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Ailesel Akdeniz Ateşi (AAA) Hastalarında Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) ve B Cell Chemoattractant Chemokine Ligand 13(CXCL 13) Genlerinin Ekpresyon Düzeylerinin İncelenmesi

Year 2023, Volume: 15 Issue: 1, 59 - 68, 15.03.2023
https://doi.org/10.18521/ktd.1162175

Abstract

Amaç: Bu çalışma genetik analizi Düzce Üniversitesi Araştırma ve Uygulama Hastanesi'nde yapılan ve Tell-Hashomer Kriterleri’ne göre Ailesel Akdeniz Ateşi tanısı konan hastalarda ASC (Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) ve CXCL 13(B Cell Chemoatractant Chemokine Ligand 13) genlerinin ekspresyon düzeylerini sağlıklı kontroller ile karşılaştırmak ve AAA'daki klinik önemini belirlemek amacıyla yapılmıştır.
Metod: Çalışmaya 36 hasta (20 kız, 16 erkek) ve 12 sağlıklı kontrol (7 kız, 5 erkek) dahil edildi. Her bireyin periferik kanından RNA izole edildi ve ASC, TL-1a ve CXCL 13 genlerinin ekspresyon seviyeleri belirlendi. Rutin biyokimyasal parametreler de belirlendi.
Bulgular: AAA hastalarında CXCL 13 ve TL-1a gen ekspresyon seviyeleri anlamlı olarak artarken, ASC geninin ekspresyon seviyesinin arttığı ancak anlamlı olmadığı bulundu.
Sonuç: Bu genlerin ekspresyon düzeyleri hastalığın patogenezi ile ilişkili olabilir ve bu genler hastalığın erken tanısında bir belirteç olarak kullanılabilir.

