Research Article
Year 2022,
Volume: 44 Issue: 6, 779 - 785, 28.11.2022
Abstract
The pineal gland metastatic disease is relatively uncommon. Our research’s objective was to assess pineal gland metastasis findings from magnetic resonance imaging (MRI). We queried the radiology reports of brain MRI examinations performed between September 2010 and December 2019. After identifying cases, patient characteristics including sex, age, diagnosis, survival time, and MRI features including size (largest cross-sectional diameter), T1- Weighted Image (WI) signal, T2-WI signal, contrast enhancement, and additional brain metastatic involvement area were evaluated. Our investigation identified 7 patients with pineal gland metastasis. Underlying malignancies were lung (N 2), breast (N 2), prostate cancer (N 1), neuroblastoma (N 1), and non-Hodgkin lymphoma (N 1). The average survival period after the detection of the pineal gland metastasis is 3.14 ± 3.93 months. The lesions ranged in size from 0.8 to 1.8 cm (mean 1.18±0.38 cm). Six tumors were isointense to gray matter both on T1-WI and T2-WI. One showed heterogeneous signal intensities on T1-WI and T2-WI. 6 out of 7 tumors showed homogenous solid enhancement while one tumor showed heterogeneous enhancement due to necrosis. Two patients had leptomeningeal, one patient had pituitary stalk, one patient had parenchyma, and one patient had calvarium-dural metastases. In the remaining 3 patients, no accompanying metastases were observed in brain. The presence of pineal gland lesions in patients with known malignancy should increase suspicion of metastatic involvement.
Supporting Institution
Not applicable
References
- Ji J, Gu C, Zhang M, et al. Pineal region metastasis with intraventricular seeding: A case report and literature review. Medicine (Baltimore). 2019;98(34):e16652.
- Ortega P, Malamud N, Shimkin MB. Metastasis to the pineal body. AMA Arch Pathol. 1952;52:518-528.
- Lassman AB, Bruce JN, Fetell MR. Metastases to the pineal gland. Neurology. 2006;67:1303-1304.
- Su SC, Hsieh MJ, Yang WE, et al. Cancer metastasis: Mechanisms of inhibition by melatonin. J Pineal Res. 2017;62(1):10.1111/jpi.12370.
- Xin Z, Jiang S, Jiang P, et al. Melatonin as a treatment for gastrointestinal cancer: a review. J Pineal Res. 2015;58:375-387.
- Menendez-Menendez J, Martínez-Campa C. Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers. Int J Endocrinol. 2018;2018:3271948.
- Li J, Wang P, Wang B. Unique Case Report of Pineal Gland Metastasis From Bladder Carcinoma. Medicine (Baltimore). 2016;95:e3622.
- Tahtabasi M, Erturk SM, Basak M. Comparison of MRI and 18F-FDG PET/CT in the Liver Metastases of Gastrointestinal and Pancreaticobiliary Tumors. Sisli Etfal Hastan Tip Bul. 2021;55(1): 12-17.
- James SH, Halliday WC, Branson HM. Best cases from the AFIP: Trilateral retinoblastoma. Radiographics. 2010;30:833-837.
- Nemoto K, Aoshiba K, Itoh M, et al. Isolated pineal region metastasis from lung adenocarcinoma with obstructive hydrocephalus: a case report. J Med Case Rep. 2013;7:71.
- Kim K, Greenblatt SH, Robinson MG. Choroid plexus carcinoma. Report of a case with cytopathologic differential diagnosis. Acta Cytol. 1985;29:846-89.
- Bilgin C, Korkmaz B, Soylu E, et al. Diffuse large B-cell lymphoma presenting with masses in the pineal and adrenal glands. Clin Case Rep. 2019;7:577-579.
- Gupta A, Johnson M, Hussain A. Pineal Gland Lymphoma: Case Report and Literature Review. J Clin Imaging Sci. 2015;5:51.
- Taydas O, Yesilyurt M, Ogul Y, et al. Isolated pineal gland metastasis of acute lymphocytic leukemia: case report. Cancer Biol Ther. 2020;21(6):503-505.
- Abdallah MA, Shahid M, Ellithi M, et al. Pulmonary Adenocarcinoma Presenting as a Pineal Gland Mass With Obstructive Hydrocephalus. The Ochsner journal. 2020;20(2):232–235.
- Matsuda K, Sakurada K, Kokubo Y, et al. Esophageal neuroendocrine tumor metastatic to the pineal region. Brain Tumor Pathol. 2014;31(3):192-7.
- Kanai H, Yamada K, Aihara N, et al. Pineal region metastasis appearing as hypointensity on T2-weighted magnetic resonance imaging-case report. Neurol Med Chir (Tokyo). 2000;40(5):283-6.
- Fang AS, Meyers SP. Magnetic resonance imaging of pineal region tumours. Insights Imaging. 2013;4: 369-382.
- Alolyani AM, Al Luwimi I, Ammar A. An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations. Cureus. 2021;13(4):e14771.
