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Risk Factors in Patients with Retinal Vein Branch Occlusion

Year 2019, Volume: 10 Issue: 36, 10 - 13, 26.03.2019
https://doi.org/10.17944/mkutfd.492301

Abstract

Aim:Retinal vein occlusion is among the causes of preventable blindness. The most important risk factors are age and hypertension. The aim of our study was to determine the prevalence of venous occlusion and to determine risk factors in a large rural area.

Material and Methods: The patients who were admitted to the health centers in the rural areas of Eskişehir and who had retinal fundus photographs with non-mydriatic fundus camera were examined retrospectively. The data of about age, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), history of diabetes mellitus (DM) /hypertension (HT), smoking and alcohol use, medication and body mass index (BMI) were obtained from the questionnaire forms. Venous branch occlusion (VBO) diagnosis of the participants was investigated the relationship with the above factors. SPSS 15.0 and SigmaStat 3.5 were used for statistical analysis. The data were evaluated by Kolmogorov-Smirnov test for normal distribution. Chi-Square test was used to evaluate categorical variables (gender, smoking/alcohol use, presence of DM / HT), Mann Whitney U test was used to evaluate continuous variables (age, body mass index and blood pressure values). p<0.05 was considered statistically significant.

Results:Gender, age, presence of HT, SKB and DKB values were different between the two groups; No difference was observed between the two groups in terms of alcohol and smoking, DM and BMI.

Conclusion:Age and HT are the most important risk factors for VBO. As HT is a manageable variable, HT control is important for patient survival.

References

  • Ip M, Hendrick A. Retinal Vein Occlusion Review. Asia-Pacific journal of ophthalmology (Philadelphia, Pa). 2018;7(1):40-5.
  • Scott IU, VanVeldhuisen PC, Ip MS, Blodi BA, Oden NL, Awh CC, et al. Effect of Bevacizumab vs Aflibercept on Visual Acuity Among Patients With Macular Edema Due to Central Retinal Vein Occlusion: The SCORE2 Randomized Clinical Trial. Jama. 2017;317(20):2072-87.
  • Yen YC, Weng SF, Chen HA, Lin YS. Risk of retinal vein occlusion in patients with systemic lupus erythematosus: a population-based cohort study. The British journal of ophthalmology. 2013;97(9):1192-6.
  • Risk factors for branch retinal vein occlusion. The Eye Disease Case-control Study Group. Am J Ophthalmol. 1993;116(3):286-96.
  • Koylu MT, Kucukevcilioglu M, Erdurman FC, Durukan AH, Sobaci G, Torun D, et al. Association of retinal vein occlusion, homocysteine, and the thrombophilic mutations in a Turkish population: A case-control study. Ophthalmic genetics. 2017;38(4):352-6.
  • Simsek S, Demirok A, Cinal A, Yasar T. Effect of sex in branch retinal vein occlusion. European journal of ophthalmology. 1998;8(1):48-51.
  • Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313-9.e1.
  • Shin KU, Lee JY, Han K, Song SJ. Sex-specific age threshold for increased risk of retinal vein occlusion in Koreans. Thrombosis research. 2018;167:60-3.
  • Adenuga OO, Ramyil AV, Odugbo OP, Oyediji FJ. Prevalence, Pattern And Risk Factors For Retinal Vascular Occlusions In A Tertiary Hospital In Jos, Nigeria. Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria. 2015;24(4):331-6.
  • Schwaber EJ, Fogelman N, Sobol EK, Mehrotra D, Powell JA, Mian U, et al. Associations with retinal vascular occlusions in a diverse, urban population. Ophthalmic epidemiology. 2018;25(3):220-6.
  • Shin YU, Cho H, Kim JM, Bae K, Kang MH, Shin JP, et al. Prevalence and associated factors of retinal vein occlusion in the Korean National Health and Nutritional Examination Survey, 2008-2012: A cross-sectional observational study. Medicine. 2016;95(44):e5185.
  • Blair K, Czyz CN. Central Retinal Vein Occlusion. StatPearls. Treasure Island (FL): StatPearls PublishingStatPearls Publishing LLC.; 2018.
  • Zhao J, Sastry SM, Sperduto RD, Chew EY, Remaley NA. Arteriovenous crossing patterns in branch retinal vein occlusion. The Eye Disease Case-Control Study Group. Ophthalmology. 1993;100(3):423-8.
  • Christoffersen NL, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology. 1999;106(11):2054-62.
  • Trope GE, Lowe GD, McArdle BM, Douglas JT, Forbes CD, Prentice CM, et al. Abnormal blood viscosity and haemostasis in long-standing retinal vein occlusion. The British journal of ophthalmology. 1983;67(3):137-42.
  • O'Mahoney PR, Wong DT, Ray JG. Retinal vein occlusion and traditional risk factors for atherosclerosis. Archives of ophthalmology (Chicago, Ill : 1960). 2008;126(5):692-9.
  • Kolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. Journal of Ophthalmology. 2014;2014:724780.
  • Newman-Casey PA, Stem M, Talwar N, Musch DC, Besirli CG, Stein JD. Risk factors associated with developing branch retinal vein occlusion among enrollees in a United States managed care plan. Ophthalmology. 2014;121(10):1939-48.
  • Lam HD, Lahey JM, Kearney JJ, Ng RR, Lehmer JM, Tanaka SC. Young patients with branch retinal vein occlusion: a review of 60 cases. Retina (Philadelphia, Pa). 2010;30(9):1520-3.
  • Kanai H, Shiba T, Hori Y, Saishin Y, Maeno T, Takahashi M. [Prevalence of sleep-disordered breathing in patients with retinal vein occlusion]. Nippon Ganka Gakkai zasshi. 2012;116(2):81-5.
  • Jonas JB, Nangia V, Khare A, Sinha A, Lambat S. Prevalence and associations of retinal vein occlusions: the Central India Eye and Medical Study. Retina (Philadelphia, Pa). 2013;33(1):152-9.
  • Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS, et al. Prevalence, pattern and risk factors of retinal vein occlusion in an elderly population in Nepal: the Bhaktapur retina study. BMC ophthalmology. 2017;17(1):162.
  • Xu L, You QS, Jonas JB. Prevalence of alcohol consumption and risk of ocular diseases in a general population: the Beijing Eye Study. Ophthalmology. 2009;116(10):1872-9.

