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COVID-19 Hastalarının Bazı Biyokimyasal Parametrelerinin Biyobelirteç Olarak Değerlendirilmesi

Year 2023, Volume: 15 Issue: 2, 248 - 256, 22.06.2023
https://doi.org/10.18521/ktd.1268351

Abstract

Amaç: SARS-CoV-2, Dünya çapında 664 milyondan fazla doğrulanmış vaka ve 6,7 milyondan fazla ölümle küresel bir pandemiye neden olmuştur. Pandemide tanı ve tedaviye yardımcı olmak amacıyla bazı biyokimyasal ve hematolojik parametrelerin COVID-19 ile ilişkisi üzerine birçok çalışma yapılmıştır. Ancak pek çok bilgi tam değildir ve verilerde çelişkiler vardır. Bu çalışmada COVID-19 hastaları ve sağlıklı bireyler de dahil olmak üzere bireylerin biyokimyasal parametrelerinin yaş ve cinsiyet ilişkisi incelenmiştir.
Gereç ve Yöntem: Şubat 2022-Kasım 2022 tarihleri arasında Pandemi Polikliniği'ne COVID-19 şüphesiyle başvuran 317 kişi laboratuvar testleri ile değerlendirilmiştir. İstatistiksel analiz, IBM SPSS 20.0 kullanılarak yapılmıştır.
Bulgular: COVID-19' hastası erkek hastalarda ÜREA, KREA, FER, AST, ALT, HSTI, CK, CRP gibi değerlerin COVID-19 hastası kadın hastalara göre daha yüksek olduğu belirlenmiştir. Ayrıca 18-65 yaş arası COVID-19 hastalarında GLU, FER, AST, LDH, HSTI, CK ve CRP gibi parametrelerde istatistiksel olarak anlamlı artış olduğu tespit edilmiştir.
Sonuç: Prognostik öneme sahip birçok biyobelirteçlerin pahalı olmasına karşı COVID-19 enfeksiyonu olan hastalarda hastalığın izlenmesi amacıyla basit ve uygun maliyetli FER, AST, LDH, HSTI, CK ve CRP gibi biyokimyasal parametrelerin biyobelirteç olarak kullanımı sözkonusudur.

