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Examination of Serum BDNF (Brain-Derived Neurotrophic Factor) Levels in Judokas

Year 2023, Volume: 7 Issue: 2, 252 - 257, 31.08.2023

Geylan Bostan Murat Can Mustafa Gümüş

https://doi.org/10.29058/mjwbs.1320287

Abstract

Aim: The purpose of this study is to investigate the potential effects of judo on Brain-Derived Neurotrophic
Factor (BDNF) levels, and to understand its impact on athletic performance and overall brain health Additionally, by comparing BDNF levels between sedentary individuals and judokas, the study aims to gain deeper insights into the potential
impact of a sedentary lifestyle on BDNF levels. Judo, with its training principles, is considered a sport that could positively affect BDNF levels.
The specific objective of this research is to analyze the serum BDNF levels of members of the Turkish National Judo Team.
Material and Methods: The sample of our study consists of a total of 40 healthy volunteers, including 20 national-level judokas and
20 sedentary control subjects (with no exercise for at least a year), aged between 17 and 22. The participating judokas were randomly
selected from Turkish national teams, while the control group was selected through random sampling from individuals who had not previously
engaged in regular physical activity. Body mass index (BMI) measurements of the subjects were taken using the Segmental Body Analysis
Scale. Blood samples for BDNF measurement were drawn intravenously. For all statistical analyses in the study, results with a p-value less
than 0.05 were considered statistically significant.
Results: Statistically significant differences were observed in age, fat percentage, and fat mass between judokas and sedentary participants
(p<0.05). However, no statistically significant differences were observed in height, weight, lean mass, and BMI values (p>0.05). When
biochemical parameters were analyzed, BDNF levels in the judoka group [1264.8 ± 438.0 pg/mL (466 - 1822 pg/mL)] were higher than the
sedentary group [1166.2 pg/mL ± 314.9 (473 - 1645 pg/mL)], although the difference was not statistically significant (p>0.05). A statistically
significant positive correlation was found between serum BDNF and weight in the judoka group, and between serum BDNF and height in
the sedentary group (p<0.05).
Conclusion: According to the results of our study, no statistically significant difference was found in serum BDNF levels between judokas
and sedentary individuals. However, the higher serum BDNF levels observed in judokas could indicate a positive impact of the sport on
serum BDNF concentrations. These findings highlight the need for more comprehensive studies to further investigate the potential effects
of judo on BDNF levels

