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Year 2021, Volume: 14 Issue: 3, 776 - 783, 01.07.2021

İlknur Hatice Akbudak Özgen Kılıç Egem Tuzcu Hilmiye Pakyürek Z. Melek Bor Küçükatay

https://doi.org/10.31362/patd.923805

Abstract

Purpose: Some anesthetic drugs are known to have influence on circulation due to hemorheological effects.
We aimed to investigate the possible effects of ketamin-xylazine anesthesia, which is extensively used in
experimental animal laboratories on hemorheological parameters.
Materials and methods: Adult, male Wistar-Albino rats were divided into two as control (pre-anesthesia)
and post-anesthesia (n=17). Ketamin-HCl/Xylazine-HCl (90 mg/kg-10 mg/kg) were injected intraperitoneally.
Intracardiac heparinized blood was collected either without anesthesia (control group) or after anesthesia
(post-anesthesia group) following the loss of reflexes such as righting, cornea and withdrawal. Erythrocyte
deformability was determined by an ektacytometer, while WBV (at shear rates of 38, 76 and 190 s-1) and PV
(at 190 s-1 shear rate) at standard (40%) and otolog hematocrit (Hct) were measured via a cone-plate rotational
viscometer.
Results: Mean time taken for the disappearance of righting reflex was 4±3.6, corneal reflex 8±6.8 and for
withdrawal reflex 10±6.7 min. 90 mg/kg Ketamin-10 mg/kg Xylazine administration did not affect RBC
deformability, WBV and PV of the rats.
Conclusion: These results demonstrate that, use of Ketamin/Xylazine anesthesia may be recommended
especially when dealing with hemorheological, cardiovascular and hematological parameters.

References

  • Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), Handbook of Hemorheology and Hemodynamics. IOS Press: Netherlands, 2007
  • Rampling MW. History of Hemorheology, In: Handbook of Hemorheology and Hemodynamics, Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), IOS Press: Netherlands, 2007
  • Sengoz, T., E. Kilic-Toprak, O. Yaylali, O. Kilic-Erkek, Y. Ozdemir, B. Oymak, H. Senol, D. Yuksel, V. Kucukatay, ve M.Bor-Kucukatay, “Hemorheology and oxidative stress in patients with differentiated thyroid cancer following I-131 ablation/metastasis treatment.” Clin. Hemorheol. Microcirc., 74 (2), 209-221 (2020). https://doi.org/10.3233/CH-190717. PMID: 31884456
  • Unver F., E. Kilic-Toprak, O. Kilic-Erkek, H. Korkmaz, O. Yasin, B. Oymak, A. Oskay ve M. Bor-Kucukatay, “Hemorheological alterations following an acute bout of nordic hamstring exercise in active male participants1.” Clin. Hemorheol. Microcirc., 71(4):463-473 (2019) https://doi.org/10.3233/CH-180402.
  • Yaylali Y.T., E. Kilic-Toprak, Y. Ozdemir, H. Senol ve M.Bor-Kucukatay, “Impaired Blood Rheology in Pulmonary Arterial Hypertension.” Heart Lung Circ., Jul;28(7):1067-1073 (2019) https://doi.org/10.1016/j.hlc.2018.07.014.
  • Lowe GDO, Barbenel JC: Plasma and blood viscosity. In: Lowe GDO (eds.), Clinical Blood Rheology. Boca Raton: FL CRC Press, 1998; 11–44
  • Myung J, Park SJ, Lim J, Kim YH, Shin S, Lim CH. Effects of lipopolysaccharide on changes in red blood cells in a mice endotoxemia model. Clin Hemorheol Microcirc. 2016 Oct 5;63(4):305-312. https://doi.org/10.3233/CH-152017

Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor 'yazarın yanıtı'

Year 2021, Volume: 14 Issue: 3, 776 - 783, 01.07.2021

İlknur Hatice Akbudak Özgen Kılıç Egem Tuzcu Hilmiye Pakyürek Z. Melek Bor Küçükatay

https://doi.org/10.31362/patd.923805

Abstract

Akbudak ve ark.’nın “Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor” başlıklı araştırma makalesi ile ilgili bir “Editöre Mektup” yazılarak çalışmayla ilgili bazı eleştirilerde bulunulmuş ve çalışmanın özgün olmadığı iddia edilmiştir. Bu yazı, iddialara cevap verilmesi ve çalışmanın “ÖZGÜN” olduğunun bilimsel kurallara uyularak, gerekli literatür bilgileri sunularak net biçimde ortaya konması amacıyla kaleme alınmıştır.

