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Year 2023, Volume: 36 Issue: 3, 290 - 296, 29.09.2023

Zubeyde Eres Sarıtas Bilal Olcay Peker Dilek Çolak Imran Saglık Rabia Can Sarinoğlu Murat Turhan Aslı Bostancı Toptaş Derya Mutlu Gözde Öngüt Nihal Oygur Munire Erman

https://doi.org/10.5472/marumj.1367753

Abstract

References

  • Manicklal S, Emery VC, Lazzarotto T, et al. The “silent” global burden of congenital Cytomegalovirus. Clin Microbiol Rev 2013;26:86-102. doi: 10.1128/CMR.00062-12
  • Grosse S, Ross DS, Dollard SC. Congenital Cytomegalovirus infection as a cause of permanent bilateral hearing loss: a quantitative assessment. J Clin Virol 2018;41:57-62. doi: 10.1016/j.jcv.2007.09.004
  • Mussi-Pinhata MM, Yamamoto AY, Moura Brito RM, et al. Birth prevalence and natural history of congenital Cytomegalovirus infection in a highly seroimmune population. Clin Infect Dis 2009;49:522-8. doi: 10.1086/600882.
  • Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital Cytomegalovirus (CMV) infection. Rev Med Virol 2007;17:253-76. doi: 10.1002/ rmv.535
  • Ataman S, Colak D, Günseren F, et al. Investigation of Cytomegalovirus seroepidemiology in Antalya with a population-based cross-sectional study and review of related data in Turkey. Mikrobiyol Bul 2007;41:545-55.
  • Satilmiş A, Güra A, Ongun H, et al. CMV seroconversion in pregnants and the incidence of congenital CMV infection. Turk J Pediatr 2007;49:30-6.
  • Uysal A, Taner CE, Cüce M, et al. Cytomegalovirus and rubella seroprevalence in pregnant women in Izmir/Turkey: follow-up and results of pregnancy outcome. Arch Gynecol Obstet 2012;286:605-8. doi: 10.1007/s00404.012.2353-z
  • Parlak M, Çim N, Nalça Erdin B, et al. Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus among pregnant women in Van. Turk J Obstet Gynecol 2015;12:79-82. doi: 10.4274/tjod.35902
  • Sahiner F, Cekmez, Cetinkaya FM, et al. Congenital Cytomegalovirus infections and glycoprotein B genotypes in live-born infants: a prevalence study in Turkey. Infect Dis (Lond) 2015;47:465-71. doi: 10.3109/23744.235.2015.1018316
  • Zeytinoğlu A, Terek D, Arslan A, et al. Investigation of congenital CMV infection with the presence of CMV DNA in saliva samples of new born babies. Mikrobiyol Bul 2019;53:53- 60. doi: 10.5578/mb.67724
  • Chiopris G, Veronese P, Cusenza F, et al. Congenital Cytomegalovirus Infection: Update on Diagnosis and Treatment. Microorganisms 2020;8:1-17. doi: 10.3390/ microorganisms8101516
  • Royackers L, Rector E, Verhaert N, et al. Long-term audiological follow-up of children with congenital cytomegalovirus. B-ENT 2013;Suppl 21:57-64.
  • Joint Committee on Infant Hearing of the American Academy of Pediatrics et al. Supplement to the JCIH 2007 position statement: principles and guidelines for early intervention after confirmation that a child is deaf or hard of hearing. Pediatrics 2013;131: e1324-49. doi:10.1542/ peds.2013-0008
  • Luck SE, Wieringa JW, Blázquez-Gamero D, et al. Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management. Pediatr Infect Dis J 2017;36:1205- 13. doi: 10.1097/INF.000.000.0000001763
  • Fowler KB, Ross SA, Shimamura M, et al. Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection. J Pediatr 2018;200:196-201.e1. doi: 10.1016/j. jpeds.2018.04.043
  • Noyola DE, Mejía-Elizondo AR, Canseco-Lima JM, et al. Congenital Cytomegalovirus infection in San Luis Potosi, Mexico. Pediatr Infect Dis J 2003;22:89-90. doi: 10.1097/00006.454.200301000-00022
  • Marin LJ, Santos de Carvalho Cardoso E, Bispo Sousa SM, et al. Prevalence and clinical aspects of CMV congenital Infection in a low-income population. Virol J 2016;13:148. doi: 10.1186/s12985.016.0604-5