Keywords

BDNF judo physical activity

Project Number

Yok

References

  • 1. Ropper A, Samuels M, Klein J, et al. Adams and Victor’s principles of neurology 10th edition. McGraw Hill Professional. 2014.
  • 2. Sadock BJ. Kaplan & Sadock’s synopsis of psychiatry: behavioral sciences/clinical psychiatry. Wolters Kluwer Philadelphia, PA, 2015.
  • 3. Allard JS, Ntekim O, Johnson SP, et al. APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study. Experimental gerontology. 2017; 87: 129-36.
  • 4. Lu B, Chang JH. Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory. Neuron Glia Biol 2004;1(4):377-84.
  • 5. Rethorst CD, Wipfli BM, Landers DM. The antidepressive effects of exercise: a meta-analysis of randomized trials. Sports Med 2009;39(6):491-511.
  • 6. Poo MM. Neurotrophins as synaptic modulators. Nat Rev Neurosci 2001;2(1):24-32.
  • 7. Erickson KI, Raji CA,Newman AB, Gach HM, Thompson PM, Ho AJ, Kuller LH. Lopez OL, Becker JT, Rosano C, Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology 2010;75(16):1415- 1422.
  • 8. Barde YA, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J 1982;1(5):549-553.
  • 9. Taliaz D, Loya A, Gersner R, Haramati S, Chen A, Zangen A. Resilience to chronic stress is mediated by hippocampal brainderived neurotrophic factor. J Neurosci 2011;31(12):4475- 4483.
  • 10. Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 2005;136(1-2):29-37.
  • 11. Lu Y, Christian K, Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 2008;89(3):312-23.
  • 12. Abuelezz SA, Hendawy N, Magdy Y. The potential benefit of combined versus monotherapy of coenzyme Q10 and fluoxetine on depressive-like behaviors and intermediates coupled to Gsk-3β in rats. Toxicol Appl Pharmacol 2018;340:39-48.
  • 13. Lewin GR, Barde YA. Physiology of the neurotrophins. Annu Rev Neurosci 1996;19:289-317.
  • 14. Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 2009;94(10):1062-1069.
  • 15. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 2011;108(7):3017-3022.
  • 16. Hamilton GF, Rhodes JS. Exercise regulation of cognitive function and neuroplasticity in the healthy and diseased brain. Prog Mol Biol Transl Sci 2015;135:381-406.
  • 17. Kujach S, Chroboczek M, Jaworska J, Sawicka A, Smaruj M, Winklewski P, Laskowski R. Judo training program improves brain and muscle function and elevates the peripheral BDNF concentration among the elderly. Sci Rep 2022;12(1):13900.
  • 18. Griffin ÉW, Mullally S, Foley C, Warmington SA, O’Mara SM, Kelly AM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 2011;104(5):934-941.
  • 19. Dinoff A, Herrmann N, Swardfager W, Liu CS, Sherman C, Chan S, Lanctôt KL. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PLoS One 2016;11(9):e0163037.
  • 20. Arazi H, Babaei P, Moghimi M, Asadi A. Acute effects of strength and endurance exercise on serum BDNF and IGF-1 levels in older men. BMC Geriatr 2021;21(1):50.
  • 21. Jaworska J, Laskowski R, Ziemann E, Zuczek K, Lombardi G, Antosiewicz J, Zurek P. The specific judo training program combined with the whole body cryostimulation ınduced an ıncrease of serum concentrations of growth factors and changes in amino acid profile in professional judokas. Front Physiol 2021;12:627657.
  • 22. Trejo JL, Carro E, Torres-Aleman I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci 2001;21(5):1628-1634.
  • 23. Liang Z, Zhang Z, Qi S, Yu J, Wei Z. Effects of a single bout of endurance exercise on brain-derived neurotrophic factor in humans: a systematic review and meta-analysis of randomized controlled trials. Biology (Basel) 2023;12(1):126.
  • 24. Fakhoury M, Eid F, El Ahmad P, Khoury R, Mezher A, El Masri D, Haddad Z, Zoghbi Y, Ghayad LM, Sleiman SF, Stephan JS. Exercise and dietary factors mediate neural plasticity through modulation of BDNF signaling. Brain Plast 2022;8(1):121-128.
  • 25. Rezaee Z, Marandi SM, Alaei H. Molecular mechanisms of exercise in brain disorders: a focus on the function of brainderived neurotrophic factor-a narrative review. Neurotox Res 2022;40(4):1115-1124.
  • 26. Ziemba A, Adamczyk JG, Barczak A, Boguszewski D, Kozacz A, Dąbrowski J, Steczkowska M, Pepłońska B, Żekanowski C. Changes in the Hormonal Profile of Athletes following a Combat Sports Performance. Biomed Res Int 2020;2020:9684792.
  • 27. Oztasyonar Y. Interaction between different sports branches such as taekwondo, box, athletes and serum brain derived neurotrophic factor levels. J Sports Med Phys Fitness 2017;57(4):457-460.
  • 28. Schor B, Silva SGD, Almeida AA, Pereira CAB, Arida RM. Plasma brain-derived neurotrophic factor is higher after combat training (Randori) than incremental ramp test in elite judo athletes. Braz J Med Biol Res 2019;52(4):e8154.
  • 28. Zhang W, Li Y, Wang P. [Retracted Article] Long non-coding RNA-ROR aggravates myocardial ischemia/reperfusion injury. Braz J Med Biol Res 2018; 51.
  • 29. Gomez-Pinilla F, Hillman C. The influence of exercise on cognitive abilities. Compr Physiol 2013;3(1):403-428.
  • 30. Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 2014;25(2):89-98.
  • 31. Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 2015;60:56-64.
  • 32. Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 2011;10(3):209-219.
  • 33. Wagner G, Herbsleb M, de la Cruz F, Schumann A, Köhler S, Puta C, Gabriel HW, Reichenbach JR, Bär KJ. Changes in fMRI activation in anterior hippocampus and motor cortex during memory retrieval after an intense exercise intervention. Biol Psychol 2017;124:65-78.
  • 34. Goekint M, Roelands B, De Pauw K, Knaepen K, Bos I, Meeusen R. Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor? Neurosci Lett 2010;486(3):146-149.
  • 35. Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 2005;76(2):99-125.