References

  • Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), Handbook of Hemorheology and Hemodynamics. IOS Press: Netherlands, 2007
  • Rampling MW. History of Hemorheology, In: Handbook of Hemorheology and Hemodynamics, Baskurt OK, Hardeman MR, Rampling MW, Meiselman HJ. (eds), IOS Press: Netherlands, 2007
  • Sengoz, T., E. Kilic-Toprak, O. Yaylali, O. Kilic-Erkek, Y. Ozdemir, B. Oymak, H. Senol, D. Yuksel, V. Kucukatay, ve M.Bor-Kucukatay, “Hemorheology and oxidative stress in patients with differentiated thyroid cancer following I-131 ablation/metastasis treatment.” Clin. Hemorheol. Microcirc., 74 (2), 209-221 (2020). https://doi.org/10.3233/CH-190717. PMID: 31884456
  • Unver F., E. Kilic-Toprak, O. Kilic-Erkek, H. Korkmaz, O. Yasin, B. Oymak, A. Oskay ve M. Bor-Kucukatay, “Hemorheological alterations following an acute bout of nordic hamstring exercise in active male participants1.” Clin. Hemorheol. Microcirc., 71(4):463-473 (2019) https://doi.org/10.3233/CH-180402.
  • Yaylali Y.T., E. Kilic-Toprak, Y. Ozdemir, H. Senol ve M.Bor-Kucukatay, “Impaired Blood Rheology in Pulmonary Arterial Hypertension.” Heart Lung Circ., Jul;28(7):1067-1073 (2019) https://doi.org/10.1016/j.hlc.2018.07.014.
  • Lowe GDO, Barbenel JC: Plasma and blood viscosity. In: Lowe GDO (eds.), Clinical Blood Rheology. Boca Raton: FL CRC Press, 1998; 11–44
  • Myung J, Park SJ, Lim J, Kim YH, Shin S, Lim CH. Effects of lipopolysaccharide on changes in red blood cells in a mice endotoxemia model. Clin Hemorheol Microcirc. 2016 Oct 5;63(4):305-312. https://doi.org/10.3233/CH-152017
There are 7 citations in total.

Details

Primary Language Turkish
Subjects Anaesthesiology
Journal Section Letter to Editor
Authors

İlknur Hatice Akbudak 0000-0001-9937-9169

Özgen Kılıç This is me 0000-0001-8037-099X

Egem Tuzcu This is me 0000-0002-9499-2316

Hilmiye Pakyürek This is me 0000-0002-7084-3770

Z. Melek Bor Küçükatay 0000-0002-9366-0205

Publication Date July 1, 2021
Submission Date May 10, 2021
Acceptance Date May 27, 2021
Published in Issue Year 2021 Volume: 14 Issue: 3

Cite

APA Akbudak, İ. H., Kılıç, Ö., Tuzcu, E., Pakyürek, H., et al. (2021). Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor ’yazarın yanıtı’. Pamukkale Medical Journal, 14(3), 776-783. https://doi.org/10.31362/patd.923805
AMA Akbudak İH, Kılıç Ö, Tuzcu E, Pakyürek H, Bor Küçükatay ZM. Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor ’yazarın yanıtı’. Pam Med J. July 2021;14(3):776-783. doi:10.31362/patd.923805
Chicago Akbudak, İlknur Hatice, Özgen Kılıç, Egem Tuzcu, Hilmiye Pakyürek, and Z. Melek Bor Küçükatay. “Ketamin/ksilazin Anestezi Hemoreolojik bakış açısından güvenlidir: Bir Ilk Rapor ’yazarın yanıtı’”. Pamukkale Medical Journal 14, no. 3 (July 2021): 776-83. https://doi.org/10.31362/patd.923805.
EndNote Akbudak İH, Kılıç Ö, Tuzcu E, Pakyürek H, Bor Küçükatay ZM (July 1, 2021) Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor ’yazarın yanıtı’. Pamukkale Medical Journal 14 3 776–783.
IEEE İ. H. Akbudak, Ö. Kılıç, E. Tuzcu, H. Pakyürek, and Z. M. Bor Küçükatay, “Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor ’yazarın yanıtı’”, Pam Med J, vol. 14, no. 3, pp. 776–783, 2021, doi: 10.31362/patd.923805.
ISNAD Akbudak, İlknur Hatice et al. “Ketamin/ksilazin Anestezi Hemoreolojik bakış açısından güvenlidir: Bir Ilk Rapor ’yazarın yanıtı’”. Pamukkale Medical Journal 14/3 (July 2021), 776-783. https://doi.org/10.31362/patd.923805.
JAMA Akbudak İH, Kılıç Ö, Tuzcu E, Pakyürek H, Bor Küçükatay ZM. Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor ’yazarın yanıtı’. Pam Med J. 2021;14:776–783.
MLA Akbudak, İlknur Hatice et al. “Ketamin/ksilazin Anestezi Hemoreolojik bakış açısından güvenlidir: Bir Ilk Rapor ’yazarın yanıtı’”. Pamukkale Medical Journal, vol. 14, no. 3, 2021, pp. 776-83, doi:10.31362/patd.923805.
Vancouver Akbudak İH, Kılıç Ö, Tuzcu E, Pakyürek H, Bor Küçükatay ZM. Ketamin/ksilazin anestezi hemoreolojik bakış açısından güvenlidir: bir ilk rapor ’yazarın yanıtı’. Pam Med J. 2021;14(3):776-83.

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