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Year 2021, Volume: 38 Issue: 4, 599 - 603, 09.10.2021

Abstract

References

  • Alizargar, J., Bai, C.H., 2018. Comparison of carotid ultrasound indices and the triglyceride glucose index in hypertensive and normotensive community-dwelling individuals: a case control study for evaluating atherosclerosis. Medicina (Kaunas, Lithuania). 54, 71.
  • Cho, Y.R., Ann, S.H., Won, K.B., Park, G.M., Kim, Y.G., Yang, D.H., Kang, J.W., Lim, T.H., Kim, H.K., Choe, J., Lee, S.W., Kim, Y.H., Kim, S.J., Lee, S.G., 2019. Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes. Sci. Rep. 9, 6129.
  • da Silva, A., Caldas, A.P.S., Hermsdorff, H.H.M., Bersch-Ferreira, Â.C., Torreglosa, C.R., Weber, B., Bressan, J., 2019. Triglyceride‑glucose index is associated with sympto‑ matic coronary artery disease in patients in secondary care. Cardiovasc. Diabetol. 18, 89.
  • Dhingra, R., Vasan, R.S., 20102. Age as a Cardiovascular Risk Factor. Med. Clin. North Am. 96, 87-91.
  • Gensini, G.G., 1983. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol., 51, 606.
  • Irace. C., Carallo, C., Scavelli, F.B., De Franceschi, M.S., Esposito, T., Tripolino, C., Gnasso, A., 2013. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int. J. Clin. Pract. 67, 665-72.
  • Jin, J.L., Cao, Y.X., Wu, L.G., You, X.D., Guo, Y.L., Wu, N.Q., Zhu, C.G., Gao, Y., Dong, Q.T., Zhang, H.W., Sun, D., Liu, G., Dong, Q., Li, J.J., 2018. Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease. J Thorac Dis. 10, 6137-6146.
  • Kim, J.H., Lee, D.Y., Park, S.E., Park, C.Y., Lee, W.Y., Oh, K.W., Park, S.W., Rhee, E.J., 2017. Triglyceride glucose index predicts coronary artery calcification better than other indices of insulin resistance in Korean adults: the Kangbuk Samsung Health Study. Precis. Future Med. 1, 43-51.
  • Kim, M.K., Ahn, C.W., Kang, S., Nam, J.S., Kim, K.R., Park, J.S., 2017. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc. Diabetol. 16, 108.
  • Lambrinoudaki, I., Kazani, M.V., Armeni, E., Georgiopoulos, G., Tampakis, K., Rizos, D., Augoulea, A., Kaparos, G., Alexandrou, A., Stamatelopoulos, K., 2018. The TyG index as a marker of subclinical atherosclerosis and arterial stiffness in lean and overweight postmenopausal women. Heart Lung Circ. 27, 716-24.
  • Lee, E.Y., Yang, H.K., Lee, J., Kang, B., Yang, Y., Lee, S.H., Ko, S.H., Ahn, Y.B., Cha, BY, Yoon, K.H., Cho, J.H., 2016. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 15, 155.
  • Lee, S.B., Ahn, C.W., Lee, B.K., Kang, S., Nam, J.S., You, J.H., Kim, M.J., Kim, M.K., Park, J.S., 2018. Association between triglyceride glucose index and arterial stiffness in Korean adults. Cardiovasc. Diabetol. 17, 41.
  • Mao, Q., Zhou, D., Li, Y., Wang, Y., Xu, S.C., Zhao, X.H., 2019. The triglyceride-glucose index predicts coronary artery disease severity and cardiovascular outcomes in patients with non-ST segment elevation acute coronary syndrome. Dis. Markers. 6891537.
  • Ormazabal, V., Nair, S., Elfeky, O., Aguayo, C., Salomon, C., Zuñiga, F.A., 2018. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc. Diabetol. 17, 122.
  • Park, G.M., Cho, Y.R., Won, K.B., Yang, Y.J., Park, S., Ann, S.H., Kim, Y.G., Park, E.J., Kim, S.J., Lee, S.G., Yang, D.H., Kang, J.W., Lim, T.H., Kim, H.K., Choe, J., Lee, S.W., Kim, Y.H., 2020. Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors. Lipids Health Dis. 19, 7.
  • Park, K., Ahn, C.W., Lee, S.B., Kang, S., Nam, J.S., Lee, B.K., Kim, J.H., Park, J.S., 2019. Elevated TyG index predicts progression of coronary artery calcification. Diabetes Care. 42, 1569-1573.
  • Sánchez-Iñigo. L., Navarro-González. D., Fernández-Montero. A., Pastrana-Delgado, J., Martínez, J.A., 2017. Risk of incident ischemic stroke according to the metabolic health and obesity states in the Vascular-Metabolic CUN cohort. Int. J. Stroke 12, 187-91.
  • Sánchez-Íñigo, L., Navarro-González, D., Fernández-Montero, A., Pastrana-Delgado, J., Martínez, JA., 2016. The TyG index may predict the development of cardiovascular events. Eur. J. Clin. Invest. 46, 189-197.
  • Simental‑Mendía, L.E., Rodríguez‑Morán, M., Guerrero‑Romero, F., 2008. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab. Syndr. Relat. Disord. 6, 299-304.
  • Sulistyono, T., Nughara, T., Wasyanto, T., 2020. Glucose trigliserdie index as a predictor of severity of coronary artery assesesed with syntax score I in acıuye coronary sydrome patients. ACI. 6, 127-134.
  • SYNTAX working group. SYNTAX score calculator. Available at http://www.syntaxscore.com. Accessed May 20, 2012.
  • Thai, P.V., Tien, H.A., Minh, H., Valensi, P., 2020. Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes Cardiovasc. Diabetol. 19, 137.
  • Vega, G.L., Barlow, C.E., Grundy, S.M., Leonard, D., De Fina, L.F., 2014. Triglyceride-to-high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men. J. Investig. Med. 62, 345-349.
  • Won, K.B., Park, E.J., Han, D., Lee, J.H., Choi, S.Y., Chun, E.J., Park, S.H., Han, H.W., Sung, J., Jung, H.O., Chang, H.J., 2020. Triglyceride glucose index is an independent predictor for the progression of coronary artery calcication in the absence of heavy coronary artery calcication at baseline. Cardiovasc. Diabetol.19, 34.
  • Zhao, Q., Zhang, T.Y., Cheng, Y.J., Ma, Y., Xu, Y.K., Yang, J.Q., Zhou, Y.J., 2020 Impacts of triglyceride glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST segment elevation acute coronary syndrome: results from an observational cohort study in China. Cardiovasc. Diabetol. 19, 108.