Judocuların Serum Beyin-Kaynaklı Nörotrofik Faktör (BDNF) Seviyelerinin İncelenmesi

Year 2023, Volume: 7 Issue: 2, 252 - 257, 31.08.2023

Geylan Bostan Murat Can Mustafa Gümüş

https://doi.org/10.29058/mjwbs.1320287

Abstract

Amaç: Bu çalışma, judonun Beyin-Kaynaklı Nörotrofik Faktör (BDNF) üzerindeki olası etkilerini
belirlemeyi ve spor performansı ile genel beyin sağlığı üzerindeki etkisini anlamayı amaçlamaktadır.
Ayrıca, sedanter bireylerin BDNF seviyeleri ile judocu bireyler arasında bir karşılaştırma yaparak,
sedanter yaşam tarzının BDNF üzerindeki potansiyel etkisini daha derinlemesine kavramak da
çalışmanın hedeflerindendir. Judo’nun antrenman prensipleri, BDNF seviyelerine olumlu bir etki
yapabileceği düşünülen bir spor dalı olarak kabul edilir. Bu çalışmanın spesifik hedefi, Türk Milli Judo
Takımı üyelerinin serum BDNF seviyelerinin analizini yapmaktır.
Gereç ve Yöntemler: Çalışmamızın örneklemi, 20 milli judocu ve 20 sedanter kontrol grubu (en az
bir yıl ve üzeri egzersiz yapmamış) dahil olmak üzere toplam 40 sağlıklı gönüllüden (17-22 yaş arası)
oluşmaktadır. Çalışmaya katılan judocular, Türk milli takımları içerisinden rastgele örnekleme yöntemi
kullanılarak seçilmiştir. Kontrol grubu ise, daha önce düzenli fiziksel aktivite ile ilgilenmemiş bireyler
arasından rastgele örnekleme yöntemi kullanılarak seçilmiştir. Deneklerin vücut kütle indeksi (VKİ)
ölçümleri Segmental Vücut Analiz Tartısı ile ölçülmüştür. BDNF ölçümü için kan örnekleri damar yoluyla
alınmıştır. Çalışmanın tüm istatistiksel analizlerinde p değeri 0.05’in altında olan sonuçlar istatistiksel
olarak anlamlı olarak kabul edilmiştir.
Bulgular: Judocu ve sedanterlerin yaş, yağ yüzdesi ve yağ kütlesi değerlerinin istatistiksel olarak birbirinden
farklı olduğu görülmüştür (p<0.05). Bunun yanı sıra, boy, kilo, yağsız kütle ve VKİ değerleri
arasında istatistiksel olarak anlamlı bir farklılık gözlenmemiştir (p>0.05). Biyokimyasal parametre farklılıkları
incelendiğinde, BDNF sonuçları judocu grupta [1264,8 ± 438,0 pg/mL (466 - 1822 pg/mL)] sedanter
gruba [1166,2 pg/mL ± 314,9 (473 - 1645 pg/mL)] göre yüksek olsa da iki grup arasında istatistiksel
olarak anlamlı bir fark bulunmadı (p>0.05). Judocu grupta serum BDNF ile kilo arasında, sedanter grupta
serum BDNF ile boy arasında istatistiksel açıdan anlamlı pozitif korelasyon saptanmıştır (p<0.05).
Sonuç: Çalışmamızın sonuçlarına göre, judocu ve sedanter bireyler arasında serum BDNF düzeylerinde
istatistiksel olarak anlamlı bir fark bulunmamıştır. Bununla birlikte, judocularda gözlemlenen yüksek
serum BDNF düzeyleri, sporun serum BDNF konsantrasyonları üzerinde olumlu bir etki yapabileceğine
işaret edebilir. Bu bulgular, judonun BDNF üzerindeki potansiyel etkilerini daha ayrıntılı olarak incelemek
amacıyla daha kapsamlı araştırmaların gerekliliğini vurgulamaktadır.