Supporting Institution

Düzce Üniversitesi Bilimsel Araştırma Projeleri

Project Number

2016.04.03.471

Thanks

Düzce Üniversitesi

References

  • Referans1. Dundar M, Fahrioglu U, Yildiz SH, Bakir-Gungor B, Temel SG, Akin H et al; National Genetics Consortium Study. Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium. Funct Integr Genomics. 2022; 22(3): 291-315.
  • Referans2. French FMF Consortium. A Candidate Gene For Familial Mediterranean Fever. Nat Genet. 1997; 17: 25-31./ The International FMF Consortium. Ancient Missense Mutations in a New Member of the RoRet Gene Family are Likely to Cause Familial Mediterranean Fever. Cell 1997; 90: 97–807.
  • Referans3. https://www.ncbi.nlm.nih.gov/gene/29108
  • Referans4. https://www.ncbi.nlm.nih.gov/gene/9966
  • Referans5. http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?db=gene&cmd=Retrieve&dopt= full_report &list_uids=10563
  • Referans6. Beştaş A, Bolu S, Unal E, Aktar Karakaya A, Eröz R, Tekin M, Haspolat YK. A rare cause of delayed puberty and primary amenorrhea: 17α-hydroxylase enzyme deficiency. Endocrine. 2022; 75(3): 927-933.
  • Referans7. Doğan M, Eröz R, Tecellioğlu M, Gezdirici A, Çevik B, Barış I. Clinical and Molecular Findings in a Turkish Family Who Had a (c.869- 1G>A) Splicing Variant in PSEN1 Gene with A Rare Condition: The Variant Alzheimer's Disease with Spastic Paraparesis. Curr Alzheimer Res. 2022; 19(3): 223-35.
  • Referans8. Doğan M, Eröz R, Bolu S, Yüce H, Gezdirici A, Arslanoğlu İ, Teralı K. Study of ten causal genes in Turkish patients with clinically suspected maturity-onset diabetes of the young (MODY) using a targeted next-generation sequencing panel. Mol Biol Rep. 2022; 49(8): 7483-95.
  • Referans9. Türay S, Eröz R. White-Sutton syndrome with hot water epilepsy and coexistence of SHOX gene variations. Acta Neurol Belg. 2021; 121(3): 749-55.
  • Referans10. Dogan M, Teralı K, Eroz R, Demirci H, Kocabay K. Clinical and molecular findings in a Turkish family with an ultra-rare condition, ELP2-related neurodevelopmental disorder. Mol Biol Rep. 2021; 48(1): 701-8.
  • Referans11. Doğan M, Eröz R, Öztürk E. Chorioretinal dystrophy, hypogonadotropic hypogonadism, and cerebellar ataxia: Boucher-Neuhauser syndrome due to a homozygous (c.3524C>G (p.Ser1175Cys)) variant in PNPLA6 gene. Ophthalmic Genet. 2021; 42(3): 276-282.
  • Referans12. Doğan M, Eröz R, Terali K, Gezdirici A, Bolu S. Clinical, radiological and computational studies on two novel GNPTG variants causing mucolipidosis III gamma phenotypes with varying severity. Mol Biol Rep. 2021; 48(2): 1465-74.
  • Referans13. Türay S, Eröz R, Başak AN. A novel pathogenic variant in the 3' end of the AGTPBP1 gene gives rise to neurodegeneration without cerebellar atrophy: an expansion of the disease phenotype? Neurogenetics. 2021; 22(2): 127-32.
  • Referans14. Gezdirici A, Teralı K, Gülec EY, Bornaun H, Dogan M, Eröz R. An integrated clinical and molecular study of a cohort of Turkish patients with Marfan syndrome harboring known and novel FBN1 variants. J Hum Genet. 2021; 66(7): 647-57.
  • Referans15. Bolu S, Eroz R, Dogan M, Arslanoglu I, Dundar I. Genotype-Phenotype Characteristics of Turkish Children With Glucokinase Mutations Associated Maturity-Onset Diabetes of the Young. Indian Pediatr. 2020; 57(11): 1037-39.
  • Referans16. Karagün E, Eroz R, Gamsızkan M, Baysak S, Eyup Y, Ozcan Y. Novel mutation identified in the DDB2 gene in patients with xeroderma pigmentosum group-E. Int J Dermatol. 2020; 59(8): 989-96.
  • Referans17. Eroz R, Damar İH, Kılıçaslan O. Thrombosis risk of Alport syndrome patients: evaluation of cardiological, clinical, biochemical, genetic and possible causes of inherited thrombophilia and identification of a novel COL4A3 variant. Blood Coagul Fibrinolysis. 2020; 31(4): 264-69.
  • Referans18. Bolu S, Eröz R, Tekin M, Doğan M. Atypical presentation in patients with 17 α-hydroxylase deficiency caused by a deletion in the CYP17A1 gene: short stature. Turk J Pediatr. 2020; 62(5): 851-7.
  • Referans19. Bolu S, Eröz R, Doğan M, Arslanoğlu İ, Uzun H, Timur F. A family with novel homozygous deletion mutation (c.1255delT; p.Phe419Serfs*12) in the glucokinase gene, which is a rare cause of permanent neonatal diabetes mellitus. Turk Pediatri Ars. 2020; 55(4): 434-7.
  • Referans20. Damar IH, Eroz R. Evaluation of Cases with Myotonia Congenita for Cardiovascular Risk. Medeni Med J. 2019; 34(4): 374-9.
  • Referans21. Okur M, Eroz R, Bektas MS, Gulsen S, Bahadir A, Turker Y, Gunes C. The Relationship between congenital heart defects and e-NOS gene ın down syndrome. Genet Couns. 2016; 27(3): 285-93.
