Research Article
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Year 2020, Volume: 1 Issue: 1, 29 - 34, 15.06.2020

Abstract

References

  • 1. Tuncer AA, Bozkurt MF, Koken T, et al. The Protective Effects of Alpha-Lipoic Acid and Coenzyme Q10 Combination on Ovarian Ischemia-Reperfusion Injury: An Experimental Study. Adv Med 2016; doi: 10.1155/2016/3415046
  • 2. Sasaki KJ, Miller CE. Adnexal torsion: review of the literature. J Minim Invasive Gynecol 2014; 21:196-202
  • 3. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol 2000; 190:255-266
  • 4. Ozler A, Turgut A, Soydinç HE, et al. The biochemical and histologic effects of adnexal torsion and early surgical intervention to unwind detorsion on ovarian reserve: an experimental study. Reprod Sci 2013; 20:1349-1355
  • 5. Behroozi-Lak T, Zarei L, Moloody-Tapeh M, et al. Protective effects of intraperitoneal administration of nimodipine on ischemia-reperfusion injury in ovaries: Histological and biochemical assessments in a rat model. J Pediatr Surg 2017; 52:602-608
  • 6. Kurt RK, Dogan AC, Dogan M, et al. Protective effect of colchicine on ovarian ischemia-reperfusion injury: an experimental study. Reprod Sci 2015; 22:545-550
  • 7. Gungor AN, Turkon H, Albayrak A, et al. Does Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion? Eur J Obstet Gynecol Reprod Biol 2014; 181:240-245
  • 8. Sengul O, Ferah I, Polat B, et al. Blockade of endothelin receptors with bosentan limits ischaemia/reperfusion-induced injury in rat ovaries. Eur J Obstet Gynecol Reprod Biol 2013; 170:458-463
  • 9. Park ES, Kim J, Ha TU, et al. TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts. Experimental & molecular medicine 2013; 45:e35
  • 10. Kohen R, Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. 2002; Toxicologic pathology 30:620-650
  • 11. Yapca OE, Borekci B, Suleyman H. 2013. Ischemia-reperfusion damage. Eurasian J Med 2013; 2013; 45:126-137
  • 12. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38:1103-1111
  • 13. Karhausen J, Qing M, Gibson A, et al. Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. Critical care medicine 2013; 41:e200-210
  • 14. Zhuang P, Wan Y, Geng S, et al. Salvianolic Acids for Injection (SAFI) suppresses inflammatory responses in activated microglia to attenuate brain damage in focal cerebral ischemia. Journal of ethnopharmacology 2017; 198:194-204
  • 15. Van Antwerpen P, Boudjeltia KZ, Babar S, et al. Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation. Biochemical and biophysical research communications 2005; 337:82-88
  • 16. Eraslan E, Tanyeli A, Polat E, et al. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. 2019; J Cell Physiol 234:4572-4581
  • 17. Eraslan E, Tanyeli A, Polat E, et al. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. 2019; J Cell Biochem 120:17159-17266
  • 18. Ozturk D, Erdogan DG, Tanyeli A, et al. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 2019; 44:539-548
  • 19. Tanyeli A, Guler MC, Eraslan E, et al. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 2020; 9:246-250
  • 20. Dogan C, Halici Z, Topcu A, et al. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. 2016; Andrologia 48:441-452
  • 21. Han Q, Yuan Q, Meng X, Huo J, Bao Y, et al. 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ. Oncotarget 2017; 8:42001-42006
  • 22. Na JY, Song K, Lee JW, et al. Pretreatment of 6-shogaol attenuates oxidative stress and inflammation in middle cerebral artery occlusion-induced mice. 2016; Eur J Pharmacol 788:241-257
  • 23. Moon M, Kim HG, Choi JG, et al. 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochem Biophys Res Commun 2014; 449:8-13
  • 24. Celik M, Aksoy AN, Aksoy H, et al. Sildenafil Reduces Ischemia-Reperfusion Injury in Rat Ovary: Biochemical and Histopathological Evaluation. Gynecologic and Obstetric Investigation 2014; 78:162-167
  • 25. Hassan SM, Hassan AH. The possibility of using shogaol for treatment of ulcerative colitis. Iran J Basic Med Sci 2018; 21:943-949
  • 26. Ohkawa H, Ohishi N, Yagi K. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 1979; 95:351-358
  • 27. Sun Y, Oberley LW, Li Y. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 1988; 34:497-500
