Clinical Research
Year 2023,
Volume: 5 Issue: 1, 160 - 3, 15.01.2023
Abstract
References
- 1. Bloudek LM, Stokes M, Buse DC, et al. Cost of healthcare for patients with migraine in five European countries: results from the International Burden of Migraine Study (IBMS). J Headache Pain. 2012;13:361-78.
- 2. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2163-96.
- 3. Steiner TJ, Stovner LJ, Birbeck GL. Migraine: the seventh disabler. Cephalalgia. 2013;33:289-90.
- 4. Vanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalalgia. 2007;27:843-6.
- 5. Reuter U, Bolay H, Jansen-Olesen I, et al. Delayed inflammation in rat meninges: implications for migraine pathophysiology. Brain. 2001;124:2490-502.
- 6. Taneja R, Parodo J, Jia SH, et al. Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med. 2004;32:1460-9.
- 7. Vidal AC, Howard LE, de Hoedt A, et al. Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database. Cancer Causes Control. 2018;29:581-8.
- 8. Wada H, Dohi T, Miyauchi K, et al. Pre-procedural neutrophil-to-lymphocyte ratio and long-term cardiac outcomes after percutaneous coronary intervention for stable coronary artery disease. Atherosclerosis. 2017;265:35-40.
- 9. Kotfis K, Bott-Olejnik M, Szylinska A, et al. Could neutrophil-to-lymphocyte ratio (NLR) serve as a potential marker for delirium prediction in patients with acute ischemic stroke? a prospective observational study. J Clin Med. 2019;8.
- 10. Hemond CC, Glanz BI, Bakshi R, et al. The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis. BMC Neurol. 2019;19:23.
- 11. Bressi E, Mangiacapra F, Ricottini E, et al. Impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on 5-year clinical outcomes of patients with stable coronary artery disease undergoing elective percutaneous coronary intervention. J Cardiovasc Transl Res. 2018;11:517-23.
- 12. Simsek F, Bilge N, Ceylan M. The relationship of migraine clinical features with neutrophil- lymphocyte ratio. ACU Sağlık Bil Derg. 2020;11:434-8.
- 13. Panpalli Ates M. Is neutrophils/lymphocytes ratio affected during ‘migraine attacks with aura’ in migraine patients? J Basic Clin Health Sci. 2021;2:36-40.
- 14. Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629-808.
- 15. Delgado DA, Lambert BS, Boutris N, et al. Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults. J Am Acad Orthop Surg Glob Res Rev. 2018;2:e088.
- 16. Boonstra AM, Schiphorst Preuper HR, Balk GA, et al. Cut-off points for mild, moderate, and severe pain on the visual analogue scale for pain in patients with chronic musculoskeletal pain. Pain. 2014;155:2545-50.
- 17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
- 18. Menges T, Engel J, Welters I, et al. Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications. Crit Care Med. 1999;27:733-40.
- 19. Kumarasamy C, Sabarimurugan S, Madurantakam RM, et al. Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer-A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2019;98:e14834.
- 20. Jiang J, Liu R, Yu X, et al. The neutrophil-lymphocyte count ratio as a diagnostic marker for bacteraemia: A systematic review and meta-analysis. Am J Emerg Med. 2019;37:1482-9.
- 21. Faria SS, Fernandes PC Jr, Silva MJ, et al. The neutrophil-to-lymphocyte ratio: a narrative review. Ecancermedicalscience. 2016;10:702.
- 22. Nagy GR, Kemeny L, Bata-Csorgo Z. Neutrophil-to-lymphocyte ratio: a biomarker for predicting systemic involvement in adult IgA vasculitis patients. J Eur Acad Dermatol Venereol. 2017;31:1033-7.
- 23. Huang Z, Fu Z, Huang W, et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis. Am J Emerg Med. 2020;38:641-7.
- 24. Karabulut KU, Egercioglu TU, Uyar M, et al. The change of neutrophils/lymphocytes ratio in migraine attacks: A case-controlled study. Ann Med Surg (Lond). 2016;10:52-6.
- 25. Ocak Ö, Şahin E. The relationship of migraine headache with neutrophil-lymphocyte ratio, platelet lymphocyte ratio and erythrocyte distribution width. The Medical Journal of Mustafa Kemal University. 2021;12:114-8.
Year 2023,
Volume: 5 Issue: 1, 160 - 3, 15.01.2023
Abstract
Aim: As in many chronic pain syndromes, self-reported pain is the main criterion used by clinicians assessing patients with migraine. However, it is subjective, and there is no reliable marker for follow-up, and it hinders adequate follow-up and treatment. Therefore, in this study, we aimed to investigate the correlation of the NLR (neutrophil-lymphocyte ratio) level, which is increased due to the neuroinflammatory process and oxidative stress, with the clinical and demographic characteristics of the patients, and to investigate its feasibility as an objective marker during follow-ups.
Materials and Methods: Our study included one hundred migraine patients without aura who met the “The International Classification of Headache Disorders 3rd edition” (ICHD-3) criteria. The demographic characteristics of all patients and the clinical features of migraine pain were obtained. In addition, blood NLR level and its correlation to these features were examined.