  • Referans22. Soysal Z, Okur M, Eroz R, Gun E, Kocabay K, Besir FH. Megalencephalıc leukoencephalopathy wıth subcortıcal cysts wıth homozygous mutatıon (C.448DELC, P.LEU150 SER FSX11) on exon 6 of MLC1 gene. Genet Couns. 2015; 26(2): 233-6.
  • Referans23. Karatas A, Eroz R, Bahadır A, Keskin F, Ozlu T, Ozyalvaclı ME. Endothelial nitric oxide synthase gene polymorphisms (promoter -786T/C, exon 894 G/T and intron G10T) in unexplained female infertility. Gynecol Obstet Invest. 2014; 77(2): 89-93.
  • Referans24. Okur M, Eroz R, Mundlos S, Senses DA, Ulgen E, Ismailler ZB, Ozcelik D. EEC syndrome with a de novo mutation (c.953g > a) on exon 7 of P63 gene: a case report. Genet Couns. 2012; 23(4): 483-5.
  • Referans25. Yildiz Gulhan P, Eroz R, Ataoglu O, İnce N, Davran F, Öztürk CE, Gamsızkan Z, Balbay OA. The evaluation of both the expression and serum protein levels of Caspase-3 gene in patients with different degrees of SARS-CoV2 infection. J Med Virol. 2022; 94(3): 897-905. Referans26. Tasdemir S, Eroz R, Dogan H, Erdem HB, Sahin I, Kara M, Engin RI, Turkez H. Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes. Genet Test Mol Biomarkers. 2016; 20(4): 197-202.
  • Referans27. A Novel Deletion Mutation 334-335 DelG (P.Glu112fs, C.334-335delg) Identified In Exon 2 Of The MEFV Gene Associated With Familial Mediterranean Fever. Congress abstract, 14. Ulusal Tıbbi Biyoloji ve Genetik Kongresi 27–30 Ekim 2015; Ölüdeniz /Fethiye.
  • Referans28. Eroz R, Dogan M, Kocabay K. A Novel Mutation K447M (P.LYS447MET, C.1340 A>T) Identıfıed ın Exon 4 of the MEFV Gene. Genetıc Counselıng, Vol. 27, No 4, 2016, pp 525-8.
  • Referans29. Eroz R, Dogan M, Yuce H, Kocabay K, Yuksel E. A Turkish Family with A89T (p. Ala89Thr, c.265G>A) Mutation on The MEFV Gene, Their Clinical Findings and Review of The Literature. F.Ü.Sağ.Bil.Tıp Derg. 2016; 30(2): 67-70.
  • Referans 30. Eroz R, Yuce H, Koksal M. A family with rare E167D mutation from Turkey with a total of four members clinically diagnosed as FMF International Participated Erciyes Medical Genetics Days 2019 21–23 February 2019, Erciyes University, Kayseri, Turkey.
  • Referans31. Eroz R, Dogan M, Yuce H, Ozmerdivenli R. A Family From Turkey With 761_764dupCCGC p.Asn256Argfs70,c.761_764dupCCGC MEFV Gene Mutation, Their Clinical Features and Review of The Literature. Konuralp Tıp Dergisi 2016; 8(3): 214-7.
  • Referans32. Dogan M, Eroz R, Yuce H, Kocabay K, Gun E, Ozmerdivenli R. MEFV Geninde S288Y (P.SER863TYR, C.863 C>A) Mutasyonu ve Kliniğinin Araştırılması. Düzce Tıp Fakültesi Dergisi 2016; 18(2): 66-8.
  • Referans33. Eroz R, Dogan M, Bolu S, Yuce H. A Seven Years Old Girl with Klippel-Feil Syndrome, Bilateral Sprengel Deformity, Congenital Unilateral Renal Agenesis and A Heterozygous Mutation M680I(G>C) in The MEFV Gene. Konuralp Tıp Dergisi 2017; 9(2): 90-3.
  • Referans34. Damar IH, Eroz R. Do all Familial Mediterranean Fever (FMF) patients with recurrent chest pain have cardiac problems? Kuwait Medical Journal 2021; 53(2): 131-5.
  • Referans35. Grossman C, Farberov I, Feld O , Livneh A , Ben-Zvi. Efficacy and Safety of Long-Term Treatment with Intravenous Colchicine for Familial Mediterranean Fever (FMF) Refractory to Oral Colchicine. Rheumatol Int. 2019; 39(3): 517-23.
  • Referans36. Delibaş A, Oner A, Balci B, et al. Genetic Risk Factors of Amyloidogenesis in Familial Mediterranean Fever. Am J Nephrol. 2005; 25(5): 434-40.
  • Referans37. Said SM, Grogg KL, Smyrk TC. Gastric Amyloidosis: Clinicopathological Correlations in 79 Cases from a Single Institution. Um Pathol. 2015; 46(4): 491-8.
  • Referans 38. Kasifoglu T, Bilge SY, Sari I, et al. Amyloidosis and Its Related Factors in Turkish Patients with Familial Mediterranean Fever: a Multicentre Study. Rheumatology (Oxford). 2014; 53(4): 741-5.
  • Referans39. Yu MH, Chen MH, Han F, et al. Prognostic Value of the Biomarkers Serum Amyloid A and Nitric Oxide in Patients with Sepsis. Int Immunopharmacol. 2018; 62: 287-92.
  • Referans40. Schellekens DH, Hulsewé KW, van Acker BA et al. Evaluation of the Diagnostic Accuracy of Plasma Markers for Early Diagnosis in Patients Suspected for Acute Appendicitis. Acad Emerg Med. 2013; 20(7): 703-10.
  • Referans41. Nalbantoğlu S, Tanyolaç B , Berdelibir. Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) Expression Profiles in Familial Mediterranean Fever (FMF) Patients with Different MEFV Mutation Patterns. Scand J Rheumatol. 2013; 42(2): 159-62.

Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients

Year 2023, Volume: 15 Issue: 1, 59 - 68, 15.03.2023
https://doi.org/10.18521/ktd.1162175

Abstract

Objectives: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Düzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF.
Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined.
Result: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly.
Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.

Project Number

2016.04.03.471

References

  • Referans1. Dundar M, Fahrioglu U, Yildiz SH, Bakir-Gungor B, Temel SG, Akin H et al; National Genetics Consortium Study. Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium. Funct Integr Genomics. 2022; 22(3): 291-315.
  • Referans2. French FMF Consortium. A Candidate Gene For Familial Mediterranean Fever. Nat Genet. 1997; 17: 25-31./ The International FMF Consortium. Ancient Missense Mutations in a New Member of the RoRet Gene Family are Likely to Cause Familial Mediterranean Fever. Cell 1997; 90: 97–807.
  • Referans3. https://www.ncbi.nlm.nih.gov/gene/29108
  • Referans4. https://www.ncbi.nlm.nih.gov/gene/9966
  • Referans5. http://www.ncbi.nlm.nih.gov/entrez/ query.fcgi?db=gene&cmd=Retrieve&dopt= full_report &list_uids=10563
  • Referans6. Beştaş A, Bolu S, Unal E, Aktar Karakaya A, Eröz R, Tekin M, Haspolat YK. A rare cause of delayed puberty and primary amenorrhea: 17α-hydroxylase enzyme deficiency. Endocrine. 2022; 75(3): 927-933.
  • Referans7. Doğan M, Eröz R, Tecellioğlu M, Gezdirici A, Çevik B, Barış I. Clinical and Molecular Findings in a Turkish Family Who Had a (c.869- 1G>A) Splicing Variant in PSEN1 Gene with A Rare Condition: The Variant Alzheimer's Disease with Spastic Paraparesis. Curr Alzheimer Res. 2022; 19(3): 223-35.
  • Referans8. Doğan M, Eröz R, Bolu S, Yüce H, Gezdirici A, Arslanoğlu İ, Teralı K. Study of ten causal genes in Turkish patients with clinically suspected maturity-onset diabetes of the young (MODY) using a targeted next-generation sequencing panel. Mol Biol Rep. 2022; 49(8): 7483-95.
  • Referans9. Türay S, Eröz R. White-Sutton syndrome with hot water epilepsy and coexistence of SHOX gene variations. Acta Neurol Belg. 2021; 121(3): 749-55.
  • Referans10. Dogan M, Teralı K, Eroz R, Demirci H, Kocabay K. Clinical and molecular findings in a Turkish family with an ultra-rare condition, ELP2-related neurodevelopmental disorder. Mol Biol Rep. 2021; 48(1): 701-8.
  • Referans11. Doğan M, Eröz R, Öztürk E. Chorioretinal dystrophy, hypogonadotropic hypogonadism, and cerebellar ataxia: Boucher-Neuhauser syndrome due to a homozygous (c.3524C>G (p.Ser1175Cys)) variant in PNPLA6 gene. Ophthalmic Genet. 2021; 42(3): 276-282.
  • Referans12. Doğan M, Eröz R, Terali K, Gezdirici A, Bolu S. Clinical, radiological and computational studies on two novel GNPTG variants causing mucolipidosis III gamma phenotypes with varying severity. Mol Biol Rep. 2021; 48(2): 1465-74.
  • Referans13. Türay S, Eröz R, Başak AN. A novel pathogenic variant in the 3' end of the AGTPBP1 gene gives rise to neurodegeneration without cerebellar atrophy: an expansion of the disease phenotype? Neurogenetics. 2021; 22(2): 127-32.
