Research Article
BibTex RIS Cite

Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma

Year 2023, Volume: 3 Issue: 2, 1 - 8, 13.09.2023

Zehra Pınar Koç Pelin Özcan Kara Emel Sezer Aydan Akdeniz Gülhan Temel

Abstract

The aim of this study is to decide the diagnostic value of F-18 FDG PET/CT in the predictive value of survival of the patients with diagnosis of head and neck extranodal lymphoma (ENL).

Materials and Methods: Eighteen patients (10 F, 8 M; mean: 54,3±21.1 years old) with the diagnosis of head and neck ENL were included in the study. The FDG PET/CT images of the patients were analyzed retrospectively and the maximum standardized uptake value (SUVmax) levels of the primary tumors at the initial evaluation were recorded and compared with mortality results of the patients in the follow up.

Results: The initial SUVmax levels of the patients with progressive and stable-responsive disease were not significantly different and the difference between the SUVmax levels of the patients who died was not statistically significant.

Discussion and Conclusion: FDG PET/CT is the gold standard imaging modality in the diagnosis and follow up of the lymphoma. Head and neck ENL is a special group of lymphoma with different prognosis. This analysis demonstrated that the mortality of the patients with high grade head and neck ENL might not be predicted by means of initial SUVmax levels.

Keywords

lymphoma extranodal FDG SUV PET/CT

References

  • Broadwater, D. R., & Peker, D. (2018). Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity. Head and neck pathology, 12(4), 481–487. https://doi.org/10.1007/s12105-017-0881-3
  • Siddiqui, N. A., Branstetter, B. F., 4th, Hamilton, B. E., Ginsberg, L. E., Glastonbury, C. M., Harnsberger, H. R., Barnes, E. L., & Myers, E. N. (2010). Imaging characteristics of primary laryngeal lymphoma. AJNR. American journal of neuroradiology, 31(7), 1261–1265. https://doi.org/10.3174/ajnr.A2085
  • Zhang, M. J., Jiang, J. J., Jiang, M. S., & He, W. (2010). F-18 FDG PET/CT in primary tonsillar lymphoma. Clinical nuclear medicine, 35(9), 710–712. https://doi.org/10.1097/RLU.0b013e3181e9fc29
  • Ilica, A. T., Kocacelebi, K., Savas, R., & Ayan, A. (2011). Imaging of extranodal lymphoma with PET/CT. Clinical nuclear medicine, 36(10), e127–e138. https://doi.org/10.1097/RLU.0b013e31821c99cd
  • Suh, C., Kang, Y. K., Roh, J. L., Kim, M. R., Kim, J. S., Huh, J., Lee, J. H., Jang, Y. J., & Lee, B. J. (2008). Prognostic value of tumor 18F-FDG uptake in patients with untreated extranodal natural killer/T-cell lymphomas of the head and neck. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(11), 1783–1789. https://doi.org/10.2967/jnumed.108.053355
  • Broadwater, D. R., & Peker, D. (2018). Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity. Head and neck pathology, 12(4), 481–487. https://doi.org/10.1007/s12105-017-0881-3
  • Han, A. Y., Kuan, E. C., Alonso, J. E., Badran, K. W., & St John, M. A. (2017). Epidemiology of Nasopharyngeal Lymphoma in the United States: A Population-Based Analysis of 1119 Cases. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 156(5), 870–876. https://doi.org/10.1177/0194599817695808
  • Siddiqui, N. A., Branstetter, B. F., 4th, Hamilton, B. E., Ginsberg, L. E., Glastonbury, C. M., Harnsberger, H. R., Barnes, E. L., & Myers, E. N. (2010). Imaging characteristics of primary laryngeal lymphoma. AJNR. American journal of neuroradiology, 31(7), 1261–1265. https://doi.org/10.3174/ajnr.A2085
  • King, A. D., Yuen, E. H., Lei, K. I., Ahuja, A. T., & Van Hasselt, A. (2004). Non-Hodgkin lymphoma of the larynx: CT and MR imaging findings. AJNR. American journal of neuroradiology, 25(1), 12–15.
