Abstract
Objective
Helicobacter pylori (H. pylori) is a gram-negative bacterium. It is urease positive, mobile, microaerophilic, and spiral-shaped, and it settles in the stomach and the proximal duodenum. It is associated with chronic gastritis, stomach ulcers, duodenal ulcers, stomach cancer, and MALT lymphoma. It can also cause premalignant lesions, such as metaplasia and gastric atrophy. Although several studies are investigating the correlation between H. pylori and hyperplastic polyps (HPs) of the stomach, uncertainty in this regard continues.
Methods
Data from 5378 patients who underwent esophagogastroduodenoscopy at the Department of Gastroenterology, Gülhane Training and Research Hospital,
University Of Health Sciences between October 2016 and March 2019 were retrospectively analyzed, and patients with gastric polyps were evaluated for polyp pathologies and normal mucosa biopsies.
Results
Sixty-one stomach polyps were detected in 49 patients after the retrospective analysis of the data between October 2016 and March 2019. Of the polyps found, 36 were hyperplastic (73%). There was no statistically significant difference between HPs and the presence of H. pylori, age, gender, anatomical location of polyps in the stomach, size, number, presence of metaplasia, or atrophy. The mean age was statistically lower in H. pylori-positive cases.
Conclusions
No correlation was observed between HPs and the presence of H. pylori. There is a need for more extensive, multi-centered, and prospective studies evaluating the relationship between HPs and H. pylori.
Keywords
References
- Referans 1. Marshall BJ, Warren JR. Unindentified curved bacilli in the stomach of patients witch gastritis and peptic ulceration. Lancet 1984;1:1311-5.
- Referans 2. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-86.
- Referans 3. Oluwasola AO, Ola SO, Saliu L, Solanke TF. Helicobacter pylori infection in South Nigerians: a serological study of dyspeptic patients and healthy individuals. West Afr J Med 2002;21:138-41.
- Referans 4. Singh M, Prasad KN, Yachha SK, Saxena A, Krishnani N. Helicobacter pylori infection in children: prevalence, diagnosis and treatment outcome. Trans R Soc Trop Med Hyg 2006;100:227-33.
- Referans 5. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013;13:1215.
- Referans 6. Peterson WL. Helicobacter pylori and peptic ulcer disease. N Engl J Med 1991;324:1043-8.
- Referans 7. Peterson WL. Review article: Helicobacter pylori and gastric adenocarcinoma. Aliment Pharmacol Ther 2002;16:40-6.
- Referans 8. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N,et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991;325:1127-31.
- Referans 9. Hansson LE, Engstrand L, Nyren O, Evans DJ Jr, Lindgren A, Bergström R et al. Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. Gastroenterology 1993;105:1098-103.
- Referans 10. Kimura N, Ariga M, Icatlo FC Jr, Kuroki M, Ohsugi M, Ikemori Y et al. A euthymic hairless mouse model of Helicobacter pylori colonization and adherence to gastric epithelial cells in vivo. Clin Diagn Lab Immunol 1998;5:578-82.
- Referans 11. Rugge M, Capelle LG, Cappellesso R, Nitti D, Kuipers EJ. Precancerous lesions in the stomach: from biology to clinical patient management. Best Pract Res Clin Gastroenterol 2013;27:205-23.
- Referans 12. de Vries AC, van Grieken NC, Looman CW, Casparie MK, de Vries E, Meijer GA et al. Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands. Gastroenterology 2008;134:945-52.
- Referans 13. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA. Gastric polyps:a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol 2007;44:14-7.
- Referans 14. Carmack SW, Genta RM, Schuler CM, Saboorian MH. The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am J Gastroenterol 2009;104:1524-32.
- Referans 15. Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Avsar E, Sav A, Tozun N. Gastric polypoid lesions: analysis of 150 endoscopic polypectomy specimens from 91 patients. World J Gastroenterol 2003;9:2236-9.
- Referans16. Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS. Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial. Dig Dis Sci 2020 doi: 10.1007/s10620-020-06065-0. [Epub ahead of print]
- Referans 17. Horvath B, Pai RK. Prevalence of Helicobacter pylori in Gastric Hyperplastic Polyps. Int J Surg Pathol 2016;24:704-8.
- Referans 18. Elhanafi S, Saadi M, Lou W, Mallawaarachchi I, Dwivedi A, Zuckerman M et al. Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study. World J Gastrointest Endosc 2015;7:995-1002.
- Referans 19. Ljubicić N, Banić M, Kujundzić M, Antić Z, Vrkljan M, Kovacević I et al. The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps. Eur J Gastroenterol Hepatol 1999;11:727-30.
- Referans 20. Dirschmid K, Platz-Baudin C, Stolte M. Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa? Virchows Arch 2006;448:80-4.
Abstract
Amaç
Helikobakter pilori (H. pilori), gram-negatif bakteridir. Üreaz pozitif, hareketli, mikroaerofilik, spiral şekilli olup mide ve proksimal duodenuma yerleşmektedir. Kronik gastrit, mide ülseri, duodenum ülseri, mide kanseri ve MALT Lenfoma gibi hastalıklarla ilişkilidir. Ayrıca metaplazi, gastrik atrofi gibi premalign lezyonlara neden olabilir. H. pilori ile midenin hiperplastik polipleri (HP) arasındaki ilişkiyi araştıran çalışmalar olmasına rağmen bu konudaki belirsizlik sürmektedir.