  • Referans14. Gezdirici A, Teralı K, Gülec EY, Bornaun H, Dogan M, Eröz R. An integrated clinical and molecular study of a cohort of Turkish patients with Marfan syndrome harboring known and novel FBN1 variants. J Hum Genet. 2021; 66(7): 647-57.
  • Referans15. Bolu S, Eroz R, Dogan M, Arslanoglu I, Dundar I. Genotype-Phenotype Characteristics of Turkish Children With Glucokinase Mutations Associated Maturity-Onset Diabetes of the Young. Indian Pediatr. 2020; 57(11): 1037-39.
  • Referans16. Karagün E, Eroz R, Gamsızkan M, Baysak S, Eyup Y, Ozcan Y. Novel mutation identified in the DDB2 gene in patients with xeroderma pigmentosum group-E. Int J Dermatol. 2020; 59(8): 989-96.
  • Referans17. Eroz R, Damar İH, Kılıçaslan O. Thrombosis risk of Alport syndrome patients: evaluation of cardiological, clinical, biochemical, genetic and possible causes of inherited thrombophilia and identification of a novel COL4A3 variant. Blood Coagul Fibrinolysis. 2020; 31(4): 264-69.
  • Referans18. Bolu S, Eröz R, Tekin M, Doğan M. Atypical presentation in patients with 17 α-hydroxylase deficiency caused by a deletion in the CYP17A1 gene: short stature. Turk J Pediatr. 2020; 62(5): 851-7.
  • Referans19. Bolu S, Eröz R, Doğan M, Arslanoğlu İ, Uzun H, Timur F. A family with novel homozygous deletion mutation (c.1255delT; p.Phe419Serfs*12) in the glucokinase gene, which is a rare cause of permanent neonatal diabetes mellitus. Turk Pediatri Ars. 2020; 55(4): 434-7.
  • Referans20. Damar IH, Eroz R. Evaluation of Cases with Myotonia Congenita for Cardiovascular Risk. Medeni Med J. 2019; 34(4): 374-9.
  • Referans21. Okur M, Eroz R, Bektas MS, Gulsen S, Bahadir A, Turker Y, Gunes C. The Relationship between congenital heart defects and e-NOS gene ın down syndrome. Genet Couns. 2016; 27(3): 285-93.
  • Referans22. Soysal Z, Okur M, Eroz R, Gun E, Kocabay K, Besir FH. Megalencephalıc leukoencephalopathy wıth subcortıcal cysts wıth homozygous mutatıon (C.448DELC, P.LEU150 SER FSX11) on exon 6 of MLC1 gene. Genet Couns. 2015; 26(2): 233-6.
  • Referans23. Karatas A, Eroz R, Bahadır A, Keskin F, Ozlu T, Ozyalvaclı ME. Endothelial nitric oxide synthase gene polymorphisms (promoter -786T/C, exon 894 G/T and intron G10T) in unexplained female infertility. Gynecol Obstet Invest. 2014; 77(2): 89-93.
  • Referans24. Okur M, Eroz R, Mundlos S, Senses DA, Ulgen E, Ismailler ZB, Ozcelik D. EEC syndrome with a de novo mutation (c.953g > a) on exon 7 of P63 gene: a case report. Genet Couns. 2012; 23(4): 483-5.
  • Referans25. Yildiz Gulhan P, Eroz R, Ataoglu O, İnce N, Davran F, Öztürk CE, Gamsızkan Z, Balbay OA. The evaluation of both the expression and serum protein levels of Caspase-3 gene in patients with different degrees of SARS-CoV2 infection. J Med Virol. 2022; 94(3): 897-905. Referans26. Tasdemir S, Eroz R, Dogan H, Erdem HB, Sahin I, Kara M, Engin RI, Turkez H. Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes. Genet Test Mol Biomarkers. 2016; 20(4): 197-202.
  • Referans27. A Novel Deletion Mutation 334-335 DelG (P.Glu112fs, C.334-335delg) Identified In Exon 2 Of The MEFV Gene Associated With Familial Mediterranean Fever. Congress abstract, 14. Ulusal Tıbbi Biyoloji ve Genetik Kongresi 27–30 Ekim 2015; Ölüdeniz /Fethiye.
