Sleep Quality in Children with Iron Deficiency Anemia

Gülfer Akça

doi:10.26453/otjhs.1233627

Research Article

Sleep Quality in Children with Iron Deficiency Anemia

Year 2023, Volume: 8 Issue: 2, 233 - 238, 06.06.2023

Gülfer Akça

https://doi.org/10.26453/otjhs.1233627

Abstract

Objective: Iron deficiency is the most common cause of anemia in our country as well as all over the world. In this study, it was aimed to evaluate the subjective sleep quality of patients with iron deficiency anemia in childhood.

Materials and Methods: One hundred thirty patients diagnosed with iron deficiency anemia and 110 healthy individuals, gender and age-matched, who applied to the Pediatrics clinic between April 2022 and September 2022, were included in the study. All participants were requested to fill out three forms: a socio-demographic form (age, gender, income level), hemogram laboratory findings and The Pittsburg Sleep Quality Index (PSQI) measures subjective sleep quality, was applied, and the data were analyzed.

Results: Total PSQI score was 6.563.51 in patients, and 4.362.34 in controls. There was a difference between the study and control groups in terms of low hemoglobin, hematocrit, mean erythrocyte volume (MCV) and mean erythrocyte hemoglobin concentration (MCHC) values and decreased sleep quality.

Conclusion: Iron deficiency anemia is a significant public health problem that adversely affects sleep quality in childhood.

