Case Report
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Year 2021, Volume: 38 Issue: 4, 685 - 688, 09.10.2021

Abstract

References

  • World Health Organization. Coronavirus disease (COVID-19) Situation Report, 3 December 2020. [Internet] 2020 [cited 24.12.2020]. Available from: https://covid19.who.int/.
  • Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol, 2020; 19(9): 767-83.
  • Giamberardino MA, Affaitati G, Costantini R, Guglielmetti M, Martelletti P. Acute headache management in emergency department. A narrative review. Internal and Emergency Medicine, 2020: 1-9.
  • Li L, Huang T, Wang Y, Wang Z, Liang Y, Huang T, et al. COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis. J Med Virol, 2020; 92(6): 577-83.
  • Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol, 2020; 77(6): 683-90.
  • Lippi G, Mattiuzzi C, Bovo C, Henry BM. Headache is an important symptom in patients with coronavirus disease 2019 (COVID-19). Diagnosis, 2020; 7(4): 409-11.
  • Bolay H, Gül A, Baykan B. COVID‐19 is a Real Headache! Headache, 2020; 60: 1415-21.
  • Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 2020.
  • Sampaio Rocha-Filho PA, Magalhães JE. Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia. Cephalalgia, 2020; 40(13): 1443-51.
  • Toptan T, Aktan C, Basari A, Bolay H. Case Series of Headache Characteristics in COVID‐19: Headache Can Be an Isolated Symptom. Headache, 2020; 60(8): 1788-92.
  • Karadas O, Ozturk B, Sonkaya AR. A prospective clinical study of detailed neurological manifestations in patients with COVID-19. Neurol Sci, 2020; 41(8): 1991-5.
  • Freilinger TM, Lieb M, Schankin C, Noachtar S. Herpes simplex virus type 2 meningitis and symptomatic migraine. J Neurol, 2011; 258(4): 689-90.
  • Sriwastava S, Kanna A, Basha O, Xu J, Yarraguntla K, George E. Varicella zoster encephalitis in an immunocompromised patient presented with migraine type headache: A case report. eNeurologicalSci, 2019; 16: 100205.
  • Vacchiano V, Riguzzi P, Volpi L, Tappata M, Avoni P, Rizzo G, et al. Early neurological manifestations of hospitalized COVID-19 patients. Neurol Sci, 2020; 41(8): 2029-31.
  • Pinzon RT, Wijaya VO, Buana RB, Al Jody A, Nunsio PN. Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis. Front Neurol, 2020; 11: 565.

Headache can be the only symptom of COVID-19: a case series

Year 2021, Volume: 38 Issue: 4, 685 - 688, 09.10.2021

Abstract

Headache is the fourth most common cause among the total applications to emergency services; it constitutes 5% of the applications to hospitals every year. Five-fold increase was detected in the incidence of headache in the regions affected by coronavirus disease-2019 (COVID-19) pandemic. While the symptoms of respiratory systems have been frequently observed, the occurrence of symptoms and complications in peripheral and central nervous system has become increasingly prevalent in the cases of COVID-19 disease. In this case series, we highlight that the patients with isolated headache may be diagnosed with COVID-19 infection. Three female patients (forty, sixty and sixty-two years of old) were admitted to the emergency service with complaints of severe headache. Their headache did not respond to the paracetamol and the nonsteroidal anti-inflammatory drug (NSAID) they used prior to their application to the hospital. No pathologic finding was detected in cerebral imaging. All patients were diagnosed with COVID-19 by their clinical status and history. The headache was the isolated symptom of the COVID-19 in all the three cases. The possibility of COVID-19 infection must be considered in the evaluation of the patients admitted to hospital with complaints of headache, one of the most frequent reasons for hospital assistance requests.