  • Referans28. Eroz R, Dogan M, Kocabay K. A Novel Mutation K447M (P.LYS447MET, C.1340 A>T) Identıfıed ın Exon 4 of the MEFV Gene. Genetıc Counselıng, Vol. 27, No 4, 2016, pp 525-8.
  • Referans29. Eroz R, Dogan M, Yuce H, Kocabay K, Yuksel E. A Turkish Family with A89T (p. Ala89Thr, c.265G>A) Mutation on The MEFV Gene, Their Clinical Findings and Review of The Literature. F.Ü.Sağ.Bil.Tıp Derg. 2016; 30(2): 67-70.
  • Referans 30. Eroz R, Yuce H, Koksal M. A family with rare E167D mutation from Turkey with a total of four members clinically diagnosed as FMF International Participated Erciyes Medical Genetics Days 2019 21–23 February 2019, Erciyes University, Kayseri, Turkey.
  • Referans31. Eroz R, Dogan M, Yuce H, Ozmerdivenli R. A Family From Turkey With 761_764dupCCGC p.Asn256Argfs70,c.761_764dupCCGC MEFV Gene Mutation, Their Clinical Features and Review of The Literature. Konuralp Tıp Dergisi 2016; 8(3): 214-7.
  • Referans32. Dogan M, Eroz R, Yuce H, Kocabay K, Gun E, Ozmerdivenli R. MEFV Geninde S288Y (P.SER863TYR, C.863 C>A) Mutasyonu ve Kliniğinin Araştırılması. Düzce Tıp Fakültesi Dergisi 2016; 18(2): 66-8.
  • Referans33. Eroz R, Dogan M, Bolu S, Yuce H. A Seven Years Old Girl with Klippel-Feil Syndrome, Bilateral Sprengel Deformity, Congenital Unilateral Renal Agenesis and A Heterozygous Mutation M680I(G>C) in The MEFV Gene. Konuralp Tıp Dergisi 2017; 9(2): 90-3.
  • Referans34. Damar IH, Eroz R. Do all Familial Mediterranean Fever (FMF) patients with recurrent chest pain have cardiac problems? Kuwait Medical Journal 2021; 53(2): 131-5.
  • Referans35. Grossman C, Farberov I, Feld O , Livneh A , Ben-Zvi. Efficacy and Safety of Long-Term Treatment with Intravenous Colchicine for Familial Mediterranean Fever (FMF) Refractory to Oral Colchicine. Rheumatol Int. 2019; 39(3): 517-23.
  • Referans36. Delibaş A, Oner A, Balci B, et al. Genetic Risk Factors of Amyloidogenesis in Familial Mediterranean Fever. Am J Nephrol. 2005; 25(5): 434-40.
  • Referans37. Said SM, Grogg KL, Smyrk TC. Gastric Amyloidosis: Clinicopathological Correlations in 79 Cases from a Single Institution. Um Pathol. 2015; 46(4): 491-8.
  • Referans 38. Kasifoglu T, Bilge SY, Sari I, et al. Amyloidosis and Its Related Factors in Turkish Patients with Familial Mediterranean Fever: a Multicentre Study. Rheumatology (Oxford). 2014; 53(4): 741-5.
  • Referans39. Yu MH, Chen MH, Han F, et al. Prognostic Value of the Biomarkers Serum Amyloid A and Nitric Oxide in Patients with Sepsis. Int Immunopharmacol. 2018; 62: 287-92.
  • Referans40. Schellekens DH, Hulsewé KW, van Acker BA et al. Evaluation of the Diagnostic Accuracy of Plasma Markers for Early Diagnosis in Patients Suspected for Acute Appendicitis. Acad Emerg Med. 2013; 20(7): 703-10.
  • Referans41. Nalbantoğlu S, Tanyolaç B , Berdelibir. Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC) Expression Profiles in Familial Mediterranean Fever (FMF) Patients with Different MEFV Mutation Patterns. Scand J Rheumatol. 2013; 42(2): 159-62.
There are 40 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Fatih Kurt 0000-0003-1975-6492