Retinal Ven Dal Oklüzyonu Olan Hastalarda Risk Faktörleri

Year 2019, Volume: 10 Issue: 36, 10 - 13, 26.03.2019
https://doi.org/10.17944/mkutfd.492301

Abstract

Amaç:Retinal ven oklüzyonu önlenebilir körlük nedenleri arasında yeralmaktadır. En önemli risk faktörleri yaş ve hipertansiyondur. Çalışmamızın amacı geniş bir kırsal kesimde ven oklüzyonu prevelansını saptama ve risk faktörlerini belirlemekti.

Gereç ve Yöntem: Eskişehir kırsal bölgesinde sağlık ocaklarına başvuran ve non-midriyatik fundus kamara ile retinal fundus fotoğrafları çekilebilen hastaların fotoğrafları retrospektif olarak incelendi. Ven dal oklüzyonu (VDO) saptanan hastaların yaş, cinsiyet, sistolik kan basıncı (SKB), diyastolik kan basıncı (DKB), diyabetes mellitus (DM) / hipertansiyon (HT) hikayesi, sigara ve alkol kullanımı, kullanılan ilaçların ve vücut kitle indeksinin (VKİ) yazılı olduğu anket formları değerlendirildi. Sonuçların istatistiksel analizi SPSS 15.0 ve SigmaStat 3.5 paket programları kullanılarak yapıldı. Verilerin normal dağılıma uygunlukları Kolmogorov-Smirnov testi ile değerlendirildi. Kategorik değişkenlerin (cinsiyet, sigara/alkol kullanımı, DM/HT varlığı) değerlendirilmesinde Ki-Kare testi, sürekli değişkenlerin (yaş, vücut kitle indeksi ve kan basıncı değerleri) değerlendirilmesinde Mann Whitney U testi kullanıldı. p<0.05 değeri istatistiksel olarak anlamlı kabul edildi.

Bulgular:Cinsiyet, yaş, HT varlığı, SKB, DKB değerleri iki grup arasında farklı iken; alkol ve sigara kullanımı, DM ve VKİ açısından iki grup arasında fark gözlenmemiştir.

Sonuç:Yaş ve HT VDO için en önemli risk faktörleridir. HT müdahale edilebilen bir değişken olduğundan, HT kontrolü hasta sağ kalımı açısından önemlidir.