  • Schlesinger Y, Reich D, Eidelman AI, et al. Congenital Cytomegalovirus infection in Israel: screening in different subpopulations. Isr Med Assoc J 2005;7:237-40.
  • Wang S, Wang T, Zhang W, et al. Cohort study on maternal Cytomegalovirus seroprevalence and prevalence and clinical manifestations of congenital infection in China. Medicine (Baltimore) 2017;96:e6007. doi: 10.1097/ MD.000.000.0000006007
  • Van der Sande MA, Kaye S, Miles DJ, et al. Risk factors for and clinical outcome of congenital Cytomegalovirus infection in a peri-urban West-African birth cohort. PLoS One 2007;2:e492. doi: 10.1371/journal.pone.0000492
  • Dar L, Pati SK, Patro AR, et al. Congenital Cytomegalovirus infection in a highly seropositive semi-urban population in India. Pediatr Infect Dis J 2008;27:841-843. doi: 10.1097/ INF.0b013e3181723d55
  • Javid N, Cheraghali F, Moradi A, et al. Newborn Screening for Congenital Cytomegalovirus Infection in Iran. Pediatr Infect Dis J 2016;35:1052. doi: 10.1097/INF.000.000.0000001257
  • Boppana SB, Ross SA, Shimamura M, et al. Saliva Polymerase- Chain-Reaction Assay for Cytomegalovirus Screening in Newborns. N Engl J Med 2011;364:2111-8. doi: 10.1056/ NEJMoa1006561
  • Gunkel J, Wolfs TF, de Vries LS, et al. Predictors of severity for postnatal Cytomegalovirus infection in preterm infants and implications for treatment. Expert Rev Anti Infect Ther 2014;12:1345-55. doi: 10.1586/14787.210.2014.966080
  • Yılmaz E, Öcal FD, Yılmaz ZV, et al. Early initiation and exclusive breastfeeding: Factors influencing the attitudes of mothers who gave birth in an baby friendly hospital. Turk J Obtet Gynecol 2017;14:1-9. doi: 10.4274/tjod.90018
  • Hacettepe University Institute of Population Studies 2013 Turkey Demographic and Health Survey, T.R. Ministry of Development and TÜBİTAK, Ankara. https://dhsprogram. com/pubs/pdf/FR352/FR352.pdf. (Accessed on August 16, 2022)
  • Koyano S, Inoue N, Nagamori T. Newborn screening of congenital Cytomegalovirus infection using saliva can be influenced by breast feding. Arch Dis Child Fetal Neonatal Ed 2013;98:F182. doi: 10.1136/archdischild-2012-302230
  • Fujii T, Oka A, Morioka I, et al. Japanese Congenital Cytomegalovirus Study Group. Newborn Congenital Cytomegalovirus Screening Based on Clinical Manifestations and Evaluation of DNA-based Assays for In Vitro Diagnostics. Pediatr Infect Dis J 2017;3:942-6. doi: 10.1097/ INF.000.000.0000001630
  • Ornoy A, av-Citrin O. Fetal effects of primary and secondary Cytomegalovirus infection in pregnancy. Reprod Toxicol 2006;21:399-409. doi: 10.1016/j.reprotox.2005.02.002
  • Fowler KB, Stagno S, Pass RF, et al. The outcome of congenital Cytomegalovirus infection in relation to maternal antibody status. N Engl J 1992;326:663-7. doi: 10.1056/ NEJM199.203.053261003
  • Lilleri D, Kabanova A, Revello MG, et al. Fetal human Cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection. PLoS One 2013;8:e59863. doi: 10.1371/journal.pone.0059863
  • Fornara C, Cassaniti I, Zavattoni M, et al. Human Cytomegalovirus-specific memory CD4+ T-cell response and its correlation with virüs transmission to the fetus in pregnant women with primary infection. Clin Infect Dis 2017;65:1659- 65. doi: 10.1093/cid/cix622
  • Çelikel E, Tezer H, Kanik-Yüksek S, et al. Evaluation of immunocompetent children with cytomegalovirus infection: importance of neurodevelopmental follow-up. Eur J Pediatr 2015;174:1101-7. doi: 10.1007/s00431.015.2513-9
  • Fowler KB, McCollister FP, Sabo DL, et al. A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening. Pediatrics 2017;139:e20162128. doi: 10.1542/peds.2016-2128
  • Fletcher KT, Horrell EMW, Ayugi J, et al. The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review. Otol Neurotol 2018;39:854-64. doi: 10.1097/MAO.000.000.0000001861

Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey

Year 2023, Volume: 36 Issue: 3, 290 - 296, 29.09.2023

Zubeyde Eres Sarıtas Bilal Olcay Peker Dilek Çolak Imran Saglık Rabia Can Sarinoğlu Murat Turhan Aslı Bostancı Toptaş Derya Mutlu Gözde Öngüt Nihal Oygur Munire Erman

https://doi.org/10.5472/marumj.1367753

Abstract

Objective: To investigate the presence of cCMV infection and the CMV-DNA virus in the newborns who applied for newborn hearing
screening test (NHST) and CMV-DNA viruria with physical, mental-motor development and hearing status of cCMV cases in the
second year of age.
Patients and Methods: CMV-DNA was investigated in 1150 newborns’ oral swabs (0-21 days) by polymerase chain reaction kit and
urine of patients with positive CMV-DNA in saliva. Transient Evoked Otoacoustic Emission test was performed for NHST.
Results: CMV-DNA was posititve in saliva of 38 (3.3%) newborns and urine of 10 out of 37 newborns. The prevalence of cCMV
was 0.87% (95% CI=0.697-1.042). All newborns passed the NHST. In newborns with cCMV:jaundice in 60% (6/10), low birthweight
in 40% (4/10), small for gestational age in 50% (5/10) of them. Jaundice was the most significant variable (P<0.001, OR:23.411, 95%
CI=5.772-94.960) and bilirubin levels were slightly elevated. In the second year of 8 cases, CMV-DNA viruria was detected in all of
them and sensorineural hearing loss was detected in one infant.
Conclusion: The cCMV infection rate is 0.87% in a population with high maternal seropositivity.When diagnosing cCMV, saliva
may give false-positive results and urine should be tested. Bilirubin levels may not be as high as expected in cCMV cases in highly
seroimmune populations and sequelaes may occur in the following years.

