Research Article
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Hematological and Inflammatory Parameters to Predict the Develop Surgical Site Infection After Cesarean Section

Year 2024, Volume: 10 Issue: 1, 71 - 80, 28.03.2024
https://doi.org/10.19127/mbsjohs.1405504

Abstract

Objective: This study seeks to illustrate the efficacy of inflammatory hematological markers in patients who develop site infections following a cesarean section, while also establishing reference values for these parameters.
Methods: This retrospective, single-center study was conducted at Ordu University Training and Research Hospital from January 2016 to January 2023. A comparison was made between 42 cases where surgical site infection developed after cesarean section and 42 cases. The data for this study were obtained from hospital medical records, which encompass of demographic, general medical, obstetric, and neonatal information. Preoperative complete blood count (CBC) was included in the analysis.
Results: Statistically significant differences were observed among preoperative hematological and inflammation markers, including "PLT, WBC, NOT, PCT, MLR, DNLR, NLO, PLO, MPVPR, LP, RDWPR, NLRNPR, SII. ROC analysis revealed that optimal cutoff values were statistically significant for most laboratory parameters and blood count-derived ratios in patients with post-Cesarean wound infection. The largest AUC for SII was 0.861 with the cut-off value of 892.03 (sensivity %76 and specifity %76).
Conclusion: This article has revealed differences between hematological and inflammatory markers in patients developing complications at the incision site after cesarean section. To assess the risk of surgical site infection development and reduce morbidity and hospitalization durations, further research in this area is needed.

References

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  • Isik H, Aynioglu O, Sahbaz A, Arikan I, Karçaaltincaba D, Sahin H, & Köroglu M. Can plateletcrit, an underestimated platelet parameter, be related with preterm labour?. Journal of Obstetrics and Gynaecology, 2015;35(7):676-680.
  • Belaj K, Pichler M, Hackl G, Rief P, Eller P, Hafner F, & Gary T. Association of the derived neutrophil–lymphocyte ratio with critical limb ischemia. Angiology, 2016;67(4):350-354.
  • Biyik I, Albayrak M, & Keskin F. Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in missed abortion. Revista Brasileira de Ginecologia e Obstetrícia/RBGO Gynecology and Obstetrics, 2020;42(05):235-239.
  • Yuce E. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) Can Predict Spontaneous Preterm Birth?. Journal of Inflammation Research, 2023;2423-2429.
  • Keles A, Dagdeviren G, Yucel Celik O, Karatas Sahin E., Obut M, Kahraman C, et al. Systemic immune‐inflammation index to predict placenta accreta spectrum and its histological subtypes. Journal of Obstetrics and Gynaecology Research,2022;48(7):1675-1682.
  • Zhang H, Lin F, & Wang Z. Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study. BMC cancer, 2023;23(1):1-8.
  • Zhu R, Chen C, Wang Q, Zhang X, Lu C, & Sun Y. Routine blood parameters are helpful for early identification of influenza infection in children. BMC Infectious Diseases, 2020;20(1):1-10.
  • Wang H, Wang Y, Liang X, Zhang C, & Guo B. Value of red cell distribution width-to-platelet ratio as a predictor for morbidity and mortality in neonatal intensive care unit. Clinical Hemorheology and Microcirculation, 2022;81(4):281-291.
  • Keskin S, & Keskin DD One Year Analysis of Hematological and Inflammatory Parameters to Predict the Severity of COVID-19 Infection in Pregnant Women. Middle Black Sea Journal of Health Science, 2022;8(1):146-157.
  • Akdulum MFC., Demirdağ E, Arık Sİ, Safarova S, et al. Is the First-Trimester Systemic Immune-Inflammation Index Associated with Preeclampsia? Cureus, 2023;15(8).
Year 2024, Volume: 10 Issue: 1, 71 - 80, 28.03.2024
https://doi.org/10.19127/mbsjohs.1405504