Keywords

BDNF Judo fiziksel aktivite

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

References

  • 1. Ropper A, Samuels M, Klein J, et al. Adams and Victor’s principles of neurology 10th edition. McGraw Hill Professional. 2014.
  • 2. Sadock BJ. Kaplan & Sadock’s synopsis of psychiatry: behavioral sciences/clinical psychiatry. Wolters Kluwer Philadelphia, PA, 2015.
  • 3. Allard JS, Ntekim O, Johnson SP, et al. APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study. Experimental gerontology. 2017; 87: 129-36.
  • 4. Lu B, Chang JH. Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory. Neuron Glia Biol 2004;1(4):377-84.
  • 5. Rethorst CD, Wipfli BM, Landers DM. The antidepressive effects of exercise: a meta-analysis of randomized trials. Sports Med 2009;39(6):491-511.
  • 6. Poo MM. Neurotrophins as synaptic modulators. Nat Rev Neurosci 2001;2(1):24-32.
  • 7. Erickson KI, Raji CA,Newman AB, Gach HM, Thompson PM, Ho AJ, Kuller LH. Lopez OL, Becker JT, Rosano C, Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology 2010;75(16):1415- 1422.
  • 8. Barde YA, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J 1982;1(5):549-553.
  • 9. Taliaz D, Loya A, Gersner R, Haramati S, Chen A, Zangen A. Resilience to chronic stress is mediated by hippocampal brainderived neurotrophic factor. J Neurosci 2011;31(12):4475- 4483.
  • 10. Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 2005;136(1-2):29-37.
  • 11. Lu Y, Christian K, Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 2008;89(3):312-23.
  • 12. Abuelezz SA, Hendawy N, Magdy Y. The potential benefit of combined versus monotherapy of coenzyme Q10 and fluoxetine on depressive-like behaviors and intermediates coupled to Gsk-3β in rats. Toxicol Appl Pharmacol 2018;340:39-48.
  • 13. Lewin GR, Barde YA. Physiology of the neurotrophins. Annu Rev Neurosci 1996;19:289-317.
  • 14. Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 2009;94(10):1062-1069.
  • 15. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 2011;108(7):3017-3022.
  • 16. Hamilton GF, Rhodes JS. Exercise regulation of cognitive function and neuroplasticity in the healthy and diseased brain. Prog Mol Biol Transl Sci 2015;135:381-406.
  • 17. Kujach S, Chroboczek M, Jaworska J, Sawicka A, Smaruj M, Winklewski P, Laskowski R. Judo training program improves brain and muscle function and elevates the peripheral BDNF concentration among the elderly. Sci Rep 2022;12(1):13900.
  • 18. Griffin ÉW, Mullally S, Foley C, Warmington SA, O’Mara SM, Kelly AM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 2011;104(5):934-941.
  • 19. Dinoff A, Herrmann N, Swardfager W, Liu CS, Sherman C, Chan S, Lanctôt KL. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis. PLoS One 2016;11(9):e0163037.
  • 20. Arazi H, Babaei P, Moghimi M, Asadi A. Acute effects of strength and endurance exercise on serum BDNF and IGF-1 levels in older men. BMC Geriatr 2021;21(1):50.
  • 21. Jaworska J, Laskowski R, Ziemann E, Zuczek K, Lombardi G, Antosiewicz J, Zurek P. The specific judo training program combined with the whole body cryostimulation ınduced an ıncrease of serum concentrations of growth factors and changes in amino acid profile in professional judokas. Front Physiol 2021;12:627657.