  • Zhang, M. J., Jiang, J. J., Jiang, M. S., & He, W. (2010). F-18 FDG PET/CT in primary tonsillar lymphoma. Clinical nuclear medicine, 35(9), 710–712. https://doi.org/10.1097/RLU.0b013e3181e9fc29
  • Zucca, E., Conconi, A., & Cavalli, F. (2002). Treatment of extranodal lymphomas. Best practice & research. Clinical haematology, 15(3), 533–547. https://doi.org/10.1053/beha.2002.0218
  • Arcega, R. S., Feinstein, A. J., Bhuta, S., Blackwell, K. E., Rao, N. P., & Pullarkat, S. T. (2015). An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. Diagnostic pathology, 10, 209. https://doi.org/10.1186/s13000-015-0444-4
  • Boland, G. W., Blake, M. A., Holalkere, N. S., & Hahn, P. F. (2009). PET/CT for the characterization of adrenal masses in patients with cancer: qualitative versus quantitative accuracy in 150 consecutive patients. AJR. American journal of roentgenology, 192(4), 956–962. https://doi.org/10.2214/AJR.08.1431
  • Lam, P. D., Kuribayashi, A., Sakamoto, J., Nakamura, S., Harada, H., & Kurabayashi, T. (2017). Imaging findings of childhood B-cell lymphoblastic lymphoma in the mental region: a case report. Dento maxillo facial radiology, 46(3), 20160313. https://doi.org/10.1259/dmfr.20160313
  • Schrepfer, T., Haerle, S. K., Strobel, K., Schaefer, N., Hälg, R. A., & Huber, G. F. (2010). The value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography for staging of primary extranodal head and neck lymphomas. The Laryngoscope, 120(5), 937–944. https://doi.org/10.1002/lary.20843
  • Hutchings, M., & Barrington, S. F. (2009). PET/CT for therapy response assessment in lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 50 Suppl 1, 21S–30S. https://doi.org/10.2967/jnumed.108.057190
  • Dang, N., Xu, W., Song, X., Dai, D., Zhu, L., Zhu, X., Ma, W., & Wang, J. (2014). Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 35(1), 35–39. https://doi.org/10.3760/cma.j.issn.0253-2727.2014.01.009
  • Byun, B. H., Na, I. I., Cheon, G. J., Kang, H. J., Kim, K. M., Lee, S. S., Ryoo, B. Y., Choi, C. W., Lim, S. M., & Yang, S. H. (2008). Clinical significance of 18F-FDG uptake by primary sites in patients with diffuse large B cell lymphoma in the head and neck: a pilot study. Annals of nuclear medicine, 22(8), 645–651. https://doi.org/10.1007/s12149-008-0181-9
  • Schöder, H., Noy, A., Gönen, M., Weng, L., Green, D., Erdi, Y. E., Larson, S. M., & Yeung, H. W. (2005). Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23(21), 4643–4651. https://doi.org/10.1200/JCO.2005.12.072
  • Cheson, B. D., Horning, S. J., Coiffier, B., Shipp, M. A., Fisher, R. I., Connors, J. M., Lister, T. A., Vose, J., Grillo-López, A., Hagenbeek, A., Cabanillas, F., Klippensten, D., Hiddemann, W., Castellino, R., Harris, N. L., Armitage, J. O., Carter, W., Hoppe, R., & Canellos, G. P. (1999). Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17(4), 1244. https://doi.org/10.1200/JCO.1999.17.4.1244
  • Ohtsuka, T., Nomori, H., Watanabe, K., Kaji, M., Naruke, T., Suemasu, K., & Uno, K. (2006). Prognostic significance of [(18)F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma. Cancer, 107(10), 2468–2473. https://doi.org/10.1002/cncr.22268
  • Rodriguez, M., Rehn, S., Ahlström, H., Sundström, C., & Glimelius, B. (1995). Predicting malignancy grade with PET in non-Hodgkin's lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 36(10), 1790–1796.
  • Wiggins RH, Hoffman JM, Fine GC, Covington MF, Salem AE, Koppula BR, Morton KA. (2022). PET-CT in Clinical Adult Oncology-V. Head and Neck and Neuro Oncology. Cancers (Basel), 14(11), 2726.