Results: There was a significant and positive correlation between NLR level with disease duration and pain severity (r=0.43 p<0.001, r=0.76 p<0.001, respectively), however, it was independent of age, gender, and migraine subtypes (episodic/chronic) (p=0.48, p=0.14, p=0.13, respectively).
Conclusions: Our study found a significant correlation between the NLR level and the clinical features of migraine patients, indicating that this easily accessible parameter may be a promising marker that can be used during the follow-up period.
Keywords
References
- 1. Bloudek LM, Stokes M, Buse DC, et al. Cost of healthcare for patients with migraine in five European countries: results from the International Burden of Migraine Study (IBMS). J Headache Pain. 2012;13:361-78.
- 2. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2163-96.
- 3. Steiner TJ, Stovner LJ, Birbeck GL. Migraine: the seventh disabler. Cephalalgia. 2013;33:289-90.
- 4. Vanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalalgia. 2007;27:843-6.
- 5. Reuter U, Bolay H, Jansen-Olesen I, et al. Delayed inflammation in rat meninges: implications for migraine pathophysiology. Brain. 2001;124:2490-502.
- 6. Taneja R, Parodo J, Jia SH, et al. Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med. 2004;32:1460-9.
- 7. Vidal AC, Howard LE, de Hoedt A, et al. Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database. Cancer Causes Control. 2018;29:581-8.
- 8. Wada H, Dohi T, Miyauchi K, et al. Pre-procedural neutrophil-to-lymphocyte ratio and long-term cardiac outcomes after percutaneous coronary intervention for stable coronary artery disease. Atherosclerosis. 2017;265:35-40.
- 9. Kotfis K, Bott-Olejnik M, Szylinska A, et al. Could neutrophil-to-lymphocyte ratio (NLR) serve as a potential marker for delirium prediction in patients with acute ischemic stroke? a prospective observational study. J Clin Med. 2019;8.
- 10. Hemond CC, Glanz BI, Bakshi R, et al. The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis. BMC Neurol. 2019;19:23.
- 11. Bressi E, Mangiacapra F, Ricottini E, et al. Impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on 5-year clinical outcomes of patients with stable coronary artery disease undergoing elective percutaneous coronary intervention. J Cardiovasc Transl Res. 2018;11:517-23.
- 12. Simsek F, Bilge N, Ceylan M. The relationship of migraine clinical features with neutrophil- lymphocyte ratio. ACU Sağlık Bil Derg. 2020;11:434-8.
- 13. Panpalli Ates M. Is neutrophils/lymphocytes ratio affected during ‘migraine attacks with aura’ in migraine patients? J Basic Clin Health Sci. 2021;2:36-40.
- 14. Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629-808.
- 15. Delgado DA, Lambert BS, Boutris N, et al. Validation of Digital Visual Analog Scale Pain Scoring With a Traditional Paper-based Visual Analog Scale in Adults. J Am Acad Orthop Surg Glob Res Rev. 2018;2:e088.
- 16. Boonstra AM, Schiphorst Preuper HR, Balk GA, et al. Cut-off points for mild, moderate, and severe pain on the visual analogue scale for pain in patients with chronic musculoskeletal pain. Pain. 2014;155:2545-50.
- 17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
- 18. Menges T, Engel J, Welters I, et al. Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications. Crit Care Med. 1999;27:733-40.
- 19. Kumarasamy C, Sabarimurugan S, Madurantakam RM, et al. Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer-A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2019;98:e14834.
- 20. Jiang J, Liu R, Yu X, et al. The neutrophil-lymphocyte count ratio as a diagnostic marker for bacteraemia: A systematic review and meta-analysis. Am J Emerg Med. 2019;37:1482-9.
- 21. Faria SS, Fernandes PC Jr, Silva MJ, et al. The neutrophil-to-lymphocyte ratio: a narrative review. Ecancermedicalscience. 2016;10:702.
- 22. Nagy GR, Kemeny L, Bata-Csorgo Z. Neutrophil-to-lymphocyte ratio: a biomarker for predicting systemic involvement in adult IgA vasculitis patients. J Eur Acad Dermatol Venereol. 2017;31:1033-7.
- 23. Huang Z, Fu Z, Huang W, et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis. Am J Emerg Med. 2020;38:641-7.
- 24. Karabulut KU, Egercioglu TU, Uyar M, et al. The change of neutrophils/lymphocytes ratio in migraine attacks: A case-controlled study. Ann Med Surg (Lond). 2016;10:52-6.
- 25. Ocak Ö, Şahin E. The relationship of migraine headache with neutrophil-lymphocyte ratio, platelet lymphocyte ratio and erythrocyte distribution width. The Medical Journal of Mustafa Kemal University. 2021;12:114-8.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Original Articles |
| Authors | |
| Early Pub Date | January 15, 2023 |
| Publication Date | January 15, 2023 |
| Acceptance Date | December 13, 2022 |
| Published in Issue | Year 2023 Volume: 5 Issue: 1 |
Chief Editors
Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye
Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye
E-mail: medrecsjournal@gmail.com
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Medical Records Association (Tıbbi Kayıtlar Derneği)
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