Recep Eröz 0000-0003-0840-2613

Kenan Kocabay 0000-0002-4030-1145

Project Number 2016.04.03.471
Publication Date March 15, 2023
Acceptance Date January 2, 2023
Published in Issue Year 2023 Volume: 15 Issue: 1

Cite

APA Kurt, F., Eröz, R., & Kocabay, K. (2023). Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients. Konuralp Medical Journal, 15(1), 59-68. https://doi.org/10.18521/ktd.1162175
AMA Kurt F, Eröz R, Kocabay K. Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients. Konuralp Medical Journal. March 2023;15(1):59-68. doi:10.18521/ktd.1162175
Chicago Kurt, Fatih, Recep Eröz, and Kenan Kocabay. “Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) Expression Profiles in Familial Mediterranean Fever (FMF) Patients”. Konuralp Medical Journal 15, no. 1 (March 2023): 59-68. https://doi.org/10.18521/ktd.1162175.
EndNote Kurt F, Eröz R, Kocabay K (March 1, 2023) Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients. Konuralp Medical Journal 15 1 59–68.
IEEE F. Kurt, R. Eröz, and K. Kocabay, “Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients”, Konuralp Medical Journal, vol. 15, no. 1, pp. 59–68, 2023, doi: 10.18521/ktd.1162175.
ISNAD Kurt, Fatih et al. “Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) Expression Profiles in Familial Mediterranean Fever (FMF) Patients”. Konuralp Medical Journal 15/1 (March 2023), 59-68. https://doi.org/10.18521/ktd.1162175.
JAMA Kurt F, Eröz R, Kocabay K. Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients. Konuralp Medical Journal. 2023;15:59–68.
MLA Kurt, Fatih et al. “Apoptosis-Associated Speck-Like Protein Containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) Expression Profiles in Familial Mediterranean Fever (FMF) Patients”. Konuralp Medical Journal, vol. 15, no. 1, 2023, pp. 59-68, doi:10.18521/ktd.1162175.
Vancouver Kurt F, Eröz R, Kocabay K. Apoptosis-associated speck-like protein containing a CARD (ASC), TNF Like Factor 1a(TL-1a) and B Cell Chemoattractant Chemokine Ligand 13(CXCL-13) expression profiles in familial Mediterranean fever (FMF) patients. Konuralp Medical Journal. 2023;15(1):59-68.