Research Article
The Clinical Predictive Value of the Neutrophil to Lymphocyte Ratio as a Biomarker in Lumbar Disc Herniation
Abstract
Objective: Low back pain is a frequently seen problem in the society and causes loss
of labor. Although etiology of lumbar disc herniation is multi-factorial it is
known that it is determinant for the etiology of intervertebral disc
degeneration herniation. In recent studies, it has been shown that it has an
efficient role in the process of inflamation and inflamatory cytokine disc. We
aimed to investigate the association between the neutrophil to Lymphocyte Ratio level as an inflammatory biomarker in
patients with lumbar disc herniation.
Methods: 394 patients between the age
of 18-80 applying to our center because of low back pain complaint and having
lumbar MR were included in the study. The patients were divided into two groups
as having lumbar disc hernia and not having based on the lumbar MR result.
Blood samples were taken from all patients during application and neutrophil lymphocyte
rates were calculated.
Results. Average age of group with lumbar disc hernia
was 46 and 55 of these cases were female and 45 of them were male. N/L rate was
measured as 3.81+/-1.85 (p=0.001) in the group having lumbar disc hernia and
significant difference compared to the control group was noted. It was found
out that lifting weight (β=0.121 95% Cl (0.052-0.281), P<0.001),BMI
(β=0.226, 95% Cl (0.080-0.640) P=0.005), DM (β=0.268 95% Cl (0.074-0.969),
P=0.045), smoking (β=3.226 95% Cl (1,343-7.749), P<0.009), educational
background (β=5.268 95% Cl (1.941-9.796), P=0.001) and NLR (β=1.302 95% Cl
(1.013-1.673), P=0.039) were the independent predictors in the presence of
lumbar disc herniation.
Conclusion:
NLR may be used as a simple and reliable premise independent predictor of
lumbar disc herniation in patients with low back pain.
References
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- Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what tcauses it? Spine.2006; 31(18):2151–2161.
- Ala-Kokko L. Genetic risk factors for lumbar disc disease. Ann Med 2002; 34 (1):42–47.
- Battié MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K. et al. Volvo Award in clinical sciences: Determinants of lumbar disc degeneration. Spine 2005; 20 (24) : 2601–2612.
- Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Wiesel S. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bon JointSurgAm.1990; 72( 8) :403–408.
- En'Wezoh DC, Leonard DA, Schoenfeld AJ, Harris MB, Zampini JM, Bono CM Effectiveness of micro discectomy for lumbardisc herniation: A randomized controlled trial with 2 years of follow-up. Spin.2016 ;31( 6) : 2409–2414.
- Harjai KJ, Raizada A, Shenoy C, Sattur S, Orshaw P, Yaeger K,et al. A comparison of contemporary definitions of contrast nephropathy in patient sunder going percutaneous coronary intervention and a proposal for a novel nephron pathygrading system. Am J Cardiol 2008;101( 6) :812-819.
- Karin W, Lisbet H. Inflammatory Mediators in Intervertebral disc degeneration and discogenic pain Global Spine J.2013; 3 (3) :175–184.
- Kaya A, Kaya Y, Topcu S, Gunaydin ZY, Kurt M, Tanboga IH, et al. Neutrophil-to Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneou s Coronary Intervention. Angiology.2014; 5 (1): 51-56.
- Kaya A, Kurt M, Tanboga IH, Isik T, Ekinci M, Aksakal E et al. Relation of neutrophil to lymphocyte ratio with the presence and severity of stable coronary artery disease. Clin Appl Thromb Hemost.2014;2 ( 5) :473-477.
- LiW, LiuT, WuL, ChenC, JiaZ, BaiX, etal.Blocking the function of inflammatory cytokines and mediators by using IL-10 and TGF-β: a potential biological immune therapy for intervertebral disc degeneration in a beagle model.nt J MolSci 2014; 15(10) :172-183.
- Osterman H, Seitsalo S, Karppinen J, Malmivaara A. Effectiveness of micro discectomy for lumbar disc herniation: A randomized controlled trial with 2 years of follow-up. Spin.2006; 31( 21) :2409–2414.
- Parker SL, Godil SS, Mendenhall SK, Zuckerman SL, Shau DN, McGirt MJ. Two-year comprehensive medical management of degenerative lumbar spine disease (lumbar spondylo listhesis, stenosis, or disc herniation) a value analysis of cost, pain, disability, and quality of life: clinical article. J Neurosurg Spine.2014; 21( 2) :43-149.
- Russo D, Minutolo R, Cianciaruso B, Memoli B, Conte G et al. Earlyeffects of contrast media on renal hemodynamics and tubular function in chronic renal failure. J AmSocNephrol 1995; 6( 5) :1451-1458.
- Sari S, Aydogan M, As a common cause of backpain: Lumbar disc herniation Sarı, Totbid Dergisi. 2015; 14:298–304..
- Sen BB, Rifaioglu EN, Ekiz O, Sen T, Celik E, Dogramaci AC. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014;33( 3) :223-227.
- Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L et al. Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum.2010; 62(7) :1974.
- Shen FH, Samartis D, Anderson GB. Nonsurgical management of acute and chronic low back pain. JAmAcad Orthop Surg.2006;4(14) :477-487.