References

  • World Health Organization. Coronavirus disease (COVID-19) Situation Report, 3 December 2020. [Internet] 2020 [cited 24.12.2020]. Available from: https://covid19.who.int/.
  • Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. Lancet Neurol, 2020; 19(9): 767-83.
  • Giamberardino MA, Affaitati G, Costantini R, Guglielmetti M, Martelletti P. Acute headache management in emergency department. A narrative review. Internal and Emergency Medicine, 2020: 1-9.
  • Li L, Huang T, Wang Y, Wang Z, Liang Y, Huang T, et al. COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis. J Med Virol, 2020; 92(6): 577-83.
  • Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol, 2020; 77(6): 683-90.
  • Lippi G, Mattiuzzi C, Bovo C, Henry BM. Headache is an important symptom in patients with coronavirus disease 2019 (COVID-19). Diagnosis, 2020; 7(4): 409-11.
  • Bolay H, Gül A, Baykan B. COVID‐19 is a Real Headache! Headache, 2020; 60: 1415-21.
  • Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 2020.
  • Sampaio Rocha-Filho PA, Magalhães JE. Headache associated with COVID-19: Frequency, characteristics and association with anosmia and ageusia. Cephalalgia, 2020; 40(13): 1443-51.
  • Toptan T, Aktan C, Basari A, Bolay H. Case Series of Headache Characteristics in COVID‐19: Headache Can Be an Isolated Symptom. Headache, 2020; 60(8): 1788-92.
  • Karadas O, Ozturk B, Sonkaya AR. A prospective clinical study of detailed neurological manifestations in patients with COVID-19. Neurol Sci, 2020; 41(8): 1991-5.
  • Freilinger TM, Lieb M, Schankin C, Noachtar S. Herpes simplex virus type 2 meningitis and symptomatic migraine. J Neurol, 2011; 258(4): 689-90.
  • Sriwastava S, Kanna A, Basha O, Xu J, Yarraguntla K, George E. Varicella zoster encephalitis in an immunocompromised patient presented with migraine type headache: A case report. eNeurologicalSci, 2019; 16: 100205.
  • Vacchiano V, Riguzzi P, Volpi L, Tappata M, Avoni P, Rizzo G, et al. Early neurological manifestations of hospitalized COVID-19 patients. Neurol Sci, 2020; 41(8): 2029-31.
  • Pinzon RT, Wijaya VO, Buana RB, Al Jody A, Nunsio PN. Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis. Front Neurol, 2020; 11: 565.
There are 15 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Nur Şimşek Yurt 0000-0002-6585-9663

Yusuf Can Yurt 0000-0003-0732-289X

Metin Ocak 0000-0002-9978-0216

Publication Date October 9, 2021
Submission Date March 9, 2021
Acceptance Date March 27, 2021
Published in Issue Year 2021 Volume: 38 Issue: 4

Cite

APA Şimşek Yurt, N., Yurt, Y. C., & Ocak, M. (2021). Headache can be the only symptom of COVID-19: a case series. Journal of Experimental and Clinical Medicine, 38(4), 685-688.
AMA Şimşek Yurt N, Yurt YC, Ocak M. Headache can be the only symptom of COVID-19: a case series. J. Exp. Clin. Med. October 2021;38(4):685-688.
Chicago Şimşek Yurt, Nur, Yusuf Can Yurt, and Metin Ocak. “Headache Can Be the Only Symptom of COVID-19: A Case Series”. Journal of Experimental and Clinical Medicine 38, no. 4 (October 2021): 685-88.
EndNote Şimşek Yurt N, Yurt YC, Ocak M (October 1, 2021) Headache can be the only symptom of COVID-19: a case series. Journal of Experimental and Clinical Medicine 38 4 685–688.
IEEE N. Şimşek Yurt, Y. C. Yurt, and M. Ocak, “Headache can be the only symptom of COVID-19: a case series”, J. Exp. Clin. Med., vol. 38, no. 4, pp. 685–688, 2021.
ISNAD Şimşek Yurt, Nur et al. “Headache Can Be the Only Symptom of COVID-19: A Case Series”. Journal of Experimental and Clinical Medicine 38/4 (October 2021), 685-688.
JAMA Şimşek Yurt N, Yurt YC, Ocak M. Headache can be the only symptom of COVID-19: a case series. J. Exp. Clin. Med. 2021;38:685–688.
MLA Şimşek Yurt, Nur et al. “Headache Can Be the Only Symptom of COVID-19: A Case Series”. Journal of Experimental and Clinical Medicine, vol. 38, no. 4, 2021, pp. 685-8.
Vancouver Şimşek Yurt N, Yurt YC, Ocak M. Headache can be the only symptom of COVID-19: a case series. J. Exp. Clin. Med. 2021;38(4):685-8.