Does neutrophil and platelets to lymphocyte ratios predict gleason score upgrading in low-risk prostate cancer patients?
Abstract
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Objective: Some of decision-making factors predicting treatment selection, active surveillance (AS) and active treatment (AT), are expensive and not easily accessible in patients with a low-risk prostate cancer (PCa). Hence, we aimed to determine another tools to accurately identify patients with PCa.
Methods: We retrospectively reviewed the records of 59 men undergoing radical prostatectomy with clinical stage T2a PCa, Gleason score (GS) ≤6 grade , prostate-specific antigen level <10 ng/mL. The patients’ ages, preoperative prostate specific antigen (PSA) lymphocyte ratio (NLR) or platelets to lymphocyte ratio (PLR), pathologic stage, pathologic Gleason score, tumor volume, were noted and compared between groups (upgrade or not upgrade, upstage or not upstage)
Results: The mean age of patients was 64,71±7,59 years, mean PSA value was 9,47±6,17 ng/Ml, mean N/L ratio was 1,86±0,76 and mean N/L ratio was 103,13±32,8. We found that NLR and PLR upgrading were not significantly associated with upgrading or upstaging.
Conclusion: Our results showed that NLR, PLR, are not predictors of Gleason and stage upgrading. Therefore, these tests might not be useful in the assessment of low-risk PCa, when considering patients for AS.
References
- 1-Moyer VA: Screening for prostate cancer: U.S. preventive services task force recommendation statement. Ann Intern Med 2012;157:120–134.
- 2-Bastian PJ, Carter BH, Bjartell A, et al: Insignificant prostate cancer and active surveillance: from definition to clinical implications. Eur Urol 2009;55:1321–1330.
- 3-McVey GP, McPhail S, Fowler S, McIntosh G,Gillatt D, Parker CC: Initial management of low-risk localized prostate cancer in the UK: analysis of the British association of urological surgeons cancer registry. BJU Int 2010;106:1161–1164. .
Düşük risk prostat kanserinde nötrofil lenfosit oranı veya platelet lenfosit oranı tümörde evre yükselmesini öngörebilir mi ?
Abstract
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Amaç: Düşük riskli prostat kanseri (PK) olan hastalarda tedavi seçimi, aktif sürveyans (AS) ve aktif tedaviyi (AT) öngören bazı karar verme faktörleri pahalıdır ve kolayca erişilebilir değildir. Bu nedenle, PCa'lı hastaları doğru bir şekilde tanımlamak için başka bir araç belirlemeyi amaçladık.
Yöntemler: Radikal prostatektomi uygulanan 59 erkeğin, klinik evre T2a, Gleason skor (GS) ≤6, prostat spesifik antijen seviyesi <10 ng/mL, kayıtları retrospektif olarak incelendi. Hastaların yaşları, preoperatif prostat spesifik antijen düzeyleri (PSA), Nötrofil lenfosit oranı (NLO), trombosit lenfosit oranı (PLO), patolojik evresi, patolojik Gleason skoru, tümör hacmi kaydedildi ve gruplar arasında karşılaştırıldı (Klinik evre veya gleason skrounda artış)
Bulgular: Hastaların ortalama yaşı 64,71 ± 7,59 yıl, ortalama PSA değeri 9,47 ± 6,17 ng / Ml, ortalama N / L oranı 1,86 ± 0,76 ve ortalama N / L oran 103,13 ± 32,8'dir. NLO ve PLO yükseltmelerinin yükseltme veya yükseltme ile önemli ölçüde ilişkili olmadığını bulduk.
Sonuç: Sonuçlarımız NLR, PLR'nin Gleason ve aşamalı iyileşmenin yordayıcıları olmadığını göstermiştir. Bu nedenle, bu testler AS için hasta düşünüldüğünde düşük riskli PCa'nın değerlendirilmesinde yararlı olmayabilir.
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References
- 1-Moyer VA: Screening for prostate cancer: U.S. preventive services task force recommendation statement. Ann Intern Med 2012;157:120–134.
- 2-Bastian PJ, Carter BH, Bjartell A, et al: Insignificant prostate cancer and active surveillance: from definition to clinical implications. Eur Urol 2009;55:1321–1330.
- 3-McVey GP, McPhail S, Fowler S, McIntosh G,Gillatt D, Parker CC: Initial management of low-risk localized prostate cancer in the UK: analysis of the British association of urological surgeons cancer registry. BJU Int 2010;106:1161–1164. .
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Urology |
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 4, 2021 |
| Submission Date | July 24, 2020 |
| Acceptance Date | September 30, 2020 |
| Published in Issue | Year 2021 Volume: 14 Issue: 1 |
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