The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study

Year 2021, Volume: 38 Issue: 4, 599 - 603, 09.10.2021

Abstract

Triglyceride glucose index (TyG) plays an important role in metabolic syndrome (MetS), which predisposes to the development of cardiovascular diseases (CVD). Mostly, the association between the TyG index and coronary artery disease (CAD) has been investigated in healthy individuals on long-term follow-up or in asymptomatic patients with a mild and mild-moderate cardiovascular risk profile. However there are few studies evaluating the association of TyG index with CAD in symptomatic patients. In hence, we aimed to determine the role of the TyG index in the presence and severity of CAD in symptomatic patients with high suspicion of CAD in this study. 100 patients who underwent coronary angiography were included and the patients were divided into two groups according to the presence of CAD. TyG index was calculated by the formula Ln [fasting triglycerides (mg/dl)xfasting glucose (mg/dl)/2]. The severity of CAD was assessed by angiographic risk scores GENSINI, SYNTAX I, and the number of diseased vessels. TyG index did not differ significantly between patients with and without CAD. Also, there was no significant correlation between TyG index and GENSINI, SYNTAX I, and the number of diseased vessels. (for all p>0.05) In multiple logistic regression analysis, the only independent predictor of CAD was age. (p=0.03, OR=1.048, 95% CI=1.004-1.094) In conclusion, TyG index may not be a useful marker for predicting the presence or severity of CAD. According to the results of this study, age is the only predictor of CAD independent of all causes.