Gereç ve Yöntem
Sağlık Bilimleri Üniversitesi Gülhane Eğitim ve Araştırma Hastanesi Gastroenteroloji Kliniği Endoskopi Ünitesinde Ekim 2016 - Mart 2019 tarihleri arasında özofagogastroduodenoskopi yapılan 5378 hastanın verileri retrospektif olarak analiz edildi ve mide polibi saptanan olguların polip patolojileri ve normal mukoza biyopsileri değerlendirildi.
Bulgular
Ekim 2016 - Mart 2019 arasında verilerin retrospektif taramasında 49 hastada 61 adet mide polibi saptandı. Poliplerin 36’sı (%73) hiperplastik polipti. HP ile H. pilori varlığı, yaş, cinsiyet, polibin midedeki anatomik lokalizasyonu, boyutu, sayısı, metaplazi ve atrofi varlığı açısından istatistiksel olarak anlamlı fark gözlenmedi. H. pilori pozitif olgularda ortalama yaş ise istatistiksel olarak anlamlı şekilde daha düşük bulundu.
Sonuç
Sonuç olarak; hiperplastik polipler ile H. pilori varlığı arasında korelasyon gözlenmedi. HP ile H. pilori arasındaki ilişkiyi değerlendiren daha büyük sayıda, çok merkezli, prospektif çalışmalara ihtiyaç vardır.
Keywords
References
- Referans 1. Marshall BJ, Warren JR. Unindentified curved bacilli in the stomach of patients witch gastritis and peptic ulceration. Lancet 1984;1:1311-5.
- Referans 2. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-86.
- Referans 3. Oluwasola AO, Ola SO, Saliu L, Solanke TF. Helicobacter pylori infection in South Nigerians: a serological study of dyspeptic patients and healthy individuals. West Afr J Med 2002;21:138-41.
- Referans 4. Singh M, Prasad KN, Yachha SK, Saxena A, Krishnani N. Helicobacter pylori infection in children: prevalence, diagnosis and treatment outcome. Trans R Soc Trop Med Hyg 2006;100:227-33.
- Referans 5. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013;13:1215.
- Referans 6. Peterson WL. Helicobacter pylori and peptic ulcer disease. N Engl J Med 1991;324:1043-8.
- Referans 7. Peterson WL. Review article: Helicobacter pylori and gastric adenocarcinoma. Aliment Pharmacol Ther 2002;16:40-6.
- Referans 8. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N,et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991;325:1127-31.
- Referans 9. Hansson LE, Engstrand L, Nyren O, Evans DJ Jr, Lindgren A, Bergström R et al. Helicobacter pylori infection: independent risk indicator of gastric adenocarcinoma. Gastroenterology 1993;105:1098-103.
- Referans 10. Kimura N, Ariga M, Icatlo FC Jr, Kuroki M, Ohsugi M, Ikemori Y et al. A euthymic hairless mouse model of Helicobacter pylori colonization and adherence to gastric epithelial cells in vivo. Clin Diagn Lab Immunol 1998;5:578-82.
- Referans 11. Rugge M, Capelle LG, Cappellesso R, Nitti D, Kuipers EJ. Precancerous lesions in the stomach: from biology to clinical patient management. Best Pract Res Clin Gastroenterol 2013;27:205-23.
- Referans 12. de Vries AC, van Grieken NC, Looman CW, Casparie MK, de Vries E, Meijer GA et al. Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands. Gastroenterology 2008;134:945-52.
- Referans 13. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA. Gastric polyps:a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol 2007;44:14-7.
- Referans 14. Carmack SW, Genta RM, Schuler CM, Saboorian MH. The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am J Gastroenterol 2009;104:1524-32.
- Referans 15. Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Avsar E, Sav A, Tozun N. Gastric polypoid lesions: analysis of 150 endoscopic polypectomy specimens from 91 patients. World J Gastroenterol 2003;9:2236-9.
- Referans16. Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS. Helicobacter pylori Eradication Regressed Gastric Hyperplastic Polyp: A Randomized Controlled Trial. Dig Dis Sci 2020 doi: 10.1007/s10620-020-06065-0. [Epub ahead of print]
- Referans 17. Horvath B, Pai RK. Prevalence of Helicobacter pylori in Gastric Hyperplastic Polyps. Int J Surg Pathol 2016;24:704-8.
- Referans 18. Elhanafi S, Saadi M, Lou W, Mallawaarachchi I, Dwivedi A, Zuckerman M et al. Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study. World J Gastrointest Endosc 2015;7:995-1002.
- Referans 19. Ljubicić N, Banić M, Kujundzić M, Antić Z, Vrkljan M, Kovacević I et al. The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps. Eur J Gastroenterol Hepatol 1999;11:727-30.
- Referans 20. Dirschmid K, Platz-Baudin C, Stolte M. Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa? Virchows Arch 2006;448:80-4.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 7, 2021 |
| Acceptance Date | April 18, 2021 |
| Published in Issue | Year 2021 Volume: 13 Issue: 2 |