Year 2022,
Volume: 44 Issue: 6, 779 - 785, 28.11.2022
Abstract
Pineal bez metastazları oldukça nadirdir. Çalışmamızın amacı, pineal bez metastazlarının manyetik rezonans görüntüleme bulgularını değerlendirmektir. Bu çalışmada Eylül 2010 ile Aralık 2019 tarihleri arasında hastane/ radyoloji arşivindeki beyin manyetik rezonans görüntülemelerinin raporları retrospektif olarak tarandı. Olgular belirlendikten sonra, hastaların cinsiyet, yaş, tanı, sağkalım süresi gibi özellikleri ve boyut (en büyük kesit çap), T1 ağırlıklı, T2 ağırlıklı sinyaller, kontrast tutulumu, ek beyin metastatik tutulum alanları gibi özellikler değerlendirildi. Araştırmamızda pineal metastazlı 7 hasta tespit edildi. Altta yatan maligniteler akciğer (N 2), meme (N 2), prostat kanseri (N 1), nöroblastom (N 1), non-Hodgkin lenfoma (N 1) idi. Pineal metastaz saptandıktan sonra ortalama yaşam süresi 3.14 aydı. Lezyonların boyutları 0.8 ile 1.8 cm arasında değişiyordu. Altı tümör, hem T1 ağırlıklı hem de T2 ağırlıklı olarak gri cevhere göre izointens idi. Biri T1 ağırlıklı ve T2 ağırlıklı görüntülerde heterojen sinyal intensitesi gösterdi. 7 tümörden 6'sı homojen solid kontrastlanma gösterirken, bir tümör nekroza bağlı heterojen kontrastlanma gösterdi. İki hastada leptomeningeal, bir hastada hipofiz sapı, bir hastada parankim, bir hastada kalvaryum-dural metastaz vardı. Kalan 3 hastada ise beyinde eşlik eden metastaz izlenmedi. Bilinen malignitesi olan hastalarda pineal lezyonların varlığı metastatik tutulum şüphesini artırmalıdır.
Keywords
pineal bez metastaz manyetik rezonans görüntüleme pineal pineal görüntüleme pineal lezyonlar
References
- Ji J, Gu C, Zhang M, et al. Pineal region metastasis with intraventricular seeding: A case report and literature review. Medicine (Baltimore). 2019;98(34):e16652.
- Ortega P, Malamud N, Shimkin MB. Metastasis to the pineal body. AMA Arch Pathol. 1952;52:518-528.
- Lassman AB, Bruce JN, Fetell MR. Metastases to the pineal gland. Neurology. 2006;67:1303-1304.
- Su SC, Hsieh MJ, Yang WE, et al. Cancer metastasis: Mechanisms of inhibition by melatonin. J Pineal Res. 2017;62(1):10.1111/jpi.12370.
- Xin Z, Jiang S, Jiang P, et al. Melatonin as a treatment for gastrointestinal cancer: a review. J Pineal Res. 2015;58:375-387.
- Menendez-Menendez J, Martínez-Campa C. Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers. Int J Endocrinol. 2018;2018:3271948.
- Li J, Wang P, Wang B. Unique Case Report of Pineal Gland Metastasis From Bladder Carcinoma. Medicine (Baltimore). 2016;95:e3622.
- Tahtabasi M, Erturk SM, Basak M. Comparison of MRI and 18F-FDG PET/CT in the Liver Metastases of Gastrointestinal and Pancreaticobiliary Tumors. Sisli Etfal Hastan Tip Bul. 2021;55(1): 12-17.
- James SH, Halliday WC, Branson HM. Best cases from the AFIP: Trilateral retinoblastoma. Radiographics. 2010;30:833-837.
- Nemoto K, Aoshiba K, Itoh M, et al. Isolated pineal region metastasis from lung adenocarcinoma with obstructive hydrocephalus: a case report. J Med Case Rep. 2013;7:71.
- Kim K, Greenblatt SH, Robinson MG. Choroid plexus carcinoma. Report of a case with cytopathologic differential diagnosis. Acta Cytol. 1985;29:846-89.
- Bilgin C, Korkmaz B, Soylu E, et al. Diffuse large B-cell lymphoma presenting with masses in the pineal and adrenal glands. Clin Case Rep. 2019;7:577-579.
- Gupta A, Johnson M, Hussain A. Pineal Gland Lymphoma: Case Report and Literature Review. J Clin Imaging Sci. 2015;5:51.
- Taydas O, Yesilyurt M, Ogul Y, et al. Isolated pineal gland metastasis of acute lymphocytic leukemia: case report. Cancer Biol Ther. 2020;21(6):503-505.
- Abdallah MA, Shahid M, Ellithi M, et al. Pulmonary Adenocarcinoma Presenting as a Pineal Gland Mass With Obstructive Hydrocephalus. The Ochsner journal. 2020;20(2):232–235.
- Matsuda K, Sakurada K, Kokubo Y, et al. Esophageal neuroendocrine tumor metastatic to the pineal region. Brain Tumor Pathol. 2014;31(3):192-7.
- Kanai H, Yamada K, Aihara N, et al. Pineal region metastasis appearing as hypointensity on T2-weighted magnetic resonance imaging-case report. Neurol Med Chir (Tokyo). 2000;40(5):283-6.
- Fang AS, Meyers SP. Magnetic resonance imaging of pineal region tumours. Insights Imaging. 2013;4: 369-382.
- Alolyani AM, Al Luwimi I, Ammar A. An Elderly Man Suffers a Renal Cell Carcinoma Metastasis in the Pineal Gland: Lessons Learned and Ethical Considerations. Cureus. 2021;13(4):e14771.
There are 19 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | ORİJİNAL MAKALE |
| Authors | |
| Publication Date | November 28, 2022 |
| Published in Issue | Year 2022 Volume: 44 Issue: 6 |