  • 22. Trejo JL, Carro E, Torres-Aleman I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J Neurosci 2001;21(5):1628-1634.
  • 23. Liang Z, Zhang Z, Qi S, Yu J, Wei Z. Effects of a single bout of endurance exercise on brain-derived neurotrophic factor in humans: a systematic review and meta-analysis of randomized controlled trials. Biology (Basel) 2023;12(1):126.
  • 24. Fakhoury M, Eid F, El Ahmad P, Khoury R, Mezher A, El Masri D, Haddad Z, Zoghbi Y, Ghayad LM, Sleiman SF, Stephan JS. Exercise and dietary factors mediate neural plasticity through modulation of BDNF signaling. Brain Plast 2022;8(1):121-128.
  • 25. Rezaee Z, Marandi SM, Alaei H. Molecular mechanisms of exercise in brain disorders: a focus on the function of brainderived neurotrophic factor-a narrative review. Neurotox Res 2022;40(4):1115-1124.
  • 26. Ziemba A, Adamczyk JG, Barczak A, Boguszewski D, Kozacz A, Dąbrowski J, Steczkowska M, Pepłońska B, Żekanowski C. Changes in the Hormonal Profile of Athletes following a Combat Sports Performance. Biomed Res Int 2020;2020:9684792.
  • 27. Oztasyonar Y. Interaction between different sports branches such as taekwondo, box, athletes and serum brain derived neurotrophic factor levels. J Sports Med Phys Fitness 2017;57(4):457-460.
  • 28. Schor B, Silva SGD, Almeida AA, Pereira CAB, Arida RM. Plasma brain-derived neurotrophic factor is higher after combat training (Randori) than incremental ramp test in elite judo athletes. Braz J Med Biol Res 2019;52(4):e8154.
  • 28. Zhang W, Li Y, Wang P. [Retracted Article] Long non-coding RNA-ROR aggravates myocardial ischemia/reperfusion injury. Braz J Med Biol Res 2018; 51.
  • 29. Gomez-Pinilla F, Hillman C. The influence of exercise on cognitive abilities. Compr Physiol 2013;3(1):403-428.
  • 30. Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab 2014;25(2):89-98.
  • 31. Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 2015;60:56-64.
  • 32. Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 2011;10(3):209-219.
  • 33. Wagner G, Herbsleb M, de la Cruz F, Schumann A, Köhler S, Puta C, Gabriel HW, Reichenbach JR, Bär KJ. Changes in fMRI activation in anterior hippocampus and motor cortex during memory retrieval after an intense exercise intervention. Biol Psychol 2017;124:65-78.
  • 34. Goekint M, Roelands B, De Pauw K, Knaepen K, Bos I, Meeusen R. Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor? Neurosci Lett 2010;486(3):146-149.
  • 35. Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 2005;76(2):99-125.
There are 36 citations in total.

Details

Primary Language Turkish
Subjects Sports Training
Journal Section Research Article
Authors

Geylan Bostan 0000-0002-8386-8248

Murat Can 0000-0002-1539-3973

Mustafa Gümüş 0000-0002-0666-9237

Project Number Yok
Publication Date August 31, 2023
Acceptance Date August 24, 2023
Published in Issue Year 2023 Volume: 7 Issue: 2

Cite

Vancouver Bostan G, Can M, Gümüş M. Judocuların Serum Beyin-Kaynaklı Nörotrofik Faktör (BDNF) Seviyelerinin İncelenmesi. Med J West Black Sea. 2023;7(2):252-7.
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