Keywords

Childhood, iron deficiency anemia, sleep quality

Supporting Institution

none

References

1. Subramaniam G, Girish M. Iron deficiency anemia in children. Indian J Pediatr. 2015;82(6):558-564. doi:10.1007/s12098-014-1643-9
2. Akin F, Solak ES, Kilicaslan C, Boke SB, Arslan S. Iron Deficiency Anemia among Hospitalized Children in Konya, Turkey. Anemia. 2013; 2013:514801. doi:10.1155/2013/514801
3. Mantadakis E, Chatzimichael E, Zikidou P. Iron Deficiency Anemia in Children Residing in High and Low-Income Countries: Risk Factors, Prevention, Diagnosis and Therapy. Mediterr J Hematol Infect Dis. 2020;12(1):e2020041. doi:10.4084/MJHID.2020.041
4. Saboor M, Zehra A, Hamali HA, Mobarki AA. Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia. Clin Lab. 2021. doi:10.7754/Clin.Lab.2020.200742
5. Shah HE, Bhawnani N, Ethirajulu A, et al. Iron Deficiency-Induced Changes in the Hippocampus, Corpus Striatum, and Monoamines Levels That Lead to Anxiety, Depression, Sleep Disorders, and Psychotic Disorders. Cureus.2021;13(9):e18138. doi:10.7759/cureus.18138
6. Mason GM, Lokhandwala S, Riggins T, Spencer RMC. Sleep and human cognitive development. Sleep Med Rev. 2021; 57:101472. doi: 10.1016/j.smrv.2021.101472
7. Kansagra S. Sleep Disorders in Adolescents. Pediatrics. 2020;145(Suppl 2):S204-S209. doi:10.1542/peds.2019-2056I
8. Benca RM, Teodorescu M. Sleep physiology and disorders in aging and dementia. Handb Clin Neurol. 2019;167:477-493. doi:10.1016/B978-0-12-804766-8.00026-1
9. Peirano PD, Algarín CR, Chamorro R, et al. Sleep and neurofunctions throughout child development: lasting effects of early iron deficiency. J Pediatr Gastroenterol Nutr. 2009;48 Suppl 1(0 1): 8-15. doi:10.1097/MPG.0b013e31819773b
10. Fertrin KY. Diagnosis and management of iron deficiency in chronic inflammatory conditions (CIC): is too little iron making your patient sick?. Hematology Am Soc Hematol Educ Program. 2020;2020(1):478-486. doi:10.1182/hematology.2020000132
11. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213. doi:10.1016/0165-1781(89)90047-4
12. Ağargün MY, Kara H, Anlar Ö. Pittsburgh uyku kalitesi indeksi’nin geçerliliği ve güvenirliliği. Türk Psikiyatri Dergisi.1996;7(2):107-115
13. Pivina L, Semenova Y, Doşa MD, Dauletyarova M, Bjørklund G. Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children. J Mol Neurosci. 2019;68(1):1-10. doi:10.1007/s12031-019-01276-1
14. Holst SC, Landolt HP. Sleep-Wake Neurochemistry. Sleep Med Clin. 2018;13(2):137-146. doi:10.1016/j.jsmc.2018.03.002
15. Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci. 2014;34(2):566-573. doi:10.1523/JNEUROSCI.4128-13.2014
16. Fifel K, Vezoli J, Dzahini K, et al. Alteration of daily and circadian rhythms following dopamine depletion in MPTP treated non-human primates. PLoS One. 2014;9(1): e86240. doi:10.1371/journal.pone.0086240
17. Perihan PD, Algarín CR, Garrido MI, Lozoff B. Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood. Pediatr Res. 2007;62(6):715-719. doi:10.1203/PDR.0b013e3181586aef
18. Baker RD, Greer FR; Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010;126(5):1040–1050
19. Allen RP. Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Med Clin. 2015;10(3):207-xi. doi:10.016/j.jsmc.2015.05.022
20. Al-Shawwa B, Sharma M, Ingram DG. Terrible twos: intravenous iron ameliorates a toddler's iron deficiency and sleep disturbance. J Clin Sleep Med. 2022;18(2):677-680. doi:10.5664/jcsm.9690
21. DelRosso LM, Mogavero MP, Ferri R, Bruni O. Restless Sleep Disorder (RSD): a New Sleep Disorder in Children. A Rapid Review. Curr Neurol Neurosci Rep. 2022;22(7):395-404. doi:10.1007/s11910-022-01200-y
22. Kotagal S. Sleep-Wake Disorders of Childhood. Continuum (Minneap Minn). 2017;23(4, Sleep Neurology):1132-1150. doi:10.1212/CON.0000000000000504
23. Ryan CS, Edlund W, Mandrekar J, Wong-Kisiel LC, Gavrilova RH, Kotagal S. Iron Deficiency and Its Role in Sleep Disruption in Patients With Angelman Syndrome. J Child Neurol. 2020;35(14):963-969. doi:10.1177/0883073820941755
24. Murat S, Ali U, Serdal K, et al. Assessment of subjective sleep quality in iron deficiency anaemia. Afr Health Sci. 2015;15(2):621-627. doi:10.4314/ahs.v15i2.40
25. Kara B, Tenekeci EG. Sleep Quality and Associated Factors in Older Turkish Adults With Hypertension: A Pilot Study. J Transcult Nurs. 2017;28(3):296-305. doi:10.1177/1043659615623330
26. Mikami K, Akama F, Kimoto K, et al. Iron Supplementation for Hypoferritinemia-Related Psychological Symptoms in Children and Adolescents. J Nippon Med Sch. 2022;89(2):203-211. doi: 10.1272/jnms.JNMS.2022_89-216
27. Leung W, Singh I, McWilliams S, Stockler S, Ipsiroglu OS. Iron deficiency and sleep - A scoping review. Sleep Med Rev. 2020;51:101274. doi:10.1016/j.smrv.2020.101274
28. Yehuda S, Rabinovitz-Shenkar S, Carasso RL. Effects of essential fatty acids in iron deficient and sleep-disturbed attention deficit hyperactivity disorder (ADHD) children. Eur J Clin Nutr. 2011;65(10):1167-1169. doi:10.1038/ejcn.2011.80

Demir Eksikliği Anemisi Olan Çocuklarda Uyku Kalitesi

Year 2023, Volume: 8 Issue: 2, 233 - 238, 06.06.2023

Gülfer Akça

https://doi.org/10.26453/otjhs.1233627

Abstract

Amaç: Tüm dünyada olduğu gibi ülkemizde de aneminin en sık sebebi demir eksikliğidir. Bu çalışmada çocukluk çağında demir eksikliği anemisi saptanan hastalarda sübjektif uyku kalitesinin değerlendirilmesi amaçlanmıştır.