References

  • 1. Maier HJ, Bickerton E, Britton P. Coronaviruses: Methods and protocols.Coronaviruses: Methods and Protoc. 2015:1-282.
  • 2. Paules CI, Marston HD, Fauci AS. Coronavirus infections-more than just the common cold. JAMA. 2020;323:707-8.
  • 3. Dünya Sağlık Örgütü (20 Aralık 2019). “MERS-Cov”. URL:https://www.who.int/news-room/q-a-detail/middle-east-respiratory-syndrom...(mers-cov)
  • 4. Abdulla AK, Salman OA, Mahmood AA. Study of Some Hematological, and Biochemical Parameters in Patients with SARS-CoV-2 in Kirkuk City/Iraq. Sys Rev Pharm. 2020;11(11):515-22.
  • 5. Bilgir F, Çalık Ş, Demir İ, Bilgir O. Roles of certain biochemical and hematological parameters in predicting mortality and ICU admission in COVID 19 patients. Rev Assoc Med Bras. 2021;67:67-73
  • 6. Bogiel T, Rzepka M, Depka DJD. Reliable Diagnostics of SARS-CoV-2 Infections Using One-and Two-Gene Molecular Tests for a Viral RNA Detection—Results Questioning Previous Observations. Diagnostics. 2021;11(10):1839.
  • 7. Dünya Sağlık Örgütü (25 January 2023). COVID 19 Weekly Epidemiological Update Edition 127 published 25 January 2023 https://www.who.int/publications/m/item/weekly-epidemiological-update-on-COVID 19---25-january-2023 8. Wajahat M, Muhammad J, Ali SS, Khan N, Saad M. COVID 19 Impact on Hematological and Biochemical Parameters on Outcomes of Admitted Patients. Res Sq 2022.
  • 9. Malik YA. Properties of Coronavirus and SARS-CoV-2. Malaysian J Pathol 2020;42(1):3-11.
  • 10. Jan HC, Yang WH, Ou CH. Combination of the Preoperative Systemic Immune-Inflammation Index and Monocyte-Lymphocyte Ratio as a Novel Prognostic Factor in Patients with Upper-Tract Urothelial Carcinoma. Ann Surg Oncol. 2019;26(2):669-84.
  • 11. Khaleel KJ, Ahmed AA, Fadhel AA. Assessment Of Some Hematologıcal And Bıochemıcal Parameters For COVID 19 Patıent’s In Baghdad Provınce. Biochem Cell Arch. 2021;21(1):2355-9.
  • 12. Mir SM, Tahamtan A, Nikoo HR, Arabi MS, Moradi AW, Ardakanian S, Tabarraei A. Evaluation of biochemical characteristics of 183 COVID 19 patients: A retrospective study. Gene Rep 2022;26:101448.
  • 13. Pan Y, Ye G, Zeng X, Liu G, Zeng X, Jiang X, et al. Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia? Clin Transl Med 2020;10(1):161-8.
  • 14. Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, et al. Preliminary study to identify severe from moderate cases of COVID 19 using combined hematology parameters. Ann Transl Med. 2020;8(9):593.
  • 15. Atici Y, Kaçaroglu D, Yilmaz A, Bakir F, Besirbellioglu B, Yucel D, Yildirimkaya M. Investigation of Hematological and Inflammatory Parameters in COVID 19 Infection. Eurasian JHS. 2022;5(3):37-44.
  • 16. Yılmaz A, Kaçaroğlu D, Atıcı Y, Şamandar Aydaş H. (). COVID 19’da Cinsiyet Hormonlarının İmmün Yanıt Üzerine Etkileri. Uludağ Üniv Tıp Fak Derg. 2021;47(3).
  • 17. Kar F, Yılmaz S, Musmul A, Şentürk H. COVID 19-Related Biochemical and Hematological Parameters: A Single-Center Population Index Study. Kocaeli Üniversitesi Sag Bil Derg. 2022;8(1):54-8.
  • 18. Guneysu F, Durmuş E, Yürümez Y. Evaluation of the Blood Parameters Success in Predicting the COVID 19 Patients Applying to the Emergency Room in the COVID 19 Pandemic. Sakarya Med J. 2021;11(3):479-88.
  • 19. Harbalıoğlu H, Genç Ö, Yıldırım, A. 3 predictors of hospitalization patients with coronavirus (COVID 19): old age, lactate dehydrogenase and neutrophil/lymphocyte ratio. Pamukkale Tıp Derg. 2021;14(1):57-62.
  • 20. Balcı Ş, Poyraz Z, Gulum C, Aslan G, Tamer L, Çimen MBY. Evaluation of biochemical parameters in COVID 19 patients in early stage. Mersin Univ Saglık Bilim Derg. 2021;14(3):378-84.
  • 21. Sarhan AR, Hussein TA, Flaih MH, Hussein KR. A Biochemical analysis of patients with COVID 19 Infection. Biochem Res Int 2021;22:1383830.
  • 22. Al Hayek AAAl, Robert AA, Matar AB, et al. Risk factors for hospital admission among COVID 19 patients with diabetes. A study from Saudi Arabia. Saudi Med J. 2020;41(10):1090–1097.
  • 23. Merzon E, Green I, Shpigelman M, et al. Haemoglobin A1c is a predictor of COVID 19 severity in patients with diabetes. Diabetes Metab Res Rev. 2021;37(5):e3398.
  • 24. Niraula A, Baral N, Lamsal M, Bataju M, Thapa S. Potential role of biochemical markers in the prognosis of COVID 19 patients. SAGE Open Med 2022;10:1–10.
  • 25. Cai Q, Huang D, Yu H, et al. COVID 19: abnormal function tests. J Hepatol. 2020;73(3):566–574.
  • 26. Gursoy Doruk Ö, Örmen M, Tuncel P. Bıochemıcal And Hematologıcal Parameters in COVID 19. J DEU Med 2021;35:71-80.
  • 27. Rahman MA, Shanjana Y, Tushar MI, et al. Hematological abnormalities and comorbidities are associated with COVID 19 severity among hospitalized patients: experience from Bangladesh. PLoS One. 2021;16(7):e0255379.
  • 28. Dietzen DJ. Amino acids, peptides, and proteins. In: Rifai N, Horvath AR and Wittwer CT (eds) Teitz textbook of clinical chemistry and molecular diagnostics. 6th ed. Philadelphia, PA: Elseiver, 2018;373–403.e5.

Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers

Year 2023, Volume: 15 Issue: 2, 248 - 256, 22.06.2023
https://doi.org/10.18521/ktd.1268351

Abstract

Objective: SARS-CoV-2 has caused a global pandemic with more than 664 million confirmed cases and more than 6.7 million deaths worldwide. In pandemic, several studies have been done about the relationship of some biochemical and hematological parameters with COVID 19 in order to assist diagnosis and treatment. However, a lot of information is not completely complete and there are contradictions in the data. In the present study, it was focused to compare the biochemical parameters of patients and healthy individuals due to COVID 19 by investigating the relationship between age and gender.
Methods: The 317 individuals who consulted to the Pandemic Outpatient Clinic with the suspicion of COVID 19 between February 2022 and November 2022 were evaluated by laboratory tests. In present study, biochemical parameter values of individuals with positive and negative COVID 19 test outcomes were used as material. These biochemical parameters were compared statistically based on different age ranges and gender groups.
Results: It was ascertained that the values such as UREA, KREA, FER, AST, ALT, HSTI, CK and CRP in male patients with COVID 19 were higher than female patients with COVID 19. Moreover, it was detected that there was a statistically significant increase in parameters such as GLU, FER, AST, LDH, HSTI, CK and CRP in COVID 19 patients aged 18-65 years.
Conclusions: Many biomarkers of prognostic importance are expensive, ordinary and pricey-effective biomarkers such as FER, AST, LDH, HSTI, CK and CRP can be used to monitor disease in patients with COVID 19 infection.

