Research Article
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Year 2024, Volume: 10 Issue: 1, 50 - 58, 28.03.2024

Osman Bektaş Melih Ürkmez

https://doi.org/10.19127/mbsjohs.1398018

Abstract

References

  • Singh M, Koyfman A, Martinez JP. Abdominal Vascular Catastrophes. Emerg Med Clin North Am. 2016 May;34(2):327-39. doi: 10.1016/j.emc.2015.12.014.
  • Günay Ş, Güllülü NS. Yaşlılarda aort anevrizmalarına yaklaşım [Approach to aortic aneurysms in the elderly]. Turk Kardiyol Dern Ars. 2017 Sep;45(Suppl 5):93-95. Turkish. doi: 10.5543/tkda.2017.57034.
  • Pisano C, Balistreri CR, Ricasoli A, Ruvolo G. Cardiovascular disease in ageing: an overview on thoracic aortic aneurysm as an emerging inflammatory disease. Mediators Inflamm. 2017;2017:1274034.doi:10.1155/2017/1274034.
  • Gonzalez-Hidalgo C, De Haro J, Bleda S, Cañibano C, Michel I, Acin F. Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease. Ther Adv Cardiovasc Dis. 2018;12(4):123–9. doi:10.1177/1753944717750338.
  • Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W,et al., Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014 Dec 1;20(23):6212-22. doi: 10.1158/1078-0432.CCR-14-0442.
  • Tang T, Boyle JR, Dixon AK, Varty K. Inflammatory abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2005 Apr;29(4):353-62. doi: 10.1016/j.ejvs.2004.12.009. PMID: 15749035.
  • Gardin JM, Arnold AM, Polak J, Jackson S, Smith V, Gottdiener J. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular health study). Am J Cardiol. 2006;97(2):270-5. doi:10.1016/j.amjcard.2005.08.039.
  • Ruvolo G, Pisano C, Candore G, Lio D, Palmeri C, Maresi E, et al. Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"? Mediators Inflamm. 2014;2014:349476. doi:10.1155/2014/349476.
  • Jia LX, Zhang WM, Zhang HJ, Li TT, Wang YL, Qin YW, et al. Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. J Pathol. 2015;236(3):373-83. doi:10.1002/path.4534.
  • Yuan SM, Shi YH, Wang JJ, Lü FQ, Gao S. Elevated plasma D-dimer and hypersensitive C-reactive protein levels may indicate aortic disorders. Rev Bras Cir Cardiovasc. 2011;26(4):573-81. doi:10.5935/1678-9741.20110047.
  • Bancroft AJ, Abel EW, McLaren M, Belch JJ. Mean platelet volume is a useful parameter: A reproducible routine method using a modified Coulter thrombocytometer. Platelets 2000;11:379 87. doi: 10.1080/09537100020008311.
  • Karaman H, Karakukcu C, Kocer D. Can mean platelet volume serve as a marker for prostatitis? Int J Med Sci. 2013 Aug 21;10(10):1387-91. doi: 10.7150/ijms.6126.
  • Canpolat F, Akpinar H, Eskioğlu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010 Mar;29(3):325-8. doi: 10.1007/s10067-009-1323-8.
  • Soydinc S, Turkbeyler IH, Pehlivan Y, Soylu G, Goktepe MF, Bilici M, et al. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation. 2014 Feb;37(1):100-6. doi: 10.1007/s10753-013-9716-x.
  • Moon G, Noh H, Cho IJ, Lee JI, Han A. Prediction of late recurrence in patients with breast cancer: elevated neutrophil to lymphocyte ratio (NLR) at 5 years after diagnosis and late recurrence. Breast Cancer. 2020 Jan;27(1):54-61. doi: 10.1007/s12282-019-00994-z.
  • Jomrich G, Gruber ES, Winkler D, Hollenstein M, Gnant M, Sahora K, et al. Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection. J Gastrointest Surg. 2020 Mar;24(3):610-618. doi: 10.1007/s11605-019-04187-z.
  • Bhutta H, Agha R, Wong J, Tang TY, Wilson YG, Walsh SR. Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study. Vasc Endovascular Surg. 2011 Apr;45(3):227-31. doi: 10.1177/1538574410396590.
  • Hajibandeh S, Hajibandeh S, Hobbs N, Mansour M. Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis. Am J Surg. 2020 Jan;219(1):154-163. doi: 10.1016/j.amjsurg.2019.04.018.
  • Zhang HF, Ge YL, Wang HY, Zhang Q, Li WQ, Chen Y,et al. Neutrophil-to-Lymphocyte Ratio Improves the Accuracy and Sensitivity of Pneumonia Severity Index in Predicting 30-Day Mortality of CAP Patients. Clin Lab. 2019 Oct 1;65(10). doi: 10.7754/Clin.Lab.2019.190226.
  • Angkananard T, Anothaisintawee T, McEvoy M, Attia J, Thakkinstian A. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018 Nov 11;2018:2703518. doi: 10.1155/2018/2703518.
  • Appleton ND, Bailey DM, Morris-Stiff G, Lewis MH. Neutrophil to lymphocyte ratio predicts perioperative mortality following open elective repair of abdominal aortic aneurysms. Vasc Endovascular Surg. 2014 May;48(4):311-6. doi: 10.1177/1538574413519713.
  • Dale MA, Ruhlman MK, Baxter BT. Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1746-55. doi: 10.1161/ATVBAHA.115.305269. Epub 2015 Jun 4.
  • Simpson E, Cantor H. Regulation of the immune response by subclasses of T lymphocytes. II. The effect of adult thymectomy upon humoral and cellular responses in mice. Eur J Immunol. 1975 May;5(5):337-43. doi: 10.1002/eji.1830050509.
  • Gong S, Gao X, Xu F, Shang Z, Li S, Chen W, Yang J, Li J. Association of lymphocyte to monocyte ratio with severity of coronary artery disease. Medicine (Baltimore). 2018 Oct;97(43):e12813. doi: 10.1097/MD.0000000000012813.
  • Kordzadeh A, Malietzis G, Browne T, Prionidis I, Panayiotopoulos YP. Neutrophil to lymphocyte ratio (NLR) of five predicts 30-day morbidity in ruptured abdominal aortic aneurysms (rAAA): a retrospective cohort study. Int J Surg. 2015 Mar;15:45-8. doi: 10.1016/j.ijsu.2015.01.013.
  • Barnes M, Boult M, Maddern G, Fitridge R. A model to predict outcomes for endovascular aneurysm repair using preoperative variables. Eur J Vasc Endovasc Surg. 2008 May;35(5):571-9. doi: 10.1016/j.ejvs.2007.12.003.