Materyal ve Metot: Nisan 2022-Eylül 2022 tarihleri arasında Pediatri kliniğine başvuran yaşları ve cinsiyetleri eşleşmiş 130 demir eksikliği anemisi tanısı alan hasta ve 110 sağlıklı birey çalışmaya dahil edildi. Tüm katılımcılara yaş, cinsiyet, gelir düzeyleri gibi sosyodemografik bilgileri, hemogram laboratuvar bulguları ve subjektif uyku kalitesini ölçen Pittsburg Uyku Kalitesi İndeksi (PUKİ) ölçeğini içeren 3 formdan oluşan anket uygulandı. Veriler analiz edildi.

Bulgular: Hasta grubun toplam PUKİ puanı 6,563,51 kontrol grubun 4,362,34 idi.
Düşük olan hemoglobin, hematokrit, ortalama eritrosit hacmi (MCV) ve ortalama eritrosit hemoglobin konsantrasyonu (MCHC) değerleri ile azalmış uyku kalitesi açısından çalışma ve kontrol grubu arasında fark saptanmıştır

Sonuç: Önemli bir halk sağlığı sorunu olan demir eksikliği anemisi çocukluk çağında uyku kalitesini kötü yönde etkilemektedir.

Keywords

Çocukluk çağı, demir eksikliği anemisi, uyku kalitesi

References

1. Subramaniam G, Girish M. Iron deficiency anemia in children. Indian J Pediatr. 2015;82(6):558-564. doi:10.1007/s12098-014-1643-9
2. Akin F, Solak ES, Kilicaslan C, Boke SB, Arslan S. Iron Deficiency Anemia among Hospitalized Children in Konya, Turkey. Anemia. 2013; 2013:514801. doi:10.1155/2013/514801
3. Mantadakis E, Chatzimichael E, Zikidou P. Iron Deficiency Anemia in Children Residing in High and Low-Income Countries: Risk Factors, Prevention, Diagnosis and Therapy. Mediterr J Hematol Infect Dis. 2020;12(1):e2020041. doi:10.4084/MJHID.2020.041
4. Saboor M, Zehra A, Hamali HA, Mobarki AA. Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia. Clin Lab. 2021. doi:10.7754/Clin.Lab.2020.200742
5. Shah HE, Bhawnani N, Ethirajulu A, et al. Iron Deficiency-Induced Changes in the Hippocampus, Corpus Striatum, and Monoamines Levels That Lead to Anxiety, Depression, Sleep Disorders, and Psychotic Disorders. Cureus.2021;13(9):e18138. doi:10.7759/cureus.18138
6. Mason GM, Lokhandwala S, Riggins T, Spencer RMC. Sleep and human cognitive development. Sleep Med Rev. 2021; 57:101472. doi: 10.1016/j.smrv.2021.101472
7. Kansagra S. Sleep Disorders in Adolescents. Pediatrics. 2020;145(Suppl 2):S204-S209. doi:10.1542/peds.2019-2056I
8. Benca RM, Teodorescu M. Sleep physiology and disorders in aging and dementia. Handb Clin Neurol. 2019;167:477-493. doi:10.1016/B978-0-12-804766-8.00026-1
9. Peirano PD, Algarín CR, Chamorro R, et al. Sleep and neurofunctions throughout child development: lasting effects of early iron deficiency. J Pediatr Gastroenterol Nutr. 2009;48 Suppl 1(0 1): 8-15. doi:10.1097/MPG.0b013e31819773b
10. Fertrin KY. Diagnosis and management of iron deficiency in chronic inflammatory conditions (CIC): is too little iron making your patient sick?. Hematology Am Soc Hematol Educ Program. 2020;2020(1):478-486. doi:10.1182/hematology.2020000132
11. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213. doi:10.1016/0165-1781(89)90047-4
12. Ağargün MY, Kara H, Anlar Ö. Pittsburgh uyku kalitesi indeksi’nin geçerliliği ve güvenirliliği. Türk Psikiyatri Dergisi.1996;7(2):107-115