  • 28. Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78:206-209
  • 29. McWilliams GD, Hill MJ, Dietrich CS. Gynecologic emergencies. Surg Clin North Am 2008; 88:265-283, vi
  • 30. Houry D, Abbott JT. Ovarian torsion: a fifteen-year review. Ann Emerg Med 2001; 38:156-169
  • 31. Ugurel V, Cicek AC, Cemek M, et al. Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury. Iran J Basic Med Sci 2017; 20:53-68
  • 32. Zimmerman BJ, Granger DN. Reperfusion injury. Surg Clin North Am 1992; 72:65-83
  • 33. Borekci B, Gundogdu C, Altunkaynak BZ, et al. The protective effect of dehydroepiandrosterone on ovarian tissues after torsion-detorsion injury: a stereological and histopathological study. Eurasian J Med 2009; 41:22-7
  • 34. Wu MY, Yiang GT, Liao WT, et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem 2018; 46:1650-1667
  • 35. Pınar N, Soylu Karapınar O, Özcan O, et al. Protective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino rats. Can J Physiol Pharmacol 2017; 95:861-875
  • 36. Tanyeli A, Güzel D. Investigation into the Biochemical Effects of Barbaloin on Renal Tissue in Cecal Ligation and Puncture-Induced Polymicrobial Sepsis Model in Rats. Southern Clinics of Istanbul Eurasia 2019; 30:285-299
  • 37. Tanyeli A, Güzel D. Alliin mitigates Cecal Ligation Puncture (CLP)-induced lung injury through antioxidant and antiinflammatory effects. Turhish Journal of Sciences 2019; 4:46-59
  • 38. Ekinci Akdemir FN, Tanyeli A. The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture. 2019; 4:22-29
  • 39. Tanyeli A, Guler MC, Sebin SO, et al. Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats. Medicine Science International Medical Journal 2019; 8:644-650
  • 40. Refaie MMM, El-Hussieny M. Protective effect of pioglitazone on ovarian ischemia reperfusion injury of female rats via modulation of peroxisome proliferator activated receptor gamma and heme-oxygenase 1. Int Immunopharmacol 2018; 62:7-14
  • 41. Erkanli Senturk G, Erkanli K, Aydin U, et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 2013; 40:82-88
  • 42. Gough DR, Cotter TG. Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell death & disease 2011; 2:e213
  • 43. Tang Y, Li S, Zhang P, et al. Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats. Oxid Med Cell Longev 2016; doi: 10.1155/2016/5057405
  • 44. Yazici S, Demirtas S, Guclu O, et al. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 2014; 29:450-465
  • 45. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical biochemistry 2004; 37:112-129
  • 46. Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. British medical bulletin 2004; 70:71-86
  • 47. Dinarello CA. Proinflammatory cytokines. Chest 2000; 118:503-518
  • 48. Tanyeli A, Ekinci Akdemir F, Eraslan E, et al. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal 2020; 9:166-173
  • 49. Topdagi O, Tanyeli A, Akdemir Ekinci FN, et al. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences 2020; 242:117217
  • 50. Güzel D, Tanyeli A. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal 2018; 8:410-415
  • 51. Güzel D, Tanyeli A. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal 2018; 8:260-265
  • 52. Topdağı O, Akdemir Ekinci NF, Erdoğan Güzel D, et al.Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 2019; (4)2:92-99
  • 53. Tanyeli A, Akdemir Ekinci NF, Eraslan E, et al. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal 2020; 9:166-173
  • 54. Mascolo N, Jain R, Jain SC, et al. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol 1989; 27:129-140
  • 55. Suekawa M, Ishige A, Yuasa K, et al. Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn 1984; 7:836-848
  • 56. Park G, Kim HG, Ju MS, et al. 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation. Acta Pharmacol Sin 2013; 34:1131-1139
  • 57. Shim S, Kim S, Kwon YB, et al. Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor. Food Chem Toxicol 2012; 50:597-602
  • 58. Ha SK, Moon E, Ju MS, et al. 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology 2012; 63:211-223
  • 59. Butt MS, Sultan MT. Ginger and its health claims: molecular aspects. Crit Rev Food Sci Nutr 2011; 51:383-393
  • 60. Kim MO, Lee MH, Oi N, et al. [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. Carcinogenesis 2014; 35:683-691