References

  • Alizargar, J., Bai, C.H., 2018. Comparison of carotid ultrasound indices and the triglyceride glucose index in hypertensive and normotensive community-dwelling individuals: a case control study for evaluating atherosclerosis. Medicina (Kaunas, Lithuania). 54, 71.
  • Cho, Y.R., Ann, S.H., Won, K.B., Park, G.M., Kim, Y.G., Yang, D.H., Kang, J.W., Lim, T.H., Kim, H.K., Choe, J., Lee, S.W., Kim, Y.H., Kim, S.J., Lee, S.G., 2019. Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes. Sci. Rep. 9, 6129.
  • da Silva, A., Caldas, A.P.S., Hermsdorff, H.H.M., Bersch-Ferreira, Â.C., Torreglosa, C.R., Weber, B., Bressan, J., 2019. Triglyceride‑glucose index is associated with sympto‑ matic coronary artery disease in patients in secondary care. Cardiovasc. Diabetol. 18, 89.
  • Dhingra, R., Vasan, R.S., 20102. Age as a Cardiovascular Risk Factor. Med. Clin. North Am. 96, 87-91.
  • Gensini, G.G., 1983. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol., 51, 606.
  • Irace. C., Carallo, C., Scavelli, F.B., De Franceschi, M.S., Esposito, T., Tripolino, C., Gnasso, A., 2013. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int. J. Clin. Pract. 67, 665-72.
  • Jin, J.L., Cao, Y.X., Wu, L.G., You, X.D., Guo, Y.L., Wu, N.Q., Zhu, C.G., Gao, Y., Dong, Q.T., Zhang, H.W., Sun, D., Liu, G., Dong, Q., Li, J.J., 2018. Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease. J Thorac Dis. 10, 6137-6146.
  • Kim, J.H., Lee, D.Y., Park, S.E., Park, C.Y., Lee, W.Y., Oh, K.W., Park, S.W., Rhee, E.J., 2017. Triglyceride glucose index predicts coronary artery calcification better than other indices of insulin resistance in Korean adults: the Kangbuk Samsung Health Study. Precis. Future Med. 1, 43-51.
  • Kim, M.K., Ahn, C.W., Kang, S., Nam, J.S., Kim, K.R., Park, J.S., 2017. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc. Diabetol. 16, 108.
  • Lambrinoudaki, I., Kazani, M.V., Armeni, E., Georgiopoulos, G., Tampakis, K., Rizos, D., Augoulea, A., Kaparos, G., Alexandrou, A., Stamatelopoulos, K., 2018. The TyG index as a marker of subclinical atherosclerosis and arterial stiffness in lean and overweight postmenopausal women. Heart Lung Circ. 27, 716-24.
  • Lee, E.Y., Yang, H.K., Lee, J., Kang, B., Yang, Y., Lee, S.H., Ko, S.H., Ahn, Y.B., Cha, BY, Yoon, K.H., Cho, J.H., 2016. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 15, 155.
  • Lee, S.B., Ahn, C.W., Lee, B.K., Kang, S., Nam, J.S., You, J.H., Kim, M.J., Kim, M.K., Park, J.S., 2018. Association between triglyceride glucose index and arterial stiffness in Korean adults. Cardiovasc. Diabetol. 17, 41.
  • Mao, Q., Zhou, D., Li, Y., Wang, Y., Xu, S.C., Zhao, X.H., 2019. The triglyceride-glucose index predicts coronary artery disease severity and cardiovascular outcomes in patients with non-ST segment elevation acute coronary syndrome. Dis. Markers. 6891537.
  • Ormazabal, V., Nair, S., Elfeky, O., Aguayo, C., Salomon, C., Zuñiga, F.A., 2018. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc. Diabetol. 17, 122.
  • Park, G.M., Cho, Y.R., Won, K.B., Yang, Y.J., Park, S., Ann, S.H., Kim, Y.G., Park, E.J., Kim, S.J., Lee, S.G., Yang, D.H., Kang, J.W., Lim, T.H., Kim, H.K., Choe, J., Lee, S.W., Kim, Y.H., 2020. Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors. Lipids Health Dis. 19, 7.
  • Park, K., Ahn, C.W., Lee, S.B., Kang, S., Nam, J.S., Lee, B.K., Kim, J.H., Park, J.S., 2019. Elevated TyG index predicts progression of coronary artery calcification. Diabetes Care. 42, 1569-1573.
  • Sánchez-Iñigo. L., Navarro-González. D., Fernández-Montero. A., Pastrana-Delgado, J., Martínez, J.A., 2017. Risk of incident ischemic stroke according to the metabolic health and obesity states in the Vascular-Metabolic CUN cohort. Int. J. Stroke 12, 187-91.
  • Sánchez-Íñigo, L., Navarro-González, D., Fernández-Montero, A., Pastrana-Delgado, J., Martínez, JA., 2016. The TyG index may predict the development of cardiovascular events. Eur. J. Clin. Invest. 46, 189-197.
  • Simental‑Mendía, L.E., Rodríguez‑Morán, M., Guerrero‑Romero, F., 2008. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab. Syndr. Relat. Disord. 6, 299-304.
  • Sulistyono, T., Nughara, T., Wasyanto, T., 2020. Glucose trigliserdie index as a predictor of severity of coronary artery assesesed with syntax score I in acıuye coronary sydrome patients. ACI. 6, 127-134.
  • SYNTAX working group. SYNTAX score calculator. Available at http://www.syntaxscore.com. Accessed May 20, 2012.
  • Thai, P.V., Tien, H.A., Minh, H., Valensi, P., 2020. Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes Cardiovasc. Diabetol. 19, 137.
  • Vega, G.L., Barlow, C.E., Grundy, S.M., Leonard, D., De Fina, L.F., 2014. Triglyceride-to-high-density-lipoprotein-cholesterol ratio is an index of heart disease mortality and of incidence of type 2 diabetes mellitus in men. J. Investig. Med. 62, 345-349.
  • Won, K.B., Park, E.J., Han, D., Lee, J.H., Choi, S.Y., Chun, E.J., Park, S.H., Han, H.W., Sung, J., Jung, H.O., Chang, H.J., 2020. Triglyceride glucose index is an independent predictor for the progression of coronary artery calcication in the absence of heavy coronary artery calcication at baseline. Cardiovasc. Diabetol.19, 34.
  • Zhao, Q., Zhang, T.Y., Cheng, Y.J., Ma, Y., Xu, Y.K., Yang, J.Q., Zhou, Y.J., 2020 Impacts of triglyceride glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST segment elevation acute coronary syndrome: results from an observational cohort study in China. Cardiovasc. Diabetol. 19, 108.
There are 25 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Sara Çetin Şanlıalp 0000-0001-9328-9197

