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A case of neurobrucellosis

Year 2015, Volume: 32 Issue: 1, 0 - , 24.04.2015

Abstract

Brucellosis is a multisystemic disease that may present with a broad spectrum of clinical manifestations and complications. Neurological symptoms are common in brucellosis. Neurobrucellosis associated with central nervous system involvement is a rare clinical form of disease, (1.7-7% of prevalence). A 50-year-old man presented with confusion, bilateral vestibulocochlear nerve paralysis, symptoms of cerebellar dysfunction, atrophy and paralysis of multiple muscles. Involvement of both central and peripheral nervous system as well as the production of Brucella melitensis in the cerebro-spinal fluid culture was thought to be eligible for presentation. In laboratory tests; Rose-Bengal test in blood serum was positive; brucella tube agglutination test was 1/160 positive and Brucella melitensis was reproduced in cerebro-spinal fluid culture. He was treated with rifampicin (600 mg/day), doxycycline (200 mg/day) and ceftriaxone (2000 mg/day) combination. After one month, the patient was hospitalized for a second time as symptoms and findings of prior clinical picture were again detected. Rose-Bengal in blood serum, Brucella tube agglutination (1/160 titration) and Brucella tube agglutination with coombs (1/160 titration) tests were positive. In conclusion; in a case of subacute progressive neurobrucellosis, successful results may be attained by application of a proper antibacterial combination in a sufficient dose and for a sufficient time period.

References

  • Al-Sous, M.W., Bohlega, S., Al-Kawi, M.Z., Al, Watban, J., McLean, D.R., 2004. Neurobrucellosis: Clinical and neuroimaging correlation. Am. J. Neuroradiol. 25, 395-401.
  • Bilgin, R.R., Özes, İ., Gedizlioğlu, M., 1994. Nörobruselloz: Bir olgu nedeni ile önemli bir ayırıcı tanı seçeneğinin anımsanması. Nöropsikiyatri Arşivi. 31, 66-73.
  • Ceran, N., Turkoglu, R., Erdem, İ., İnan, A., Engin, D., Tireli, H., Göktaş, P., 2011. Neurobrucellosis: Clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region. Braz. J. Infect. Dis. 15, 52-59. doi: 10.1590/S1413-86702011000100010.
  • Demiroğlu, Y.Z., Turun, T., Karaca, S., Arlıer, Z., Alışkan, H., Çolakoğlu, Ş., Arslan, H., 2011. Brusellozda sinir sistemi tutulumu; klinik sınıflama, tedavi ve sonuçlar. Mikrobiyol. Bul. 45, 401-410.
  • Karaca, S., Selçuki, D., Mavioğlu, H., Dönmez, H., 2001. Nörobruselloz: Olgu Sunumu. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 54, 381- 386.
  • Okuyucu, A.A., Yılmazer, S., Dede, H.Ö., Melek, İ., Duman, T., 2011. Bir nörobruselloz olgusu. Türk Serebrovasküler Hastalıklar Dergisi. 17, 73-76.
  • Özdemir, D., Albayrak, F., Cesur, S., Gönenli, B., Sözen, T.H., Tekeli, E., 2003. Bir nörobruselloz olgusu. İnfeksiyon dergisi. 17, 499-500.
  • Pelit, M., Ergüven, M., Laloğlu, F., Çetiner, N., Arıyaylalıoğlu, S., 2009. Papillit ile seyreden nörobruselloz olgusu. İstanbul Tıp Fakültesi Dergisi. 72, 61-64.
  • Sengoz, A.I., Ceran, N., Erdem, İ., Engin, D., Senbayrak, S., Ozyurek, S.C., Goktas, P., 2010. Neurobrucellosis with transient ischemic attack, vasculopathic changes, intracerebral granulomas and basal ganglia infarction: A case report. J. Med. Case Reports. 4, 340. doi: 10.1186/1752- 1947-4-340.
  • Shakir, R.A., Al-Din, A.S., Araj, G.F., Lulu, A.R., Mousa, A.R., Saadah, M.A., 1987. Clinical categories of neurobrucellosis. A report on 19 cases. Brain. 110, 13-223. doi: 10.1093/brain/110.1.213.
  • Yetkin, M.A., Bulut, C., Erdinc, F.Ş., Oral, B., Tulek, N., 2006. Evaluation of the clinical presentations in neurobrucellosis. Int. J. Infect. Dis. 10, 446–452. doi:10.1016/j.ijid.2006.05.007.
Year 2015, Volume: 32 Issue: 1, 0 - , 24.04.2015