Relationship Between Abdominal Aortic Aneurysm and Inflammatory Markers

Year 2024, Volume: 10 Issue: 1, 50 - 58, 28.03.2024

Osman Bektaş Melih Ürkmez

https://doi.org/10.19127/mbsjohs.1398018

Abstract

Objective: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm and systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and other inflammatory markers, especially those derived from complete blood count.
Methods: Retrospectively, 72 consecutive patients admitted to our clinic for Abdominal Endovascular Aneurysm Repair (EVAR) for abdominal aortic aneurysm (AAA) between January 2019 and January 2022 were included in the study. Routine blood samples were taken before EVAR operation. NLR, PLR, SII of the patients were calculated and, RDW, Mean Platelet Volume (MPV), C-reactive protein values and other laboratory tests were recorded. They were compared with an age-matched control group.
Results: The age of the patients included in the study was 67.7 ± 10.6 years and the majority were male. The frequency of hypertension and coronary artery disease was also higher. In the comparison of hematologic parameters with the control group, MPV was 10.4(9.6-11.2) versus 9.5(8.6-10.1), p<0.001; CRP was 5(1.625-42.135) versus 3.21(2.08-4.75), p=0.04, NLR was 3.46(2.15-6.69) versus 2.29(1.65-2.78), p<0.001. SII was 682.54(417.08-1522.72) versus 558.22(405.33-711.31), p=0.02. The most significant association with the presence of ascending aortic aneurysm was observed between NLR.
Conclusion: Inflammatory markers, CRP, SII, NLR, MPV are significantly higher in patients with AAA. In patients with AAA, the association between aneurysm and NLR appears to be better. When following up these patients, it may be especially useful to look at CRP, SII, NLR, MPV levels.

