Abstract
Introduction: Lymphadenopathy is the rapid or slow growth of lymph nodes. The differential diagnosis of lymphadenopathy frequently encountered in internal diseases, Ear Nose Throat and infectious diseases clinics has a wide range. The growth of lymph nodes is a common finding during physical examination and most of them are benign. It usually develops due to infectious, neoplastic or autoimmune diseases Localization of lymphadenopathies may also provide important clues in diagnosis. Lymphoma, toxoplasma, rubella, tuberculous lymphadenitis in cervical lymphadenopathies; gastrointestinal system malignancies or lymphoma in supraclavicular lymphadenopathies; In patients with axillary lymphadenopathies, infections such as lymphoma, brucellosis and catarrest disease are common. Objective: To review the diagnostic data of lymphadenopathies in the pathology department of the Faculty of Medicine of Ataturk University. Materials and Methods: The diagnostic results of lymph node excisions in Ataturk University Faculty of Medicine Pathology Department were retrospectively analyzed, categorized, and the number of cases was determined according to the ages. Results: Of the 1658 patients, 835 (52.7%) were reactive lymphadenitis, 462 (29.1%) were malignant tumor metastasis positive lymph node, and 165 (10.4%) were lymphoid malignancy, 122 (7.7%) Non-Hodgkin lymphoma, 41 (2.5%) were reported as Hodgkin lymphoma and 2 (0.1%) as plasma cell dyscrasias. 96 (6.0%) of the cases were diagnosed as necrotizing granulomatous lymphadenitis and 27 (1.7%) were diagnosed as non-necrotizing granulomatous lymphadenitis. No histomorphological details of the lymph node were found in 73 specimens (4.6%) that were sent as lymph node excision. Most of the cases were excised from the cervical region and the second line was axillary region. Conclusion: Lymphadenopathies may be the first manifestation of infections and various cancers. In these patients, delayed diagnosis may cause significant medical problems and should be excised without delay for histopathological diagnosis.
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References
- 1. Baytan B, Güneş A.M, Günay Ü. Çocukluk Çağında Lenfadenomegaliler. Güncel Pediatri 2006; 2: 49-51. 2. Newman K, Hayes-Jordan AA. Lymph Node Disorders. In: Grosfeld JL, O’Neil JA, Fonkalsrud EW, Coran AG ( eds). Pediatric Surgery, Mosby Elsevier, Philadelphia, USA, 6 th ed. 2006: p.844-9. 3. Akyüz C. Lenfadenopatili çocuğa yaklaşım. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Sempozyumu 2006; 49: 17-28. 4. Lanzkowsky P. Lymphadenopathy and Splenomegaly. In: Philip Lanzkowsky (ed). Manual of Pediatric Hematology and Oncology, Elsevier Academic Pres. New York, USA, 5th ed. 2011;463- 8 5. Nolder AR. Paediatric cervical lymphadenopathy: When to biopsy. Curr Opin Otolaryngol Head Neck Surg 2013;21:567-70. 6. Şen M. Çocukluk çağı lenfadenopatilerinin değerlendirilmesi. Selçuk Üniversitesi, Uzmanlık Tezi, 2009. 7. Leung AK, Robson WL. Childhood cervical lymphadenopathy. J Pediatr Health Care 2004; 18: 3-7. 8. Oguz A. Çocukluk çağındaki periferal lenfadenopatiler. Sürekli Tıp Egitim Dergisi 1993;2: 335-9 9. Sibanda EN, Stanczuk G. Lymph node pathology in Zimbabwe: A review of 2194 specimens. Q J Med 1993;86:811- 817. 10. Adeniji KA, Anjorin AS. Peripheral lymphadenopathy in Nigeria. Afr J Med Med Sci 2000;29:233-237. 11. Mohan A, Reddy MK, Phaneendra BV, et al. Aetiology of peripheral lymphadenopathy in adults: Analysis of 1724 cases seen at a tertiary care teaching hospital in southern India. Natl Med J India 2007;20:78-80. 12. Cianchetti M, Mancuso AA, Amdur RJ, Werning JW, Kirwan J, Morris CG et all. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Laryngoscope 2009;119(12): 2348-2354. 13. Dilber M, Erişen I, Yerci Ö, Coşkun H, Basut O, Onart S, Hızalan İ. Tiroid dışı baş boyun kitlelerinde ince iğne aspirasyon sitolojisi sonuçlarımız. Türk Otolarengeloji Arşivi, 2005;43:86-93.. 14. Darnal HK, Karim N, Kamini K, et al. The profile of lymphadenopathy in adults and children. Med J Malaysia 2005; 60:590-598. 15. Desforges ]F, Rutherford C], Piro A. Hodgkin’s Disease. N Engl J Med 1979;301:1212-1222. 16. 40.M. Gül ve ark. Erişkin çağı periferik lenfadenopatileriDicle Tıp Derg / Dicle Med J www.diclemedj.org Cilt / Vol 40, No 2, 245-249. 17. Öksüz RYÇ, Dağdemir A, Acar S, Elli M, Öksüz M. Çocukluk çağı periferik lenfadenomegalili olguların retrospektif değerlendirilmesi. OMÜ Tıp Dergisi 2008;25:94–101. 18. Adesuwa Olu-Eddo N, Egbagbe EE. Peripheral lymphadenopathy in Nigerian children. Niger J Clin Pract 2006;9:134-8.