Role of 6-Shogaol Against Ovarian Torsion Detorsion-Induced Reproductive Organ Damage

Year 2020, Volume: 1 Issue: 1, 29 - 34, 15.06.2020

Abstract

6-Shogaol was examined on ovarian torsion detorsion (T/D) rat model to find out the potential beneficial results exist or not. 4 groups were composed to establish the experimental step. Sprague-Dawley female rats were used in the experiment. Each group included 8 rats and 32 rats were examined totally. Groups were designed as: Sham, T/D, T/D+Dimethyl sulfoxide (DMSO) and T/D+6-Shogaol groups. Sham group: Only abdominal incision was performed and closed without any additional process. T/D group: 3 hours torsion and 3 hours detorsion process were established following the abdominal incision. T/D+DMSO group: 0.3 ml of DMSO was given as intraperitoneal 30 minutes before detorsion. T/D+6-Shogaol group: 6-Shogaol was administered as intraperitoneal 30 minutes prior to detorsion. At the end of the experiment, high doses of anesthesia was preferred for the euthanasia of the rats and the ovarian tissues were excised in order to obtain samples. Oxidative biomarkers such as MPO activity, OSI, IL-1β, MDA, TNF-α and TOS levels elevated significantly but TAS and SOD levels diminished in T/D group compared to sham group. On the other hand, 6-Shogaol administration provided a decrease in oxidant parameters and elevated TAS and SOD levels, antioxidant mediators. Consequently, 6-Shogaol demonstrated beneficial activity by protecting the ovarian tissues against ovarian injury induced by experimental T/D rat model.

