion Formation. Asian J Surg 2009;32(3):180–6 11. Dörthe Brüggmann Et Al. Intra-Abdominal Adhesi Deutsches Ärzteblatt International | Dtsch Arztebl Int 2010; 107(44): 769–75 12. Cheng-Chung Fang Et Al. Peritoneal Infusion With Cold Saline Decreased Postoperative IntraAbdominal Adhesion Formation. World J Surg (2010) 34. 721–727 13. B. W. J. Hellebrekers Et Al. Effects Of Five Different Barrier Materials On Postsurgical Adhesion Formation Ġn The Rat. European Society Of Human Reproduction And Embryology. Vol. 15 No. 6 Pp. 1358–1363, 2007 14. Oktay I E Tal. Reduction Of Surgıcal Adhesions Ġn A Rat Model: A Comparative Study. Clinics 2009; 64 (2);143–8 15. Corrales F Et Al. Preventing Ġntraperitoneal Adhesions With Vitamin E And Sodium Hyaluronate/ Carboxymethylcellulose. A Comparative Study Ġn Rats. Acta Cirúrgica Brasileira - 2008: Vol 23 (1);36-41 16. Chris I. Use Of A Modified Chitosanedextran Gel To Prevent Peritoneal Adhesions Ġn A Rat Model. Journal Of Surgical Research, 1e6 (2010) Doi:10. 1016/J. Jss. 2010. 06. 28 17. Zhou XL Et Al. Preventive Effect Of Gelatinizedly-Modified Chitosan Film On Peritoneal Adhesion Of Different Types. World J Gastroenterol 2007 February 28; 13(8): 1262–1267 18. Şahin M, Çakır M. Ameliyat Sonrası Karın İci Yapışıklıkların Onlenmesinde Chıtın’in Etkinliğinin Diğer Adezyon Bariyerleri İle Karşılaştırılması. Selçuk Tıp Derg 2007; 24: Cilt: 23 Sayı: 4 Sayfa: 189–195 19. De La Portılla Et Al. Prevention Of Peritoneal Adhesions By Intraperitoneal Administration Of Vitamin E: An Experimental Study Ġn Rats. Dis Colon Rectum, 2004; December Vol. 47, No. 12;2157– 2161
Year 2020,
Volume: 12 Issue: 1, 131 - 136, 02.03.2020
Abstract
Objective: We aimed to evaluate and compare the effects of anti-adhesion materials, Seprafilm, Suprofilm, olive oil, and olive oil containing Vitamin E by measuring tension forces.
Method: 60 male Wistar-Albino rats were divided into six groups. The front side of the cecum and right abdominal parietal peritoneal wall were abrased. The rats were euthanized on the 14th postoperative day. Adhesions between intestines, omentum, other abdominal organs, cecum, incisionsites, and abdominal anterior wall peritoneum were all evaluated. Adhesion strength was measured with dynamometer. Histopathological evaluations of the adhesion area was performed.
Results: Stage-I (0.43Newton) in Group-I, stage-IV (1.0540N) in Group-II, stage-II (0.6370N) in Group-III, stage-II in Group-IV (0, 5230N), stage-III (0.7620N) in Group-V, stage-IV (1.3560N) in Group-VI, were detected. A significant difference was found between these findings. P = 0.001, (p <0.05). Histopathological examination: It was found that GroupV-VI reduced inflammation, increased collagen production, fibroblastic activity and vascular proliferation.
Conclusion: More objective evaluation can be made by measuring the tension force of the adhesions. Suprafilm can also be effectively used as an antiadhesive, such as Seprafilm. Olive oil and vitamin E require more studies to be used as antiadhesives.