References

  • Ip M, Hendrick A. Retinal Vein Occlusion Review. Asia-Pacific journal of ophthalmology (Philadelphia, Pa). 2018;7(1):40-5.
  • Scott IU, VanVeldhuisen PC, Ip MS, Blodi BA, Oden NL, Awh CC, et al. Effect of Bevacizumab vs Aflibercept on Visual Acuity Among Patients With Macular Edema Due to Central Retinal Vein Occlusion: The SCORE2 Randomized Clinical Trial. Jama. 2017;317(20):2072-87.
  • Yen YC, Weng SF, Chen HA, Lin YS. Risk of retinal vein occlusion in patients with systemic lupus erythematosus: a population-based cohort study. The British journal of ophthalmology. 2013;97(9):1192-6.
  • Risk factors for branch retinal vein occlusion. The Eye Disease Case-control Study Group. Am J Ophthalmol. 1993;116(3):286-96.
  • Koylu MT, Kucukevcilioglu M, Erdurman FC, Durukan AH, Sobaci G, Torun D, et al. Association of retinal vein occlusion, homocysteine, and the thrombophilic mutations in a Turkish population: A case-control study. Ophthalmic genetics. 2017;38(4):352-6.
  • Simsek S, Demirok A, Cinal A, Yasar T. Effect of sex in branch retinal vein occlusion. European journal of ophthalmology. 1998;8(1):48-51.
  • Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313-9.e1.
  • Shin KU, Lee JY, Han K, Song SJ. Sex-specific age threshold for increased risk of retinal vein occlusion in Koreans. Thrombosis research. 2018;167:60-3.
  • Adenuga OO, Ramyil AV, Odugbo OP, Oyediji FJ. Prevalence, Pattern And Risk Factors For Retinal Vascular Occlusions In A Tertiary Hospital In Jos, Nigeria. Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria. 2015;24(4):331-6.
  • Schwaber EJ, Fogelman N, Sobol EK, Mehrotra D, Powell JA, Mian U, et al. Associations with retinal vascular occlusions in a diverse, urban population. Ophthalmic epidemiology. 2018;25(3):220-6.
  • Shin YU, Cho H, Kim JM, Bae K, Kang MH, Shin JP, et al. Prevalence and associated factors of retinal vein occlusion in the Korean National Health and Nutritional Examination Survey, 2008-2012: A cross-sectional observational study. Medicine. 2016;95(44):e5185.
  • Blair K, Czyz CN. Central Retinal Vein Occlusion. StatPearls. Treasure Island (FL): StatPearls PublishingStatPearls Publishing LLC.; 2018.
  • Zhao J, Sastry SM, Sperduto RD, Chew EY, Remaley NA. Arteriovenous crossing patterns in branch retinal vein occlusion. The Eye Disease Case-Control Study Group. Ophthalmology. 1993;100(3):423-8.
  • Christoffersen NL, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology. 1999;106(11):2054-62.
  • Trope GE, Lowe GD, McArdle BM, Douglas JT, Forbes CD, Prentice CM, et al. Abnormal blood viscosity and haemostasis in long-standing retinal vein occlusion. The British journal of ophthalmology. 1983;67(3):137-42.
  • O'Mahoney PR, Wong DT, Ray JG. Retinal vein occlusion and traditional risk factors for atherosclerosis. Archives of ophthalmology (Chicago, Ill : 1960). 2008;126(5):692-9.
  • Kolar P. Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data. Journal of Ophthalmology. 2014;2014:724780.
  • Newman-Casey PA, Stem M, Talwar N, Musch DC, Besirli CG, Stein JD. Risk factors associated with developing branch retinal vein occlusion among enrollees in a United States managed care plan. Ophthalmology. 2014;121(10):1939-48.
  • Lam HD, Lahey JM, Kearney JJ, Ng RR, Lehmer JM, Tanaka SC. Young patients with branch retinal vein occlusion: a review of 60 cases. Retina (Philadelphia, Pa). 2010;30(9):1520-3.
  • Kanai H, Shiba T, Hori Y, Saishin Y, Maeno T, Takahashi M. [Prevalence of sleep-disordered breathing in patients with retinal vein occlusion]. Nippon Ganka Gakkai zasshi. 2012;116(2):81-5.
  • Jonas JB, Nangia V, Khare A, Sinha A, Lambat S. Prevalence and associations of retinal vein occlusions: the Central India Eye and Medical Study. Retina (Philadelphia, Pa). 2013;33(1):152-9.
  • Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS, et al. Prevalence, pattern and risk factors of retinal vein occlusion in an elderly population in Nepal: the Bhaktapur retina study. BMC ophthalmology. 2017;17(1):162.
  • Xu L, You QS, Jonas JB. Prevalence of alcohol consumption and risk of ocular diseases in a general population: the Beijing Eye Study. Ophthalmology. 2009;116(10):1872-9.
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Articles
Authors

Hakika Erdogan 0000-0001-7749-2814

Publication Date March 26, 2019
Submission Date December 5, 2018
Acceptance Date March 5, 2019
Published in Issue Year 2019 Volume: 10 Issue: 36

Cite

Vancouver Erdogan H. Retinal Ven Dal Oklüzyonu Olan Hastalarda Risk Faktörleri. mkutfd. 2019;10(36):10-3.