References

  • 1. Maier HJ, Bickerton E, Britton P. Coronaviruses: Methods and protocols.Coronaviruses: Methods and Protoc. 2015:1-282.
  • 2. Paules CI, Marston HD, Fauci AS. Coronavirus infections-more than just the common cold. JAMA. 2020;323:707-8.
  • 3. Dünya Sağlık Örgütü (20 Aralık 2019). “MERS-Cov”. URL:https://www.who.int/news-room/q-a-detail/middle-east-respiratory-syndrom...(mers-cov)
  • 4. Abdulla AK, Salman OA, Mahmood AA. Study of Some Hematological, and Biochemical Parameters in Patients with SARS-CoV-2 in Kirkuk City/Iraq. Sys Rev Pharm. 2020;11(11):515-22.
  • 5. Bilgir F, Çalık Ş, Demir İ, Bilgir O. Roles of certain biochemical and hematological parameters in predicting mortality and ICU admission in COVID 19 patients. Rev Assoc Med Bras. 2021;67:67-73
  • 6. Bogiel T, Rzepka M, Depka DJD. Reliable Diagnostics of SARS-CoV-2 Infections Using One-and Two-Gene Molecular Tests for a Viral RNA Detection—Results Questioning Previous Observations. Diagnostics. 2021;11(10):1839.
  • 7. Dünya Sağlık Örgütü (25 January 2023). COVID 19 Weekly Epidemiological Update Edition 127 published 25 January 2023 https://www.who.int/publications/m/item/weekly-epidemiological-update-on-COVID 19---25-january-2023 8. Wajahat M, Muhammad J, Ali SS, Khan N, Saad M. COVID 19 Impact on Hematological and Biochemical Parameters on Outcomes of Admitted Patients. Res Sq 2022.
  • 9. Malik YA. Properties of Coronavirus and SARS-CoV-2. Malaysian J Pathol 2020;42(1):3-11.
  • 10. Jan HC, Yang WH, Ou CH. Combination of the Preoperative Systemic Immune-Inflammation Index and Monocyte-Lymphocyte Ratio as a Novel Prognostic Factor in Patients with Upper-Tract Urothelial Carcinoma. Ann Surg Oncol. 2019;26(2):669-84.
  • 11. Khaleel KJ, Ahmed AA, Fadhel AA. Assessment Of Some Hematologıcal And Bıochemıcal Parameters For COVID 19 Patıent’s In Baghdad Provınce. Biochem Cell Arch. 2021;21(1):2355-9.
  • 12. Mir SM, Tahamtan A, Nikoo HR, Arabi MS, Moradi AW, Ardakanian S, Tabarraei A. Evaluation of biochemical characteristics of 183 COVID 19 patients: A retrospective study. Gene Rep 2022;26:101448.
  • 13. Pan Y, Ye G, Zeng X, Liu G, Zeng X, Jiang X, et al. Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia? Clin Transl Med 2020;10(1):161-8.
  • 14. Wang C, Deng R, Gou L, Fu Z, Zhang X, Shao F, et al. Preliminary study to identify severe from moderate cases of COVID 19 using combined hematology parameters. Ann Transl Med. 2020;8(9):593.
  • 15. Atici Y, Kaçaroglu D, Yilmaz A, Bakir F, Besirbellioglu B, Yucel D, Yildirimkaya M. Investigation of Hematological and Inflammatory Parameters in COVID 19 Infection. Eurasian JHS. 2022;5(3):37-44.
  • 16. Yılmaz A, Kaçaroğlu D, Atıcı Y, Şamandar Aydaş H. (). COVID 19’da Cinsiyet Hormonlarının İmmün Yanıt Üzerine Etkileri. Uludağ Üniv Tıp Fak Derg. 2021;47(3).
  • 17. Kar F, Yılmaz S, Musmul A, Şentürk H. COVID 19-Related Biochemical and Hematological Parameters: A Single-Center Population Index Study. Kocaeli Üniversitesi Sag Bil Derg. 2022;8(1):54-8.
  • 18. Guneysu F, Durmuş E, Yürümez Y. Evaluation of the Blood Parameters Success in Predicting the COVID 19 Patients Applying to the Emergency Room in the COVID 19 Pandemic. Sakarya Med J. 2021;11(3):479-88.
  • 19. Harbalıoğlu H, Genç Ö, Yıldırım, A. 3 predictors of hospitalization patients with coronavirus (COVID 19): old age, lactate dehydrogenase and neutrophil/lymphocyte ratio. Pamukkale Tıp Derg. 2021;14(1):57-62.
  • 20. Balcı Ş, Poyraz Z, Gulum C, Aslan G, Tamer L, Çimen MBY. Evaluation of biochemical parameters in COVID 19 patients in early stage. Mersin Univ Saglık Bilim Derg. 2021;14(3):378-84.
  • 21. Sarhan AR, Hussein TA, Flaih MH, Hussein KR. A Biochemical analysis of patients with COVID 19 Infection. Biochem Res Int 2021;22:1383830.
  • 22. Al Hayek AAAl, Robert AA, Matar AB, et al. Risk factors for hospital admission among COVID 19 patients with diabetes. A study from Saudi Arabia. Saudi Med J. 2020;41(10):1090–1097.
  • 23. Merzon E, Green I, Shpigelman M, et al. Haemoglobin A1c is a predictor of COVID 19 severity in patients with diabetes. Diabetes Metab Res Rev. 2021;37(5):e3398.
  • 24. Niraula A, Baral N, Lamsal M, Bataju M, Thapa S. Potential role of biochemical markers in the prognosis of COVID 19 patients. SAGE Open Med 2022;10:1–10.
  • 25. Cai Q, Huang D, Yu H, et al. COVID 19: abnormal function tests. J Hepatol. 2020;73(3):566–574.
  • 26. Gursoy Doruk Ö, Örmen M, Tuncel P. Bıochemıcal And Hematologıcal Parameters in COVID 19. J DEU Med 2021;35:71-80.
  • 27. Rahman MA, Shanjana Y, Tushar MI, et al. Hematological abnormalities and comorbidities are associated with COVID 19 severity among hospitalized patients: experience from Bangladesh. PLoS One. 2021;16(7):e0255379.
  • 28. Dietzen DJ. Amino acids, peptides, and proteins. In: Rifai N, Horvath AR and Wittwer CT (eds) Teitz textbook of clinical chemistry and molecular diagnostics. 6th ed. Philadelphia, PA: Elseiver, 2018;373–403.e5.
There are 27 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Ümit Karadeniz 0000-0001-5326-8607