Abstract

References

  • Boley JP. The history of caesarean section. CMAJ 1991;145(4):319–22.
  • Hammad IA, Chauhan SP, Magann EF, Alfred Z. Peripartum complications with cesarean delivery: a review of Maternal-Fetal Medicine Units Network publications. J Matern Fetal Neonatal Med 2014;7058, doi:http://dx.doi.org/ 10.3109/14767058.2013.818970.
  • Conroy K, Koenig AF, Yu Y, Courtney A, Lee HJ, Norwitz ER. Infectious morbidity after cesarean delivery: 10 strategies to reduce risk. Rev Obstet Gynecol 2012;5 (2):69–77, doi:http://dx.doi.org/10.3909/riog0188.
  • Wloch C, Wilson J, Lamagni T, Harrington P, Charlett A, Sheridan E. Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study. BJOG 2012;1324–33, doi:http://dx.doi.org/10.1111/ j.1471-0528.2012.03452.x.
  • Nabhan AF, Allam NE, Hamed Abdel-Aziz Salama M. Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section (Review). Cochrane Database Syst Rev 2016;17(6), doi:http://dx.doi.org/ 10.1002/14651858.CD011876.pub2.www.cochranelibrary.com.
  • Balta S, Ozturk C, Balta S, Ozturk C. The platelet-lymphocyte ratio: a simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets 2015;7104:2014–6, doi:http://dx.doi.org/10.3109/09537104.2014.979340.
  • Büyükavcı R, Aktürk SSS. Comparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients with different grades of knee osteoarthritis. J Back Musculoskelet Rehabil 2018;31(6):1035–9.
  • Verit FF, Cetin O, Yildirim O, Neutrophil to lymphocyte ratio is superior to platelet to lymphocyte ratio as an early predictor of moderate/severe ovarian hyperstimulation syndrome. J Obstet Gynaecol 2014;3615, doi:http://dx.doi.org/10.3109/01443615.2014.920792.
  • Kurtoglu E, Kokcu A, Celik H . May ratio of neutrophil to lymphocyte be useful in predicting the risk of developing preeclampsia? A pilot study. J Matern Fetal Neonatal Med 2015;7058, doi:http://dx.doi.org/10.3109/14767058.2014.905910.
  • Sonmez, O., & Sonmez, M. Role of platelets in immune system and inflammation. Porto biomedical journal, 2017;2(6): 311-314.
  • Feng, J. R., Qiu, X., Wang, F., Chen, P. F., Gao, Q., Peng, Y. N., et al. Diagnostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in Crohn’s disease. Gastroenterology research and practice, 2017.
  • Rosales, C.Neutrophil: a cell with many roles in inflammation or several cell types?. Frontiers in physiology,2018;9:113.
  • Celik T, Balta S, Demir M., Yildirim, AO, Kaya MG, Ozturk C, et al. Predictive value of admission red cell distribution width-platelet ratio for no-reflow phenomenon in acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiology journal,2016;23(1):84-92.
  • Isik H, Aynioglu O, Sahbaz A, Arikan I, Karçaaltincaba D, Sahin H, & Köroglu M. Can plateletcrit, an underestimated platelet parameter, be related with preterm labour?. Journal of Obstetrics and Gynaecology, 2015;35(7):676-680.
  • Belaj K, Pichler M, Hackl G, Rief P, Eller P, Hafner F, & Gary T. Association of the derived neutrophil–lymphocyte ratio with critical limb ischemia. Angiology, 2016;67(4):350-354.
  • Biyik I, Albayrak M, & Keskin F. Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in missed abortion. Revista Brasileira de Ginecologia e Obstetrícia/RBGO Gynecology and Obstetrics, 2020;42(05):235-239.
  • Yuce E. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) Can Predict Spontaneous Preterm Birth?. Journal of Inflammation Research, 2023;2423-2429.
  • Keles A, Dagdeviren G, Yucel Celik O, Karatas Sahin E., Obut M, Kahraman C, et al. Systemic immune‐inflammation index to predict placenta accreta spectrum and its histological subtypes. Journal of Obstetrics and Gynaecology Research,2022;48(7):1675-1682.
  • Zhang H, Lin F, & Wang Z. Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study. BMC cancer, 2023;23(1):1-8.
  • Zhu R, Chen C, Wang Q, Zhang X, Lu C, & Sun Y. Routine blood parameters are helpful for early identification of influenza infection in children. BMC Infectious Diseases, 2020;20(1):1-10.
  • Wang H, Wang Y, Liang X, Zhang C, & Guo B. Value of red cell distribution width-to-platelet ratio as a predictor for morbidity and mortality in neonatal intensive care unit. Clinical Hemorheology and Microcirculation, 2022;81(4):281-291.
  • Keskin S, & Keskin DD One Year Analysis of Hematological and Inflammatory Parameters to Predict the Severity of COVID-19 Infection in Pregnant Women. Middle Black Sea Journal of Health Science, 2022;8(1):146-157.
  • Akdulum MFC., Demirdağ E, Arık Sİ, Safarova S, et al. Is the First-Trimester Systemic Immune-Inflammation Index Associated with Preeclampsia? Cureus, 2023;15(8).
There are 23 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Research articles
Authors

Turan Kaan Karakaya 0000-0001-7730-7690

Deha Denizhan Keskin 0000-0002-6108-7619

Publication Date March 28, 2024
Submission Date December 15, 2023
Acceptance Date March 3, 2024
Published in Issue Year 2024 Volume: 10 Issue: 1

Cite

Vancouver Karakaya TK, Keskin DD. Hematological and Inflammatory Parameters to Predict the Develop Surgical Site Infection After Cesarean Section. Mid Blac Sea J Health Sci. 2024;10(1):71-80.

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