Gokay Nar 0000-0001-6159-7785

Publication Date October 9, 2021
Submission Date February 25, 2021
Acceptance Date March 7, 2021
Published in Issue Year 2021 Volume: 38 Issue: 4

Cite

APA Çetin Şanlıalp, S., & Nar, G. (2021). The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study. Journal of Experimental and Clinical Medicine, 38(4), 599-603.
AMA Çetin Şanlıalp S, Nar G. The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study. J. Exp. Clin. Med. October 2021;38(4):599-603.
Chicago Çetin Şanlıalp, Sara, and Gokay Nar. “The Evaluation of the Triglyceride Glucose Index in Symptomatic Patients With High Suspicion of Coronary Artery Disease: A Single Center Study”. Journal of Experimental and Clinical Medicine 38, no. 4 (October 2021): 599-603.
EndNote Çetin Şanlıalp S, Nar G (October 1, 2021) The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study. Journal of Experimental and Clinical Medicine 38 4 599–603.
IEEE S. Çetin Şanlıalp and G. Nar, “The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study”, J. Exp. Clin. Med., vol. 38, no. 4, pp. 599–603, 2021.
ISNAD Çetin Şanlıalp, Sara - Nar, Gokay. “The Evaluation of the Triglyceride Glucose Index in Symptomatic Patients With High Suspicion of Coronary Artery Disease: A Single Center Study”. Journal of Experimental and Clinical Medicine 38/4 (October 2021), 599-603.
JAMA Çetin Şanlıalp S, Nar G. The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study. J. Exp. Clin. Med. 2021;38:599–603.
MLA Çetin Şanlıalp, Sara and Gokay Nar. “The Evaluation of the Triglyceride Glucose Index in Symptomatic Patients With High Suspicion of Coronary Artery Disease: A Single Center Study”. Journal of Experimental and Clinical Medicine, vol. 38, no. 4, 2021, pp. 599-03.
Vancouver Çetin Şanlıalp S, Nar G. The evaluation of the triglyceride glucose index in symptomatic patients with high suspicion of coronary artery disease: a single center study. J. Exp. Clin. Med. 2021;38(4):599-603.