Serpil Uğraş 0000-0002-1867-5781

Pınar Göç Rasgele 0000-0002-7558-3138

Publication Date June 22, 2023
Acceptance Date June 16, 2023
Published in Issue Year 2023 Volume: 15 Issue: 2

Cite

APA Karadeniz, Ü., Uğraş, S., & Göç Rasgele, P. (2023). Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers. Konuralp Medical Journal, 15(2), 248-256. https://doi.org/10.18521/ktd.1268351
AMA Karadeniz Ü, Uğraş S, Göç Rasgele P. Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers. Konuralp Medical Journal. June 2023;15(2):248-256. doi:10.18521/ktd.1268351
Chicago Karadeniz, Ümit, Serpil Uğraş, and Pınar Göç Rasgele. “Evaluation of Some Biochemical Parameters of COVID-19 Patients As Biomarkers”. Konuralp Medical Journal 15, no. 2 (June 2023): 248-56. https://doi.org/10.18521/ktd.1268351.
EndNote Karadeniz Ü, Uğraş S, Göç Rasgele P (June 1, 2023) Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers. Konuralp Medical Journal 15 2 248–256.
IEEE Ü. Karadeniz, S. Uğraş, and P. Göç Rasgele, “Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers”, Konuralp Medical Journal, vol. 15, no. 2, pp. 248–256, 2023, doi: 10.18521/ktd.1268351.
ISNAD Karadeniz, Ümit et al. “Evaluation of Some Biochemical Parameters of COVID-19 Patients As Biomarkers”. Konuralp Medical Journal 15/2 (June 2023), 248-256. https://doi.org/10.18521/ktd.1268351.
JAMA Karadeniz Ü, Uğraş S, Göç Rasgele P. Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers. Konuralp Medical Journal. 2023;15:248–256.
MLA Karadeniz, Ümit et al. “Evaluation of Some Biochemical Parameters of COVID-19 Patients As Biomarkers”. Konuralp Medical Journal, vol. 15, no. 2, 2023, pp. 248-56, doi:10.18521/ktd.1268351.
Vancouver Karadeniz Ü, Uğraş S, Göç Rasgele P. Evaluation of Some Biochemical Parameters of COVID-19 Patients as Biomarkers. Konuralp Medical Journal. 2023;15(2):248-56.