- Singh K, Masuda K, An HS. Animal models for human disc degeneration. Spine J. 2006;5( 6) :267–279.
- Solomon R,Dauerman HL. Contrast-induce dacute kidney injury. Circulation 2010;22(23):2451-2455.
- Spengler DM, Ouellette EA, Battié M.Elective discectomy for herniation of a lumbar disc. Additional experience with an objective method. J Bone Joint Surg Am.1990;72(2): 230–237.
- Stefan D, Daniel H, Stephen J. Fracture of the vertebral endplates, but not equienergetic ımpact load, promotes disc degeneration ın vitro. Journal of orthopaedıc research 2012; 3(5):,809-816.
Year 2019,
Volume: 5 Issue: 2, 145 - 150, 28.08.2019
Abstract
References
- Andersson GB.Epidemiological features of chronic low-backpain.Lancet. 1999; 581-585.
- Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what tcauses it? Spine.2006; 31(18):2151–2161.
- Ala-Kokko L. Genetic risk factors for lumbar disc disease. Ann Med 2002; 34 (1):42–47.
- Battié MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K. et al. Volvo Award in clinical sciences: Determinants of lumbar disc degeneration. Spine 2005; 20 (24) : 2601–2612.
- Boden SD, McCowin PR, Davis DO, Dina TS, Mark AS, Wiesel S. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bon JointSurgAm.1990; 72( 8) :403–408.
- En'Wezoh DC, Leonard DA, Schoenfeld AJ, Harris MB, Zampini JM, Bono CM Effectiveness of micro discectomy for lumbardisc herniation: A randomized controlled trial with 2 years of follow-up. Spin.2016 ;31( 6) : 2409–2414.
- Harjai KJ, Raizada A, Shenoy C, Sattur S, Orshaw P, Yaeger K,et al. A comparison of contemporary definitions of contrast nephropathy in patient sunder going percutaneous coronary intervention and a proposal for a novel nephron pathygrading system. Am J Cardiol 2008;101( 6) :812-819.
- Karin W, Lisbet H. Inflammatory Mediators in Intervertebral disc degeneration and discogenic pain Global Spine J.2013; 3 (3) :175–184.
- Kaya A, Kaya Y, Topcu S, Gunaydin ZY, Kurt M, Tanboga IH, et al. Neutrophil-to Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneou s Coronary Intervention. Angiology.2014; 5 (1): 51-56.
- Kaya A, Kurt M, Tanboga IH, Isik T, Ekinci M, Aksakal E et al. Relation of neutrophil to lymphocyte ratio with the presence and severity of stable coronary artery disease. Clin Appl Thromb Hemost.2014;2 ( 5) :473-477.
- LiW, LiuT, WuL, ChenC, JiaZ, BaiX, etal.Blocking the function of inflammatory cytokines and mediators by using IL-10 and TGF-β: a potential biological immune therapy for intervertebral disc degeneration in a beagle model.nt J MolSci 2014; 15(10) :172-183.
- Osterman H, Seitsalo S, Karppinen J, Malmivaara A. Effectiveness of micro discectomy for lumbar disc herniation: A randomized controlled trial with 2 years of follow-up. Spin.2006; 31( 21) :2409–2414.
- Parker SL, Godil SS, Mendenhall SK, Zuckerman SL, Shau DN, McGirt MJ. Two-year comprehensive medical management of degenerative lumbar spine disease (lumbar spondylo listhesis, stenosis, or disc herniation) a value analysis of cost, pain, disability, and quality of life: clinical article. J Neurosurg Spine.2014; 21( 2) :43-149.
- Russo D, Minutolo R, Cianciaruso B, Memoli B, Conte G et al. Earlyeffects of contrast media on renal hemodynamics and tubular function in chronic renal failure. J AmSocNephrol 1995; 6( 5) :1451-1458.
- Sari S, Aydogan M, As a common cause of backpain: Lumbar disc herniation Sarı, Totbid Dergisi. 2015; 14:298–304..
- Sen BB, Rifaioglu EN, Ekiz O, Sen T, Celik E, Dogramaci AC. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014;33( 3) :223-227.
- Shamji MF, Setton LA, Jarvis W, So S, Chen J, Jing L et al. Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. Arthritis Rheum.2010; 62(7) :1974.
- Shen FH, Samartis D, Anderson GB. Nonsurgical management of acute and chronic low back pain. JAmAcad Orthop Surg.2006;4(14) :477-487.
- Singh K, Masuda K, An HS. Animal models for human disc degeneration. Spine J. 2006;5( 6) :267–279.
- Solomon R,Dauerman HL. Contrast-induce dacute kidney injury. Circulation 2010;22(23):2451-2455.
- Spengler DM, Ouellette EA, Battié M.Elective discectomy for herniation of a lumbar disc. Additional experience with an objective method. J Bone Joint Surg Am.1990;72(2): 230–237.
- Stefan D, Daniel H, Stephen J. Fracture of the vertebral endplates, but not equienergetic ımpact load, promotes disc degeneration ın vitro. Journal of orthopaedıc research 2012; 3(5):,809-816.
There are 22 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research articles |
| Authors | |
| Publication Date | August 28, 2019 |
| Published in Issue | Year 2019 Volume: 5 Issue: 2 |
Cited By
e-ISSN 2149-7796