Abstract
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References
- 1. Baytan B, Güneş A.M, Günay Ü. Çocukluk Çağında Lenfadenomegaliler. Güncel Pediatri 2006; 2: 49-51. 2. Newman K, Hayes-Jordan AA. Lymph Node Disorders. In: Grosfeld JL, O’Neil JA, Fonkalsrud EW, Coran AG ( eds). Pediatric Surgery, Mosby Elsevier, Philadelphia, USA, 6 th ed. 2006: p.844-9. 3. Akyüz C. Lenfadenopatili çocuğa yaklaşım. İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Sempozyumu 2006; 49: 17-28. 4. Lanzkowsky P. Lymphadenopathy and Splenomegaly. In: Philip Lanzkowsky (ed). Manual of Pediatric Hematology and Oncology, Elsevier Academic Pres. New York, USA, 5th ed. 2011;463- 8 5. Nolder AR. Paediatric cervical lymphadenopathy: When to biopsy. Curr Opin Otolaryngol Head Neck Surg 2013;21:567-70. 6. Şen M. Çocukluk çağı lenfadenopatilerinin değerlendirilmesi. Selçuk Üniversitesi, Uzmanlık Tezi, 2009. 7. Leung AK, Robson WL. Childhood cervical lymphadenopathy. J Pediatr Health Care 2004; 18: 3-7. 8. Oguz A. Çocukluk çağındaki periferal lenfadenopatiler. Sürekli Tıp Egitim Dergisi 1993;2: 335-9 9. Sibanda EN, Stanczuk G. Lymph node pathology in Zimbabwe: A review of 2194 specimens. Q J Med 1993;86:811- 817. 10. Adeniji KA, Anjorin AS. Peripheral lymphadenopathy in Nigeria. Afr J Med Med Sci 2000;29:233-237. 11. Mohan A, Reddy MK, Phaneendra BV, et al. Aetiology of peripheral lymphadenopathy in adults: Analysis of 1724 cases seen at a tertiary care teaching hospital in southern India. Natl Med J India 2007;20:78-80. 12. Cianchetti M, Mancuso AA, Amdur RJ, Werning JW, Kirwan J, Morris CG et all. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Laryngoscope 2009;119(12): 2348-2354. 13. Dilber M, Erişen I, Yerci Ö, Coşkun H, Basut O, Onart S, Hızalan İ. Tiroid dışı baş boyun kitlelerinde ince iğne aspirasyon sitolojisi sonuçlarımız. Türk Otolarengeloji Arşivi, 2005;43:86-93.. 14. Darnal HK, Karim N, Kamini K, et al. The profile of lymphadenopathy in adults and children. Med J Malaysia 2005; 60:590-598. 15. Desforges ]F, Rutherford C], Piro A. Hodgkin’s Disease. N Engl J Med 1979;301:1212-1222. 16. 40.M. Gül ve ark. Erişkin çağı periferik lenfadenopatileriDicle Tıp Derg / Dicle Med J www.diclemedj.org Cilt / Vol 40, No 2, 245-249. 17. Öksüz RYÇ, Dağdemir A, Acar S, Elli M, Öksüz M. Çocukluk çağı periferik lenfadenomegalili olguların retrospektif değerlendirilmesi. OMÜ Tıp Dergisi 2008;25:94–101. 18. Adesuwa Olu-Eddo N, Egbagbe EE. Peripheral lymphadenopathy in Nigerian children. Niger J Clin Pract 2006;9:134-8.
Details
| Primary Language | English |
|---|---|
| Subjects | Infectious Diseases |
| Journal Section | Research Articles |
| Authors | |
| Project Number | - |
| Publication Date | June 15, 2020 |
| Submission Date | May 31, 2020 |
| Published in Issue | Year 2020 Volume: 1 Issue: 1 |
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