Keywords

Aortic Aneurysm Systemic İmmune İnflammation İndex Neurophil Lymphocyte Ratio

Ethical Statement

:Ethics committee approval was received for this study from 23.06.2023 Clinical Research Ethics Committee of Ordu University.

References

  • Singh M, Koyfman A, Martinez JP. Abdominal Vascular Catastrophes. Emerg Med Clin North Am. 2016 May;34(2):327-39. doi: 10.1016/j.emc.2015.12.014.
  • Günay Ş, Güllülü NS. Yaşlılarda aort anevrizmalarına yaklaşım [Approach to aortic aneurysms in the elderly]. Turk Kardiyol Dern Ars. 2017 Sep;45(Suppl 5):93-95. Turkish. doi: 10.5543/tkda.2017.57034.
  • Pisano C, Balistreri CR, Ricasoli A, Ruvolo G. Cardiovascular disease in ageing: an overview on thoracic aortic aneurysm as an emerging inflammatory disease. Mediators Inflamm. 2017;2017:1274034.doi:10.1155/2017/1274034.
  • Gonzalez-Hidalgo C, De Haro J, Bleda S, Cañibano C, Michel I, Acin F. Differential mRNA expression of inflammasome genes NLRP1 and NLRP3 in abdominal aneurysmal and occlusive aortic disease. Ther Adv Cardiovasc Dis. 2018;12(4):123–9. doi:10.1177/1753944717750338.
  • Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W,et al., Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014 Dec 1;20(23):6212-22. doi: 10.1158/1078-0432.CCR-14-0442.
  • Tang T, Boyle JR, Dixon AK, Varty K. Inflammatory abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2005 Apr;29(4):353-62. doi: 10.1016/j.ejvs.2004.12.009. PMID: 15749035.
  • Gardin JM, Arnold AM, Polak J, Jackson S, Smith V, Gottdiener J. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular health study). Am J Cardiol. 2006;97(2):270-5. doi:10.1016/j.amjcard.2005.08.039.
  • Ruvolo G, Pisano C, Candore G, Lio D, Palmeri C, Maresi E, et al. Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"? Mediators Inflamm. 2014;2014:349476. doi:10.1155/2014/349476.
  • Jia LX, Zhang WM, Zhang HJ, Li TT, Wang YL, Qin YW, et al. Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. J Pathol. 2015;236(3):373-83. doi:10.1002/path.4534.
  • Yuan SM, Shi YH, Wang JJ, Lü FQ, Gao S. Elevated plasma D-dimer and hypersensitive C-reactive protein levels may indicate aortic disorders. Rev Bras Cir Cardiovasc. 2011;26(4):573-81. doi:10.5935/1678-9741.20110047.
  • Bancroft AJ, Abel EW, McLaren M, Belch JJ. Mean platelet volume is a useful parameter: A reproducible routine method using a modified Coulter thrombocytometer. Platelets 2000;11:379 87. doi: 10.1080/09537100020008311.
  • Karaman H, Karakukcu C, Kocer D. Can mean platelet volume serve as a marker for prostatitis? Int J Med Sci. 2013 Aug 21;10(10):1387-91. doi: 10.7150/ijms.6126.
  • Canpolat F, Akpinar H, Eskioğlu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010 Mar;29(3):325-8. doi: 10.1007/s10067-009-1323-8.
  • Soydinc S, Turkbeyler IH, Pehlivan Y, Soylu G, Goktepe MF, Bilici M, et al. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation. 2014 Feb;37(1):100-6. doi: 10.1007/s10753-013-9716-x.
  • Moon G, Noh H, Cho IJ, Lee JI, Han A. Prediction of late recurrence in patients with breast cancer: elevated neutrophil to lymphocyte ratio (NLR) at 5 years after diagnosis and late recurrence. Breast Cancer. 2020 Jan;27(1):54-61. doi: 10.1007/s12282-019-00994-z.