Abstract

References

  • Al-Sous, M.W., Bohlega, S., Al-Kawi, M.Z., Al, Watban, J., McLean, D.R., 2004. Neurobrucellosis: Clinical and neuroimaging correlation. Am. J. Neuroradiol. 25, 395-401.
  • Bilgin, R.R., Özes, İ., Gedizlioğlu, M., 1994. Nörobruselloz: Bir olgu nedeni ile önemli bir ayırıcı tanı seçeneğinin anımsanması. Nöropsikiyatri Arşivi. 31, 66-73.
  • Ceran, N., Turkoglu, R., Erdem, İ., İnan, A., Engin, D., Tireli, H., Göktaş, P., 2011. Neurobrucellosis: Clinical, diagnostic, therapeutic features and outcome. Unusual clinical presentations in an endemic region. Braz. J. Infect. Dis. 15, 52-59. doi: 10.1590/S1413-86702011000100010.
  • Demiroğlu, Y.Z., Turun, T., Karaca, S., Arlıer, Z., Alışkan, H., Çolakoğlu, Ş., Arslan, H., 2011. Brusellozda sinir sistemi tutulumu; klinik sınıflama, tedavi ve sonuçlar. Mikrobiyol. Bul. 45, 401-410.
  • Karaca, S., Selçuki, D., Mavioğlu, H., Dönmez, H., 2001. Nörobruselloz: Olgu Sunumu. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 54, 381- 386.
  • Okuyucu, A.A., Yılmazer, S., Dede, H.Ö., Melek, İ., Duman, T., 2011. Bir nörobruselloz olgusu. Türk Serebrovasküler Hastalıklar Dergisi. 17, 73-76.
  • Özdemir, D., Albayrak, F., Cesur, S., Gönenli, B., Sözen, T.H., Tekeli, E., 2003. Bir nörobruselloz olgusu. İnfeksiyon dergisi. 17, 499-500.
  • Pelit, M., Ergüven, M., Laloğlu, F., Çetiner, N., Arıyaylalıoğlu, S., 2009. Papillit ile seyreden nörobruselloz olgusu. İstanbul Tıp Fakültesi Dergisi. 72, 61-64.
  • Sengoz, A.I., Ceran, N., Erdem, İ., Engin, D., Senbayrak, S., Ozyurek, S.C., Goktas, P., 2010. Neurobrucellosis with transient ischemic attack, vasculopathic changes, intracerebral granulomas and basal ganglia infarction: A case report. J. Med. Case Reports. 4, 340. doi: 10.1186/1752- 1947-4-340.
  • Shakir, R.A., Al-Din, A.S., Araj, G.F., Lulu, A.R., Mousa, A.R., Saadah, M.A., 1987. Clinical categories of neurobrucellosis. A report on 19 cases. Brain. 110, 13-223. doi: 10.1093/brain/110.1.213.
  • Yetkin, M.A., Bulut, C., Erdinc, F.Ş., Oral, B., Tulek, N., 2006. Evaluation of the clinical presentations in neurobrucellosis. Int. J. Infect. Dis. 10, 446–452. doi:10.1016/j.ijid.2006.05.007.
There are 11 citations in total.

Details

Primary Language English
Journal Section Internal Medical Sciences
Authors

Aslı Akın

Feyza Demiralin This is me

Rıfat Bilgin This is me

Selma Tosun

Gülşen Mermut This is me

Muhteşem Gedizoğlu This is me

Publication Date April 24, 2015
Submission Date October 12, 2013
Published in Issue Year 2015 Volume: 32 Issue: 1

Cite

APA Akın, A., Demiralin, F., Bilgin, R., Tosun, S., et al. (2015). A case of neurobrucellosis. Journal of Experimental and Clinical Medicine, 32(1). https://doi.org/10.5835/jecm.omu.32.01.008
AMA Akın A, Demiralin F, Bilgin R, Tosun S, Mermut G, Gedizoğlu M. A case of neurobrucellosis. J. Exp. Clin. Med. May 2015;32(1). doi:10.5835/jecm.omu.32.01.008
Chicago Akın, Aslı, Feyza Demiralin, Rıfat Bilgin, Selma Tosun, Gülşen Mermut, and Muhteşem Gedizoğlu. “A Case of Neurobrucellosis”. Journal of Experimental and Clinical Medicine 32, no. 1 (May 2015). https://doi.org/10.5835/jecm.omu.32.01.008.
EndNote Akın A, Demiralin F, Bilgin R, Tosun S, Mermut G, Gedizoğlu M (May 1, 2015) A case of neurobrucellosis. Journal of Experimental and Clinical Medicine 32 1
IEEE A. Akın, F. Demiralin, R. Bilgin, S. Tosun, G. Mermut, and M. Gedizoğlu, “A case of neurobrucellosis”, J. Exp. Clin. Med., vol. 32, no. 1, 2015, doi: 10.5835/jecm.omu.32.01.008.
ISNAD Akın, Aslı et al. “A Case of Neurobrucellosis”. Journal of Experimental and Clinical Medicine 32/1 (May 2015). https://doi.org/10.5835/jecm.omu.32.01.008.
JAMA Akın A, Demiralin F, Bilgin R, Tosun S, Mermut G, Gedizoğlu M. A case of neurobrucellosis. J. Exp. Clin. Med. 2015;32. doi:10.5835/jecm.omu.32.01.008.
MLA Akın, Aslı et al. “A Case of Neurobrucellosis”. Journal of Experimental and Clinical Medicine, vol. 32, no. 1, 2015, doi:10.5835/jecm.omu.32.01.008.
Vancouver Akın A, Demiralin F, Bilgin R, Tosun S, Mermut G, Gedizoğlu M. A case of neurobrucellosis. J. Exp. Clin. Med. 2015;32(1).