Keywords

Congenital CMV infection High seroprevalence population Urine Saliva CMV-DNA PCR

References

  • Manicklal S, Emery VC, Lazzarotto T, et al. The “silent” global burden of congenital Cytomegalovirus. Clin Microbiol Rev 2013;26:86-102. doi: 10.1128/CMR.00062-12
  • Grosse S, Ross DS, Dollard SC. Congenital Cytomegalovirus infection as a cause of permanent bilateral hearing loss: a quantitative assessment. J Clin Virol 2018;41:57-62. doi: 10.1016/j.jcv.2007.09.004
  • Mussi-Pinhata MM, Yamamoto AY, Moura Brito RM, et al. Birth prevalence and natural history of congenital Cytomegalovirus infection in a highly seroimmune population. Clin Infect Dis 2009;49:522-8. doi: 10.1086/600882.
  • Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital Cytomegalovirus (CMV) infection. Rev Med Virol 2007;17:253-76. doi: 10.1002/ rmv.535
  • Ataman S, Colak D, Günseren F, et al. Investigation of Cytomegalovirus seroepidemiology in Antalya with a population-based cross-sectional study and review of related data in Turkey. Mikrobiyol Bul 2007;41:545-55.
  • Satilmiş A, Güra A, Ongun H, et al. CMV seroconversion in pregnants and the incidence of congenital CMV infection. Turk J Pediatr 2007;49:30-6.
  • Uysal A, Taner CE, Cüce M, et al. Cytomegalovirus and rubella seroprevalence in pregnant women in Izmir/Turkey: follow-up and results of pregnancy outcome. Arch Gynecol Obstet 2012;286:605-8. doi: 10.1007/s00404.012.2353-z
  • Parlak M, Çim N, Nalça Erdin B, et al. Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus among pregnant women in Van. Turk J Obstet Gynecol 2015;12:79-82. doi: 10.4274/tjod.35902
  • Sahiner F, Cekmez, Cetinkaya FM, et al. Congenital Cytomegalovirus infections and glycoprotein B genotypes in live-born infants: a prevalence study in Turkey. Infect Dis (Lond) 2015;47:465-71. doi: 10.3109/23744.235.2015.1018316
  • Zeytinoğlu A, Terek D, Arslan A, et al. Investigation of congenital CMV infection with the presence of CMV DNA in saliva samples of new born babies. Mikrobiyol Bul 2019;53:53- 60. doi: 10.5578/mb.67724
  • Chiopris G, Veronese P, Cusenza F, et al. Congenital Cytomegalovirus Infection: Update on Diagnosis and Treatment. Microorganisms 2020;8:1-17. doi: 10.3390/ microorganisms8101516
  • Royackers L, Rector E, Verhaert N, et al. Long-term audiological follow-up of children with congenital cytomegalovirus. B-ENT 2013;Suppl 21:57-64.
  • Joint Committee on Infant Hearing of the American Academy of Pediatrics et al. Supplement to the JCIH 2007 position statement: principles and guidelines for early intervention after confirmation that a child is deaf or hard of hearing. Pediatrics 2013;131: e1324-49. doi:10.1542/ peds.2013-0008
  • Luck SE, Wieringa JW, Blázquez-Gamero D, et al. Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management. Pediatr Infect Dis J 2017;36:1205- 13. doi: 10.1097/INF.000.000.0000001763
  • Fowler KB, Ross SA, Shimamura M, et al. Racial and Ethnic Differences in the Prevalence of Congenital Cytomegalovirus Infection. J Pediatr 2018;200:196-201.e1. doi: 10.1016/j. jpeds.2018.04.043
  • Noyola DE, Mejía-Elizondo AR, Canseco-Lima JM, et al. Congenital Cytomegalovirus infection in San Luis Potosi, Mexico. Pediatr Infect Dis J 2003;22:89-90. doi: 10.1097/00006.454.200301000-00022
  • Marin LJ, Santos de Carvalho Cardoso E, Bispo Sousa SM, et al. Prevalence and clinical aspects of CMV congenital Infection in a low-income population. Virol J 2016;13:148. doi: 10.1186/s12985.016.0604-5
  • Schlesinger Y, Reich D, Eidelman AI, et al. Congenital Cytomegalovirus infection in Israel: screening in different subpopulations. Isr Med Assoc J 2005;7:237-40.
  • Wang S, Wang T, Zhang W, et al. Cohort study on maternal Cytomegalovirus seroprevalence and prevalence and clinical manifestations of congenital infection in China. Medicine (Baltimore) 2017;96:e6007. doi: 10.1097/ MD.000.000.0000006007
  • Van der Sande MA, Kaye S, Miles DJ, et al. Risk factors for and clinical outcome of congenital Cytomegalovirus infection in a peri-urban West-African birth cohort. PLoS One 2007;2:e492. doi: 10.1371/journal.pone.0000492
  • Dar L, Pati SK, Patro AR, et al. Congenital Cytomegalovirus infection in a highly seropositive semi-urban population in India. Pediatr Infect Dis J 2008;27:841-843. doi: 10.1097/ INF.0b013e3181723d55
  • Javid N, Cheraghali F, Moradi A, et al. Newborn Screening for Congenital Cytomegalovirus Infection in Iran. Pediatr Infect Dis J 2016;35:1052. doi: 10.1097/INF.000.000.0000001257
  • Boppana SB, Ross SA, Shimamura M, et al. Saliva Polymerase- Chain-Reaction Assay for Cytomegalovirus Screening in Newborns. N Engl J Med 2011;364:2111-8. doi: 10.1056/ NEJMoa1006561
  • Gunkel J, Wolfs TF, de Vries LS, et al. Predictors of severity for postnatal Cytomegalovirus infection in preterm infants and implications for treatment. Expert Rev Anti Infect Ther 2014;12:1345-55. doi: 10.1586/14787.210.2014.966080
  • Yılmaz E, Öcal FD, Yılmaz ZV, et al. Early initiation and exclusive breastfeeding: Factors influencing the attitudes of mothers who gave birth in an baby friendly hospital. Turk J Obtet Gynecol 2017;14:1-9. doi: 10.4274/tjod.90018
  • Hacettepe University Institute of Population Studies 2013 Turkey Demographic and Health Survey, T.R. Ministry of Development and TÜBİTAK, Ankara. https://dhsprogram. com/pubs/pdf/FR352/FR352.pdf. (Accessed on August 16, 2022)
  • Koyano S, Inoue N, Nagamori T. Newborn screening of congenital Cytomegalovirus infection using saliva can be influenced by breast feding. Arch Dis Child Fetal Neonatal Ed 2013;98:F182. doi: 10.1136/archdischild-2012-302230
  • Fujii T, Oka A, Morioka I, et al. Japanese Congenital Cytomegalovirus Study Group. Newborn Congenital Cytomegalovirus Screening Based on Clinical Manifestations and Evaluation of DNA-based Assays for In Vitro Diagnostics. Pediatr Infect Dis J 2017;3:942-6. doi: 10.1097/ INF.000.000.0000001630
  • Ornoy A, av-Citrin O. Fetal effects of primary and secondary Cytomegalovirus infection in pregnancy. Reprod Toxicol 2006;21:399-409. doi: 10.1016/j.reprotox.2005.02.002
  • Fowler KB, Stagno S, Pass RF, et al. The outcome of congenital Cytomegalovirus infection in relation to maternal antibody status. N Engl J 1992;326:663-7. doi: 10.1056/ NEJM199.203.053261003
  • Lilleri D, Kabanova A, Revello MG, et al. Fetal human Cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection. PLoS One 2013;8:e59863. doi: 10.1371/journal.pone.0059863
  • Fornara C, Cassaniti I, Zavattoni M, et al. Human Cytomegalovirus-specific memory CD4+ T-cell response and its correlation with virüs transmission to the fetus in pregnant women with primary infection. Clin Infect Dis 2017;65:1659- 65. doi: 10.1093/cid/cix622
  • Çelikel E, Tezer H, Kanik-Yüksek S, et al. Evaluation of immunocompetent children with cytomegalovirus infection: importance of neurodevelopmental follow-up. Eur J Pediatr 2015;174:1101-7. doi: 10.1007/s00431.015.2513-9
  • Fowler KB, McCollister FP, Sabo DL, et al. A Targeted Approach for Congenital Cytomegalovirus Screening Within Newborn Hearing Screening. Pediatrics 2017;139:e20162128. doi: 10.1542/peds.2016-2128
  • Fletcher KT, Horrell EMW, Ayugi J, et al. The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review. Otol Neurotol 2018;39:854-64. doi: 10.1097/MAO.000.000.0000001861
There are 35 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Original Research
Authors