  • Jomrich G, Gruber ES, Winkler D, Hollenstein M, Gnant M, Sahora K, et al. Systemic Immune-Inflammation Index (SII) Predicts Poor Survival in Pancreatic Cancer Patients Undergoing Resection. J Gastrointest Surg. 2020 Mar;24(3):610-618. doi: 10.1007/s11605-019-04187-z.
  • Bhutta H, Agha R, Wong J, Tang TY, Wilson YG, Walsh SR. Neutrophil-lymphocyte ratio predicts medium-term survival following elective major vascular surgery: a cross-sectional study. Vasc Endovascular Surg. 2011 Apr;45(3):227-31. doi: 10.1177/1538574410396590.
  • Hajibandeh S, Hajibandeh S, Hobbs N, Mansour M. Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis. Am J Surg. 2020 Jan;219(1):154-163. doi: 10.1016/j.amjsurg.2019.04.018.
  • Zhang HF, Ge YL, Wang HY, Zhang Q, Li WQ, Chen Y,et al. Neutrophil-to-Lymphocyte Ratio Improves the Accuracy and Sensitivity of Pneumonia Severity Index in Predicting 30-Day Mortality of CAP Patients. Clin Lab. 2019 Oct 1;65(10). doi: 10.7754/Clin.Lab.2019.190226.
  • Angkananard T, Anothaisintawee T, McEvoy M, Attia J, Thakkinstian A. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018 Nov 11;2018:2703518. doi: 10.1155/2018/2703518.
  • Appleton ND, Bailey DM, Morris-Stiff G, Lewis MH. Neutrophil to lymphocyte ratio predicts perioperative mortality following open elective repair of abdominal aortic aneurysms. Vasc Endovascular Surg. 2014 May;48(4):311-6. doi: 10.1177/1538574413519713.
  • Dale MA, Ruhlman MK, Baxter BT. Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1746-55. doi: 10.1161/ATVBAHA.115.305269. Epub 2015 Jun 4.
  • Simpson E, Cantor H. Regulation of the immune response by subclasses of T lymphocytes. II. The effect of adult thymectomy upon humoral and cellular responses in mice. Eur J Immunol. 1975 May;5(5):337-43. doi: 10.1002/eji.1830050509.
  • Gong S, Gao X, Xu F, Shang Z, Li S, Chen W, Yang J, Li J. Association of lymphocyte to monocyte ratio with severity of coronary artery disease. Medicine (Baltimore). 2018 Oct;97(43):e12813. doi: 10.1097/MD.0000000000012813.
  • Kordzadeh A, Malietzis G, Browne T, Prionidis I, Panayiotopoulos YP. Neutrophil to lymphocyte ratio (NLR) of five predicts 30-day morbidity in ruptured abdominal aortic aneurysms (rAAA): a retrospective cohort study. Int J Surg. 2015 Mar;15:45-8. doi: 10.1016/j.ijsu.2015.01.013.
  • Barnes M, Boult M, Maddern G, Fitridge R. A model to predict outcomes for endovascular aneurysm repair using preoperative variables. Eur J Vasc Endovasc Surg. 2008 May;35(5):571-9. doi: 10.1016/j.ejvs.2007.12.003.
There are 26 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Research articles
Authors

Osman Bektaş 0000-0002-6616-9891

Melih Ürkmez 0000-0002-0961-6659

Publication Date March 28, 2024
Submission Date November 29, 2023
Acceptance Date January 17, 2024
Published in Issue Year 2024 Volume: 10 Issue: 1

Cite

Vancouver Bektaş O, Ürkmez M. Relationship Between Abdominal Aortic Aneurysm and Inflammatory Markers. Mid Blac Sea J Health Sci. 2024;10(1):50-8.
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