Keywords
References
- REFERENCES 1. Attard JA, MacLean AR. Adhesive small bowel obstruction: epidemiology, biology and prevention. Can J Surg. 2007;50:291–300. 2. Wilson MS, Hawkswell J, McCloy RF. Natural history of adhesional small bowel obstruction: counting the cost. Br J Surg 1998; 85: 1294–1298. 3. K. Erol, Adhesiv Ince Bağırsak Obstrüksiyonlarının Görülme Sıklıgı Van Tıp Dergisi: 2004,11 (1):13–16 4. Beck DE, Cohen Z, Fleshman JW, et al. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum 2003;46:1310-9. 5. Gago LA, Saed GM, Chauhan S, Elhammady EF, Diamond MP: Seprafilm (modified hyaluronic acid and carboxymethylcellulose) acts as a physical barrier. Fertil Steril 2003, 80:612-616. 6. Bahar Uslu, Serap Arbak, Doku Mühendisliğinde Kitozanın Kullanım AlanlarıAcıbadem Üniversitesi Sağlık Bilimleri Dergisi Temmuz 2010 Cilt: 1 Sayı: 3 Sayfa: 129 7. Sahin M, Çakir M, Avsar FM, Tekin A, Küçükkartallar T, Aköz M. Comparıson of antı-adhesıon materıals ın preventıng postsurgıcal adhesıon ın abdomınal cavıty Selçuk Tıp Dergisi 2007:23:4:189–195 8. Tokmak H, Tibet HB, Balkanli M, Oner K, Aydin R. The synergıstıc effects of vıtamın e on the preventıon of postoperatıve adhesıons. Turk J Surg 1995,11:3 162–167 9. Gunal 0, Ghandour s, Deniz M, Aslaner A. Intestinal blood flow alterations in postoperative intraabdominal adhesion formation and the role of Endothelin-1 blockade. Ulus Travma Acil Cerrahi Derg. 2006; 12(2): 101-106. 10. Cheung Et Al. Adjuvant Therapy For The Reduction Of Postoperative Intra-Abdominal Adhesion Formation. Asian J Surg 2009;32(3):180–6 11. Dörthe Brüggmann Et Al. Intra-Abdominal Adhesi Deutsches Ärzteblatt International | Dtsch Arztebl Int 2010; 107(44): 769–75 12. Cheng-Chung Fang Et Al. Peritoneal Infusion With Cold Saline Decreased Postoperative IntraAbdominal Adhesion Formation. World J Surg (2010) 34. 721–727 13. B. W. J. Hellebrekers Et Al. Effects Of Five Different Barrier Materials On Postsurgical Adhesion Formation Ġn The Rat. European Society Of Human Reproduction And Embryology. Vol. 15 No. 6 Pp. 1358–1363, 2007 14. Oktay I E Tal. Reduction Of Surgıcal Adhesions Ġn A Rat Model: A Comparative Study. Clinics 2009; 64 (2);143–8 15. Corrales F Et Al. Preventing Ġntraperitoneal Adhesions With Vitamin E And Sodium Hyaluronate/ Carboxymethylcellulose. A Comparative Study Ġn Rats. Acta Cirúrgica Brasileira - 2008: Vol 23 (1);36-41 16. Chris I. Use Of A Modified Chitosanedextran Gel To Prevent Peritoneal Adhesions Ġn A Rat Model. Journal Of Surgical Research, 1e6 (2010) Doi:10. 1016/J. Jss. 2010. 06. 28 17. Zhou XL Et Al. Preventive Effect Of Gelatinizedly-Modified Chitosan Film On Peritoneal Adhesion Of Different Types. World J Gastroenterol 2007 February 28; 13(8): 1262–1267 18. Şahin M, Çakır M. Ameliyat Sonrası Karın İci Yapışıklıkların Onlenmesinde Chıtın’in Etkinliğinin Diğer Adezyon Bariyerleri İle Karşılaştırılması. Selçuk Tıp Derg 2007; 24: Cilt: 23 Sayı: 4 Sayfa: 189–195 19. De La Portılla Et Al. Prevention Of Peritoneal Adhesions By Intraperitoneal Administration Of Vitamin E: An Experimental Study Ġn Rats. Dis Colon Rectum, 2004; December Vol. 47, No. 12;2157– 2161
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Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | March 2, 2020 |
| Acceptance Date | February 17, 2020 |
| Published in Issue | Year 2020 Volume: 12 Issue: 1 |