13. Pivina L, Semenova Y, Doşa MD, Dauletyarova M, Bjørklund G. Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children. J Mol Neurosci. 2019;68(1):1-10. doi:10.1007/s12031-019-01276-1
14. Holst SC, Landolt HP. Sleep-Wake Neurochemistry. Sleep Med Clin. 2018;13(2):137-146. doi:10.1016/j.jsmc.2018.03.002
15. Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci. 2014;34(2):566-573. doi:10.1523/JNEUROSCI.4128-13.2014
16. Fifel K, Vezoli J, Dzahini K, et al. Alteration of daily and circadian rhythms following dopamine depletion in MPTP treated non-human primates. PLoS One. 2014;9(1): e86240. doi:10.1371/journal.pone.0086240
17. Perihan PD, Algarín CR, Garrido MI, Lozoff B. Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood. Pediatr Res. 2007;62(6):715-719. doi:10.1203/PDR.0b013e3181586aef
18. Baker RD, Greer FR; Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010;126(5):1040–1050
19. Allen RP. Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Med Clin. 2015;10(3):207-xi. doi:10.016/j.jsmc.2015.05.022
20. Al-Shawwa B, Sharma M, Ingram DG. Terrible twos: intravenous iron ameliorates a toddler's iron deficiency and sleep disturbance. J Clin Sleep Med. 2022;18(2):677-680. doi:10.5664/jcsm.9690
21. DelRosso LM, Mogavero MP, Ferri R, Bruni O. Restless Sleep Disorder (RSD): a New Sleep Disorder in Children. A Rapid Review. Curr Neurol Neurosci Rep. 2022;22(7):395-404. doi:10.1007/s11910-022-01200-y
22. Kotagal S. Sleep-Wake Disorders of Childhood. Continuum (Minneap Minn). 2017;23(4, Sleep Neurology):1132-1150. doi:10.1212/CON.0000000000000504
23. Ryan CS, Edlund W, Mandrekar J, Wong-Kisiel LC, Gavrilova RH, Kotagal S. Iron Deficiency and Its Role in Sleep Disruption in Patients With Angelman Syndrome. J Child Neurol. 2020;35(14):963-969. doi:10.1177/0883073820941755
24. Murat S, Ali U, Serdal K, et al. Assessment of subjective sleep quality in iron deficiency anaemia. Afr Health Sci. 2015;15(2):621-627. doi:10.4314/ahs.v15i2.40
25. Kara B, Tenekeci EG. Sleep Quality and Associated Factors in Older Turkish Adults With Hypertension: A Pilot Study. J Transcult Nurs. 2017;28(3):296-305. doi:10.1177/1043659615623330
26. Mikami K, Akama F, Kimoto K, et al. Iron Supplementation for Hypoferritinemia-Related Psychological Symptoms in Children and Adolescents. J Nippon Med Sch. 2022;89(2):203-211. doi: 10.1272/jnms.JNMS.2022_89-216
27. Leung W, Singh I, McWilliams S, Stockler S, Ipsiroglu OS. Iron deficiency and sleep - A scoping review. Sleep Med Rev. 2020;51:101274. doi:10.1016/j.smrv.2020.101274
28. Yehuda S, Rabinovitz-Shenkar S, Carasso RL. Effects of essential fatty acids in iron deficient and sleep-disturbed attention deficit hyperactivity disorder (ADHD) children. Eur J Clin Nutr. 2011;65(10):1167-1169. doi:10.1038/ejcn.2011.80

There are 28 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Research article
Authors	Gülfer Akça 0000-0002-7139-3521
Early Pub Date	May 31, 2023
Publication Date	June 6, 2023
Submission Date	January 14, 2023
Acceptance Date	April 20, 2023
Published in Issue	Year 2023 Volume: 8 Issue: 2

Cite

AMA	Akça G. Sleep Quality in Children with Iron Deficiency Anemia. OTJHS. June 2023;8(2):233-238. doi:10.26453/otjhs.1233627

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