Year 2023, Volume: 3 Issue: 2, 1 - 8, 13.09.2023

Zehra Pınar Koç Pelin Özcan Kara Emel Sezer Aydan Akdeniz Gülhan Temel

Abstract

Supporting Institution

Mersin Üniversitesi

References

  • Broadwater, D. R., & Peker, D. (2018). Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity. Head and neck pathology, 12(4), 481–487. https://doi.org/10.1007/s12105-017-0881-3
  • Siddiqui, N. A., Branstetter, B. F., 4th, Hamilton, B. E., Ginsberg, L. E., Glastonbury, C. M., Harnsberger, H. R., Barnes, E. L., & Myers, E. N. (2010). Imaging characteristics of primary laryngeal lymphoma. AJNR. American journal of neuroradiology, 31(7), 1261–1265. https://doi.org/10.3174/ajnr.A2085
  • Zhang, M. J., Jiang, J. J., Jiang, M. S., & He, W. (2010). F-18 FDG PET/CT in primary tonsillar lymphoma. Clinical nuclear medicine, 35(9), 710–712. https://doi.org/10.1097/RLU.0b013e3181e9fc29
  • Ilica, A. T., Kocacelebi, K., Savas, R., & Ayan, A. (2011). Imaging of extranodal lymphoma with PET/CT. Clinical nuclear medicine, 36(10), e127–e138. https://doi.org/10.1097/RLU.0b013e31821c99cd
  • Suh, C., Kang, Y. K., Roh, J. L., Kim, M. R., Kim, J. S., Huh, J., Lee, J. H., Jang, Y. J., & Lee, B. J. (2008). Prognostic value of tumor 18F-FDG uptake in patients with untreated extranodal natural killer/T-cell lymphomas of the head and neck. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(11), 1783–1789. https://doi.org/10.2967/jnumed.108.053355
  • Broadwater, D. R., & Peker, D. (2018). Systemic Non-Hodgkin T Cell Lymphomas Presenting in the Head and Neck Region: An Institutional Experience of a Rare Entity. Head and neck pathology, 12(4), 481–487. https://doi.org/10.1007/s12105-017-0881-3
  • Han, A. Y., Kuan, E. C., Alonso, J. E., Badran, K. W., & St John, M. A. (2017). Epidemiology of Nasopharyngeal Lymphoma in the United States: A Population-Based Analysis of 1119 Cases. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 156(5), 870–876. https://doi.org/10.1177/0194599817695808
  • Siddiqui, N. A., Branstetter, B. F., 4th, Hamilton, B. E., Ginsberg, L. E., Glastonbury, C. M., Harnsberger, H. R., Barnes, E. L., & Myers, E. N. (2010). Imaging characteristics of primary laryngeal lymphoma. AJNR. American journal of neuroradiology, 31(7), 1261–1265. https://doi.org/10.3174/ajnr.A2085
  • King, A. D., Yuen, E. H., Lei, K. I., Ahuja, A. T., & Van Hasselt, A. (2004). Non-Hodgkin lymphoma of the larynx: CT and MR imaging findings. AJNR. American journal of neuroradiology, 25(1), 12–15.
  • Zhang, M. J., Jiang, J. J., Jiang, M. S., & He, W. (2010). F-18 FDG PET/CT in primary tonsillar lymphoma. Clinical nuclear medicine, 35(9), 710–712. https://doi.org/10.1097/RLU.0b013e3181e9fc29
  • Zucca, E., Conconi, A., & Cavalli, F. (2002). Treatment of extranodal lymphomas. Best practice & research. Clinical haematology, 15(3), 533–547. https://doi.org/10.1053/beha.2002.0218
  • Arcega, R. S., Feinstein, A. J., Bhuta, S., Blackwell, K. E., Rao, N. P., & Pullarkat, S. T. (2015). An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. Diagnostic pathology, 10, 209. https://doi.org/10.1186/s13000-015-0444-4
  • Boland, G. W., Blake, M. A., Holalkere, N. S., & Hahn, P. F. (2009). PET/CT for the characterization of adrenal masses in patients with cancer: qualitative versus quantitative accuracy in 150 consecutive patients. AJR. American journal of roentgenology, 192(4), 956–962. https://doi.org/10.2214/AJR.08.1431
  • Lam, P. D., Kuribayashi, A., Sakamoto, J., Nakamura, S., Harada, H., & Kurabayashi, T. (2017). Imaging findings of childhood B-cell lymphoblastic lymphoma in the mental region: a case report. Dento maxillo facial radiology, 46(3), 20160313. https://doi.org/10.1259/dmfr.20160313
  • Schrepfer, T., Haerle, S. K., Strobel, K., Schaefer, N., Hälg, R. A., & Huber, G. F. (2010). The value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography for staging of primary extranodal head and neck lymphomas. The Laryngoscope, 120(5), 937–944. https://doi.org/10.1002/lary.20843
  • Hutchings, M., & Barrington, S. F. (2009). PET/CT for therapy response assessment in lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 50 Suppl 1, 21S–30S. https://doi.org/10.2967/jnumed.108.057190
  • Dang, N., Xu, W., Song, X., Dai, D., Zhu, L., Zhu, X., Ma, W., & Wang, J. (2014). Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 35(1), 35–39. https://doi.org/10.3760/cma.j.issn.0253-2727.2014.01.009
  • Byun, B. H., Na, I. I., Cheon, G. J., Kang, H. J., Kim, K. M., Lee, S. S., Ryoo, B. Y., Choi, C. W., Lim, S. M., & Yang, S. H. (2008). Clinical significance of 18F-FDG uptake by primary sites in patients with diffuse large B cell lymphoma in the head and neck: a pilot study. Annals of nuclear medicine, 22(8), 645–651. https://doi.org/10.1007/s12149-008-0181-9
  • Schöder, H., Noy, A., Gönen, M., Weng, L., Green, D., Erdi, Y. E., Larson, S. M., & Yeung, H. W. (2005). Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23(21), 4643–4651. https://doi.org/10.1200/JCO.2005.12.072
  • Cheson, B. D., Horning, S. J., Coiffier, B., Shipp, M. A., Fisher, R. I., Connors, J. M., Lister, T. A., Vose, J., Grillo-López, A., Hagenbeek, A., Cabanillas, F., Klippensten, D., Hiddemann, W., Castellino, R., Harris, N. L., Armitage, J. O., Carter, W., Hoppe, R., & Canellos, G. P. (1999). Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17(4), 1244. https://doi.org/10.1200/JCO.1999.17.4.1244
  • Ohtsuka, T., Nomori, H., Watanabe, K., Kaji, M., Naruke, T., Suemasu, K., & Uno, K. (2006). Prognostic significance of [(18)F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma. Cancer, 107(10), 2468–2473. https://doi.org/10.1002/cncr.22268
  • Rodriguez, M., Rehn, S., Ahlström, H., Sundström, C., & Glimelius, B. (1995). Predicting malignancy grade with PET in non-Hodgkin's lymphoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 36(10), 1790–1796.
  • Wiggins RH, Hoffman JM, Fine GC, Covington MF, Salem AE, Koppula BR, Morton KA. (2022). PET-CT in Clinical Adult Oncology-V. Head and Neck and Neuro Oncology. Cancers (Basel), 14(11), 2726.
There are 23 citations in total.