Zubeyde Eres Sarıtas This is me 0000-0002-8482-3228

Bilal Olcay Peker 0000-0001-8735-2962

Dilek Çolak 0000-0002-8739-0130

Imran Saglık This is me 0000-0003-0864-4989

Rabia Can Sarinoğlu 0000-0001-9222-8659

Murat Turhan This is me

Aslı Bostancı Toptaş 0000-0002-1535-2661

Derya Mutlu This is me 0000-0002-6786-137X

Gözde Öngüt 0000-0003-2808-1829

Nihal Oygur 0000-0003-4379-6793

Munire Erman 0000-0002-3856-3787

Publication Date September 29, 2023
Published in Issue Year 2023 Volume: 36 Issue: 3

Cite

APA Eres Sarıtas, Z., Peker, B. O., Çolak, D., Saglık, I., et al. (2023). Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey. Marmara Medical Journal, 36(3), 290-296. https://doi.org/10.5472/marumj.1367753
AMA Eres Sarıtas Z, Peker BO, Çolak D, Saglık I, Sarinoğlu RC, Turhan M, Bostancı Toptaş A, Mutlu D, Öngüt G, Oygur N, Erman M. Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey. Marmara Med J. September 2023;36(3):290-296. doi:10.5472/marumj.1367753
Chicago Eres Sarıtas, Zubeyde, Bilal Olcay Peker, Dilek Çolak, Imran Saglık, Rabia Can Sarinoğlu, Murat Turhan, Aslı Bostancı Toptaş, Derya Mutlu, Gözde Öngüt, Nihal Oygur, and Munire Erman. “Congenital Cytomegalovirus Infection Cases and Follow-up Findings in Antalya, Turkey”. Marmara Medical Journal 36, no. 3 (September 2023): 290-96. https://doi.org/10.5472/marumj.1367753.
EndNote Eres Sarıtas Z, Peker BO, Çolak D, Saglık I, Sarinoğlu RC, Turhan M, Bostancı Toptaş A, Mutlu D, Öngüt G, Oygur N, Erman M (September 1, 2023) Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey. Marmara Medical Journal 36 3 290–296.
IEEE Z. Eres Sarıtas, “Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey”, Marmara Med J, vol. 36, no. 3, pp. 290–296, 2023, doi: 10.5472/marumj.1367753.
ISNAD Eres Sarıtas, Zubeyde et al. “Congenital Cytomegalovirus Infection Cases and Follow-up Findings in Antalya, Turkey”. Marmara Medical Journal 36/3 (September 2023), 290-296. https://doi.org/10.5472/marumj.1367753.
JAMA Eres Sarıtas Z, Peker BO, Çolak D, Saglık I, Sarinoğlu RC, Turhan M, Bostancı Toptaş A, Mutlu D, Öngüt G, Oygur N, Erman M. Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey. Marmara Med J. 2023;36:290–296.
MLA Eres Sarıtas, Zubeyde et al. “Congenital Cytomegalovirus Infection Cases and Follow-up Findings in Antalya, Turkey”. Marmara Medical Journal, vol. 36, no. 3, 2023, pp. 290-6, doi:10.5472/marumj.1367753.
Vancouver Eres Sarıtas Z, Peker BO, Çolak D, Saglık I, Sarinoğlu RC, Turhan M, Bostancı Toptaş A, Mutlu D, Öngüt G, Oygur N, Erman M. Congenital cytomegalovirus infection cases and follow-up findings in Antalya, Turkey. Marmara Med J. 2023;36(3):290-6.
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