References

  • 1. Tuncer AA, Bozkurt MF, Koken T, et al. The Protective Effects of Alpha-Lipoic Acid and Coenzyme Q10 Combination on Ovarian Ischemia-Reperfusion Injury: An Experimental Study. Adv Med 2016; doi: 10.1155/2016/3415046
  • 2. Sasaki KJ, Miller CE. Adnexal torsion: review of the literature. J Minim Invasive Gynecol 2014; 21:196-202
  • 3. Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol 2000; 190:255-266
  • 4. Ozler A, Turgut A, Soydinç HE, et al. The biochemical and histologic effects of adnexal torsion and early surgical intervention to unwind detorsion on ovarian reserve: an experimental study. Reprod Sci 2013; 20:1349-1355
  • 5. Behroozi-Lak T, Zarei L, Moloody-Tapeh M, et al. Protective effects of intraperitoneal administration of nimodipine on ischemia-reperfusion injury in ovaries: Histological and biochemical assessments in a rat model. J Pediatr Surg 2017; 52:602-608
  • 6. Kurt RK, Dogan AC, Dogan M, et al. Protective effect of colchicine on ovarian ischemia-reperfusion injury: an experimental study. Reprod Sci 2015; 22:545-550
  • 7. Gungor AN, Turkon H, Albayrak A, et al. Does Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion? Eur J Obstet Gynecol Reprod Biol 2014; 181:240-245
  • 8. Sengul O, Ferah I, Polat B, et al. Blockade of endothelin receptors with bosentan limits ischaemia/reperfusion-induced injury in rat ovaries. Eur J Obstet Gynecol Reprod Biol 2013; 170:458-463
  • 9. Park ES, Kim J, Ha TU, et al. TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts. Experimental & molecular medicine 2013; 45:e35
  • 10. Kohen R, Nyska A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. 2002; Toxicologic pathology 30:620-650
  • 11. Yapca OE, Borekci B, Suleyman H. 2013. Ischemia-reperfusion damage. Eurasian J Med 2013; 2013; 45:126-137
  • 12. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005; 38:1103-1111
  • 13. Karhausen J, Qing M, Gibson A, et al. Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. Critical care medicine 2013; 41:e200-210
  • 14. Zhuang P, Wan Y, Geng S, et al. Salvianolic Acids for Injection (SAFI) suppresses inflammatory responses in activated microglia to attenuate brain damage in focal cerebral ischemia. Journal of ethnopharmacology 2017; 198:194-204
  • 15. Van Antwerpen P, Boudjeltia KZ, Babar S, et al. Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation. Biochemical and biophysical research communications 2005; 337:82-88
  • 16. Eraslan E, Tanyeli A, Polat E, et al. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. 2019; J Cell Physiol 234:4572-4581
  • 17. Eraslan E, Tanyeli A, Polat E, et al. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. 2019; J Cell Biochem 120:17159-17266
  • 18. Ozturk D, Erdogan DG, Tanyeli A, et al. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 2019; 44:539-548
  • 19. Tanyeli A, Guler MC, Eraslan E, et al. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 2020; 9:246-250
  • 20. Dogan C, Halici Z, Topcu A, et al. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. 2016; Andrologia 48:441-452
  • 21. Han Q, Yuan Q, Meng X, Huo J, Bao Y, et al. 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ. Oncotarget 2017; 8:42001-42006
  • 22. Na JY, Song K, Lee JW, et al. Pretreatment of 6-shogaol attenuates oxidative stress and inflammation in middle cerebral artery occlusion-induced mice. 2016; Eur J Pharmacol 788:241-257
  • 23. Moon M, Kim HG, Choi JG, et al. 6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia. Biochem Biophys Res Commun 2014; 449:8-13
  • 24. Celik M, Aksoy AN, Aksoy H, et al. Sildenafil Reduces Ischemia-Reperfusion Injury in Rat Ovary: Biochemical and Histopathological Evaluation. Gynecologic and Obstetric Investigation 2014; 78:162-167
  • 25. Hassan SM, Hassan AH. The possibility of using shogaol for treatment of ulcerative colitis. Iran J Basic Med Sci 2018; 21:943-949
  • 26. Ohkawa H, Ohishi N, Yagi K. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 1979; 95:351-358
  • 27. Sun Y, Oberley LW, Li Y. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 1988; 34:497-500
  • 28. Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78:206-209
  • 29. McWilliams GD, Hill MJ, Dietrich CS. Gynecologic emergencies. Surg Clin North Am 2008; 88:265-283, vi
  • 30. Houry D, Abbott JT. Ovarian torsion: a fifteen-year review. Ann Emerg Med 2001; 38:156-169
  • 31. Ugurel V, Cicek AC, Cemek M, et al. Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury. Iran J Basic Med Sci 2017; 20:53-68