Details

Primary Language English
Subjects Clinical Oncology, Nuclear Medicine, Haematological Tumours, Biostatistics
Journal Section Research Articles
Authors

Zehra Pınar Koç

Pelin Özcan Kara 0000-0003-0147-2678

Emel Sezer This is me 0000-0001-9881-3533

Aydan Akdeniz 0000-0002-5160-4803

Gülhan Temel 0000-0002-2835-6979

Early Pub Date September 13, 2023
Publication Date September 13, 2023
Published in Issue Year 2023 Volume: 3 Issue: 2

Cite

APA Koç, Z. P., Özcan Kara, P., Sezer, E., Akdeniz, A., et al. (2023). Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma. Molecular Oncologic Imaging, 3(2), 1-8.
AMA Koç ZP, Özcan Kara P, Sezer E, Akdeniz A, Temel G. Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma. Molecular Oncologic Imaging. September 2023;3(2):1-8.
Chicago Koç, Zehra Pınar, Pelin Özcan Kara, Emel Sezer, Aydan Akdeniz, and Gülhan Temel. “Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma”. Molecular Oncologic Imaging 3, no. 2 (September 2023): 1-8.
EndNote Koç ZP, Özcan Kara P, Sezer E, Akdeniz A, Temel G (September 1, 2023) Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma. Molecular Oncologic Imaging 3 2 1–8.
IEEE Z. P. Koç, P. Özcan Kara, E. Sezer, A. Akdeniz, and G. Temel, “Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma”, Molecular Oncologic Imaging, vol. 3, no. 2, pp. 1–8, 2023.
ISNAD Koç, Zehra Pınar et al. “Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma”. Molecular Oncologic Imaging 3/2 (September 2023), 1-8.
JAMA Koç ZP, Özcan Kara P, Sezer E, Akdeniz A, Temel G. Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma. Molecular Oncologic Imaging. 2023;3:1–8.
MLA Koç, Zehra Pınar et al. “Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma”. Molecular Oncologic Imaging, vol. 3, no. 2, 2023, pp. 1-8.
Vancouver Koç ZP, Özcan Kara P, Sezer E, Akdeniz A, Temel G. Mortality Analysis by Means of F-18 FDG PET/CT in High Grade Extranodal Head and Neck Lymphoma. Molecular Oncologic Imaging. 2023;3(2):1-8.