Case Report
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Bromelain improved long-term erythema multiforme attacks induced by herpes simplex infection : A case report

Year 2019, Volume: 3 Issue: 3, 311 - 313, 26.10.2019
https://doi.org/10.30565/medalanya.515649

Abstract

Eritema multiforme, genellikle ekstremite distallerinde yerleşen, eritemli, hedef benzeri maküller, papüller ve plaklar ile mukozal tutulumla karakterize immün kökenli bir cilt hastalığıdır. Etyolojide sıklıkla ilaçlar ve herpes enfeksiyonları vardır. Herpes simpleks enfeksiyonlarının tekrarı, immünolojik açıdan duyarlı kişilerde yeni eritema multiforme lezyonlarına neden olur. Bu nedenle, herpes reaktivasyonlarını baskılamak, eritema multiforme ataklarını da baskılar. Asiklovir, valasiklovir ve famsiklovir gibi antiviral ilaçlar sürekli kullanım sonrası yetersiz etkileri nedeniyle, nükslerin önlenmesi için sınırlı kapasiteye sahiptir. Hastalar nüksleri önlemek için genellikle kesin bir tedavi arar. Bromelain, ananas bitkisinden üretilen ve proteolitik enzimler içeren iyi bilinen herbal bir üründür. Mükemmel güvenlik profili ile yıllardır sinüzit, spor yaralanmaları ve neoplastik hastalıklar gibi birçok hastalıkta kullanılmaktadır. Burada, herpes simpleks enfeksiyonlarının neden olduğu uzun süredir eritema multiforme atakları yaşayan genç bir bayan hastayı sunuyoruz. Bir yıl boyunca oral yolla 1 gram bromelain kullanan hastada herpes ve eritema multiforme atakları tamamen kayboldu. 

References

  • 1. Kamala KA, Ashok L, Annigeri RG. Herpes associated erythema multiforme. Contemp Clinic Dent.2011;2(4)372-5. PMID:22346171
  • 2. Lemak MA, Duvic M, Bean SF. Oral acyclovier for prevention of herpes-associated erythema multiforme.J Am Acad of Dermatol.1986;15(1):50-4. PMID:3722509
  • 3. Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R. Potential role of bromelain in clinical and therapeutic applications.Biomed Rep. 2106;5(3):283-8. PMID:27602208
  • 4. Konuklugil B, Kuşdemir O. Bromelain. J Lit Pharm Sci 2018;7(1):1-10. doi:10.5336/pharmsci.2017-56115
  • 5. Samim F, Auluck A, Zed C, Williams PM.Erythema multiforme: A review of epidemiology, pathogenesis, clinical features and treatment. Dent Clin North Am. 2013;57(4):583-96. PMID: 24034067
  • 6. Staikuniene J, Staneviciute J. Long-term valacyclovir treatment and immune modulation for herpes-asscociated erythema multiforme. Cent Eur J Immunol. 2015;40(3):387-90. PMID:26648786
  • 7. Braun JM,SchneiderB,Beuth HJ.Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany.In Vivo  2005;19(2):417-21. PMID:15796206

Bromelain improved long-term erythema multiforme attacks induced by herpes simplex infection : a case report

Year 2019, Volume: 3 Issue: 3, 311 - 313, 26.10.2019
https://doi.org/10.30565/medalanya.515649

Abstract

Erythema multiforme is an immune- mediated skin disorder characterized by erythematous target –like macules, papules and plaques commonly located over distal extremities as well as mucosal involvement. It is mostly induced by herpes simplex infections and various medications. Recurrences of herpes simplex infections result in new erythema multiforme lesions in immunologically susceptible people. Therefore, suppressing herpes reactivations also suppresses erythema multiforme attacks. Antiviral medications such as acyclovir, valacyclovir and famciclovir have limited capacity to prevent such recurrences due to their inadequate efficiency after continuous use . Those patients usually seek an absolute remedy to prevent recurrences. Bromelain is a well-known herbal supplement containing proteolytic enzymes produced from pineapple plant. It has been used in many clinical conditions including sinusitis, sports injuries and neoplastic diseases for years with a great safety profile. Herein, we present a young female patient with long -term erythema multiforme attacks induced by herpes simplex infections. She became free of disease after using oral bromelain 500 mg twice a day for one year. 


References

  • 1. Kamala KA, Ashok L, Annigeri RG. Herpes associated erythema multiforme. Contemp Clinic Dent.2011;2(4)372-5. PMID:22346171
  • 2. Lemak MA, Duvic M, Bean SF. Oral acyclovier for prevention of herpes-associated erythema multiforme.J Am Acad of Dermatol.1986;15(1):50-4. PMID:3722509
  • 3. Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R. Potential role of bromelain in clinical and therapeutic applications.Biomed Rep. 2106;5(3):283-8. PMID:27602208
  • 4. Konuklugil B, Kuşdemir O. Bromelain. J Lit Pharm Sci 2018;7(1):1-10. doi:10.5336/pharmsci.2017-56115
  • 5. Samim F, Auluck A, Zed C, Williams PM.Erythema multiforme: A review of epidemiology, pathogenesis, clinical features and treatment. Dent Clin North Am. 2013;57(4):583-96. PMID: 24034067
  • 6. Staikuniene J, Staneviciute J. Long-term valacyclovir treatment and immune modulation for herpes-asscociated erythema multiforme. Cent Eur J Immunol. 2015;40(3):387-90. PMID:26648786
  • 7. Braun JM,SchneiderB,Beuth HJ.Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany.In Vivo  2005;19(2):417-21. PMID:15796206
There are 7 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Case Report
Authors

Habibullah Aktaş 0000-0001-9239-1659

Publication Date October 26, 2019
Submission Date January 21, 2019
Acceptance Date June 16, 2019
Published in Issue Year 2019 Volume: 3 Issue: 3

Cite

Vancouver Aktaş H. Bromelain improved long-term erythema multiforme attacks induced by herpes simplex infection : a case report. Acta Med. Alanya. 2019;3(3):311-3.

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