  • 32. Zimmerman BJ, Granger DN. Reperfusion injury. Surg Clin North Am 1992; 72:65-83
  • 33. Borekci B, Gundogdu C, Altunkaynak BZ, et al. The protective effect of dehydroepiandrosterone on ovarian tissues after torsion-detorsion injury: a stereological and histopathological study. Eurasian J Med 2009; 41:22-7
  • 34. Wu MY, Yiang GT, Liao WT, et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem 2018; 46:1650-1667
  • 35. Pınar N, Soylu Karapınar O, Özcan O, et al. Protective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino rats. Can J Physiol Pharmacol 2017; 95:861-875
  • 36. Tanyeli A, Güzel D. Investigation into the Biochemical Effects of Barbaloin on Renal Tissue in Cecal Ligation and Puncture-Induced Polymicrobial Sepsis Model in Rats. Southern Clinics of Istanbul Eurasia 2019; 30:285-299
  • 37. Tanyeli A, Güzel D. Alliin mitigates Cecal Ligation Puncture (CLP)-induced lung injury through antioxidant and antiinflammatory effects. Turhish Journal of Sciences 2019; 4:46-59
  • 38. Ekinci Akdemir FN, Tanyeli A. The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture. 2019; 4:22-29
  • 39. Tanyeli A, Guler MC, Sebin SO, et al. Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats. Medicine Science International Medical Journal 2019; 8:644-650
  • 40. Refaie MMM, El-Hussieny M. Protective effect of pioglitazone on ovarian ischemia reperfusion injury of female rats via modulation of peroxisome proliferator activated receptor gamma and heme-oxygenase 1. Int Immunopharmacol 2018; 62:7-14
  • 41. Erkanli Senturk G, Erkanli K, Aydin U, et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 2013; 40:82-88
  • 42. Gough DR, Cotter TG. Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell death & disease 2011; 2:e213
  • 43. Tang Y, Li S, Zhang P, et al. Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats. Oxid Med Cell Longev 2016; doi: 10.1155/2016/5057405
  • 44. Yazici S, Demirtas S, Guclu O, et al. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 2014; 29:450-465
  • 45. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical biochemistry 2004; 37:112-129
  • 46. Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. British medical bulletin 2004; 70:71-86
  • 47. Dinarello CA. Proinflammatory cytokines. Chest 2000; 118:503-518
  • 48. Tanyeli A, Ekinci Akdemir F, Eraslan E, et al. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal 2020; 9:166-173
  • 49. Topdagi O, Tanyeli A, Akdemir Ekinci FN, et al. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences 2020; 242:117217
  • 50. Güzel D, Tanyeli A. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal 2018; 8:410-415
  • 51. Güzel D, Tanyeli A. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal 2018; 8:260-265
  • 52. Topdağı O, Akdemir Ekinci NF, Erdoğan Güzel D, et al.Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 2019; (4)2:92-99
  • 53. Tanyeli A, Akdemir Ekinci NF, Eraslan E, et al. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal 2020; 9:166-173
  • 54. Mascolo N, Jain R, Jain SC, et al. Ethnopharmacologic investigation of ginger (Zingiber officinale). J Ethnopharmacol 1989; 27:129-140
  • 55. Suekawa M, Ishige A, Yuasa K, et al. Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn 1984; 7:836-848
  • 56. Park G, Kim HG, Ju MS, et al. 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation. Acta Pharmacol Sin 2013; 34:1131-1139
  • 57. Shim S, Kim S, Kwon YB, et al. Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor. Food Chem Toxicol 2012; 50:597-602
  • 58. Ha SK, Moon E, Ju MS, et al. 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology 2012; 63:211-223
  • 59. Butt MS, Sultan MT. Ginger and its health claims: molecular aspects. Crit Rev Food Sci Nutr 2011; 51:383-393
  • 60. Kim MO, Lee MH, Oi N, et al. [6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. Carcinogenesis 2014; 35:683-691
There are 60 citations in total.

Details

Primary Language English
Subjects Medical Physiology
Journal Section Research Articles
Authors

Mustafa Can Güler

Ayhan Tanyeli 0000-0002-0095-0917

Ersen Eraslan 0000-0003-2424-2269

Fazile Nur Ekinci Akdemir 0000-0001-9585-3169

Publication Date June 15, 2020
Submission Date May 30, 2020
Published in Issue Year 2020 Volume: 1 Issue: 1

Cite

EndNote Güler MC, Tanyeli A, Eraslan E, Ekinci Akdemir FN (June 1, 2020) Role of 6-Shogaol Against Ovarian Torsion Detorsion-Induced Reproductive Organ Damage. New Trends in Medicine Sciences 1 1 29–34.